HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation.

PubWeight™: 1.27‹?› | Rank: Top 10%

🔗 View Article (PMC 2083643)

Published in Biochim Biophys Acta on July 20, 2007

Authors

Michael Schnekenburger1, Li Peng, Alvaro Puga

Author Affiliations

1: Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, Ohio 45267-0056, USA.

Articles citing this

Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol (2008) 2.15

The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. Biochem Pharmacol (2008) 1.90

The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer Res (2009) 1.37

Mechanistic insights into the events that lead to synergistic induction of interleukin 6 transcription upon activation of the aryl hydrocarbon receptor and inflammatory signaling. J Biol Chem (2010) 1.27

Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs. Environ Health Perspect (2009) 1.22

The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Mol Biol Cell (2008) 1.21

Molecular targets of epigenetic regulation and effectors of environmental influences. Toxicol Appl Pharmacol (2010) 1.05

Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis. Environ Health Perspect (2013) 0.97

Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment. Hum Genet (2009) 0.95

Pluripotency factors and Polycomb Group proteins repress aryl hydrocarbon receptor expression in murine embryonic stem cells. Stem Cell Res (2013) 0.95

Aryl hydrocarbon receptor ligands of widely different toxic equivalency factors induce similar histone marks in target gene chromatin. Toxicol Sci (2011) 0.94

Influence of toxicologically relevant metals on human epigenetic regulation. Toxicol Res (2015) 0.89

3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters. Toxicol Sci (2010) 0.89

Perspectives on the potential involvement of the AH receptor-dioxin axis in cardiovascular disease. Toxicol Sci (2010) 0.87

Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells. Toxicol Appl Pharmacol (2013) 0.86

Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors. Toxicology (2008) 0.85

Dioxin exposure disrupts the differentiation of mouse embryonic stem cells into cardiomyocytes. Toxicol Sci (2010) 0.85

Effects of prior oral contraceptive use and soy isoflavonoids on estrogen-metabolizing cytochrome P450 enzymes. J Steroid Biochem Mol Biol (2008) 0.82

Linking the aryl hydrocarbon receptor with altered DNA methylation patterns and developmentally induced aberrant antiviral CD8+ T cell responses. J Immunol (2015) 0.82

Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast. Cell Div (2011) 0.81

Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo. J Pharmacol Exp Ther (2010) 0.81

Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters. Biochem Biophys Res Commun (2009) 0.81

Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter. J Pharmacol Exp Ther (2010) 0.80

Epigenetic Regulation in Particulate Matter-Mediated Cardiopulmonary Toxicities: A Systems Biology Perspective. Curr Pharmacogenomics Person Med (2012) 0.80

The aryl hydrocarbon receptor: a review of its role in the physiology and pathology of the integument and its relationship to the tryptophan metabolism. Int J Tryptophan Res (2015) 0.80

Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review. Mutat Res Rev Mutat Res (2016) 0.80

The Ah receptor recruits IKKα to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation. Toxicol Sci (2014) 0.78

Ontogenic expression of hepatic Ahr mRNA is associated with histone H3K4 di-methylation during mouse liver development. Toxicol Lett (2009) 0.78

Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation. J Biol Chem (2011) 0.78

SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor. J Biol Chem (2014) 0.77

Ah Receptor Activation by Dioxin Disrupts Activin, BMP, and WNT Signals During the Early Differentiation of Mouse Embryonic Stem Cells and Inhibits Cardiomyocyte Functions. Toxicol Sci (2015) 0.77

Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1. Dev Biol (2014) 0.77

Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs. Toxicol Res (Camb) (2015) 0.77

Expression of signaling components in embryonic eyelid epithelium. PLoS One (2014) 0.75

A tryptophan derivative, ITE, enhances liver cell metabolic functions in vitro. Int J Mol Med (2016) 0.75

Loss of IκB kinase β promotes myofibroblast transformation and senescence through activation of the ROS-TGFβ autocrine loop. Protein Cell (2016) 0.75

Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention? Biomed Res Int (2016) 0.75

Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver. Sci Rep (2016) 0.75

Articles cited by this

A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80

Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med (2003) 18.04

Eukaryotic cytosine methyltransferases. Annu Rev Biochem (2005) 15.45

Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet (2004) 11.31

Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science (2006) 11.20

2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol (1982) 6.48

The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol (1995) 6.37

Signaling to chromatin through histone modifications. Cell (2000) 5.36

Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J Cell Biol (2001) 5.34

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet (2000) 5.09

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Res (1982) 4.78

Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59

Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. Genes Dev (2000) 3.38

Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation. Methods (2002) 2.99

BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev (2000) 2.83

Reversing histone methylation. Nature (2005) 2.57

Regulation of histone deacetylase activities. J Cell Biochem (2004) 2.41

Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1. Cancer Sci (2004) 2.29

Chromatin modifier enzymes, the histone code and cancer. Eur J Cancer (2005) 1.62

Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Mol Cell Biol (2002) 1.58

The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects. Crit Rev Toxicol (1989) 1.56

Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription. J Immunol (2006) 1.55

Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation. Cancer Biol Ther (2007) 1.55

Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor. Mol Cell Biol (2003) 1.51

Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction. Mol Cell Biol (1989) 1.49

Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytosplasmic proteasome following nuclear export. J Biol Chem (1999) 1.48

Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation. Mol Cell Biol (2002) 1.46

2,3,7,8-tetrachlorodibenzo-p-dioxin-induced degradation of aryl hydrocarbon receptor (AhR) by the ubiquitin-proteasome pathway. Role of the transcription activaton and DNA binding of AhR. J Biol Chem (2000) 1.43

Nuclear localization and export signals of the human aryl hydrocarbon receptor. J Biol Chem (1998) 1.43

CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt). J Biochem (1997) 1.38

Dioxin-induced CYP1A1 transcription in vivo: the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure. Mol Cell Biol (1996) 1.36

Taking LSD 1 to a new high. Cell (2005) 1.34

Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs. J Biol Chem (1999) 1.28

A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene. Mol Cell Biol (1990) 1.28

Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation. Mol Cell Biol (1992) 1.27

The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor. Mol Cell Biol (2001) 1.27

Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. Arch Biochem Biophys (1999) 1.15

Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter. J Biol Chem (2003) 1.13

Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin. J Biol Chem (2003) 1.10

BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells. J Biol Chem (2006) 1.10

Functional analysis of the transcriptional promoter for the CYP1A1 gene. Mol Cell Biol (1990) 1.07

Functional involvement of the Brahma/SWI2-related gene 1 protein in cytochrome P4501A1 transcription mediated by the aryl hydrocarbon receptor complex. J Biol Chem (2002) 1.06

Effect of a complex environmental mixture from coal tar containing polycyclic aromatic hydrocarbons (PAH) on the tumor initiation, PAH-DNA binding and metabolic activation of carcinogenic PAH in mouse epidermis. Carcinogenesis (2001) 1.06

Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin. Proc Natl Acad Sci U S A (1992) 1.04

Dioxin- and Ah receptor-dependent protein binding to xenobiotic responsive elements and G-rich DNA studied by in vivo footprinting. J Biol Chem (1992) 1.04

The potential role of DNA methylation in the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem (1989) 1.02

Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase. J Biol Chem (2004) 1.01

Epigenetic inactivation of the dioxin-responsive cytochrome P4501A1 gene in human prostate cancer. Cancer Res (2006) 0.96

Effect of the histone deacetylase inhibitor trichostatin A on the responsiveness of rat hepatocytes to dioxin. Biochem Pharmacol (1997) 0.78

Articles by these authors

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab (2005) 9.14

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A (2006) 3.05

Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Mol Cell Biol (2005) 2.32

Identification of a hormonal basis for gallbladder filling. Nat Med (2006) 2.03

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. Mol Endocrinol (2008) 1.85

The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove. Cell (2010) 1.77

Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1. Nucleic Acids Res (2007) 1.67

The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cells. Mol Cancer Ther (2002) 1.63

The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. Mol Cell (2004) 1.61

Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem Biophys Res Commun (2006) 1.59

Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis. J Cell Biochem (2005) 1.59

Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics (2010) 1.56

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Mol Endocrinol (2005) 1.55

Quantitative imaging of single, unstained viruses with coherent x rays. Phys Rev Lett (2008) 1.52

MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol (2010) 1.41

Expression of genes in the TGF-beta signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice. Toxicol Appl Pharmacol (2004) 1.37

The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer Res (2009) 1.37

Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate. Acta Crystallogr Sect E Struct Rep Online (2009) 1.33

The aryl hydrocarbon receptor displaces p300 from E2F-dependent promoters and represses S phase-specific gene expression. J Biol Chem (2004) 1.33

Functional FEN1 genetic variants contribute to risk of hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer. Carcinogenesis (2011) 1.31

Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. Mol Cell Biol (2007) 1.31

Ligand-independent regulation of transforming growth factor beta1 expression and cell cycle progression by the aryl hydrocarbon receptor. Mol Cell Biol (2007) 1.30

Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicol Sci (2005) 1.29

Recent advances in the research and development of human defensins. Peptides (2005) 1.29

pHUSH: a single vector system for conditional gene expression. BMC Biotechnol (2007) 1.27

Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. Mol Endocrinol (2007) 1.25

Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Free Radic Biol Med (2002) 1.24

Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs. Environ Health Perspect (2009) 1.22

Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration. J Neurosci (2007) 1.21

Characteristics of ambient volatile organic compounds (VOCs) measured in Shanghai, China. Sensors (Basel) (2010) 1.21

The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Mol Biol Cell (2008) 1.21

Open reading frame 33 of a gammaherpesvirus encodes a tegument protein essential for virion morphogenesis and egress. J Virol (2009) 1.18

Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochem Pharmacol (2002) 1.17

Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin. J Biol Chem (2003) 1.10

Different global gene expression profiles in benzo[a]pyrene- and dioxin-treated vascular smooth muscle cells of AHR-knockout and wild-type mice. Cardiovasc Toxicol (2004) 1.08

Association between environmental factors and hospital visits among allergic patients: A retrospective study. Asian Pac J Allergy Immunol (2016) 1.07

Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environ Res (2005) 1.05

A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity. J Biol Chem (2007) 1.05

Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. Antimicrob Agents Chemother (2009) 1.05

Arsenic co-exposure potentiates benzo[a]pyrene genotoxicity. Mutat Res (2002) 1.04

Observation of multiphoton-induced fluorescence from graphene oxide nanoparticles and applications in in vivo functional bioimaging. Angew Chem Int Ed Engl (2012) 1.03

Induction of cellular oxidative stress by aryl hydrocarbon receptor activation. Chem Biol Interact (2002) 1.03

2,3,7,8-Tetrachlorodibenzo-p-dioxin blocks androgen-dependent cell proliferation of LNCaP cells through modulation of pRB phosphorylation. Mol Pharmacol (2004) 1.01

Fitting a xenobiotic receptor into cell homeostasis: how the dioxin receptor interacts with TGFbeta signaling. Biochem Pharmacol (2008) 1.01

Sequence polymorphisms of mitochondrial D-loop and hepatocellular carcinoma outcome. Biochem Biophys Res Commun (2011) 1.00

Structural basis of human pregnane X receptor activation by the hops constituent colupulone. Mol Pharmacol (2008) 0.99

111In-LLP2A-DOTA Polyethylene Glycol-Targeting {alpha}4{beta}1 Integrin: Comparative Pharmacokinetics for Imaging and Therapy of Lymphoid Malignancies. J Nucl Med (2009) 0.98

A critical role for MAP kinases in the control of Ah receptor complex activity. Toxicol Sci (2004) 0.98

BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. J Biol Chem (2008) 0.97

Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis. Environ Health Perspect (2013) 0.97

Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner. J Mol Biol (2008) 0.95

CrossWork: software-assisted identification of cross-linked peptides. J Proteomics (2011) 0.95

MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo. Mol Cancer Ther (2012) 0.95

MiR-363 sensitizes cisplatin-induced apoptosis targeting in Mcl-1 in breast cancer. Med Oncol (2014) 0.95

In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin. Am J Physiol Regul Integr Comp Physiol (2004) 0.95

Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure. Proc Natl Acad Sci U S A (2011) 0.94

Aryl hydrocarbon receptor ligands of widely different toxic equivalency factors induce similar histone marks in target gene chromatin. Toxicol Sci (2011) 0.94

Leukocyte telomere length-related genetic variants in 1p34.2 and 14q21 loci contribute to the risk of esophageal squamous cell carcinoma. Int J Cancer (2012) 0.94

Impact of extreme temperature on hospital admission in Shanghai, China. Sci Total Environ (2011) 0.93

Effect of Wnt6 on human dental papilla cells in vitro. J Endod (2009) 0.93

Near-infrared optical imaging in glioblastoma xenograft with ligand-targeting alpha 3 integrin. Eur J Nucl Med Mol Imaging (2008) 0.92

Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation. Environ Health Perspect (2009) 0.92

The association between cold spells and pediatric outpatient visits for asthma in Shanghai, China. PLoS One (2012) 0.90

Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione. Mol Pharmacol (2010) 0.90

Aptamer-based silver nanoparticles used for intracellular protein imaging and single nanoparticle spectral analysis. J Phys Chem B (2010) 0.90

Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Mol Cell Endocrinol (2004) 0.89

Sensitive discrimination and detection of prion disease-associated isoform with a dual-aptamer strategy by developing a sandwich structure of magnetic microparticles and quantum dots. Anal Chem (2010) 0.89

Kidney prevention recipes for your office practice. Kidney Int Suppl (2005) 0.88

The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways. EXS (2009) 0.88

Interleukin-1alpha, 6 regulate the secretion of vascular endothelial growth factor A, C in pancreatic cancer. Hepatobiliary Pancreat Dis Int (2005) 0.87

Aptamer-mediated nanoparticle-based protein labeling platform for intracellular imaging and tracking endocytosis dynamics. Anal Chem (2012) 0.87

Dental enamel structure is altered by expression of dominant negative RhoA in ameloblasts. Cells Tissues Organs (2011) 0.87

Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes. Mol Pharmacol (2005) 0.86

Tpl2/AP-1 enhances murine gammaherpesvirus 68 lytic replication. J Virol (2009) 0.86

An alpha4beta1 integrin antagonist decreases airway inflammation in ovalbumin-exposed mice. Eur J Pharmacol (2008) 0.86

The hemolytic uremic syndromes. Curr Opin Crit Care (2005) 0.85

Molecular diversification based on analysis of expressed sequence tags from the venom glands of the Chinese bird spider Ornithoctonus huwena. Toxicon (2008) 0.85

Expression of vascular endothelial growth factors A and C in human pancreatic cancer. World J Gastroenterol (2006) 0.85

Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors. Toxicology (2008) 0.85

Dioxin exposure disrupts the differentiation of mouse embryonic stem cells into cardiomyocytes. Toxicol Sci (2010) 0.85

DNMT3A R882 Mutations Predict a Poor Prognosis in AML: A Meta-Analysis From 4474 Patients. Medicine (Baltimore) (2016) 0.85

A new class of analgesic agents toward prostacyclin receptor inhibition: synthesis, biological studies and QSAR analysis of 1-hydroxyl-2-substituted phenyl-4,4,5,5-tetramethylimidazolines. Eur J Med Chem (2007) 0.85

HGF enhanced proliferation and differentiation of dental pulp cells. J Endod (2006) 0.84

Renal collecting duct carcinoma: report of a case with unusual imaging findings regarding renal function. J Cancer Res Ther (2013) 0.84

Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor. Dose Response (2006) 0.84

Differentiating the associations of black carbon and fine particle with daily mortality in a Chinese city. Environ Res (2012) 0.84

Venomics of the spider Ornithoctonus huwena based on transcriptomic versus proteomic analysis. Comp Biochem Physiol Part D Genomics Proteomics (2010) 0.84

High-level production of bioactive human beta-defensin-4 in Escherichia coli by soluble fusion expression. Appl Microbiol Biotechnol (2006) 0.83

Ultra-sensitive detection of prion protein with a long range resonance energy transfer strategy. Chem Commun (Camb) (2010) 0.82

Striking life events associated with primary breast cancer susceptibility in women: a meta-analysis study. J Exp Clin Cancer Res (2013) 0.82

A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency. J Med Chem (2010) 0.82

Partial alloc-deprotection approach for ladder synthesis of "one-bead one-compound" combinatorial libraries. J Comb Chem (2005) 0.82

Carbon nanotubes as a low background signal platform for a molecular aptamer beacon on the basis of long-range resonance energy transfer. Anal Chem (2010) 0.82

Enhanced expression and primary purification of soluble HBD3 fusion protein in Escherichia coli. Appl Biochem Biotechnol (2007) 0.82

Functional polymorphisms in FAS and FASL contribute to risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population. Gene (2013) 0.81

High dose methotrexate population pharmacokinetics and Bayesian estimation in patients with lymphoid malignancy. Biopharm Drug Dispos (2009) 0.81

[Islet perifusion: a new method to evaluate first-phase insulin secretory function of beta-cell in vitro]. Zhonghua Yi Xue Za Zhi (2010) 0.81

Inhibitory effects of cocoa tea (Camellia ptilophylla) in human hepatocellular carcinoma HepG2 in vitro and in vivo through apoptosis. J Nutr Biochem (2011) 0.81

Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs. Biochem Biophys Res Commun (2006) 0.81