Published in Chem Biol on September 01, 2007
Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes. Proc Natl Acad Sci U S A (2007) 3.30
Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet (2002) 3.08
A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs. Mol Ther (2004) 2.16
Current status of pharmaceutical and genetic therapeutic approaches to treat DMD. Mol Ther (2011) 2.06
Medium chain acyl-coenzyme A dehydrogenase deficiency in a neonate. N Engl J Med (2007) 1.55
Improved nutritional management of phenylketonuria by using a diet containing glycomacropeptide compared with amino acids. Am J Clin Nutr (2009) 1.32
Efficacy of sapropterin dihydrochloride in increasing phenylalanine tolerance in children with phenylketonuria: a phase III, randomized, double-blind, placebo-controlled study. J Pediatr (2009) 1.27
Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules. J Gene Med (2006) 1.25
Endosomolysis by masking of a membrane-active agent (EMMA) for cytoplasmic release of macromolecules. Bioconjug Chem (2003) 1.18
Delivery of siRNA and siRNA expression constructs to adult mammals by hydrodynamic intravascular injection. Methods Enzymol (2005) 1.10
Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice. Nucleic Acids Res (2006) 1.08
Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes. Stem Cells (2003) 1.07
L-carnitine administration reduces number of episodes in cyclic vomiting syndrome. Clin Pediatr (Phila) (2002) 1.06
Intraarterial delivery of naked plasmid DNA expressing full-length mouse dystrophin in the mdx mouse model of duchenne muscular dystrophy. Hum Gene Ther (2004) 1.05
Correction of murine PKU following AAV-mediated intramuscular expression of a complete phenylalanine hydroxylating system. Mol Ther (2008) 1.05
Prospective diagnosis of 2-methylbutyryl-CoA dehydrogenase deficiency in the Hmong population by newborn screening using tandem mass spectrometry. Pediatrics (2003) 1.05
The effect of cell division on the cellular dynamics of microinjected DNA and dextran. Mol Ther (2002) 1.04
Mechanism of plasmid delivery by hydrodynamic tail vein injection. II. Morphological studies. J Gene Med (2006) 1.04
Systemic siRNA delivery via hydrodynamic intravascular injection. Adv Drug Deliv Rev (2007) 1.03
Effect of tissue-specific promoters and microRNA recognition elements on stability of transgene expression after hydrodynamic naked plasmid DNA delivery. Hum Gene Ther (2009) 1.02
Condensation of nonstochiometric DNA/polycation complexes by divalent cations. Biopolymers (2006) 1.00
Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation. Lab Invest (2005) 1.00
Sex differences in hepatic gene expression in a rat model of ethanol-induced liver injury. J Appl Physiol (1985) (2002) 0.99
Evaluation of hydrodynamic limb vein injections in nonhuman primates. Hum Gene Ther (2010) 0.98
Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting. J Leukoc Biol (2011) 0.95
Use of Evans blue dye to compare limb muscles in exercised young and old mdx mice. Muscle Nerve (2010) 0.94
Sustained liver-specific transgene expression from the albumin promoter in mice following hydrodynamic plasmid DNA delivery. J Gene Med (2008) 0.94
The role of molecular testing and enzyme analysis in the management of hypomorphic citrullinemia. Am J Med Genet A (2008) 0.92
Rapid intravascular injection into limb skeletal muscle: a damage assessment study. Mol Ther (2005) 0.91
Membrane activity and transfection ability of amphipathic polycations as a function of alkyl group size. Bioconjug Chem (2005) 0.90
Surgical procedures for intravascular delivery of plasmid DNA to organs. Methods Enzymol (2002) 0.89
Progress toward a nonviral gene therapy protocol for the treatment of anemia. Hum Gene Ther (2007) 0.88
Magnetic resonance imaging-monitored plasmid DNA delivery in primate limb muscle. Hum Gene Ther (2007) 0.88
Portacaval shunt causes apoptosis and liver atrophy in rats despite increases in endogenous levels of major hepatic growth factors. J Hepatol (2002) 0.88
Genetic immunization for antibody generation in research animals by intravenous delivery of plasmid DNA. Biotechniques (2006) 0.88
2-methylbutyryl-CoA dehydrogenase deficiency in Hmong infants identified by expanded newborn screen. WMJ (2007) 0.85
Functional efficacy of dystrophin expression from plasmids delivered to mdx mice by hydrodynamic limb vein injection. Hum Gene Ther (2010) 0.85
Accelerated reversal of carbon tetrachloride-induced cirrhosis in rats by the endothelin receptor antagonist TAK-044. J Gastroenterol Hepatol (2002) 0.84
Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT). J Med Chem (2011) 0.84
Dose response in rodents and nonhuman primates after hydrodynamic limb vein delivery of naked plasmid DNA. Hum Gene Ther (2011) 0.83
In vivo selection and validation of liver-specific ligands using a new T7 phage peptide display system. Drug Deliv (2007) 0.83
Self-quenched covalent fluorescent dye-nucleic acid conjugates as polymeric substrates for enzymatic nuclease assays. Anal Biochem (2002) 0.83
A single acyl-CoA dehydrogenase is required for catabolism of isoleucine, valine and short-chain fatty acids in Aspergillus nidulans. Fungal Genet Biol (2007) 0.83
Flt3-L gene therapy enhances immunocytokine-mediated antitumor effects and induces long-term memory. Cancer Immunol Immunother (2007) 0.82
Expression of phenylalanine hydroxylase (PAH) in erythrogenic bone marrow does not correct hyperphenylalaninemia in Pah(enu2) mice. J Gene Med (2003) 0.82
Entrapment and condensation of DNA in neutral reverse micelles. Biophys J (2002) 0.80
Hydrodynamic limb vein delivery of a xenogeneic DNA cancer vaccine effectively induces antitumor immunity. Mol Ther (2007) 0.80
Treg cells in pancreatic lymph nodes: the possible role in diabetogenesis and β cell regeneration in a T1D model. Cell Mol Immunol (2012) 0.80
Naked DNA gene transfer in mammalian cells. Methods Mol Biol (2004) 0.79
A new peptide ligand that targets particles and heterologous proteins to hepatocytes in vivo. Mol Ther (2003) 0.79
Muscle damage after delivery of naked plasmid DNA into skeletal muscles is batch dependent. Hum Gene Ther (2011) 0.79
Long-term RNA interference from optimized siRNA expression constructs in adult mice. Biochem Biophys Res Commun (2005) 0.79
Hybrid PET/CT for noninvasive pharmacokinetic evaluation of dynamic PolyConjugates, a synthetic siRNA delivery system. Bioconjug Chem (2010) 0.79
Targeted siRNA Delivery and mRNA Knockdown Mediated by Bispecific Digoxigenin-binding Antibodies. Mol Ther Nucleic Acids (2012) 0.79
Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt). J Med Chem (2010) 0.78
Distinct characteristics and features of allogeneic chimerism in the NOD mouse model of autoimmune diabetes. Cell Transplant (2002) 0.78
Hepatocyte targeting of nucleic acid complexes and liposomes by a T7 phage p17 peptide. Mol Pharm (2006) 0.78
PPARalpha siRNA-treated expression profiles uncover the causal sufficiency network for compound-induced liver hypertrophy. PLoS Comput Biol (2007) 0.78
Systemic gene transfer to skeletal muscle using reengineered AAV vectors. Methods Mol Biol (2011) 0.77
Use of recombinase activation gene-2 deficient mice to ascertain the role of cellular and humoral immune responses in the development of chronic rejection. J Heart Lung Transplant (2002) 0.77
Efficient in vitro and in vivo expression of covalently modified plasmid DNA. Mol Ther (2003) 0.77
The acquisition of narrow binding specificity by polyspecific natural IgM antibodies in a semi-physiological environment. Mol Immunol (2007) 0.75
The role of a microscopic colloidally stabilized phase in solubilizing oligoamine-condensed DNA complexes. Biophys J (2003) 0.75
Novel human pathological mutations. Gene symbol: ASS1. Disease: Citrullinaemia. Hum Genet (2009) 0.75
Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP). Drug Deliv (2009) 0.75
Thermo-activated Electrical Conductivity in Perylene Diimide Nanofiber Materials. J Phys Chem Lett (2016) 0.75
Novel human pathological mutations. Gene symbol: ASS1. Disease: Citrullinaemia. Hum Genet (2009) 0.75