PubRank

Nancy J Rothwell

Author PubWeight™ 90.33‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The role of inflammation in CNS injury and disease. Br J Pharmacol 2006 3.96
2 Interleukin-1 and neuronal injury. Nat Rev Immunol 2005 3.85
3 Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell 2005 2.63
4 Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms. J Neurosci 2007 2.47
5 Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurol 2004 2.30
6 Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice. J Neurosci 2008 2.21
7 An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. J Neuroimmunol 2003 1.97
8 Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death. J Cell Sci 2007 1.80
9 CNS injury: the role of the cytokine IL-1. Vet J 2004 1.65
10 Inflammation in central nervous system injury. Philos Trans R Soc Lond B Biol Sci 2003 1.56
11 Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. J Biol Chem 2001 1.52
12 Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat. Br J Pharmacol 2003 1.50
13 Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain Behav Immun 2011 1.44
14 Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages. J Immunol 2003 1.39
15 Platelet interleukin-1alpha drives cerebrovascular inflammation. Blood 2010 1.38
16 Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra. J Neurotrauma 2007 1.36
17 Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations. J Cereb Blood Flow Metab 2007 1.34
18 Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release. J Neurochem 2006 1.27
19 A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke. J Cereb Blood Flow Metab 2009 1.22
20 Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats. J Cereb Blood Flow Metab 2012 1.20
21 Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target. Cerebrovasc Dis 2011 1.18
22 A dual role for interleukin-1 in LTP in mouse hippocampal slices. J Neuroimmunol 2003 1.17
23 Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia. J Neurosci 2003 1.14
24 Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage. Br J Clin Pharmacol 2007 1.12
25 Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA. J Immunol 2012 1.10
26 Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection. Br J Pharmacol 2010 1.10
27 Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells. J Neurochem 2002 1.09
28 Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology. Dis Model Mech 2012 1.09
29 Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses. J Cereb Blood Flow Metab 2010 1.08
30 Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke. J Cereb Blood Flow Metab 2009 1.06
31 Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures. J Neurosci Res 2002 1.06
32 Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo. J Cereb Blood Flow Metab 2003 1.06
33 Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia. Glia 2006 1.06
34 Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices. Glia 2013 1.05
35 Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro. J Neuroinflammation 2012 1.02
36 Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production. BMC Neurol 2007 1.02
37 [18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats. PLoS One 2013 1.00
38 Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism. Mol Cell Neurosci 2002 1.00
39 Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity. Mol Cell Neurosci 2007 0.98
40 Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. Mol Cell Neurosci 2006 0.98
41 Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing. Nat Chem Biol 2011 0.97
42 Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones. Mol Cell Neurosci 2008 0.96
43 Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism. J Neurochem 2007 0.95
44 Variability of the systemic acute phase response after ischemic stroke. J Neurol Sci 2006 0.95
45 Regulation of expression of the novel IL-1 receptor family members in the mouse brain. J Neurochem 2005 0.94
46 Cerebrospinal fluid and plasma cytokines after subarachnoid haemorrhage: CSF interleukin-6 may be an early marker of infection. J Neuroinflammation 2012 0.93
47 Involvement of caspases and calpains in cerebrocortical neuronal cell death is stimulus-dependent. Br J Pharmacol 2002 0.92
48 No role for interleukin-18 in acute murine stroke-induced brain injury. J Cereb Blood Flow Metab 2003 0.92
49 The dynamics and mechanisms of interleukin-1alpha and beta nuclear import. Traffic 2008 0.92
50 Inflammation as a predictor for delayed cerebral ischemia after aneurysmal subarachnoid haemorrhage. J Neurointerv Surg 2012 0.91
51 PRL-releasing peptide interacts with leptin to reduce food intake and body weight. Endocrinology 2002 0.91
52 Interleukin-1 drives cerebrovascular inflammation via MAP kinase-independent pathways. Curr Neurovasc Res 2010 0.91
53 The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signaling pathways exist in the brain? Mol Neurobiol 2003 0.90
54 IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice. Br J Pharmacol 2002 0.89
55 Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phosphatidylinositol 3-kinase/AKT signaling. Mol Cell Neurosci 2005 0.89
56 Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα. Ann Neurol 2014 0.89
57 The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial. J Neuroinflammation 2014 0.88
58 Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression. Cytokine 2012 0.88
59 Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones. Mol Cell Neurosci 2007 0.87
60 Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta. J Neurochem 2003 0.87
61 Does inflammation predispose to recurrent vascular events after recent transient ischaemic attack and minor stroke? The North West of England transient ischaemic attack and minor stroke (NORTHSTAR) study. Int J Stroke 2011 0.86
62 Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice. Dis Model Mech 2013 0.86
63 A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat. Neuropharmacology 2007 0.86
64 Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain. J Neuroimmunol 2003 0.85
65 Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients. Stroke 2004 0.85
66 Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis. J Am Heart Assoc 2012 0.85
67 The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1beta signalling responses. Cytokine 2005 0.84
68 Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc. Eur J Immunol 2009 0.83
69 IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells. J Neuroimmunol 2003 0.82
70 Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat. Magn Reson Med 2008 0.81
71 Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain. Glia 2006 0.81
72 Site-specific actions of interleukin-1 on excitotoxic cell death in the rat striatum. Brain Res 2002 0.81
73 Translational pharmacokinetics: challenges of an emerging approach to drug development in stroke. Expert Opin Drug Metab Toxicol 2011 0.79
74 An immortalised astrocyte cell line maintains the in vivo phenotype of a primary porcine in vitro blood-brain barrier model. Brain Res 2012 0.79
75 Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro. Brain Res 2008 0.78
76 Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways. Neuroreport 2005 0.77
77 Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity. Eur J Immunol 2014 0.76
78 Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS. Cytokine 2003 0.75