Published in Bull NYU Hosp Jt Dis on January 01, 2007
Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity. J Rheumatol (2009) 1.64
Therapeutic antibody targeting of indoleamine-2,3-dioxygenase (IDO2) inhibits autoimmune arthritis. Clin Immunol (2017) 1.39
Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study. Arthritis Res Ther (2009) 1.39
Methotrexate inhibits NF-κB activity via long intergenic (noncoding) RNA-p21 induction. Arthritis Rheumatol (2014) 1.05
Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum (2011) 0.99
Multiparameter phospho-flow analysis of lymphocytes in early rheumatoid arthritis: implications for diagnosis and monitoring drug therapy. PLoS One (2009) 0.92
The pharmacokinetic effect of coadministration of apremilast and methotrexate in individuals with rheumatoid arthritis and psoriatic arthritis. Clin Pharmacol Drug Dev (2014) 0.91
Blood lipid profiles and peripheral blood mononuclear cell cholesterol metabolism gene expression in patients with and without methotrexate treatment. BMC Med (2011) 0.89
Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue. Arthritis Res Ther (2012) 0.85
Pre-administration of turmeric prevents methotrexate-induced liver toxicity and oxidative stress. BMC Complement Altern Med (2015) 0.82
Regulation of Cell Proliferation by the Guanosine-Adenosine Mechanism: Role of Adenosine Receptors. Physiol Rep (2013) 0.80
Nearly pain-free self-administration of subcutaneous methotrexate with an autoinjector: results of a phase 2 clinical trial in patients with rheumatoid arthritis who have functional limitations. J Clin Rheumatol (2014) 0.80
Determination of methotrexate in biological fluids and a parenteral injection using terbium-sensitized method. Iran J Pharm Res (2011) 0.80
Pharmacogenomics of Methotrexate Membrane Transport Pathway: Can Clinical Response to Methotrexate in Rheumatoid Arthritis Be Predicted? Int J Mol Sci (2015) 0.80
Methotrexate revisited: considerations for subcutaneous administration in RA. Clin Rheumatol (2014) 0.78
C677T (RS1801133 ) MTHFR gene polymorphism frequency in a colombian population. Colomb Med (Cali) (2015) 0.78
Methotrexate-mediated inhibition of nuclear factor κB activation by distinct pathways in T cells and fibroblast-like synoviocytes. Rheumatology (Oxford) (2014) 0.78
Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation. Cancer Cell Int (2016) 0.78
1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis. Autoimmunity (2014) 0.77
Protective effects of vitamin E and Cornus mas fruit extract on methotrexate-induced cytotoxicity in sperms of adult mice. Vet Res Forum (2014) 0.77
Prediction of methotrexate clinical response in Portuguese rheumatoid arthritis patients: implication of MTHFR rs1801133 and ATIC rs4673993 polymorphisms. Biomed Res Int (2014) 0.77
Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes. J Nutr Metab (2012) 0.77
Does intraperitoneal medical ozone preconditioning and treatment ameliorate the methotrexate induced nephrotoxicity in rats? Int J Clin Exp Med (2015) 0.75
In vitro inhibition of HUVECs by low dose methotrexate - insights into oral adverse events. Head Face Med (2014) 0.75
Short time administration of antirheumatic drugs - methotrexate as a strong inhibitor of osteoblast's proliferation in vitro. Head Face Med (2012) 0.75
Protective Effects of Thymoquinone against Methotrexate-Induced Germ Cell Apoptosis in Male Mice. Int J Fertil Steril (2015) 0.75
Recommendations for optimizing methotrexate treatment for patients with rheumatoid arthritis. Open Access Rheumatol (2017) 0.75
Paired Ig-Like Type 2 Receptor-Derived Agonist Ligands Ameliorate Inflammatory Reactions by Downregulating β1 Integrin Activity. Mol Cells (2016) 0.75
One-Carbon Metabolism and Colorectal Cancer: Potential Mechanisms of Chemoprevention. Curr Pharmacol Rep (2015) 0.75
Methotrexate intolerance in the treatment of rheumatoid arthritis (RA): effect of adding caffeine to the management regimen. Clin Rheumatol (2016) 0.75
Clinical Efficacy and Safety of Methotrexate versus Hydroxychloroquine in Preventing Lichen Planopilaris Progress: A Randomized Clinical Trial. Int J Prev Med (2017) 0.75
Adenosine: an endogenous regulator of innate immunity. Trends Immunol (2004) 4.07
Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1. Mol Pharmacol (2005) 2.93
Methotrexate--how does it really work? Nat Rev Rheumatol (2010) 2.24
Greater number of narcotic analgesic prescriptions for osteoarthritis is associated with falls and fractures in elderly adults. J Am Geriatr Soc (2013) 2.17
Molecular action of methotrexate in inflammatory diseases. Arthritis Res (2002) 2.04
The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn. J Immunol (2006) 1.94
Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. Br J Pharmacol (2006) 1.79
Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity. J Rheumatol (2009) 1.64
Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors. Am J Pathol (2002) 1.50
Requirements for T lymphocyte migration in explanted lymph nodes. J Immunol (2007) 1.48
Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages. Arthritis Rheum (2008) 1.43
Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68. Arthritis Rheum (2003) 1.41
Adenosine signaling contributes to ethanol-induced fatty liver in mice. J Clin Invest (2009) 1.38
Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells. J Immunol (2003) 1.34
Adenosine A(2A) receptor activation promotes wound neovascularization by stimulating angiogenesis and vasculogenesis. Am J Pathol (2004) 1.33
Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis. FASEB J (2008) 1.28
Adenosine receptor activation ameliorates type 1 diabetes. FASEB J (2007) 1.27
Adenosine A2A receptor activation prevents wear particle-induced osteolysis. Sci Transl Med (2012) 1.23
The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: findings in a study of ecto-5'-nucleotidase gene-deficient mice. Arthritis Rheum (2007) 1.22
Adenosine A(2A) receptor ligation inhibits osteoclast formation. Am J Pathol (2011) 1.21
Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function. FASEB J (2010) 1.12
Adenosine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Becaplermin gel). Inflammation (2002) 1.11
Tumor necrosis factor-alpha prevents desensitization of Galphas-coupled receptors by regulating GRK2 association with the plasma membrane. Mol Pharmacol (2005) 1.10
Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis. Arthritis Res Ther (2006) 1.09
Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice. Arthritis Rheum (2010) 1.08
Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J (2013) 1.08
CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism. J Allergy Clin Immunol (2009) 1.07
Adenosine receptor agonists for promotion of dermal wound healing. Biochem Pharmacol (2008) 1.06
Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine. Am J Pathol (2008) 1.04
Interferon-gamma impedes reverse cholesterol transport and promotes foam cell transformation in THP-1 human monocytes/macrophages. Med Sci Monit (2004) 1.03
Adenosine and bone metabolism. Trends Endocrinol Metab (2013) 1.02
Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages. J Leukoc Biol (2004) 1.00
Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death. FASEB J (2010) 1.00
Activation of adenosine A(2A) receptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation. Br J Pharmacol (2013) 1.00
Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development. J Leukoc Biol (2008) 1.00
Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammation. Arthritis Rheum (2005) 0.98
Plasma from systemic lupus patients compromises cholesterol homeostasis: a potential mechanism linking autoimmunity to atherosclerotic cardiovascular disease. Rheumatol Int (2009) 0.97
Adenosine A2A receptor blockade or deletion diminishes fibrocyte accumulation in the skin in a murine model of scleroderma, bleomycin-induced fibrosis. Inflammation (2008) 0.97
Adenosine receptors in wound healing, fibrosis and angiogenesis. Handb Exp Pharmacol (2009) 0.94
Colchicine use is associated with decreased prevalence of myocardial infarction in patients with gout. J Rheumatol (2012) 0.93
Mechanisms of action of methotrexate. Bull Hosp Jt Dis (2013) (2013) 0.93
An interaction between genetic factors and gender determines the magnitude of the inflammatory response in the mouse air pouch model of acute inflammation. Inflammation (2005) 0.91
Conflict of interest. HSS J (2006) 0.91
Enhanced CD36 scavenger receptor expression in THP-1 human monocytes in the presence of lupus plasma: linking autoimmunity and atherosclerosis. Exp Biol Med (Maywood) (2009) 0.90
Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis. Nucleosides Nucleotides Nucleic Acids (2008) 0.89
A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux. J Leukoc Biol (2010) 0.89
Pharmacological blockade of adenosine A2A receptors diminishes scarring. FASEB J (2012) 0.89
Adenosine A(2A) receptors promote collagen production by a Fli1- and CTGF-mediated mechanism. Arthritis Res Ther (2013) 0.88
Adenosine in fibrosis. Mod Rheumatol (2009) 0.86
Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis. Am J Pathol (2013) 0.84
Rolofylline, an adenosine A1 receptor antagonist, inhibits osteoclast differentiation as an inverse agonist. Br J Pharmacol (2013) 0.84
Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation. J Bone Miner Res (2015) 0.83
Therapeutic cocktails for rheumatoid arthritis: the mixmaster's guide. Arthritis Rheum (2004) 0.83
Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance. Purinergic Signal (2013) 0.83
Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3. FASEB J (2013) 0.82
Biosimilars: the debate continues. Arthritis Rheum (2011) 0.81
Non-prostaglandin effects of aspirin III and salicylate: inhibition of integrin-dependent human neutrophil aggregation and inflammation in COX 2- and NF kappa B (P105)-knockout mice. Adv Exp Med Biol (2002) 0.80
The effect of A(2A) adenosine receptor activation on C-C chemokine receptor 7 expression in human THP1 macrophages during inflammation. Inflammation (2012) 0.80
Methotrexate in rheumatoid arthritis. Expert Rev Clin Immunol (2007) 0.79
Adenosine A2A receptor and TNF-α regulate the circadian machinery of the human monocytic THP-1 cells. Inflammation (2013) 0.78
Bovine thrombin and systemic autoimmunity. Am J Pathol (2003) 0.78
Designing and implementing INTREPID, an intensive program in translational research methodologies for new investigators. Clin Transl Sci (2014) 0.78
Regulation of foam cells by adenosine. Arterioscler Thromb Vasc Biol (2012) 0.78
A public-private partnership: the New York University-Health and Hospitals Corporation Clinical and Translational Science Institute. Clin Transl Sci (2012) 0.77
Fibroblasts from methotrexate-sensitive mice accumulate methotrexate polyglutamates but those from methotrexate-resistant mice do not. Clin Exp Rheumatol (2013) 0.76
Something old, something new--colchicine in the 21st century. Curr Opin Investig Drugs (2009) 0.76
Interferon-gamma inhibits adenosine A2A receptor function in hepatic stellate cells by STAT1-mediated repression of adenylyl cyclase. Int J Interferon Cytokine Mediat Res (2010) 0.75
Restraint stress fails to modulate cutaneous hypersensitivity responses in mice lacking the adenosine A1 receptor. Purinergic Signal (2011) 0.75
Bovine thrombin and the clinical consequence of antibody development. J Am Coll Surg (2008) 0.75
Cholesterol 27-hydroxylase but not apolipoprotein apoE contributes to A2A adenosine receptor stimulated reverse cholesterol transport. Inflammation (2012) 0.75
A personal journey from the joint to the heart. Arthritis Res Ther (2010) 0.75
Folic acid and folinic acid supplements and methotrexate therapy: comment on the article by Morgan et al. Arthritis Rheum (2005) 0.75
Update on gout: pathophysiology and potential treatments. Curr Pain Headache Rep (2007) 0.75
A prize for the foreign-born. FASEB J (2006) 0.75
Gout: forgotten therapy for a common disease. Curr Rheumatol Rep (2005) 0.75