Published in Nat Chem Biol on October 01, 2007
Regulating the regulator: post-translational modification of RAS. Nat Rev Mol Cell Biol (2011) 2.81
FKBP12 binds to acylated H-ras and promotes depalmitoylation. Mol Cell (2011) 2.17
Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends Biochem Sci (2011) 1.98
How antibodies fold. Trends Biochem Sci (2009) 1.88
The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils. Blood (2010) 1.68
cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72. J Biol Chem (2010) 1.47
Lysine acetylation controls local protein conformation by influencing proline isomerization. Mol Cell (2014) 1.46
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest (2008) 1.37
Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease. Cell (2012) 1.36
RNA polymerase II C-terminal domain: Tethering transcription to transcript and template. Chem Rev (2013) 1.35
Slow conformational dynamics at C2'-endo nucleotides in RNA. J Am Chem Soc (2008) 1.35
A palmitoylation switch mechanism regulates Rac1 function and membrane organization. EMBO J (2011) 1.31
Structural basis for regulation of the Crk signaling protein by a proline switch. Nat Chem Biol (2010) 1.30
Defining the budding yeast chromatin-associated interactome. Mol Syst Biol (2010) 1.19
Novel mode of phosphorylation-triggered reorganization of the nuclear lamina during nuclear egress of human cytomegalovirus. J Biol Chem (2010) 1.14
Pin1 deficiency causes endothelial dysfunction and hypertension. Hypertension (2011) 1.13
Toward flexibility-activity relationships by NMR spectroscopy: dynamics of Pin1 ligands. J Am Chem Soc (2010) 1.13
Insights into the Mechanical Properties of the Kinesin Neck Linker Domain from Sequence Analysis and Molecular Dynamics Simulations. Cell Mol Bioeng (2009) 1.10
Proline: the distribution, frequency, positioning, and common functional roles of proline and polyproline sequences in the human proteome. PLoS One (2013) 1.09
Aberrant regulation of FBW7 in cancer. Oncotarget (2014) 1.08
Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues. Histochem Cell Biol (2008) 1.07
Molecular mechanisms of prolactin and its receptor. Endocr Rev (2012) 1.04
Functional interaction of the Ess1 prolyl isomerase with components of the RNA polymerase II initiation and termination machineries. Mol Cell Biol (2009) 1.03
Stereospecific gating of functional motions in Pin1. Proc Natl Acad Sci U S A (2011) 1.03
Chaperone domains convert prolyl isomerases into generic catalysts of protein folding. Proc Natl Acad Sci U S A (2009) 1.02
Prolyl isomerase Pin1 in cancer. Cell Res (2014) 1.01
A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease. Neurobiol Aging (2010) 1.01
Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin. Mol Cell Biol (2012) 1.01
Regulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1. Mol Cell Biol (2011) 1.00
Deciphering post-translational modification codes. FEBS Lett (2013) 0.99
Issues about the physiological functions of prolyl oligopeptidase based on its discordant spatial association with substrates and inconsistencies among mRNA, protein levels, and enzymatic activity. J Histochem Cytochem (2009) 0.99
Protein conformational switches: from nature to design. Chemistry (2012) 0.99
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nat Med (2015) 0.99
ARNT PAS-B has a fragile native state structure with an alternative beta-sheet register nearby in sequence space. Proc Natl Acad Sci U S A (2009) 0.98
Cooperativity in monomeric enzymes with single ligand-binding sites. Bioorg Chem (2011) 0.95
Nascentome analysis uncovers futile protein synthesis in Escherichia coli. PLoS One (2011) 0.95
Pin1 modulates ERα levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation. Oncogene (2013) 0.94
Complete determination of the Pin1 catalytic domain thermodynamic cycle by NMR lineshape analysis. J Biomol NMR (2011) 0.94
The prolyl isomerase Pin1 targets stem-loop binding protein (SLBP) to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitination. Mol Cell Biol (2012) 0.94
Mechanistic insight into the role of transition-state stabilization in cyclophilin A. J Am Chem Soc (2009) 0.92
Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism. Proc Natl Acad Sci U S A (2014) 0.92
Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam. J Nat Prod (2010) 0.92
Knockdown of CypA inhibits interleukin-8 (IL-8) and IL-8-mediated proliferation and tumor growth of glioblastoma cells through down-regulated NF-κB. J Neurooncol (2010) 0.92
Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcription. Mol Cell Biol (2009) 0.91
Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation. J Biol Chem (2008) 0.91
A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin. J Biol Chem (2009) 0.89
NMR reveals novel mechanisms of protein activity regulation. Protein Sci (2011) 0.89
Synthesis, Redox Properties, and Conformational Analysis of Vicinal Disulfide Ring Mimics. Tetrahedron (2009) 0.88
Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1. Circ Res (2013) 0.88
Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease. Biochim Biophys Acta (2015) 0.88
Time-dependent activation of Phox2a by the cyclic AMP pathway modulates onset and duration of p27Kip1 transcription. Mol Cell Biol (2009) 0.88
Pin1, a new player in the fate of HIF-1α degradation: an hypothetical mechanism inside vascular damage as Alzheimer's disease risk factor. Front Cell Neurosci (2014) 0.88
Dynamics of ligand binding from 13C NMR relaxation dispersion at natural abundance. J Am Chem Soc (2008) 0.88
Mapping the dynamics of ligand reorganization via 13CH3 and 13CH2 relaxation dispersion at natural abundance. J Biomol NMR (2009) 0.86
Complete thermodynamic and kinetic characterization of the isomer-specific interaction between Pin1-WW domain and the amyloid precursor protein cytoplasmic tail phosphorylated at Thr668. Biochemistry (2012) 0.86
Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity. Development (2013) 0.86
The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease. J Biol Chem (2013) 0.86
Dual regulation of Myc by Abl. Oncogene (2013) 0.85
Prolyl isomerases in gene transcription. Biochim Biophys Acta (2014) 0.85
The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly. RNA (2013) 0.85
Keep on moving: discovering and perturbing the conformational dynamics of enzymes. Acc Chem Res (2014) 0.85
Mycobacterium tuberculosis cyclophilin A uses novel signal sequence for secretion and mimics eukaryotic cyclophilins for interaction with host protein repertoire. PLoS One (2014) 0.85
Interdomain interactions support interdomain communication in human Pin1. Biochemistry (2013) 0.85
Pin1 protein regulates Smad protein signaling and pulmonary fibrosis. J Biol Chem (2012) 0.85
Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model. J Biol Chem (2012) 0.85
A remote prolyl isomerization controls domain assembly via a hydrogen bonding network. Proc Natl Acad Sci U S A (2009) 0.85
FK506-Binding Protein 10, a Potential Novel Drug Target for Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med (2015) 0.84
Cyclophilin A (CypA) interacts with NF-κB subunit, p65/RelA, and contributes to NF-κB activation signaling. PLoS One (2014) 0.84
Depletion of cyclophilins B and C leads to dysregulation of endoplasmic reticulum redox homeostasis. J Biol Chem (2014) 0.84
The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target. Nat Rev Cancer (2016) 0.84
p63 threonine phosphorylation signals the interaction with the WW domain of the E3 ligase Itch. Cell Cycle (2014) 0.84
Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions. Cell Death Differ (2016) 0.83
Prolyl isomerase Pin1-mediated conformational change and subnuclear focal accumulation of Runx2 are crucial for fibroblast growth factor 2 (FGF2)-induced osteoblast differentiation. J Biol Chem (2014) 0.83
"Wet" Versus "Dry" Folding of Polyproline. J Am Soc Mass Spectrom (2016) 0.83
The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease. J Neurochem (2015) 0.83
Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature (2015) 0.82
Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity. BMC Neurosci (2015) 0.82
Regulation of the incorporation of tissue factor into microparticles by serine phosphorylation of the cytoplasmic domain of tissue factor. J Biol Chem (2011) 0.82
Peptidyl-prolyl isomerization targets rice Aux/IAAs for proteasomal degradation during auxin signalling. Nat Commun (2015) 0.82
Molecular and biochemical characterization of the parvulin-type PPIases in Lotus japonicus. Plant Physiol (2009) 0.82
Phosphorylation of bacterial-type phosphoenolpyruvate carboxylase at Ser425 provides a further tier of enzyme control in developing castor oil seeds. Biochem J (2011) 0.82
FK506-Binding protein 22 from a psychrophilic bacterium, a cold shock-inducible peptidyl prolyl isomerase with the ability to assist in protein folding. Int J Mol Sci (2011) 0.82
Prolyl Isomerase Pin1 Negatively Regulates AMP-activated Protein Kinase (AMPK) by Associating with the CBS Domain in the γ Subunit. J Biol Chem (2015) 0.82
Phenotypic and proteomic characteristics of human dental pulp derived mesenchymal stem cells from a natal, an exfoliated deciduous, and an impacted third molar tooth. Stem Cells Int (2014) 0.81
γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation. J Biol Chem (2012) 0.81
KSHV reactivation and novel implications of protein isomerization on lytic switch control. Viruses (2015) 0.81
Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis. Protein Sci (2013) 0.81
Structural biology: The twist in Crk signaling revealed. Nat Chem Biol (2011) 0.81
Non-catalytic participation of the Pin1 peptidyl-prolyl isomerase domain in target binding. Front Physiol (2013) 0.81
Evolution of the genetic code by incorporation of amino acids that improved or changed protein function. J Mol Evol (2013) 0.81
Peptidyl-prolyl cis/trans-isomerase A1 (Pin1) is a target for modification by lipid electrophiles. Chem Res Toxicol (2012) 0.80
ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair. Front Oncol (2014) 0.80
Detection of discriminative sequence patterns in the neighborhood of proline cis peptide bonds and their functional annotation. BMC Bioinformatics (2009) 0.80
Cis phosphorylated tau as the earliest detectable pathogenic conformation in Alzheimer disease, offering novel diagnostic and therapeutic strategies. Prion (2012) 0.80
Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases. Biochemistry (2014) 0.80
Pin1-mediated Runx2 modification is critical for skeletal development. J Cell Physiol (2013) 0.80
Solution structural analysis of the single-domain parvulin TbPin1. PLoS One (2012) 0.80
Prolyl isomerase Pin1 regulates transcription factor LSF (TFCP2) by facilitating dephosphorylation at two serine-proline motifs. J Biol Chem (2010) 0.80
Rrd1 isomerizes RNA polymerase II in response to rapamycin. BMC Mol Biol (2010) 0.80
Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Nat Immunol (2006) 2.85
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature (2006) 2.61
Phosphorylation-specific prolyl isomerization: is there an underlying theme? Nat Cell Biol (2005) 2.06
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol (2013) 1.73
Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Mol Cell (2012) 1.48
Repeated domains of leptospira immunoglobulin-like proteins interact with elastin and tropoelastin. J Biol Chem (2009) 1.37
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest (2008) 1.37
The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. Dev Cell (2005) 1.34
Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Proc Natl Acad Sci U S A (2008) 1.33
Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance. Nat Cell Biol (2008) 1.27
Multi-point interrogation of FBG sensors using cascaded flexible wavelength-division Sagnac loop filters. Opt Express (2006) 1.22
The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. J Clin Invest (2011) 1.20
The N-terminal region of Pseudomonas type III effector AvrPtoB elicits Pto-dependent immunity and has two distinct virulence determinants. Plant J (2007) 1.19
Transduction-mediated transfer of unmarked deletion and point mutations through use of counterselectable suicide vectors. J Bacteriol (2002) 1.17
Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity. Nat Immunol (2011) 1.14
Fibronectin binds to and induces conformational change in a disordered region of leptospiral immunoglobulin-like protein B. J Biol Chem (2009) 1.13
Effects of DA-9701, a novel prokinetic agent, on gastric accommodation in conscious dogs. J Gastroenterol Hepatol (2012) 1.09
Targeting carcinogenesis: a role for the prolyl isomerase Pin1? Mol Carcinog (2006) 1.01
WT1 is a modifier of the Pax2 mutant phenotype: cooperation and interaction between WT1 and Pax2. Oncogene (2003) 1.01
Regulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1. Mol Cell Biol (2011) 1.00
The solution structure of type III effector protein AvrPto reveals conformational and dynamic features important for plant pathogenesis. Structure (2004) 0.99
Genistein sensitizes TRAIL-resistant human gastric adenocarcinoma AGS cells through activation of caspase-3. Cancer Lett (2007) 0.99
Ribozyme-mediated cleavage of the human survivin mRNA and inhibition of antiapoptotic function of survivin in MCF-7 cells. Cancer Gene Ther (2003) 0.97
The single kinin receptor signals to separate and independent physiological pathways in Malpighian tubules of the yellow fever mosquito. Am J Physiol Regul Integr Comp Physiol (2010) 0.96
Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation. J Biol Chem (2010) 0.96
TCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility. J Immunol (2014) 0.94
Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function. Proc Natl Acad Sci U S A (2012) 0.94
Complete determination of the Pin1 catalytic domain thermodynamic cycle by NMR lineshape analysis. J Biomol NMR (2011) 0.94
Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity. Biochem Biophys Res Commun (2005) 0.92
A novel fibronectin type III module binding motif identified on C-terminus of Leptospira immunoglobulin-like protein, LigB. Biochem Biophys Res Commun (2009) 0.92
Thermodynamic dissection of the Ezrin FERM/CERMAD interface. Biochemistry (2007) 0.92
SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function. Cancer Res (2013) 0.90
Pathophysiology of minimal change nephrotic syndrome and focal segmental glomerulosclerosis. Nephrology (Carlton) (2007) 0.90
Elucidation of a pH-folding switch in the Pseudomonas syringae effector protein AvrPto. Proc Natl Acad Sci U S A (2009) 0.87
Backbone dynamics and thermodynamics of Borrelia outer surface protein A. J Mol Biol (2002) 0.87
Sustainable wastewater treatment: how might microbial fuel cells contribute. Biotechnol Adv (2010) 0.86
Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic signal-response profiles. Cell Commun Signal (2014) 0.86
Complete thermodynamic and kinetic characterization of the isomer-specific interaction between Pin1-WW domain and the amyloid precursor protein cytoplasmic tail phosphorylated at Thr668. Biochemistry (2012) 0.86
Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1. J Biol Chem (2006) 0.86
The essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability. Biochem Biophys Res Commun (2011) 0.84
Pinning down HER2-ER crosstalk in SMRT regulation. Trends Biochem Sci (2009) 0.83
The interaction of hepatitis B virus X protein and protein phosphatase type 2 Calpha and its effect on IL-6. Biochem Biophys Res Commun (2006) 0.82
Structural biology: The twist in Crk signaling revealed. Nat Chem Biol (2011) 0.81
Cisplatin-induced apoptosis in Hep3B cells: mitochondria-dependent and -independent pathways. Biochem Pharmacol (2004) 0.80
In vitro and in vivo activities of DA-7867, a new oxazolidinone, against aerobic gram-positive bacteria. Antimicrob Agents Chemother (2005) 0.79
The microbial community in a 2,4-dinitrophenol-digesting reactor as revealed by 16S rDNA gene analysis. J Biosci Bioeng (2003) 0.78
Gene transfer of Cu/Zn SOD to cerebral vessels prevents FPI-induced CBF autoregulatory dysfunction. Am J Physiol Heart Circ Physiol (2002) 0.78
Isomerase-catalyzed binding of interleukin-1 receptor-associated kinase 1 to the EVH1 domain of vasodilator-stimulated phosphoprotein. Biochemistry (2014) 0.78
Sterins A and B, new antioxidative compounds from Stereum hirsutum. J Antibiot (Tokyo) (2002) 0.78
Folding kinetics and thermodynamics of Pseudomonas syringae effector protein AvrPto provide insight into translocation via the type III secretion system. Protein Sci (2008) 0.77
Role of sigma factor E in regulation of Salmonella Agf expression. Biochem Biophys Res Commun (2012) 0.77
Characterization of biofilms occurred in seepage groundwater contaminated with petroleum within an urban subway tunnel. J Environ Sci Health A Tox Hazard Subst Environ Eng (2004) 0.77
Factors determining the reliable description of global tumbling parameters in solution NMR. J Biomol NMR (2002) 0.76
Highly efficient deep-UV light-emitting diodes using AlN-based, deep-UV transparent glass electrodes. ACS Appl Mater Interfaces (2017) 0.75
1H, 15N and 13C chemical shift assignments of the structured core of the pseudomonas effector protein AvrPto. J Biomol NMR (2002) 0.75
Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of goserelin in rabbit plasma. J Chromatogr B Analyt Technol Biomed Life Sci (2010) 0.75
A monoclonal antibody against the paraneoplastic pemphigus (PNP) antigen, envoplakin: cDNA sequences encoding the variable regions of heavy and light chains. Mol Cells (2004) 0.75
Performance of GaN-on-Si-based vertical light-emitting diodes using silicon nitride electrodes with conducting filaments: correlation between filament density and device reliability. Opt Express (2016) 0.75
Backbone resonance assignments of Ezrin C ERMAD in a non-covalent complex with Ezrin N FERM. J Biomol NMR (2006) 0.75
Expression, purification and characterization of a recombinant levan fructotransferase. Biotechnol Appl Biochem (2002) 0.75
Individual switching of multi-wavelength lasing outputs based on switchable FBG filters. Opt Express (2007) 0.75
Advance decisions to refuse treatment component of the Mental Capacity Act. Br J Nurs (2008) 0.75