Published in Oncogene on September 17, 2007
Biology of hypoxia-inducible factor-2alpha in development and disease. Cell Death Differ (2008) 2.08
The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One (2009) 1.81
Twist-1 regulates the miR-199a/214 cluster during development. Nucleic Acids Res (2008) 1.71
Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes. Curr Opin Genet Dev (2009) 1.57
The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1. J Biol Chem (2009) 1.56
HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. J Clin Invest (2009) 1.49
E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells. Radiother Oncol (2011) 1.32
HIF1α and HIF2α independently activate SRC to promote melanoma metastases. J Clin Invest (2013) 1.32
COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion. J Clin Invest (2010) 1.28
Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers. Br J Cancer (2008) 1.24
Twist1 induces CCL2 and recruits macrophages to promote angiogenesis. Cancer Res (2013) 1.24
Hedgehog signalling in breast cancer. Carcinogenesis (2009) 1.18
Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease. Kidney Int (2009) 1.16
Constitutive proteasomal degradation of TWIST-1 in epithelial-ovarian cancer stem cells impacts differentiation and metastatic potential. Oncogene (2012) 1.13
RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. Nucleic Acids Res (2009) 1.12
ARTEMIN synergizes with TWIST1 to promote metastasis and poor survival outcome in patients with ER negative mammary carcinoma. Breast Cancer Res (2011) 1.12
Dysregulated pH in Tumor Microenvironment Checkmates Cancer Therapy. Bioimpacts (2013) 1.11
Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro. Cancer Res (2010) 1.05
Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans. Genetics (2009) 1.04
Pathophysiological Consequences of HIF Activation: HIF as a modulator of fibrosis. Ann N Y Acad Sci (2009) 1.04
Twist1 is up-regulated in gastric cancer-associated fibroblasts with poor clinical outcomes. Am J Pathol (2011) 1.03
Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Semin Cancer Biol (2015) 1.01
Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1. Oncogene (2010) 1.01
Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells. Clin Exp Metastasis (2012) 0.99
The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition. J Cell Biol (2013) 0.99
Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans. PLoS Genet (2010) 0.99
Artificially induced epithelial-mesenchymal transition in surgical subjects: its implications in clinical and basic cancer research. PLoS One (2011) 0.92
Overexpression of HIF-2α, TWIST, and CXCR4 is associated with lymph node metastasis in papillary thyroid carcinoma. Clin Dev Immunol (2013) 0.91
The inflammatory tumor microenvironment, epithelial mesenchymal transition and lung carcinogenesis. Cancer Microenviron (2011) 0.89
The role of hypoxia in inflammatory disease (review). Int J Mol Med (2015) 0.89
CCN5/WISP-2: A micromanager of breast cancer progression. J Cell Commun Signal (2012) 0.87
Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial-Mesenchymal Transition. Trends Cell Biol (2015) 0.87
The role of epithelial-mesenchymal transition in pancreatic cancer. J Gastrointest Oncol (2011) 0.86
Parasite neuropeptide biology: Seeding rational drug target selection? Int J Parasitol Drugs Drug Resist (2011) 0.86
EMT and stem cell-like properties associated with HIF-2α are involved in arsenite-induced transformation of human bronchial epithelial cells. PLoS One (2012) 0.85
Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism. EMBO J (2012) 0.85
The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons. Elife (2016) 0.85
The emerging role of Twist proteins in hematopoietic cells and hematological malignancies. Blood Cancer J (2014) 0.84
A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue. Front Endocrinol (Lausanne) (2012) 0.80
C. elegans twist gene expression in differentiated cell types is controlled by autoregulation through intron elements. Dev Biol (2010) 0.80
SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans. BMC Genet (2014) 0.78
The proto-oncogene TWIST1 is regulated by microRNAs. PLoS One (2013) 0.77
Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein. Sci Rep (2016) 0.76
Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB. Biomedicines (2017) 0.76
TWIST1 hypermethylation is observed in pancreatic cancer. Biomed Rep (2012) 0.75
Should we consider cancers as embryonic diseases or as consequences of stem-cell deregulation? Clin Med Oncol (2008) 0.75
A Synthetic Lethal Screen Identifies a Role for Lin-44/Wnt in C. elegans Embryogenesis. PLoS One (2015) 0.75
CAP protein superfamily members in Toxocara canis. Parasit Vectors (2016) 0.75
Human steroid sulfatase induces Wnt/β-catenin signaling and epithelial-mesenchymal transition by upregulating Twist1 and HIF-1α in human prostate and cervical cancer cells. Oncotarget (2017) 0.75
Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev (2000) 5.71
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc Natl Acad Sci U S A (2001) 4.51
Cloning of the essential myotonic dystrophy region and mapping of the putative defect. Nature (1992) 4.45
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J Natl Cancer Inst (2001) 4.27
MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J (1996) 4.13
Efficacy of 'radioguided occult lesion localisation' (ROLL) versus 'wire-guided localisation' (WGL) in breast conserving surgery for non-palpable breast cancer: a randomised controlled multicentre trial. Breast Cancer Res Treat (2012) 3.99
Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer. J Pathol (2001) 3.94
Cre-mediated somatic site-specific recombination in mice. Nucleic Acids Res (1997) 3.70
Sentinel lymph node procedure is highly accurate in squamous cell carcinoma of the vulva. J Clin Oncol (2000) 3.20
Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene (2009) 3.09
Randomised trial of high-dose chemotherapy and haemopoietic progenitor-cell support in operable breast cancer with extensive axillary lymph-node involvement. Lancet (1998) 3.06
Growth factor-like action of phosphatidic acid. Nature (1986) 2.87
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol (2004) 2.74
Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J Pathol (2005) 2.70
Prevalence of HPV in cytomorphologically normal cervical smears, as determined by the polymerase chain reaction, is age-dependent. Int J Cancer (1993) 2.60
CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Nat Genet (1999) 2.60
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene (2011) 2.42
Doxorubicin gradients in human breast cancer. Clin Cancer Res (1999) 2.36
Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns. J Pathol (2001) 2.33
Neuropsychological effects of bilateral STN stimulation in Parkinson disease: a controlled study. Neurology (2006) 2.32
Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins. Genes Dev (1996) 2.26
Differential prognostic impact of hypoxia induced and diffuse HIF-1alpha expression in invasive breast cancer. J Clin Pathol (2005) 2.10
A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction. EMBO J (1988) 2.09
Radioactive seed localization for non-palpable breast cancer. Br J Surg (2013) 2.07
Molecular evidence linking primary cancer of the fallopian tube to BRCA1 germline mutations. Gynecol Oncol (2000) 2.04
Sentinel lymph node biopsy in breast cancer: guidelines and pitfalls of lymphoscintigraphy and gamma probe detection. J Am Coll Surg (1998) 2.02
Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation. Cancer Res (2001) 1.95
Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells. Mol Cell Biol (1985) 1.91
Relationships between vascularization and proliferation in invasive breast cancer. J Pathol (1999) 1.90
Activated cytotoxic T cells as prognostic marker in Hodgkin's disease. Blood (1997) 1.82
High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses. J Cell Biol (1990) 1.78
Gap junction protein connexin-43 interacts directly with microtubules. Curr Biol (2001) 1.76
[The sentinel node procedure: standard intervention for surgical treatment of breast cancer]. Ned Tijdschr Geneeskd (1998) 1.76
Heterogeneity and reproducibility of microvessel counts in breast cancer. Lab Invest (1995) 1.75
Prognostic value of proliferation in invasive breast cancer: a review. J Clin Pathol (2004) 1.72
Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway. J Biol Chem (1994) 1.72
Oncogenic role of DDX3 in breast cancer biogenesis. Oncogene (2008) 1.70
Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation. J Neurol Neurosurg Psychiatry (2005) 1.69
Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1. Biochem J (1998) 1.67
Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I: An inventory in search of autocrine and paracrine loops. J Pathol (1998) 1.62
Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase. J Biol Chem (1999) 1.61
Expression of differentiation and proliferation related proteins in epithelium of prophylactically removed ovaries from women with a hereditary female adnexal cancer predisposition. Histopathology (2003) 1.59
Interlaboratory reproducibility of semiautomated cell cycle analysis of flow cytometry DNA-histograms obtained from fresh material of 1,295 breast cancer cases. Hum Pathol (1996) 1.58
Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis. J Pathol (1998) 1.58
Comparative genomic hybridisation. Mol Pathol (1999) 1.56
Progression from colorectal adenoma to carcinoma is associated with non-random chromosomal gains as detected by comparative genomic hybridisation. J Clin Pathol (1998) 1.54
Clinical and genetic evaluation of thirty ovarian cancer families. Am J Obstet Gynecol (1998) 1.49
Extended neoadjuvant chemotherapy in locally advanced breast cancer combined with GM-CSF: effect on tumour-draining lymph node dendritic cells. Eur J Cancer (2003) 1.48
Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer. Histopathology (2005) 1.47
In-transit lymph node metastases in breast cancer: a possible source of local recurrence after Sentinel Node procedure. J Clin Pathol (2008) 1.42
Impactitis: new cures for an old disease. J Clin Pathol (2001) 1.42
Histopathology of fibroadenoma of the breast. Am J Clin Pathol (2001) 1.41
DNA profiling of primary serous ovarian and fallopian tube carcinomas with array comparative genomic hybridization and multiplex ligation-dependent probe amplification. J Pathol (2007) 1.40
Inositol phosphate metabolism in bradykinin-stimulated human A431 carcinoma cells. Relationship to calcium signalling. Biochem J (1987) 1.39
cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts. J Biol Chem (1994) 1.38
Quality control methods for data entry in pathology using a computerized data management system based on an extended data dictionary. Hum Pathol (1992) 1.38
Apoptin, a protein derived from chicken anemia virus, induces p53-independent apoptosis in human osteosarcoma cells. Cancer Res (1995) 1.36
Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α. Oncogene (2011) 1.34
Predictive factors for metastatic involvement of nonsentinel nodes in patients with breast cancer. Arch Surg (2001) 1.34
Genetic relation of lobular carcinoma in situ, ductal carcinoma in situ, and associated invasive carcinoma of the breast. Mol Pathol (2000) 1.34
Primary extranodal non-Hodgkin lymphoma of the oral cavity. An analysis of 34 cases. Eur J Cancer B Oral Oncol (1994) 1.31
Immunohistochemical differentiation between primary adenocarcinomas of the ovary and ovarian metastases of colonic and breast origin. Comparison between a statistical and an intuitive approach. J Clin Pathol (1999) 1.28
Functional lymphatic anatomy for sentinel node biopsy in breast cancer: echoes from the past and the periareolar blue method. Ann Surg (2000) 1.27
Ductal invasive G2 and G3 carcinomas of the breast are the end stages of at least two different lines of genetic evolution. J Pathol (2001) 1.26
Impact of lymphoscintigraphy on sentinel node identification with technetium-99m-colloidal albumin in breast cancer. J Nucl Med (1997) 1.25
The sentinel lymph node status is an important factor for predicting clinical outcome in patients with Stage I or II cutaneous melanoma. Cancer (2001) 1.25
Histopathological workup of sentinel lymph nodes: how much is enough? J Clin Pathol (1999) 1.25
Lack of lymphangiogenesis during breast carcinogenesis. J Clin Pathol (2004) 1.25
Distinction between hereditary and sporadic breast cancer on the basis of clinicopathological data. J Clin Pathol (2006) 1.24
Prognostic role of clinical, pathological and biological characteristics in patients with locally advanced breast cancer. Br J Cancer (1998) 1.23
Gi-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc. EMBO J (1997) 1.23
Epidermal-growth-factor-induced formation of inositol phosphates in human A431 cells. Differences from the effect of bradykinin. Biochem J (1988) 1.23
Molecular imaging of breast cancer. Breast (2009) 1.22
Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer. Clin Cancer Res (2000) 1.21
Ultrasound-guided laser-induced thermal therapy for small palpable invasive breast carcinomas: a feasibility study. Ann Surg Oncol (2009) 1.20
Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis. Oncogene (2006) 1.17
Sentinel node investigation in breast cancer: detailed analysis of the yield from step sectioning and immunohistochemistry. J Clin Pathol (2001) 1.16
Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases. Am J Pathol (2000) 1.16
Current technologies for HER2 testing in breast cancer. Crit Rev Oncol Hematol (2011) 1.14
Prognostic relevance of P-glycoprotein expression in breast cancer. Ann Oncol (1995) 1.13
Molecular subtypes of breast cancer and amplification of topoisomerase II alpha: predictive role in dose intensive adjuvant chemotherapy. Br J Cancer (2006) 1.12
Association between the cellular p53 and the adenovirus 5 E1B-55kd proteins reduces the oncogenicity of Ad-transformed cells. EMBO J (1990) 1.12
Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer. Ann Oncol (2008) 1.12
Diagnosis of breast lesions: fine-needle aspiration cytology or core needle biopsy? A review. J Clin Pathol (2011) 1.12