| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).
|
J Med Chem
|
2007
|
1.14
|
|
2
|
Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine.
|
Bioorg Med Chem Lett
|
2006
|
0.96
|
|
3
|
Unraveling the aflatoxin-FAPY conundrum: structural basis for differential replicative processing of isomeric forms of the formamidopyrimidine-type DNA adduct of aflatoxin B1.
|
J Am Chem Soc
|
2006
|
0.95
|
|
4
|
Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918.
|
Bioorg Med Chem Lett
|
2010
|
0.80
|
|
5
|
Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.
|
Bioorg Med Chem Lett
|
2009
|
0.79
|
|
6
|
Synthesis of the (3R,6S)-3-amino-6-(2,3-difluorophenyl)azepan-2-one of telcagepant (MK-0974), a calcitonin gene-related peptide receptor antagonist for the treatment of migraine headache.
|
Org Lett
|
2008
|
0.78
|
|
7
|
Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.
|
Bioorg Med Chem Lett
|
2011
|
0.77
|
|
8
|
P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold.
|
Bioorg Med Chem Lett
|
2005
|
0.75
|