PubRank

P Andrew Karplus

Author PubWeight™ 88.49‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science 2003 6.96
2 Protein sulfenic acids in redox signaling. Annu Rev Pharmacol Toxicol 2004 3.56
3 A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res 2004 2.71
4 Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins. Biochemistry 2002 2.41
5 Conformation dependence of backbone geometry in proteins. Structure 2009 2.33
6 Crystal structure of mammalian cysteine dioxygenase. A novel mononuclear iron center for cysteine thiol oxidation. J Biol Chem 2006 2.30
7 A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase. Biochemistry 2008 2.09
8 Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin. Biochemistry 2005 2.01
9 Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins. Antioxid Redox Signal 2011 1.79
10 Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain. J Mol Biol 2006 1.66
11 Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin. Proc Natl Acad Sci U S A 2007 1.62
12 Cysteine-based redox switches in enzymes. Antioxid Redox Signal 2010 1.62
13 Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization. J Mol Biol 2010 1.46
14 Cysteine pK(a) values for the bacterial peroxiredoxin AhpC. Biochemistry 2008 1.42
15 Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions. J Biol Chem 2002 1.41
16 Evolutionary origin of a secondary structure: π-helices as cryptic but widespread insertional variations of α-helices that enhance protein functionality. J Mol Biol 2010 1.33
17 The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain. J Cell Sci 2004 1.31
18 Structure and dynamics of LC8 complexes with KXTQT-motif peptides: swallow and dynein intermediate chain compete for a common site. J Mol Biol 2007 1.27
19 Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin. J Mol Biol 2005 1.27
20 Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS. J Mol Biol 2007 1.26
21 Nonplanar peptide bonds in proteins are common and conserved but not biased toward active sites. Proc Natl Acad Sci U S A 2011 1.23
22 Using a conformation-dependent stereochemical library improves crystallographic refinement of proteins. Acta Crystallogr D Biol Crystallogr 2010 1.17
23 Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria. J Bacteriol 2006 1.16
24 Catalytic cycle of human glutathione reductase near 1 A resolution. J Mol Biol 2008 1.16
25 Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite. J Biol Chem 2001 1.14
26 Structural changes common to catalysis in the Tpx peroxiredoxin subfamily. J Mol Biol 2009 1.12
27 Structure of Ptr ToxA: an RGD-containing host-selective toxin from Pyrenophora tritici-repentis. Plant Cell 2005 1.09
28 Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF. Protein Sci 2005 1.08
29 Multivalency in the assembly of intrinsically disordered Dynein intermediate chain. J Biol Chem 2009 1.08
30 A forward-looking suggestion for resolving the stereochemical restraints debate: ideal geometry functions. Acta Crystallogr D Biol Crystallogr 2008 1.05
31 On the occurrence of linear groups in proteins. Protein Sci 2009 1.05
32 A conformation-dependent stereochemical library improves crystallographic refinement even at atomic resolution. Acta Crystallogr D Biol Crystallogr 2011 1.05
33 The Arg-Gly-Asp-containing, solvent-exposed loop of Ptr ToxA is required for internalization. Mol Plant Microbe Interact 2008 1.03
34 Tuning of peroxiredoxin catalysis for various physiological roles. Biochemistry 2014 1.02
35 Conformation-dependent backbone geometry restraints set a new standard for protein crystallographic refinement. FEBS J 2014 1.01
36 Peroxiredoxins in parasites. Antioxid Redox Signal 2012 1.01
37 A fresh look at the Ramachandran plot and the occurrence of standard structures in proteins. Biomol Concepts 2010 1.01
38 The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assembly. J Biol Chem 2010 1.00
39 The interplay of ligand binding and quaternary structure in the diverse interactions of dynein light chain LC8. J Mol Biol 2008 0.99
40 Iron-containing urease in a pathogenic bacterium. Proc Natl Acad Sci U S A 2011 0.99
41 Protein Geometry Database: a flexible engine to explore backbone conformations and their relationships to covalent geometry. Nucleic Acids Res 2009 0.99
42 Thiol dioxygenases: unique families of cupin proteins. Amino Acids 2010 0.98
43 The tumor suppressor merlin controls growth in its open state, and phosphorylation converts it to a less-active more-closed state. Dev Cell 2012 0.97
44 Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates. Methods Enzymol 2013 0.97
45 Structure of alpha-glycerophosphate oxidase from Streptococcus sp.: a template for the mitochondrial alpha-glycerophosphate dehydrogenase. Biochemistry 2007 0.96
46 Pyridine nucleotide complexes with Bacillus anthracis coenzyme A-disulfide reductase: a structural analysis of dual NAD(P)H specificity. Biochemistry 2008 0.96
47 Structure of coenzyme A-disulfide reductase from Staphylococcus aureus at 1.54 A resolution. Biochemistry 2006 0.96
48 Mapping the active site helix-to-strand conversion of CxxxxC peroxiredoxin Q enzymes. Biochemistry 2012 0.95
49 Cysteine dioxygenase structures from pH4 to 9: consistent cys-persulfenate formation at intermediate pH and a Cys-bound enzyme at higher pH. J Mol Biol 2013 0.90
50 (φ,ψ)₂ motifs: a purely conformation-based fine-grained enumeration of protein parts at the two-residue level. J Mol Biol 2011 0.89
51 In-house sulfur SAD phasing: a case study of the effects of data quality and resolution cutoffs. Acta Crystallogr D Biol Crystallogr 2006 0.89
52 Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC. Biochemistry 2015 0.87
53 Structure of the Cdt1 C-terminal domain: conservation of the winged helix fold in replication licensing factors. Protein Sci 2009 0.87
54 The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin. Biochemistry 2013 0.87
55 Structural basis of improved second-generation 3-nitro-tyrosine tRNA synthetases. Biochemistry 2014 0.86
56 Structure of a sedoheptulose 7-phosphate cyclase: ValA from Streptomyces hygroscopicus. Biochemistry 2014 0.84
57 The role of glutamine 114 in old yellow enzyme. J Biol Chem 2001 0.84
58 Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: implications for flavin-linked sulfur trafficking. Biochemistry 2009 0.84
59 Gleaning unexpected fruits from hard-won synthetases: probing principles of permissivity in non-canonical amino acid-tRNA synthetases. Chembiochem 2014 0.81
60 Crystal structure of Escherichia coli SsuE: defining a general catalytic cycle for FMN reductases of the flavodoxin-like superfamily. Biochemistry 2014 0.81
61 A diiron protein autogenerates a valine-phenylalanine cross-link. Science 2011 0.81
62 Engineering of fluorescent reporters into redox domains to monitor electron transfers. Methods Enzymol 2010 0.80
63 C-Terminal truncation of rabbit flavin-containing monooxygenase isoform 2 enhances solubility. Arch Biochem Biophys 2006 0.79
64 Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K. Drug Metab Dispos 2009 0.79
65 Structures of Arg- and Gln-type bacterial cysteine dioxygenase homologs. Protein Sci 2014 0.79
66 Observed octameric assembly of a Plasmodium yoelii peroxiredoxin can be explained by the replacement of native "ball-and-socket" interacting residues by an affinity tag. Protein Sci 2013 0.78
67 Symerythrin structures at atomic resolution and the origins of rubrerythrins and the ferritin-like superfamily. J Mol Biol 2011 0.78
68 Structural, thermodynamic, and kinetic effects of a phosphomimetic mutation in dynein light chain LC8. Biochemistry 2009 0.77
69 Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry. Int J Mass Spectrom 2011 0.76
70 Synthesis and characterization of photolabile o-nitrobenzyl derivatives of urea. J Org Chem 2002 0.76
71 Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds. Biochemistry 2009 0.75
72 The sedoheptulose 7-phosphate cyclases and their emerging roles in biology and ecology. Nat Prod Rep 2017 0.75
73 Crystallization and preliminary crystallographic analysis of the soluble alpha-glycerophosphate oxidase from Streptococcus sp. Acta Crystallogr D Biol Crystallogr 2001 0.75