Published in Neurology on August 21, 2007
The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med (2011) 3.16
Amyotrophic lateral sclerosis. Orphanet J Rare Dis (2009) 2.76
Phase II screening trial of lithium carbonate in amyotrophic lateral sclerosis: examining a more efficient trial design. Neurology (2011) 2.28
A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS. Amyotroph Lateral Scler (2008) 2.28
Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial. Lancet Neurol (2014) 1.81
What is next in ALS clinical trials? Neurology (2007) 1.40
The PRO-ACT database: design, initial analyses, and predictive features. Neurology (2014) 1.26
Progression of white matter degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging study. Amyotroph Lateral Scler (2011) 0.98
ALS drug development: reflections from the past and a way forward. Neurotherapeutics (2008) 0.96
ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS): study methodology, recruitment, and baseline demographic and disease characteristics. Amyotroph Lateral Scler Frontotemporal Degener (2014) 0.94
A comprehensive review of amyotrophic lateral sclerosis. Surg Neurol Int (2015) 0.93
Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO Mol Med (2011) 0.91
Moving forward in clinical trials for ALS: motor neurons lead the way please. Drug Discov Today (2013) 0.89
How can we improve clinical trials in amyotrophic lateral sclerosis? Nat Rev Neurol (2011) 0.89
Therapeutic neuroprotective agents for amyotrophic lateral sclerosis. Cell Mol Life Sci (2013) 0.88
Being PRO-ACTive: What can a Clinical Trial Database Reveal About ALS? Neurotherapeutics (2015) 0.86
Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A). Skelet Muscle (2012) 0.86
Omigapil treatment decreases fibrosis and improves respiratory rate in dy(2J) mouse model of congenital muscular dystrophy. PLoS One (2013) 0.85
Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling. Neuron (2013) 0.81
Current and emerging treatments for amyotrophic lateral sclerosis. Neuropsychiatr Dis Treat (2009) 0.81
A multi-center screening trial of rasagiline in patients with amyotrophic lateral sclerosis: Possible mitochondrial biomarker target engagement. Amyotroph Lateral Scler Frontotemporal Degener (2015) 0.80
Intraspinal stem cell transplantation for amyotrophic lateral sclerosis. Ann Neurol (2016) 0.79
Strength Testing in Motor Neuron Diseases. Neurotherapeutics (2017) 0.79
Erythropoietin in amyotrophic lateral sclerosis: a multicentre, randomised, double blind, placebo controlled, phase III study. J Neurol Neurosurg Psychiatry (2015) 0.78
Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade. Proc Natl Acad Sci U S A (2016) 0.78
Cell biology: Alternative energy for neuronal motors. Nature (2013) 0.76
Re: What is next in ALS clinical trials? Neurology (2008) 0.75
Re: What is next in ALS clinical trials? Neurology (2008) 0.75
ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment? Front Aging Neurosci (2017) 0.75
Ethanol and Acetaminophen Synergistically Induce Hepatic Aggregation and TCH346-Insensitive Nuclear Translocation of GAPDH. PLoS One (2016) 0.75
Shortcomings in the Current Amyotrophic Lateral Sclerosis Trials and Potential Solutions for Improvement. Front Neurol (2017) 0.75
El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord (2000) 15.38
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Engl J Med (1994) 8.82
The nucleotide sequence of the cloned rpoD gene for the RNA polymerase sigma subunit from E coli K12. Nucleic Acids Res (1981) 5.52
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science (2001) 5.28
Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas. Nat Genet (2001) 4.96
Randomised trial of oral and intravenous methylprednisolone in acute relapses of multiple sclerosis. Lancet (1997) 4.43
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Lancet (1996) 4.11
Dyslipidemia is a protective factor in amyotrophic lateral sclerosis. Neurology (2008) 3.88
Occurrence of amyotrophic lateral sclerosis among Gulf War veterans. Neurology (2003) 3.82
Lead poisoning among low-income children in Orange County, California. A need for regionally differentiated policy. JAMA (1993) 3.77
Sphincter denervation in anorectal incontinence and rectal prolapse. Gut (1977) 3.66
Prospective study of military service and mortality from ALS. Neurology (2005) 3.59
Increased motor unit fibre density in the external anal sphincter muscle in ano-rectal incontinence: a single fibre EMG study. J Neurol Neurosurg Psychiatry (1980) 3.36
Injury to innervation of pelvic floor sphincter musculature in childbirth. Lancet (1984) 3.27
Stress response protein (srp-27) determination in primary human breast carcinomas: clinical, histologic, and prognostic correlations. J Natl Cancer Inst (1991) 3.07
The pelvic floor musculature in the descending perineum syndrome. Br J Surg (1982) 3.06
Physiological studies of the anal sphincter musculature in faecal incontinence and rectal prolapse. Br J Surg (1981) 3.00
Wish to die in end-stage ALS. Neurology (2005) 2.97
Pathogenesis of ano-rectal incontinence. A histometric study of the anal sphincter musculature. J Neurol Sci (1979) 2.87
Slowed conduction in the pudendal nerves in idiopathic (neurogenic) faecal incontinence. Br J Surg (1984) 2.73
Study of 962 patients indicates progressive muscular atrophy is a form of ALS. Neurology (2009) 2.60
Rate of functional decline in Huntington's disease. Huntington Study Group. Neurology (2000) 2.49
Implementation of donor screening for infectious agents transmitted by blood by nucleic acid technology: update to 2003. Vox Sang (2005) 2.47
Chromosome 9p-linked families with frontotemporal dementia associated with motor neuron disease. Neurology (2009) 2.46
Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility. J Cell Biol (1992) 2.45
Effect of vaginal delivery on the pelvic floor: a 5-year follow-up. Br J Surg (1990) 2.36
'Cut down to quit' with nicotine replacement therapies in smoking cessation: a systematic review of effectiveness and economic analysis. Health Technol Assess (2008) 2.34
The natural history of primary lateral sclerosis. Neurology (2006) 2.31
Neuro-glial differentiation of human bone marrow stem cells in vitro. Exp Neurol (2005) 2.17
Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial. Neurology (2010) 2.14
Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. Gut (2011) 2.14
Effect of noninvasive positive-pressure ventilation on survival in amyotrophic lateral sclerosis. Ann Intern Med (1997) 2.12
Objective tests for upper motor neuron involvement in amyotrophic lateral sclerosis (ALS). Neurology (2004) 2.09
Assessment of pelvic-floor disorders and incontinence by electrophysiological recording of the anal reflex. Lancet (1978) 2.09
Progressive encephalomyelitis with rigidity. Brain (1976) 2.09
Electrophysiological study of motor nerve supply of pelvic floor. Lancet (1981) 2.08
Epidemiology and cost of ventral hernia repair: making the case for hernia research. Hernia (2011) 2.06
Clinical effectiveness and cost-effectiveness of different models of managing long-term oral anticoagulation therapy: a systematic review and economic modelling. Health Technol Assess (2007) 2.06
High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis. Hum Mutat (2009) 2.05
A simple screening tool for active tuberculosis in HIV-infected adults receiving antiretroviral treatment in Uganda. Int J Tuberc Lung Dis (2009) 2.02
Contribution of TARDBP mutations to sporadic amyotrophic lateral sclerosis. J Med Genet (2008) 2.00
Cutaneous T-cell lymphoma in association with silicone breast implants. J Am Acad Dermatol (1995) 1.96
Animal companions and one-year survival of patients after discharge. Public Health Rep (1982) 1.93
Epidemiologic study of 203 sibling pairs with Parkinson's disease: the GenePD study. Neurology (2002) 1.90
The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers. Cancer Res (1998) 1.88
Perineal nerve damage in genuine stress urinary incontinence. An electrophysiological study. Br J Urol (1985) 1.88
Mutations in FUS cause FALS and SALS in French and French Canadian populations. Neurology (2009) 1.87
Quality of life in multiple sclerosis in France, Germany, and the United Kingdom. Cost of Multiple Sclerosis Study Group. J Neurol Neurosurg Psychiatry (1998) 1.84
Analysis of FUS gene mutation in familial amyotrophic lateral sclerosis within an Italian cohort. Neurology (2009) 1.83
Hippocampal and neocortical ubiquitin-immunoreactive inclusions in amyotrophic lateral sclerosis with dementia. Neurosci Lett (1992) 1.82
Well-done meat intake and the risk of breast cancer. J Natl Cancer Inst (1998) 1.81
Structure of the collagen-binding domain from a Staphylococcus aureus adhesin. Nat Struct Biol (1997) 1.80
Mitochondrial encephalomyopathies: biochemical studies in two cases revealing defects in the respiratory chain. Brain (1982) 1.80
Prevalence of depressive disorders and change over time in late-stage ALS. Neurology (2005) 1.80
Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study. Neurology (2009) 1.78
A critical evaluation of HIPE data. Ir Med J (2012) 1.77
Ubiquitin deposits in anterior horn cells in motor neurone disease. Neurosci Lett (1988) 1.77
Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapy. J Neurovirol (2009) 1.75
Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity. Brain (1991) 1.74
Digital subtraction angiography (DSA) of the extracranial cerebral vessels: a direct comparison between intravenous and intra-arterial DSA. Clin Radiol (1991) 1.74
A clinical trial of creatine in ALS. Neurology (2004) 1.73
Chloroquine neuromyotoxicity. Clinical and pathologic perspective. Am J Med (1987) 1.72
Autosomal recessive congenital intrauterine infection-like syndrome of microcephaly, intracranial calcification, and CNS disease. Am J Med Genet (1994) 1.72
Respiratory syncytial virus G and/or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c mice. J Virol (1999) 1.71
Motor conduction velocity in the human spinal cord: slowed conduction in multiple sclerosis and radiation myelopathy. J Neurol Neurosurg Psychiatry (1985) 1.70
A study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosis. J Neurol (2002) 1.69
The pathology of the human muscle spindle: effect of denervation. J Neurol Sci (1974) 1.68
Novel mutations in spastin gene and absence of correlation with age at onset of symptoms. Neurology (2000) 1.67
A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology (2009) 1.67
A randomized controlled trial of resistance exercise in individuals with ALS. Neurology (2007) 1.65
Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results. Mult Scler (2009) 1.65
Longitudinal sliding of the median nerve during movements of the upper limb. J Neurol Neurosurg Psychiatry (1976) 1.65
RNA-dependent DNA polymerase activity in virus-like particles isolated from human milk. Nature (1971) 1.63
Damage to the innervation of the voluntary anal and periurethral sphincter musculature in incontinence: an electrophysiological study. J Neurol Neurosurg Psychiatry (1984) 1.62
Unifying concept of pelvic floor disorders and incontinence. J R Soc Med (1985) 1.60
Location of an F-pilin pool in the inner membrane. J Bacteriol (1981) 1.58
Aorto-left renal vein fistula: is there a place for endovascular management? J Endovasc Surg (1999) 1.57
The use of economic evaluations in NHS decision-making: a review and empirical investigation. Health Technol Assess (2008) 1.57
Dark matter search results from the CDMS II experiment. Science (2010) 1.57
Prospective study of cigarette smoking and amyotrophic lateral sclerosis. Am J Epidemiol (2004) 1.57
A systematic review of the clinical effectiveness and cost-effectiveness of enzyme replacement therapies for Fabry's disease and mucopolysaccharidosis type 1. Health Technol Assess (2006) 1.56
The syndrome of transient global amnesia. Brain (1973) 1.56
Normal proximal and delayed distal conduction in the pudendal nerves of patients with idiopathic (neurogenic) faecal incontinence. J Neurol Neurosurg Psychiatry (1984) 1.55
De Novo Purine Synthesis in Nitrogen-Fixing Nodules of Cowpea (Vigna unguiculata [L.] Walp.) and Soybean (Glycine max [L.] Merr.). Plant Physiol (1982) 1.54
Changes in motor unit synchronization following central nervous lesions in man. J Physiol (1993) 1.54
Treatment of acute exacerbations of multiple sclerosis with intravenous methyl-prednisolone. J Neurol Neurosurg Psychiatry (1982) 1.53
The association of age and semen quality in healthy men. Hum Reprod (2003) 1.52
Evidence of pudendal neuropathy in patients with perineal descent and chronic straining at stool. Gut (1984) 1.52
Low frequency epithelial cells in bone marrow aspirates from prostate carcinoma patients are cytogenetically aberrant. Cancer (1998) 1.52
Tyramine activates the EEG in epileptic patients. Nature (1975) 1.51
The alteration of serum potassium level during sample transit. Practitioner (1989) 1.51
Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer. Cancer Res (1993) 1.51
Clinical consequences of corticectomies involving the supplementary motor area in man. J Neurol Sci (1977) 1.50
Application of an artificial neural network to predict specific class I MHC binding peptide sequences. Nat Biotechnol (1998) 1.49
Elevated frequency of glycophorin A mutations in erythrocytes from Chernobyl accident victims. Radiat Res (1995) 1.48
Position sense in a damaged knee. J Neurol Neurosurg Psychiatry (1986) 1.48