Published in J Ocul Pharmacol Ther on August 01, 2007
Ocular drug delivery. AAPS J (2010) 2.19
Recent perspectives in ocular drug delivery. Pharm Res (2008) 1.72
Solubility, stability, physicochemical characteristics and in vitro ocular tissue permeability of hesperidin: a natural bioflavonoid. Pharm Res (2008) 0.96
Development and characterization of nanoparticulate formulation of a water soluble prodrug of dexamethasone by HIP complexation. J Microencapsul (2010) 0.87
Retracted Immunohistochemical and functional characterization of peptide, organic cation, neutral and basic amino acid, and monocarboxylate drug transporters in human ocular tissues. Drug Metab Dispos (2012) 0.80
Recent overview of ocular patents. Recent Pat Drug Deliv Formul (2012) 0.77
Retracted Hypoxia alters ocular drug transporter expression and activity in rat and calf models: implications for drug delivery. Mol Pharm (2013) 0.76
A comprehensive insight on ocular pharmacokinetics. Drug Deliv Transl Res (2016) 0.75
Circumvention of P-gp and MRP2 mediated efflux of lopinavir by a histidine based dipeptide prodrug. Int J Pharm (2016) 0.75
Prodrug strategies in ocular drug delivery. Med Chem (2012) 0.75
Nitric oxide represses the Arabidopsis floral transition. Science (2004) 2.41
TLR-activated B cells suppress T cell-mediated autoimmunity. J Immunol (2008) 2.25
Ocular drug delivery. AAPS J (2010) 2.19
Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells. Int J Pharm (2012) 2.07
MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem (2008) 1.93
Recent perspectives in ocular drug delivery. Pharm Res (2008) 1.72
Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation. J Cell Biol (2010) 1.58
MDR- and CYP3A4-mediated drug-drug interactions. J Neuroimmune Pharmacol (2006) 1.40
B cells and aging: molecules and mechanisms. Trends Immunol (2009) 1.38
Novel approaches to retinal drug delivery. Expert Opin Drug Deliv (2007) 1.26
The BLyS family: toward a molecular understanding of B cell homeostasis. Cell Biochem Biophys (2008) 1.23
Molecular evidence and functional expression of P-glycoprotein (MDR1) in human and rabbit cornea and corneal epithelial cell lines. Invest Ophthalmol Vis Sci (2003) 1.21
Drug delivery to the retina: challenges and opportunities. Expert Opin Biol Ther (2003) 1.18
Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations. J Ocul Pharmacol Ther (2005) 1.17
Chinese social media reaction to the MERS-CoV and avian influenza A(H7N9) outbreaks. Infect Dis Poverty (2013) 1.17
MDR- and CYP3A4-mediated drug-herbal interactions. Life Sci (2006) 1.15
Pharmacokinetics of novel dipeptide ester prodrugs of acyclovir after oral administration: intestinal absorption and liver metabolism. J Pharmacol Exp Ther (2004) 1.13
The cross-reactivity of the enterovirus 71 to human brain tissue and identification of the cross-reactivity related fragments. Virol J (2010) 1.12
Effect of hydroxypropyl beta cyclodextrin complexation on aqueous solubility, stability, and corneal permeation of acyl ester prodrugs of ganciclovir. AAPS PharmSciTech (2003) 1.12
Both P-gp and MRP2 mediate transport of Lopinavir, a protease inhibitor. Int J Pharm (2007) 1.10
Mitochondrial dysfunction in retinal diseases. Curr Eye Res (2011) 1.08
Efflux transporters- and cytochrome P-450-mediated interactions between drugs of abuse and antiretrovirals. Life Sci (2010) 1.04
Identification of a Na+-dependent cationic and neutral amino acid transporter, B(0,+), in human and rabbit cornea. Mol Pharm (2005) 1.04
Combined peptides of human enterovirus 71 protect against virus infection in mice. Vaccine (2010) 1.04
Pharmacokinetics of erythromycin in rabbit corneas after single-dose infusion: role of P-glycoprotein as a barrier to in vivo ocular drug absorption. J Pharmacol Exp Ther (2004) 1.03
Hypoxia-inducible factor-1 (HIF-1): a potential target for intervention in ocular neovascular diseases. Curr Drug Targets (2013) 1.01
Enhanced corneal absorption of erythromycin by modulating P-glycoprotein and MRP mediated efflux with corticosteroids. Pharm Res (2008) 1.01
Amino acid prodrugs of acyclovir as possible antiviral agents against ocular HSV-1 infections: interactions with the neutral and cationic amino acid transporter on the corneal epithelium. Curr Eye Res (2004) 1.01
Approaches for enhancing oral bioavailability of peptides and proteins. Int J Pharm (2013) 1.01
Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance. Int J Pharm (2010) 1.01
Role of efflux pumps and metabolising enzymes in drug delivery. Expert Opin Drug Deliv (2005) 1.00
Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor. Int J Pharm (2008) 1.00
Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux. Int J Pharm (2006) 1.00
Modulation of P-glycoprotein-mediated efflux by prodrug derivatization: an approach involving peptide transporter-mediated influx across rabbit cornea. J Ocul Pharmacol Ther (2006) 1.00
In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye model. Invest Ophthalmol Vis Sci (2003) 1.00
Identification and functional characterization of a Na+-independent large neutral amino acid transporter, LAT1, in human and rabbit cornea. Invest Ophthalmol Vis Sci (2003) 0.99
Mechanism of corneal permeation of L-valyl ester of acyclovir: targeting the oligopeptide transporter on the rabbit cornea. Pharm Res (2002) 0.99
Development and validation of a fast and sensitive bioanalytical method for the quantitative determination of glucocorticoids--quantitative measurement of dexamethasone in rabbit ocular matrices by liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal (2010) 0.99
Membrane transporter/receptor-targeted prodrug design: strategies for human and veterinary drug development. Adv Drug Deliv Rev (2004) 0.98
Development of a novel formulation containing poly(d,l-lactide-co-glycolide) microspheres dispersed in PLGA-PEG-PLGA gel for sustained delivery of ganciclovir. J Control Release (2005) 0.98
Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2. J Pharmacol Exp Ther (2003) 0.98
Circumventing P-glycoprotein-mediated cellular efflux of quinidine by prodrug derivatization. Mol Pharm (2005) 0.98
In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: changes in P-gp and CYP3A4 activity. Am J Ther (2004) 0.97
Effect of mono- and di-acylation on the ocular disposition of ganciclovir: physicochemical properties, ocular bioreversion, and antiviral activity of short chain ester prodrugs. J Pharm Sci (2002) 0.97
Study of the extent of ocular absorption of acetazolamide from a developed niosomal formulation, by microdialysis sampling of aqueous humor. Int J Pharm (2007) 0.96
Co-administration strategy to enhance brain accumulation of vandetanib by modulating P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp1/Abcg2) mediated efflux with m-TOR inhibitors. Int J Pharm (2012) 0.96
Interaction of ocular hypotensive agents (PGF2 alpha analogs-bimatoprost, latanoprost, and travoprost) with MDR efflux pumps on the rabbit cornea. J Ocul Pharmacol Ther (2009) 0.96
Mechanisms of drug resistance in cancer chemotherapy: coordinated role and regulation of efflux transporters and metabolizing enzymes. Curr Pharm Des (2013) 0.95
Evasion of P-gp mediated cellular efflux and permeability enhancement of HIV-protease inhibitor saquinavir by prodrug modification. Int J Pharm (2005) 0.95
Current and emerging antivirals for the treatment of cytomegalovirus (CMV) retinitis: an update on recent patents. Recent Pat Antiinfect Drug Discov (2012) 0.94
Synthesis, physicochemical properties and antiviral activities of ester prodrugs of ganciclovir. Int J Pharm (2005) 0.94
Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir. Int J Pharm (2008) 0.94
A LC-MS/MS method for concurrent determination of nicotine metabolites and role of CYP2A6 in nicotine metabolism in U937 macrophages: implications in oxidative stress in HIV + smokers. J Neuroimmune Pharmacol (2011) 0.94
YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locus. EMBO J (2013) 0.94
Vitreal pharmacokinetics of dipeptide monoester prodrugs of ganciclovir. J Ocul Pharmacol Ther (2006) 0.93
Effect of ethanol on spectral binding, inhibition, and activity of CYP3A4 with an antiretroviral drug nelfinavir. Biochem Biophys Res Commun (2010) 0.93
Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. Mol Pharm (2006) 0.93
Homeostatic control of B lymphocyte subsets. Immunol Res (2008) 0.92
Molecular evidence and functional expression of multidrug resistance associated protein (MRP) in rabbit corneal epithelial cells. Exp Eye Res (2006) 0.92
Recent applications of liposomes in ophthalmic drug delivery. J Drug Deliv (2011) 0.92
Microvascular complications and diabetic retinopathy: recent advances and future implications. Future Med Chem (2013) 0.92
Corneal absorption and anterior chamber pharmacokinetics of dipeptide monoester prodrugs of ganciclovir (GCV): in vivo comparative evaluation of these prodrugs with Val-GCV and GCV in rabbits. J Ocul Pharmacol Ther (2006) 0.92
Positive selection of B cells expressing low densities of self-reactive BCRs. J Exp Med (2004) 0.92
Effect of emergence of fluoroquinolone resistance on intrinsic expression of P-glycoprotein phenotype in corneal epithelial cells. J Ocul Pharmacol Ther (2011) 0.91
Long-term delivery of protein therapeutics. Expert Opin Drug Deliv (2014) 0.91
Novel strategies for anterior segment ocular drug delivery. J Ocul Pharmacol Ther (2012) 0.91
Corneal permeation of ganciclovir: mechanism of ganciclovir permeation enhancement by acyl ester prodrug design. J Ocul Pharmacol Ther (2002) 0.91
Controlled delivery of ganciclovir to the retina with drug-loaded Poly(d,L-lactide-co-glycolide) (PLGA) microspheres dispersed in PLGA-PEG-PLGA Gel: a novel intravitreal delivery system for the treatment of cytomegalovirus retinitis. J Ocul Pharmacol Ther (2007) 0.90
Ultrasound elastography of breast lesions in chinese women: a multicenter study in China. Clin Breast Cancer (2013) 0.90
Effect of polymer blending on the release of ganciclovir from PLGA microspheres. Pharm Res (2006) 0.90
Mechanism of L-ascorbic acid uptake by rabbit corneal epithelial cells: evidence for the involvement of sodium-dependent vitamin C transporter 2. Curr Eye Res (2006) 0.90
Cotransport of macrolide and fluoroquinolones, a beneficial interaction reversing P-glycoprotein efflux. Am J Ther (2004) 0.90
Enhanced transport of a novel anti-HIV agent--cosalane and its congeners across human intestinal epithelial (Caco-2) cell monolayers. Int J Pharm (2003) 0.90
Nanomicellar Topical Aqueous Drop Formulation of Rapamycin for Back-of-the-Eye Delivery. AAPS PharmSciTech (2014) 0.90
Folic acid transport via high affinity carrier-mediated system in human retinoblastoma cells. Int J Pharm (2007) 0.89
Ocular pharmacokinetics of acyclovir amino acid ester prodrugs in the anterior chamber: evaluation of their utility in treating ocular HSV infections. Int J Pharm (2008) 0.89
Vitreal pharmacokinetics of biotinylated ganciclovir: role of sodium-dependent multivitamin transporter expressed on retina. J Ocul Pharmacol Ther (2009) 0.89
Functional characterization of peptide transporters in MDCKII-MDR1 cell line as a model for oral absorption studies. Int J Pharm (2006) 0.89
Effect of HEPES buffer on the uptake and transport of P-glycoprotein substrates and large neutral amino acids. Mol Pharm (2010) 0.89
An LC-MS/MS method for concurrent determination of nicotine metabolites and the role of CYP2A6 in nicotine metabolite-mediated oxidative stress in SVGA astrocytes. Drug Alcohol Depend (2012) 0.89
Current prodrug strategies via membrane transporters/receptors. Expert Opin Biol Ther (2002) 0.89
Functional differences in nucleoside and nucleobase transporters expressed on the rabbit corneal epithelial cell line (SIRC) and isolated rabbit cornea. AAPS PharmSci (2003) 0.88
Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis. Recent Pat Inflamm Allergy Drug Discov (2011) 0.88
Molecular expression and functional activity of sodium dependent multivitamin transporter in human prostate cancer cells. Int J Pharm (2012) 0.88
Synthesis and characterization of novel dipeptide ester prodrugs of acyclovir. Spectrochim Acta A Mol Biomol Spectrosc (2003) 0.88
Targeting SVCT for enhanced drug absorption: synthesis and in vitro evaluation of a novel vitamin C conjugated prodrug of saquinavir. Int J Pharm (2011) 0.88
Biotin uptake by rabbit corneal epithelial cells: role of sodium-dependent multivitamin transporter (SMVT). Curr Eye Res (2006) 0.88
Differential expression of folate receptor-alpha, sodium-dependent multivitamin transporter, and amino acid transporter (B (0, +)) in human retinoblastoma (Y-79) and retinal pigment epithelial (ARPE-19) cell lines. J Ocul Pharmacol Ther (2012) 0.88
Identification and characterization of a Na+-dependent neutral amino acid transporter, ASCT1, in rabbit corneal epithelial cell culture and rabbit cornea. Curr Eye Res (2005) 0.87
Optimization of dexamethasone mixed nanomicellar formulation. AAPS PharmSciTech (2014) 0.87
Effect of short term and chronic administration of Sutherlandia frutescens on pharmacokinetics of nevirapine in rats. Int J Pharm (2011) 0.87
Development and characterization of nanoparticulate formulation of a water soluble prodrug of dexamethasone by HIP complexation. J Microencapsul (2010) 0.87
Novel dexamethasone-loaded nanomicelles for the intermediate and posterior segment uveitis. AAPS PharmSciTech (2014) 0.87
Effect of lactide/glycolide ratio on the in vitro release of ganciclovir and its lipophilic prodrug (GCV-monobutyrate) from PLGA microspheres. Int J Pharm (2007) 0.86
Mechanism of a model dipeptide transport across blood-ocular barriers following systemic administration. Exp Eye Res (2004) 0.86
Ocular disposition of ganciclovir and its monoester prodrugs following intravitreal administration using microdialysis. Drug Metab Dispos (2002) 0.86
Novel nanoparticulate gel formulations of steroids for the treatment of macular edema. J Ocul Pharmacol Ther (2010) 0.86
Effect of P-glycoprotein on the ocular disposition of a model substrate, quinidine. Curr Eye Res (2003) 0.85
Chemical modification and formulation approaches to elevated drug transport across cell membranes. Expert Opin Drug Deliv (2006) 0.85
Sodium dependent multivitamin transporter (SMVT): a potential target for drug delivery. Curr Drug Targets (2012) 0.85