Published in Expert Opin Ther Targets on October 01, 2007
Prevention of acute exacerbations of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline. Chest (2015) 2.32
A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response. Exp Biol Med (Maywood) (2008) 1.46
Purinergic regulation of neutrophil chemotaxis. Cell Mol Life Sci (2008) 1.04
Targeting histone deacetylases for the treatment of disease. J Cell Mol Med (2008) 0.94
Association Between Statin Medications and COPD-Specific Outcomes: A Real-World Observational Study. Drugs Real World Outcomes (2016) 0.75
The effect of vitamin D on COPD exacerbation: a double blind randomized placebo-controlled parallel clinical trial. J Diabetes Metab Disord (2016) 0.75
Pharmacology and therapeutics of bronchodilators. Pharmacol Rev (2012) 1.72
Phosphodiesterase inhibitors. Br J Pharmacol (2006) 1.72
Novel drug development opportunities for heparin. Nat Rev Drug Discov (2002) 1.68
Pulmonary biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.63
Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation. Blood (2004) 1.53
Markers of disease severity in chronic obstructive pulmonary disease. Pulm Pharmacol Ther (2005) 1.33
Inhaled beta2-adrenoceptor agonists: cardiovascular safety in patients with obstructive lung disease. Drugs (2005) 1.33
Proinflammatory modulation of the surface and cytokine phenotype of monocytes in patients with acute Charcot foot. Diabetes Care (2009) 1.32
β2-agonist therapy in lung disease. Am J Respir Crit Care Med (2013) 1.27
Platelets are essential for leukocyte recruitment in allergic inflammation. J Allergy Clin Immunol (2003) 1.26
1Alpha,25-dihydroxyvitamin D3 inhibits CD40L-induced pro-inflammatory and immunomodulatory activity in human monocytes. Cytokine (2009) 1.20
Downregulation of CD40 ligand response in monocytes from sepsis patients. Clin Vaccine Immunol (2008) 1.20
Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration. J Appl Physiol (1985) (2010) 1.19
Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation. Blood (2003) 1.12
Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated trachea. Br J Pharmacol (2004) 1.11
Markers of exacerbation severity in chronic obstructive pulmonary disease. Respir Res (2006) 1.04
Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse. Thromb Haemost (2008) 1.03
Allergen induces the migration of platelets to lung tissue in allergic asthma. Am J Respir Crit Care Med (2007) 1.02
Dual PDE3/4 and PDE4 inhibitors: novel treatments for COPD and other inflammatory airway diseases. Basic Clin Pharmacol Toxicol (2014) 1.01
Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation. J Med Chem (2005) 0.98
A role for MC3R in modulating lung inflammation. Pulm Pharmacol Ther (2008) 0.97
The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro. Pulm Pharmacol Ther (2004) 0.97
Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy. J Gerontol A Biol Sci Med Sci (2006) 0.97
Getting to the heart of asthma: can "beta blockers" be useful to treat asthma? Pharmacol Ther (2007) 0.94
Adenosine receptors and asthma. Handb Exp Pharmacol (2009) 0.93
Effects of heparin and related molecules upon neutrophil aggregation and elastase release in vitro. Br J Pharmacol (2003) 0.91
Shooting for PARs in lung diseases. Curr Opin Pharmacol (2004) 0.91
The pharmacology of cough. Trends Pharmacol Sci (2004) 0.91
Are phosphodiesterase 4 inhibitors just more theophylline? J Allergy Clin Immunol (2006) 0.91
Identification with MRI of the pleura as a major site of the acute inflammatory effects induced by ovalbumin and endotoxin challenge in the airways of the rat. Am J Physiol Lung Cell Mol Physiol (2006) 0.91
Immunohistochemical localization of vanilloid receptor subtype 1 (TRPV1) in the guinea pig respiratory system. Pulm Pharmacol Ther (2005) 0.90
High glucose enhances responsiveness of human airways smooth muscle via the Rho/ROCK pathway. Am J Respir Cell Mol Biol (2012) 0.90
Neuropsychiatric symptoms and functional status in Alzheimer's disease and vascular dementia patients. Curr Alzheimer Res (2012) 0.89
Emerging anti-inflammatory strategies for COPD. Eur Respir J (2012) 0.89
Polyvalent mechanical bacterial lysate for the prevention of recurrent respiratory infections: a meta-analysis. Pulm Pharmacol Ther (2011) 0.88
APOE epsilon 2/epsilon 4 genotype a risk factor for primary progressive aphasia in women. Arch Neurol (2009) 0.88
Roflumilast: a phosphodiesterase-4 inhibitor for the treatment of respiratory disease. Expert Opin Investig Drugs (2006) 0.88
Effect of the mixed phosphodiesterase 3/4 inhibitor RPL554 on human isolated bronchial smooth muscle tone. J Pharmacol Exp Ther (2013) 0.87
Novel bronchodilators for the treatment of chronic obstructive pulmonary disease. Trends Pharmacol Sci (2011) 0.87
Bleomycin-induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI. J Magn Reson Imaging (2007) 0.86
Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve. Br J Pharmacol (2002) 0.86
Asthma -- a need for a rethink? Trends Pharmacol Sci (2002) 0.86
A pilot comparison of helium dilution and plethysmographic lung volumes to assess the impact of a long-acting bronchodilator on lung hyperinflation in COPD. Pulm Pharmacol Ther (2009) 0.85
Noninvasive assessment of bleomycin-induced lung injury and the effects of short-term glucocorticosteroid treatment in rats using MRI. J Magn Reson Imaging (2011) 0.85
Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patients. Neurobiol Aging (2005) 0.84
Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients. Neurobiol Aging (2003) 0.84
Bleomycin-induced lung injury in mice investigated by MRI: model assessment for target analysis. Magn Reson Med (2011) 0.84
Some structural determinants of the antiproliferative effect of heparin-like molecules on human airway smooth muscle. Br J Pharmacol (2005) 0.84
Immunohistochemical localization of transient receptor potential vanilloid subtype 1 in the trachea of ovalbumin-sensitized Guinea pigs. Int Arch Allergy Immunol (2008) 0.84
Non-anticoagulant effects of heparin: an overview. Handb Exp Pharmacol (2012) 0.84
Epithelial-smooth muscle cooperation is needed for brain natriuretic peptide-dependent bronchorelaxant activity. Pulm Pharmacol Ther (2012) 0.83
Proton MRI as a noninvasive tool to assess elastase-induced lung damage in spontaneously breathing rats. Magn Reson Med (2006) 0.83
Evaluation of the effects of the R- and S-enantiomers of salbutamol on equine isolated bronchi. Pulm Pharmacol Ther (2010) 0.83
Effects of inhaled thrombin receptor agonists in mice. Br J Pharmacol (2004) 0.83
Novel bronchodilators in asthma. Curr Opin Pulm Med (2010) 0.83
Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma. J Pharmacol Exp Ther (2011) 0.83
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide. J Med Chem (2006) 0.83
Anti-adhesive glycoproteins in echinoderm mucus secretions. Comp Biochem Physiol B Biochem Mol Biol (2004) 0.82
Lipopolysaccharide desensitizes monocytes-macrophages to CD40 ligand stimulation. Immunology (2007) 0.82
Activation of corticotropin-releasing factor receptor-2 causes bronchorelaxation and inhibits pulmonary inflammation in mice. FASEB J (2006) 0.81
Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge. Br J Pharmacol (2005) 0.81
Apoe epsilon2-epsilon4 genotype is a possible risk factor for primary progressive aphasia. Ann Neurol (2006) 0.81
Immunomodulatory impact of a synbiotic in T(h)1 and T(h)2 models of infection. Ther Adv Respir Dis (2010) 0.80
Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers. Br J Clin Pharmacol (2002) 0.80
Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele. Dement Geriatr Cogn Disord (2008) 0.80
Roflumilast in chronic obstructive pulmonary disease: evidence from large trials. Expert Opin Pharmacother (2010) 0.80
Additional clinical benefit of enoxaparin in COPD patients receiving salmeterol and fluticasone propionate in combination. Pulm Pharmacol Ther (2006) 0.79
Aclidinium bromide for the treatment of chronic obstructive pulmonary disease. Expert Opin Pharmacother (2013) 0.79
Adenosine induces a cholinergic tracheal reflex contraction in guinea pigs in vivo via an adenosine A1 receptor-dependent mechanism. J Appl Physiol (1985) (2008) 0.79
Protein prenylation contributes to the effects of LPS on EFS-induced responses in human isolated bronchi. Am J Respir Cell Mol Biol (2011) 0.79
Pharmacological characterization of adenosine receptors on isolated human bronchi. Am J Respir Cell Mol Biol (2011) 0.78
Mycobacterium tuberculosis chaperonin 60.1 inhibits leukocyte diapedesis in a murine model of allergic lung inflammation. Am J Respir Cell Mol Biol (2012) 0.78
Energy expenditure and impact of bronchodilators in COPD patients. Respir Med (2010) 0.78
Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives. Bioorg Med Chem Lett (2008) 0.78
Locally available heparin modulates inflammatory cell recruitment in a manner independent of anticoagulant activity. Eur J Pharmacol (2009) 0.78
Arformoterol tartrate in the treatment of COPD. Expert Rev Respir Med (2010) 0.77
Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients. Age (Dordr) (2010) 0.77
Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294. Pulm Pharmacol Ther (2003) 0.77
Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: synthesis, biological evaluation and binding mode studies of new derivatives at indole-2-carboxamide. Antivir Chem Chemother (2006) 0.77
The effects of heparin and related molecules on vascular permeability and neutrophil accumulation in rabbit skin. Br J Pharmacol (2002) 0.77
Phosphodiesterase isoenzymes in equine platelets and their influence on platelet adhesion. Am J Vet Res (2007) 0.77
Selection of a 2-azabicyclo[2.2.2]octane-based alpha4beta1 integrin antagonist as an inhaled anti-asthmatic agent. Bioorg Med Chem (2006) 0.77
Novel approaches to the treatment of pneumonia. Trends Pharmacol Sci (2003) 0.76
Association of apolipoprotein E and angiotensin converting enzyme gene polymorphisms with the multidimensional impairment in older patients. Rejuvenation Res (2009) 0.76
Delivering antibacterials to the lungs: considerations for optimizing outcomes. Am J Respir Med (2002) 0.76
Evaluation of the effect of phosphodiesterase on equine platelet activation and the effect of antigen challenge on platelet phosphodiesterase activity in horses with recurrent airway obstruction. Am J Vet Res (2010) 0.76
Pharmacology of airway irritability. Curr Opin Pharmacol (2002) 0.75
The scientific legacy of Sir James W. Black. Trends Pharmacol Sci (2011) 0.75
Use of indacaterol for the treatment of COPD: a pharmacokinetic evaluation. Expert Opin Drug Metab Toxicol (2013) 0.75
Lack of difference in pulmonary absorption of digoxin, a P-glycoprotein substrate, in mdr1a-deficient and mdr1a-competent mice. J Pharm Pharmacol (2008) 0.75
Validating 123I-metaiodobenzylguanidine as a platelet marker for non-invasive imaging in rabbits. J Pharmacol Toxicol Methods (2010) 0.75
A new model for the continuous monitoring of polymorphonuclear leukocyte trapping in the pulmonary vasculature of the rabbit. J Pharmacol Toxicol Methods (2003) 0.75
Uncharged nucleoside inhibitors of β-1,4-galactosyltransferase with activity in cells. Chem Commun (Camb) (2016) 0.75
Lack of association between genetic variants in the mannose-binding lectin 2 (MBL2) gene and HPV infection. Eur J Epidemiol (2007) 0.75