Published in Exp Gerontol on August 14, 2007
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Mitochondrial energetics and therapeutics. Annu Rev Pathol (2010) 3.07
Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol (2008) 2.86
The individual blood cell telomere attrition rate is telomere length dependent. PLoS Genet (2009) 2.17
Energetics, epigenetics, mitochondrial genetics. Mitochondrion (2009) 2.08
Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation. Atherosclerosis (2009) 1.96
Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct (2011) 1.94
Telomere dynamics rather than age predict life expectancy in the wild. Proc Biol Sci (2009) 1.76
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res (2007) 1.60
Stress exposure in early post-natal life reduces telomere length: an experimental demonstration in a long-lived seabird. Proc Biol Sci (2014) 1.38
Lung alveolar integrity is compromised by telomere shortening in telomerase-null mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.22
An experimental demonstration that early-life competitive disadvantage accelerates telomere loss. Proc Biol Sci (2015) 1.17
Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy. Cell Death Dis (2013) 1.16
Hypoxic culture conditions as a solution for mesenchymal stem cell based regenerative therapy. ScientificWorldJournal (2013) 1.10
Short sleep duration is associated with shorter telomere length in healthy men: findings from the Whitehall II cohort study. PLoS One (2012) 1.07
Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers. Environ Health (2009) 1.07
Immune mechanisms linked to depression via oxidative stress and neuroprogression. Immunology (2015) 1.04
DNA damage responses and oxidative stress in dyskeratosis congenita. PLoS One (2013) 1.01
Association between urinary excretion of cortisol and markers of oxidatively damaged DNA and RNA in humans. PLoS One (2011) 0.94
Cellular senescence: unravelling complexity. Age (Dordr) (2009) 0.93
Nuclear damages and oxidative stress: new perspectives for laminopathies. Eur J Histochem (2012) 0.93
Satellite cells senescence in limb muscle of severe patients with COPD. PLoS One (2012) 0.92
Regulation of telomere length in Drosophila. Cytogenet Genome Res (2009) 0.91
Telomere biology and translational research. Transl Res (2013) 0.90
Coenzyme Q10 prevents accelerated cardiac aging in a rat model of poor maternal nutrition and accelerated postnatal growth. Mol Metab (2013) 0.88
DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol (2015) 0.87
Assessing the cost of helping: the roles of body condition and oxidative balance in the Seychelles warbler (Acrocephalus sechellensis). PLoS One (2011) 0.87
Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment. Aging Cell (2011) 0.87
Oxidative stress-induced telomeric erosion as a mechanism underlying airborne particulate matter-related cardiovascular disease. Part Fibre Toxicol (2012) 0.86
Telomeres shorten in response to oxidative stress in mouse skeletal muscle fibers. J Gerontol A Biol Sci Med Sci (2014) 0.86
Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer. Oncotarget (2014) 0.85
Shorter telomeres in peripheral blood mononuclear cells from older persons with sarcopenia: results from an exploratory study. Front Aging Neurosci (2014) 0.84
A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations. PLoS One (2012) 0.84
Nutritional programming of coenzyme Q: potential for prevention and intervention? FASEB J (2014) 0.83
On being the right size: increased body size is associated with reduced telomere length under natural conditions. Proc Biol Sci (2015) 0.83
Telomere length and mental well-being in elderly men from the Netherlands and Greece. Behav Genet (2011) 0.82
The cell biology of aging. Mol Biol Cell (2015) 0.82
Telomere dynamics may link stress exposure and ageing across generations. Biol Lett (2015) 0.82
Longer telomeres in chronic, moderate, unconjugated hyperbilirubinaemia: insights from a human study on Gilbert's Syndrome. Sci Rep (2016) 0.82
The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions. DNA Repair (Amst) (2013) 0.81
Telomeres are elongated in rats exposed to moderate altitude. J Physiol Anthropol (2014) 0.80
Recombination can cause telomere elongations as well as truncations deep within telomeres in wild-type Kluyveromyces lactis cells. Eukaryot Cell (2010) 0.79
Effect of low oxygen tension on the biological characteristics of human bone marrow mesenchymal stem cells. Cell Stress Chaperones (2016) 0.79
Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential. Biomaterials (2016) 0.78
Apoptosis and telomeres shortening related to HIV-1 induced oxidative stress in an astrocytoma cell line. BMC Neurosci (2009) 0.78
Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs. J Math Biol (2013) 0.78
Telomeric aging: mitotic clock or stress indicator? Front Genet (2015) 0.78
Tualang honey improves human corneal epithelial progenitor cell migration and cellular resistance to oxidative stress in vitro. PLoS One (2014) 0.78
Do we age because we have mitochondria? Protoplasma (2013) 0.77
Robust DNA Damage Response and Elevated Reactive Oxygen Species in TINF2-Mutated Dyskeratosis Congenita Cells. PLoS One (2016) 0.77
Up-regulating telomerase and tumor suppressors: focusing on anti-aging interventions at the population level. Aging Dis (2013) 0.75
Reversibility of replicative senescence in Saccharomyces cerevisiae: effect of homologous recombination and cell cycle checkpoints. DNA Repair (Amst) (2011) 0.75
Telomerase activity in pregnancy complications (Review). Mol Med Rep (2016) 0.75
Age-related sex differences in body condition and telomere dynamics of red-sided garter snakes. Proc Biol Sci (2017) 0.75
Birth mass is the key to understanding the negative correlation between lifespan and body size in dogs. Aging (Albany NY) (2016) 0.75
WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1. Nucleic Acids Res (2017) 0.75
Epipodial Tentacle Gene Expression and Predetermined Resilience to Summer Mortality in the Commercially Important Greenlip Abalone, Haliotis laevigata. Mar Biotechnol (NY) (2017) 0.75
Developmental programming: State-of-the-science and future directions-Summary from a Pennington Biomedical symposium. Obesity (Silver Spring) (2016) 0.75
Early life infection, but not breastfeeding, predicts adult blood telomere lengths in the Philippines. Am J Hum Biol (2017) 0.75
The association of occupational metals exposure and oxidative damage, telomere shortening in fitness equipments manufacturing workers. Ind Health (2017) 0.75
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet (2006) 4.43
Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol (2010) 3.27
Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study. BMJ (2009) 3.20
DNA damage response and cellular senescence in tissues of aging mice. Aging Cell (2009) 2.91
Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell (2005) 2.83
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol (2007) 2.78
DNA damage foci in mitosis are devoid of 53BP1. Cell Cycle (2009) 2.51
Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells. Stem Cells (2007) 2.07
Fat depot-specific characteristics are retained in strains derived from single human preadipocytes. Diabetes (2006) 1.99
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci (2008) 1.91
Telomere shortening reduces regenerative capacity after acute kidney injury. J Am Soc Nephrol (2009) 1.88
Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells. Stem Cells (2004) 1.67
Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study. Mech Ageing Dev (2012) 1.67
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res (2007) 1.60
The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol. BMC Geriatr (2007) 1.58
A senescent cell bystander effect: senescence-induced senescence. Aging Cell (2012) 1.54
Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening. J Biol Chem (2002) 1.50
Adult-onset, short-term dietary restriction reduces cell senescence in mice. Aging (Albany NY) (2010) 1.45
Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients. Eur J Gastroenterol Hepatol (2006) 1.38
Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study. Mech Ageing Dev (2011) 1.36
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell (2012) 1.35
Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts. J Cell Biol (2007) 1.27
No association between socio-economic status and white blood cell telomere length. Aging Cell (2006) 1.24
Mitochondria, telomeres and cell senescence. Exp Gerontol (2005) 1.17
Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep (2005) 1.16
Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936. Neurobiol Aging (2010) 1.15
Telomere length is associated with left ventricular function in the oldest old: the Newcastle 85+ study. Eur Heart J (2007) 1.14
Mitochondrial turnover in liver is fast in vivo and is accelerated by dietary restriction: application of a simple dynamic model. Aging Cell (2008) 1.13
Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J Biol Chem (2004) 1.13
Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation. Aging Cell (2011) 1.12
MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell (2003) 1.11
An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Stem Cells (2011) 1.09
Architectural changes in the thymus of aging mice. Aging Cell (2008) 1.05
Telomere-driven replicative senescence is a stress response. Nat Biotechnol (2003) 1.02
Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs. BMC Geriatr (2011) 0.97
Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2. Arthritis Rheum (2013) 0.97
Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations. Biogerontology (2008) 0.95
Premature senescence of mesothelial cells is associated with non-telomeric DNA damage. Biochem Biophys Res Commun (2007) 0.95
Will your telomeres tell your future? BMJ (2012) 0.94
Immortalisation of human ovarian surface epithelium with telomerase and temperature-sensitive SV40 large T antigen. Exp Cell Res (2003) 0.94
Cellular senescence: unravelling complexity. Age (Dordr) (2009) 0.93
Mitochondria and ageing: winning and losing in the numbers game. Bioessays (2007) 0.93
Telomere length and physical performance at older ages: an individual participant meta-analysis. PLoS One (2013) 0.92
Gross energy metabolism in mice under late onset, short term caloric restriction. Mech Ageing Dev (2011) 0.91
hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines. Cancer Lett (2002) 0.89
Telomere length and anaemia in old age: results from the Newcastle 85-plus Study and the Leiden 85-plus Study. Age Ageing (2011) 0.89
Assessment of sleep and circadian rhythm disorders in the very old: the Newcastle 85+ Cohort Study. Age Ageing (2013) 0.88
TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts. Mech Ageing Dev (2007) 0.88
Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose. Biochem Biophys Res Commun (2007) 0.88
High-throughput 13-parameter immunophenotyping identifies shifts in the circulating T-cell compartment following reperfusion in patients with acute myocardial infarction. PLoS One (2012) 0.87
Inflammation and not cardiovascular risk factors is associated with short leukocyte telomere length in 13- to 16-year-old adolescents. Arterioscler Thromb Vasc Biol (2012) 0.86
Inflammation, telomere length, and grip strength: a 10-year longitudinal study. Calcif Tissue Int (2014) 0.85
Mitochondrial dysfunction and cell senescence: cause or consequence? Rejuvenation Res (2006) 0.85
Measuring DNA repair incision activity of mouse tissue extracts towards singlet oxygen-induced DNA damage: a comet-based in vitro repair assay. Mutagenesis (2011) 0.85
Telomere shortening and haemodialysis. Blood Purif (2005) 0.84
A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations. PLoS One (2012) 0.84
Vulnerability to oxidative stress and different patterns of senescence in human peritoneal mesothelial cell strains. Am J Physiol Regul Integr Comp Physiol (2008) 0.82
Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old. Neurobiol Aging (2013) 0.82
Standardization and quality controls for the methylated DNA immunoprecipitation technique. Epigenetics (2012) 0.82
Human fibroblasts in vitro senesce with a donor-specific telomere length. FEBS Lett (2002) 0.82
Correction of radiolabel pulse-chase data by a mathematical model: application to mitochondrial turnover studies. Biochem Soc Trans (2010) 0.81
Childhood growth, IQ and education as predictors of white blood cell telomere length at age 49-51 years: the Newcastle Thousand Families Study. PLoS One (2012) 0.80
Reproducibility of Telomere Length Assessment - An International Collaborative Study. Int J Epidemiol (2015) 0.80
Methods for cell sorting of young and senescent cells. Methods Mol Biol (2007) 0.80
Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study. Biogerontology (2014) 0.79
Measuring reactive oxygen species in senescent cells. Methods Mol Biol (2013) 0.79
Tumour-cell apoptosis after cisplatin treatment is not telomere dependent. Int J Cancer (2006) 0.79
Telomeres, telomerase and the cancer cell: an introduction. Cancer Lett (2003) 0.78
Lysosomal redox-active iron is important for oxidative stress-induced DNA damage. Ann N Y Acad Sci (2004) 0.78
Cell sorting of young and senescent cells. Methods Mol Biol (2013) 0.78
The role of telomeres in Etoposide induced tumor cell death. Cell Cycle (2004) 0.78
The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult. IUBMB Life (2012) 0.78
Monitoring DNA damage during cell senescence. Methods Mol Biol (2013) 0.78
Shared Ageing Research Models (ShARM): a new facility to support ageing research. Biogerontology (2013) 0.77
The relationship between the aging- and photo-dependent T414G mitochondrial DNA mutation with cellular senescence and reactive oxygen species production in cultured skin fibroblasts. J Invest Dermatol (2008) 0.77
Tissue differences in BER-related incision activity and non-specific nuclease activity as measured by the comet assay. Mutagenesis (2013) 0.77
Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology (2015) 0.76
Telomerase as a promising target for human cancer gene therapy. Drugs Today (Barc) (2003) 0.76
Shifting focus. Cell Cycle (2010) 0.75
The epigenetic clock and telomere length are independently associated with chronological age and mortality. Int J Epidemiol (2017) 0.75
The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State? J Alzheimers Dis (2017) 0.75