Published in Mol Ther on October 23, 2007
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes. Nat Biotechnol (2008) 6.82
Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates. Mol Ther (2009) 1.66
Molecular evolution of adeno-associated virus for enhanced glial gene delivery. Mol Ther (2009) 1.57
Correction of brain oligodendrocytes by AAVrh.10 intracerebral gene therapy in metachromatic leukodystrophy mice. Hum Gene Ther (2012) 1.55
Intraganglionic AAV6 results in efficient and long-term gene transfer to peripheral sensory nervous system in adult rats. PLoS One (2013) 1.51
Recombinant adeno-associated virus type 2 pseudotypes: comparing safety, specificity, and transduction efficiency in the primate striatum. Laboratory investigation. J Neurosurg (2010) 1.50
Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression. Mol Ther (2009) 1.42
The advent of AAV9 expands applications for brain and spinal cord gene delivery. Expert Opin Biol Ther (2012) 1.30
Axonal transport of adeno-associated viral vectors is serotype-dependent. Gene Ther (2012) 1.29
Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain. PLoS One (2013) 1.19
Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis. J Biol Chem (2012) 1.18
Parkinson's disease gene therapy: success by design meets failure by efficacy. Mol Ther (2013) 1.18
Structural insight into the unique properties of adeno-associated virus serotype 9. J Virol (2012) 1.18
Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice. Mol Ther (2008) 1.17
Preventing growth of brain tumors by creating a zone of resistance. Mol Ther (2008) 1.10
Tau expression levels from various adeno-associated virus vector serotypes produce graded neurodegenerative disease states. Eur J Neurosci (2008) 1.07
Optogenetics in the nonhuman primate. Prog Brain Res (2012) 1.04
Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain. J Neurosci Methods (2010) 1.02
Engineered antibody therapies to counteract mutant huntingtin and related toxic intracellular proteins. Prog Neurobiol (2011) 1.00
New tools for investigating astrocyte-to-neuron communication. Front Cell Neurosci (2013) 1.00
Glial promoter selectivity following AAV-delivery to the immature brain. PLoS One (2013) 1.00
Rapid and simplified purification of recombinant adeno-associated virus. J Virol Methods (2012) 0.98
Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport. Hum Gene Ther (2014) 0.98
A next step in adeno-associated virus-mediated gene therapy for neurological diseases: regulation and targeting. Br J Clin Pharmacol (2013) 0.97
AAV-mediated gene delivery in adult GM1-gangliosidosis mice corrects lysosomal storage in CNS and improves survival. PLoS One (2010) 0.96
Large animal models of neurological disorders for gene therapy. ILAR J (2009) 0.95
Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. J Neurosci (2011) 0.95
Recombinant AAV9-TLK1B administration ameliorates fractionated radiation-induced xerostomia. Hum Gene Ther (2013) 0.93
Mouse gender influences brain transduction by intravascularly administered AAV9. Mol Ther (2013) 0.89
GFAP-driven GFP expression in activated mouse Müller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors. PLoS One (2010) 0.88
A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson's disease. PLoS One (2012) 0.88
A simplified purification method for AAV variant by polyethylene glycol aqueous two-phase partitioning. Bioengineered (2012) 0.88
Heparin-binding correlates with increased efficiency of AAV1- and AAV6-mediated transduction of striated muscle, but negatively impacts CNS transduction. Gene Ther (2012) 0.88
Comparison of adeno-associated virus pseudotype 1, 2, and 8 vectors administered by intramuscular injection in the treatment of murine phenylketonuria. Hum Gene Ther (2010) 0.88
Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors. Front Cell Neurosci (2013) 0.86
Intracisternal delivery of AAV9 results in oligodendrocyte and motor neuron transduction in the whole central nervous system of cats. Gene Ther (2014) 0.85
Increased hippocampal neurogenesis and accelerated response to antidepressants in mice with specific deletion of CREB in the hippocampus: role of cAMP response-element modulator τ. J Neurosci (2013) 0.85
Adeno-Associated Virus-Based Gene Therapy for CNS Diseases. Hum Gene Ther (2016) 0.84
Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Exp Neurol (2011) 0.83
Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain. Gene Ther (2013) 0.82
Comparative Analysis of Cesium Chloride- and Iodixanol-Based Purification of Recombinant Adeno-Associated Viral Vectors for Preclinical Applications. Hum Gene Ther Methods (2015) 0.82
Comparison of the efficacy of four viral vectors for transducing hypothalamic magnocellular neurosecretory neurons in the rat supraoptic nucleus. J Neurosci Methods (2011) 0.82
Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan. Hum Mol Genet (2015) 0.82
An adeno-associated viral vector transduces the rat hypothalamus and amygdala more efficient than a lentiviral vector. BMC Neurosci (2010) 0.81
AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats. Mol Ther Methods Clin Dev (2015) 0.81
CNS-directed gene therapy for the treatment of neurologic and somatic mucopolysaccharidosis type II (Hunter syndrome). JCI Insight (2016) 0.81
Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. Behav Brain Res (2012) 0.81
Transgenic models of Alzheimer's disease: better utilization of existing models through viral transgenesis. Biochim Biophys Acta (2013) 0.81
Fractalkine over expression suppresses α-synuclein-mediated neurodegeneration. Mol Ther (2014) 0.81
Current prospects and challenges for epilepsy gene therapy. Exp Neurol (2011) 0.80
Systemic AAVrh10 provides higher transgene expression than AAV9 in the brain and the spinal cord of neonatal mice. Front Mol Neurosci (2015) 0.80
Versatile somatic gene transfer for modeling neurodegenerative diseases. Neurotox Res (2009) 0.80
A single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina. PLoS One (2013) 0.80
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy. Gene Ther (2014) 0.79
Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience (2015) 0.78
Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism. Gene Ther (2016) 0.78
Recombinant adeno-associated virus: efficient transduction of the rat VMH and clearance from blood. PLoS One (2014) 0.78
Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids. Methods Mol Biol (2016) 0.77
Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates. J Med Primatol (2015) 0.76
Strategies for targeting primate neural circuits with viral vectors. J Neurophysiol (2016) 0.76
Gene transfer to the CNS using recombinant adeno-associated virus. Curr Protoc Microbiol (2013) 0.76
Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex. Gene Ther (2016) 0.76
Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B. Front Mol Neurosci (2016) 0.75
Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous System. Front Neuroanat (2017) 0.75
Pre-immunization with an intramuscular injection of AAV9-human erythropoietin vectors reduces the vector-mediated transduction following re-administration in rat brain. PLoS One (2013) 0.75
Severe respiratory changes at end stage in a FUS-induced disease state in adult rats. BMC Neurosci (2016) 0.75
Recombinant Adeno-Associated Virus Serotype 6 (rAAV6) Potently and Preferentially Transduces Rat Astrocytes In vitro and In vivo. Front Cell Neurosci (2016) 0.75
Antisense gene silencing: therapy for neurodegenerative disorders? Genes (Basel) (2013) 0.75
Multilineage transduction of resident lung cells in vivo by AAV2/8 for α1-antitrypsin gene therapy. Mol Ther Methods Clin Dev (2016) 0.75
Engineered AAV vectors for improved central nervous system gene delivery. Neurogenesis (Austin) (2015) 0.75
Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc Natl Acad Sci U S A (2002) 11.11
Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors. Methods (2002) 5.30
Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart. Nat Biotechnol (2005) 5.27
Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8. Mol Ther (2006) 4.64
Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. Proc Natl Acad Sci U S A (2000) 4.39
New recombinant serotypes of AAV vectors. Curr Gene Ther (2005) 3.87
Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo. Circ Res (2006) 3.63
Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice. J Virol (2005) 3.28
Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9, and Rh10 in the mouse brain. Mol Ther (2006) 2.67
Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain. Hum Gene Ther (2007) 2.64
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain. Neuroscience (2006) 2.19
Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease. Neurobiol Aging (2004) 2.18
A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. Brain Res Brain Res Rev (2004) 2.14
Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. Mol Ther (2005) 2.02
Enhanced survival of the LINCL mouse following CLN2 gene transfer using the rh.10 rhesus macaque-derived adeno-associated virus vector. Mol Ther (2006) 1.71
Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat. Mol Ther (2007) 1.67
Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders. Mol Ther (2006) 1.54
Recombinant adeno-associated viral vectors in the nervous system. Hum Gene Ther (2005) 1.46
Transduction profiles of recombinant adeno-associated virus vectors derived from serotypes 2 and 5 in the nigrostriatal system of rats. J Virol (2004) 1.45
Enhanced gene transfer efficiency in the murine striatum and an orthotopic glioblastoma tumor model, using AAV-7- and AAV-8-pseudotyped vectors. Hum Gene Ther (2006) 1.34
Adeno-associated virus vectors: activity and applications in the CNS. J Neurosci Methods (2000) 1.23
Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat. Neurobiol Dis (2005) 1.13
Recombinant adeno-associated virus serotype 2 effectively transduces primary rat brain astrocytes and microglia. Brain Res Brain Res Protoc (2004) 0.97
Delivery of cell cycle genes to block astrocytoma growth. J Neurooncol (2001) 0.85
Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. Mol Ther (2005) 2.02
Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression. Mol Ther (2009) 1.42
Expansive gene transfer in the rat CNS rapidly produces amyotrophic lateral sclerosis relevant sequelae when TDP-43 is overexpressed. Mol Ther (2010) 1.16
Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat. Neurobiol Dis (2005) 1.13
Tau expression levels from various adeno-associated virus vector serotypes produce graded neurodegenerative disease states. Eur J Neurosci (2008) 1.07
Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer. Neurobiol Aging (2009) 1.03
Recombinant AAV9-TLK1B administration ameliorates fractionated radiation-induced xerostomia. Hum Gene Ther (2013) 0.93
Bilateral effects of unilateral GDNF administration on dopamine- and GABA-regulating proteins in the rat nigrostriatal system. Exp Neurol (2009) 0.92
Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model. Neurosci Lett (2006) 0.84
Transcriptome analysis of a tau overexpression model in rats implicates an early pro-inflammatory response. Exp Neurol (2010) 0.79
Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates. J Med Primatol (2015) 0.76
PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models. Brain Res (2009) 0.76