Published in Neurology on October 03, 2007
A Dose-Finding Study of MK0974 in Acute Migraine (MK0974-004) | NCT00246337
Randomized, controlled trial of telcagepant for the acute treatment of migraine. Neurology (2009) 2.40
CGRP and its receptors provide new insights into migraine pathophysiology. Nat Rev Neurol (2010) 1.88
Diencephalic and brainstem mechanisms in migraine. Nat Rev Neurosci (2011) 1.71
The TRPA1 channel in migraine mechanism and treatment. Br J Pharmacol (2014) 1.50
Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine. CNS Drugs (2010) 1.48
Medullary pain facilitating neurons mediate allodynia in headache-related pain. Ann Neurol (2009) 1.48
Mechanisms involved in the cerebrovascular dilator effects of cortical spreading depression. Prog Neurobiol (2008) 1.18
Neurologic bases for comorbidity of balance disorders, anxiety disorders and migraine: neurotherapeutic implications. Expert Rev Neurother (2011) 1.13
Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation. Expert Rev Mol Med (2011) 1.13
Migraine: where and how does the pain originate? Exp Brain Res (2009) 1.06
Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Mol Pain (2008) 1.05
New drugs for migraine. J Headache Pain (2009) 1.02
Genetic enhancement of calcitonin gene-related Peptide-induced central sensitization to mechanical stimuli in mice. J Pain (2009) 1.02
Calcitonin gene-related peptide: an update on the biology. Curr Opin Neurol (2009) 1.01
Capturing the aversive state of cephalic pain preclinically. Ann Neurol (2013) 1.00
Calcitonin gene-related peptide (CGRP): a new target for migraine. Annu Rev Pharmacol Toxicol (2014) 1.00
Inhibition of calcitonin gene-related peptide function: a promising strategy for treating migraine. Headache (2008) 0.99
Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT(1B/D) agonist. J Neurosci (2012) 0.98
CGRP receptor antagonism and migraine. Neurotherapeutics (2010) 0.98
Calcitonin gene-related peptide (CGRP) antagonists and migraine: is this a new era? Neurology (2008) 0.97
Adrenomedullin stabilizes the lymphatic endothelial barrier in vitro and in vivo. Peptides (2008) 0.95
Migraine pain: reflections against vasodilatation. J Headache Pain (2009) 0.94
Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system. J Headache Pain (2008) 0.92
Two mechanisms involved in trigeminal CGRP release: implications for migraine treatment. Headache (2012) 0.92
Current and prospective pharmacological targets in relation to antimigraine action. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.92
Eccentric muscle contraction and stretching evoke mechanical hyperalgesia and modulate CGRP and P2X(3) expression in a functionally relevant manner. Pain (2010) 0.91
Investigating endogenous peptides and peptidases using peptidomics. Biochemistry (2011) 0.91
CGRP and migraine: could PACAP play a role too? Neuropeptides (2013) 0.90
CGRP function-blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat. Br J Pharmacol (2008) 0.90
Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in mice. Mol Endocrinol (2011) 0.89
Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review. J Headache Pain (2009) 0.89
Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine. Br J Pharmacol (2012) 0.89
CGRP stimulation of iNOS and NO release from trigeminal ganglion glial cells involves mitogen-activated protein kinase pathways. J Neurochem (2009) 0.89
Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level. BMC Neurosci (2011) 0.89
Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974). Br J Clin Pharmacol (2010) 0.88
Possible sites of action of the new calcitonin gene-related peptide receptor antagonists. Ther Adv Neurol Disord (2010) 0.88
Targeting TRP channels for novel migraine therapeutics. ACS Chem Neurosci (2014) 0.87
New frontiers in headache therapy. Neurol Sci (2011) 0.86
Migraine is a neuronal disease. J Neural Transm (Vienna) (2010) 0.86
Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics? BMC Neurol (2011) 0.85
A possible role for mitochondrial dysfunction in migraine. Mol Genet Genomics (2012) 0.85
Involvement of calcitonin gene-related peptide in migraine: regional cerebral blood flow and blood flow velocity in migraine patients. J Headache Pain (2008) 0.85
Changes in calcitonin gene-related peptide (CGRP) receptor component and nitric oxide receptor (sGC) immunoreactivity in rat trigeminal ganglion following glyceroltrinitrate pretreatment. J Headache Pain (2013) 0.84
Emerging peripheral receptor targets for deep-tissue craniofacial pain therapies. J Dent Res (2009) 0.84
Chemical mediators of migraine: preclinical and clinical observations. Headache (2011) 0.84
CGRP blockers in migraine therapy: where do they act? Br J Pharmacol (2008) 0.83
BGC20-1531, a novel, potent and selective prostanoid EP receptor antagonist: a putative new treatment for migraine headache. Br J Pharmacol (2009) 0.83
A randomized, double-blind, placebo-controlled study of breath powered nasal delivery of sumatriptan powder (AVP-825) in the treatment of acute migraine (The TARGET Study). Headache (2014) 0.82
The calcitonin gene-related peptide receptor antagonist MK-8825 decreases spinal trigeminal activity during nitroglycerin infusion. J Headache Pain (2013) 0.81
Pathophysiology of Migraine: A Disorder of Sensory Processing. Physiol Rev (2017) 0.81
Activation of iGluR5 kainate receptors inhibits neurogenic dural vasodilatation in an animal model of trigeminovascular activation. Br J Pharmacol (2009) 0.81
Calcitonin gene-related peptide receptor antagonists: beyond migraine pain--a possible analgesic strategy for osteoarthritis? Curr Pain Headache Rep (2013) 0.81
Antimigraine drugs: new frontiers. Neurol Sci (2009) 0.81
Is there an inherent limit to acute migraine treatment efficacy? J Headache Pain (2009) 0.81
Is there an inherent limit to the efficacy of calcitonin gene-related peptide receptor antagonists in the acute treatment of migraine? A comment. J Headache Pain (2009) 0.80
Neurovascular contributions to migraine: Moving beyond vasodilation. Neuroscience (2016) 0.80
The therapeutic future in headache. Neurol Sci (2012) 0.80
New acute treatments for headache. Neurol Sci (2010) 0.80
Update on future headache treatments. Neurol Sci (2013) 0.80
Development of anti-migraine therapeutics using the capsaicin-induced dermal blood flow model. Br J Clin Pharmacol (2015) 0.79
Are the current IHS guidelines for migraine drug trials being followed? J Headache Pain (2010) 0.79
Role of CGRP-receptor component protein (RCP) in CLR/RAMP function. Curr Protein Pept Sci (2013) 0.79
Pathophysiology of autism spectrum disorders: revisiting gastrointestinal involvement and immune imbalance. World J Gastroenterol (2014) 0.79
The PACAP receptor: a novel target for migraine treatment. Neurotherapeutics (2010) 0.79
New treatments for headache. Neurol Sci (2014) 0.79
Analysis of the proteolysis of bioactive peptides using a peptidomics approach. Nat Protoc (2013) 0.78
Trigeminal TRPs and the scent of pain. Pain (2010) 0.78
Effects of heating coagulation of middle meningeal artery on plasma CGRP level and c-fos expression in migraine rat triggered by nitroglycerin. Neurol Sci (2011) 0.78
The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men. Br J Clin Pharmacol (2011) 0.77
Effect of CGRP and sumatriptan on the BOLD response in visual cortex. J Headache Pain (2012) 0.77
Sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers. J Headache Pain (2009) 0.77
Intraganglionic signaling as a novel nasal-meningeal pathway for TRPA1-dependent trigeminovascular activation by inhaled environmental irritants. PLoS One (2014) 0.77
Optimal balance of efficacy and tolerability of oral triptans and telcagepant: a review and a clinical comment. J Headache Pain (2011) 0.76
Evidence for CGRP re-uptake in rat dura mater encephali. Br J Pharmacol (2010) 0.76
The Dose Proportionality of Telcagepant after Administration of Single Oral and Intravenous Doses in Healthy Adult Subjects. Arch Drug Inf (2010) 0.76
Endosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteries. Br J Pharmacol (2012) 0.76
Pharmacogenomics and migraine: possible implications. J Headache Pain (2008) 0.76
Migraine in the era of precision medicine. Ann Transl Med (2016) 0.76
An oral calcitonin gene-related peptide receptor antagonist for acute migraine management: sign of a possible new chapter in headache medicine. Curr Neurol Neurosci Rep (2009) 0.75
Therapeutic effects and safety of olcegepant and telcagepant for migraine: A meta-analysis. Neural Regen Res (2013) 0.75
Efficacy of (S)-Lacosamide in preclinical models of cephalic pain. Pain Rep (2016) 0.75
Update in new medications for primary care. J Gen Intern Med (2009) 0.75
Recent advances in the pharmacological management of migraine. F1000 Med Rep (2009) 0.75
The effect and safety of monoclonal antibodies to calcitonin gene-related peptide and its receptor on migraine: a systematic review and meta-analysis. J Headache Pain (2017) 0.75
Current migraine management - patient acceptability and future approaches. Neuropsychiatr Dis Treat (2008) 0.75
Migraine: Telcagepant provides new hope for people with migraine. Nat Rev Neurol (2009) 0.75
New treatments for headache. Neurol Sci (2017) 0.75
Genetic evidence for a switching and energy-transducing complex in the flagellar motor of Salmonella typhimurium. J Bacteriol (1986) 4.61
Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J Clin Invest (2001) 4.37
Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype. Gastroenterology (1998) 4.12
Purification and characterization of the flagellar hook-basal body complex of Salmonella typhimurium. J Bacteriol (1985) 4.04
Undergraduate research. Genomics Education Partnership. Science (2008) 3.45
Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat Genet (1997) 3.06
Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective immunity. Cell (1998) 2.59
Randomized, controlled trial of telcagepant for the acute treatment of migraine. Neurology (2009) 2.40
Comparison of rizatriptan and other triptans on stringent measures of efficacy. Neurology (2001) 2.29
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts. Nat Genet (2000) 2.26
PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney Int (2006) 2.05
Naratriptan in the prophylaxis of transformed migraine. Headache (2001) 2.02
Forward and backward running waves in the arteries: analysis using the method of characteristics. J Biomech Eng (1990) 1.96
latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. Neuron (1999) 1.94
Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study. Neurology (2004) 1.92
Changes in vascular endothelium related to lymphocyte collections in diseased synovia. Arthritis Rheum (1983) 1.88
Tolosa-Hunt syndrome: critical literature review based on IHS 2004 criteria. Cephalalgia (2006) 1.83
Sequential dermal microvascular and perivascular changes in the development of scleroderma. J Pathol (1992) 1.81
Complementation of DNA repair in xeroderma pigmentosum group A cell extracts by a protein with affinity for damaged DNA. EMBO J (1991) 1.80
Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide. Clin Sci (Lond) (2001) 1.76
An elastin gene mutation producing abnormal tropoelastin and abnormal elastic fibres in a patient with autosomal dominant cutis laxa. Hum Mol Genet (1998) 1.75
Hyperinsulinaemia and microvascular angina ("syndrome X") Lancet (1991) 1.69
Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes. Nat Genet (1999) 1.61
Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection. Nature (1997) 1.60
Chronic migraine and medication overuse headache: clarifying the current International Headache Society classification criteria. Cephalalgia (2009) 1.59
Endothelial control of arterial distensibility is impaired in chronic heart failure. Circulation (1995) 1.57
Multimechanistic (sumatriptan-naproxen) early intervention for the acute treatment of migraine. Neurology (2008) 1.57
Identification of proteins of the outer (L and P) rings of the flagellar basal body of Escherichia coli. J Bacteriol (1987) 1.54
Characterization of the fliE genes of Escherichia coli and Salmonella typhimurium and identification of the FliE protein as a component of the flagellar hook-basal body complex. J Bacteriol (1992) 1.52
Reversal of neuromuscular blockade: dose determination studies with atropine and glycopyrrolate given before or in a mixture with neostigmine. Anesth Analg (1981) 1.52
Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide. Mol Pharmacol (2000) 1.50
The physiological load imposed on basketball players during competition. J Sports Sci (1995) 1.48
Spatial analysis of the distribution of Ixodes dammini (Acari: Ixodidae) on white-tailed deer in Ogle County, Illinois. J Med Entomol (1992) 1.47
DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions. Proc Natl Acad Sci U S A (1993) 1.46
Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage. Mol Cell Biol (2000) 1.46
Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study. Leukemia (2012) 1.44
Notch3 signaling initiates choroid plexus tumor formation. Oncogene (2006) 1.43
Comparative study of a combination of isometheptene mucate, dichloralphenazone with acetaminophen and sumatriptan succinate in the treatment of migraine. Headache (2001) 1.43
Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia. J Am Coll Cardiol (2000) 1.42
One novel and two recurrent mutations in the keratin 5 gene identified in Chinese patients with epidermolysis bullosa simplex. Clin Exp Dermatol (2009) 1.40
Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits. Dev Biol (2001) 1.38
Endothelium and inelastic arteries: an early marker of vascular dysfunction in non-insulin dependent diabetes. BMJ (1996) 1.35
Detection of covalent DNA-protein complexes: the adenovirus DNA-terminal protein complex and HeLa DNA-protein complexes. Cold Spring Harb Symp Quant Biol (1979) 1.32
Ca2+-independent protein kinase C Apl II mediates the serotonin-induced facilitation at depressed aplysia sensorimotor synapses. J Neurosci (2001) 1.31
Proteins tightly bound to HeLa cell DNA at nuclear matrix attachment sites. Mol Cell Biol (1983) 1.31
Chronic daily headache in a tertiary care population: correlation between the International Headache Society diagnostic criteria and proposed revisions of criteria for chronic daily headache. Cephalalgia (2002) 1.30
Photocycle of halorhodopsin from Halobacterium salinarium. Biophys J (1995) 1.29
Effects of training on the visual recognition of consonants. J Speech Hear Res (1977) 1.29
Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells: potential role in CD4+ T cell activation during Helicobacter pylori infection. J Clin Invest (1997) 1.27
RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development. Mech Dev (2000) 1.26
Primary chronic daily headache and its subtypes in adolescents and adults. Neurology (2004) 1.25
The identification of glycoproteins associated with elastic-tissue microfibrils. Biochem J (1978) 1.25
Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas ligand interactions. Infect Immun (2000) 1.23
The pharmacology and pharmacokinetics of azapropazone - a review. Curr Med Res Opin (1976) 1.23
Transport magnetic proximity effects in platinum. Phys Rev Lett (2012) 1.23
Activation of caspases and p53 by bovine herpesvirus 1 infection results in programmed cell death and efficient virus release. J Virol (1999) 1.22
Purification of ADAM 10 from bovine spleen as a TNFalpha convertase. FEBS Lett (1997) 1.22
The functional regeneration of syncytiotrophoblast in cultured explants of term placenta. Am J Physiol Regul Integr Comp Physiol (2001) 1.20
The International Classification of Headache Disorders revised criteria for chronic migraine—field testing in a headache specialty clinic. Cephalalgia (2007) 1.20
Histochemical fluorescence studies on noradrenaline accumulation by Uptake 2 in the isolated rat heart. Br J Pharmacol (1969) 1.20
Chronic migraine is an earlier stage of transformed migraine in adults. Neurology (2005) 1.20
An ultrahistochemical study of the distribution of acid and alkaline phosphatases in placentae from normal and complicated pregnancies. J Pathol (1976) 1.19
Development of cytotrophoblast columns from explanted first-trimester human placental villi: role of fibronectin and integrin alpha5beta1. Biol Reprod (1999) 1.19
Migraine prophylaxis with divalproex. Arch Neurol (1995) 1.18
Role of doxapram in reducing pulmonary complications after major surgery. Br Med J (1976) 1.15
Trophoblast differentiation during formation of anchoring villi in a model of the early human placenta in vitro. Placenta (1995) 1.15
Light microscopic, histochemical and ultrastructural studies of human lymph node paracortical venules. J Anat (1983) 1.14
Mitochondrial dysfunction and migraine: evidence and hypotheses. Cephalalgia (2006) 1.14
Evidence for two nucleotide sequence orientations within the terminal repetition of adeno-associated virus DNA. J Virol (1977) 1.14
The latency-related gene of bovine herpesvirus 1 inhibits the activity of immediate-early transcription unit 1. Virology (1992) 1.12
Antioxidative activities in some common seaweeds. Plant Foods Hum Nutr (1998) 1.12
Optical liquid ring resonator sensor. Opt Express (2007) 1.12
Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism. J Immunol (1996) 1.11
An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia. Placenta (1981) 1.11
Mechanical strain inhibits expression of osteoclast differentiation factor by murine stromal cells. Am J Physiol Cell Physiol (2000) 1.11
Migraine and adiponectin: is there a connection? Cephalalgia (2007) 1.10
Human hepatocellular carcinoma is characterized by a highly consistent pattern of genomic imbalances, including frequent loss of 16q23.1-24.1. Genes Chromosomes Cancer (2001) 1.10
Isolation of tumour stem-like cells from benign tumours. Br J Cancer (2009) 1.10
Transformed migraine and medication overuse in a tertiary headache centre--clinical characteristics and treatment outcomes. Cephalalgia (2004) 1.10
Genomic indicators in the blood predict drug-induced liver injury. Pharmacogenomics J (2010) 1.09
p-Type ZnO nanowire arrays. Nano Lett (2008) 1.09
Naratriptan as short-term prophylaxis of menstrually associated migraine: a randomized, double-blind, placebo-controlled study. Headache (2001) 1.09
Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells. J Biol Chem (2001) 1.08
Effect of dietary supplementation with fish oil on systolic blood pressure in mild essential hypertension. Br Med J (Clin Res Ed) (1986) 1.08
Osteoclastogenesis is repressed by mechanical strain in an in vitro model. J Orthop Res (1999) 1.08
Detection of in situ mammary cancer in a transgenic mouse model: in vitro and in vivo MRI studies demonstrate histopathologic correlation. Phys Med Biol (2008) 1.08
I.m. or i.v. atropine or glycopyrrolate for the prevention of oculocardiac reflex in children undergoing squint surgery. Br J Anaesth (1982) 1.07
A clinical investigation using quantitative light-induced fluorescence (QLF) of the anticaries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate. J Clin Dent (2013) 1.07
New daily persistent headache in the paediatric population. Cephalalgia (2009) 1.06
Headache prevention outcome and body mass index. Cephalalgia (2006) 1.06
What stops the flow of blood from the heart? Heart Vessels (1988) 1.05
Oleic acid uptake and binding by rat adipocytes define dual pathways for cellular fatty acid uptake. J Lipid Res (2001) 1.05
Calculation of mitral regurgitant orifice area with use of a simplified proximal convergence method: initial clinical application. J Am Soc Echocardiogr (2001) 1.05
Neuroglobin-overexpression alters hypoxic response gene expression in primary neuron culture following oxygen glucose deprivation. Neuroscience (2009) 1.04
Elimination of the non-specific binding of avidin to tissue sections. Histochem J (1987) 1.04
Pressure regulates osteoclast formation and MCSF expression in marrow culture. J Cell Physiol (1997) 1.04
Lysophosphatidic acid activates NF-kappaB in fibroblasts. A requirement for multiple inputs. J Biol Chem (1999) 1.04