Ectodomain shedding of pro-TGF-alpha is required for COX-2 induction and cell survival in renal medullary cells exposed to osmotic stress.

PubWeight™: 0.84‹?›

🔗 View Article (PMID 17942633)

Published in Am J Physiol Cell Physiol on October 17, 2007

Authors

Christoph Küper1, Helmut Bartels, Maria-Luisa Fraek, Franz X Beck, Wolfgang Neuhofer

Author Affiliations

1: Department of Physiology, University of Munich, Munich, Germany.

Articles by these authors

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med (2009) 4.07

Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. J Clin Invest (2013) 1.92

Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4. Nature (2002) 1.84

Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats. Kidney Int (2004) 1.51

Sepsis-induced urinary concentration defect is related to nitric oxide-dependent inactivation of TonEBP/NFAT5, which downregulates renal medullary solute transport proteins and aquaporin-2. Crit Care Med (2012) 1.46

High salt reduces the activation of IL-4- and IL-13-stimulated macrophages. J Clin Invest (2015) 1.30

Dicer-dependent microRNAs control maturation, function, and maintenance of Langerhans cells in vivo. J Immunol (2010) 1.21

PGE2 potentiates tonicity-induced COX-2 expression in renal medullary cells in a positive feedback loop involving EP2-cAMP-PKA signaling. Am J Physiol Cell Physiol (2008) 0.96

Toll-like receptor 4 activates NF-κB and MAP kinase pathways to regulate expression of proinflammatory COX-2 in renal medullary collecting duct cells. Am J Physiol Renal Physiol (2011) 0.96

Production of ammonium by Helicobacter pylori mediates occludin processing and disruption of tight junctions in Caco-2 cells. Microbiology (2005) 0.93

Prostaglandin E2 stimulates expression of osmoprotective genes in MDCK cells and promotes survival under hypertonic conditions. J Physiol (2007) 0.91

Response of renal medullary cells to osmotic stress. Contrib Nephrol (2005) 0.88

NFAT5 contributes to osmolality-induced MCP-1 expression in mesothelial cells. Mediators Inflamm (2012) 0.87

Expression and regulation of alphaB-crystallin in the kidney in vivo and in vitro. Pflugers Arch (2006) 0.87

Relationship between intracellular ionic strength and expression of tonicity-responsive genes in rat papillary collecting duct cells. J Physiol (2002) 0.86

EGF receptor signaling is involved in expression of osmoprotective TonEBP target gene aldose reductase under hypertonic conditions. Am J Physiol Renal Physiol (2009) 0.86

Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells. Kidney Int (2011) 0.85

Differential expression of heat shock protein 27 and 70 in renal papillary collecting duct and interstitial cells - implications for urea resistance. J Physiol (2005) 0.84

Nitric oxide decreases expression of osmoprotective genes via direct inhibition of TonEBP transcriptional activity. Pflugers Arch (2008) 0.81

Osmoadaptation of Mammalian cells - an orchestrated network of protective genes. Curr Genomics (2007) 0.81

Role of focal adhesion kinase (FAK) in renal ischaemia and reperfusion. Pflugers Arch (2007) 0.80

Heat shock protein 72, a chaperone abundant in renal papilla, counteracts urea-mediated inhibition of enzymes. Pflugers Arch (2002) 0.79

Intracellular Na concentration and Rb uptake in proximal convoluted tubule cells and abundance of Na/K-ATPase alpha1-subunit in NHE3-/- mice. Pflugers Arch (2003) 0.77

Cell volume regulation in the renal papilla. Contrib Nephrol (2006) 0.76

Effect of ammonium on the expression of osmosensitive genes in Madin-Darby canine kidney cells. J Physiol (2004) 0.75

Peritoneal infection and inflammation. Mediators Inflamm (2012) 0.75