Published in J Inherit Metab Dis on October 20, 2007
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet (2003) 11.67
Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. J Clin Invest (2003) 4.42
Lp(a) lipoprotein, vascular disease, and mortality in the elderly. N Engl J Med (2003) 3.20
A NEW SERUM TYPE SYSTEM IN MAN--THE LP SYSTEM. Acta Pathol Microbiol Scand (1963) 3.13
Role of lipoprotein(a) and apolipoprotein(a) phenotype in atherogenesis: prospective results from the Bruneck study. Circulation (1999) 3.08
Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation (2000) 3.05
Effect of serum lipoprotein(a) on estimation of low-density lipoprotein cholesterol by the Friedewald formula. Clin Chem (1994) 2.71
Apolipoprotein(a) and ischaemic heart disease in familial hypercholesterolaemia. Lancet (1990) 2.55
Is lipoprotein(a) an independent risk factor for ischemic heart disease in men? The Quebec Cardiovascular Study. J Am Coll Cardiol (1998) 1.88
Outcome of case finding among relatives of patients with known heterozygous familial hypercholesterolaemia. BMJ (2000) 1.80
Report of the National Heart, Lung, and Blood Institute Workshop on Lipoprotein(a) and Cardiovascular Disease: recent advances and future directions. Clin Chem (2003) 1.74
Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia. Hum Mutat (2005) 1.54
The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients. J Intern Med (2004) 1.46
The apolipoprotein B R3500Q gene mutation in Spanish subjects with a clinical diagnosis of familial hypercholesterolemia. Atherosclerosis (2002) 1.42
Differences in Lp[a] concentrations and apo[a] polymorphs between black and white Americans. J Lipid Res (1996) 1.42
Defects in the low density lipoprotein receptor gene affect lipoprotein (a) levels: multiplicative interaction of two gene loci associated with premature atherosclerosis. Proc Natl Acad Sci U S A (1989) 1.34
Effects of age, sex, and menopausal status on plasma lipoprotein(a) levels. The Framingham Offspring Study. Circulation (1993) 1.24
The relationship of molecular genetic to clinical diagnosis of familial hypercholesterolemia in a Danish population. Atherosclerosis (2005) 1.20
Established and emerging coronary risk factors in patients with heterozygous familial hypercholesterolaemia. Heart (2004) 1.17
Serum lipoprotein(a) in patients heterozygous for familial hypercholesterolemia, their relatives, and unrelated control populations. Arterioscler Thromb (1991) 1.07
Lipoprotein(a) in homozygous familial hypercholesterolemia. Arterioscler Thromb Vasc Biol (2000) 1.07
The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans. J Clin Invest (1995) 1.07
Genetic screening protocol for familial hypercholesterolemia which includes splicing defects gives an improved mutation detection rate. Atherosclerosis (2005) 1.07
Reliable low-density DNA array based on allele-specific probes for detection of 118 mutations causing familial hypercholesterolemia. Clin Chem (2005) 1.02
Evaluation of coronary risk factors in patients with heterozygous familial hypercholesterolemia. Am J Cardiol (2001) 1.01
Universal primer quantitative fluorescent multiplex (UPQFM) PCR: a method to detect major and minor rearrangements of the low density lipoprotein receptor gene. J Med Genet (2000) 0.98
Lipoprotein(a) is an independent risk factor for cardiovascular disease in heterozygous familial hypercholesterolemia. Clin Chem (2005) 0.95
Molecular basis for "null" lipoprotein(a) phenotypes and the influence of apolipoprotein(a) size on plasma lipoprotein(a) level in the baboon. J Biol Chem (1994) 0.91
[Lipid profile of the Spanish population: the DRECE (diet and risk of cardiovascular disease in Spain) study. DRECE study group]. Med Clin (Barc) (1999) 0.89
Familial hypercholesterolemia in Spain: case-finding program, clinical and genetic aspects. Semin Vasc Med (2004) 0.86
Implementation of cascade testing for the detection of familial hypercholesterolaemia. Curr Opin Lipidol (2005) 0.85
Plasma lipoprotein(a) [Lp(a)] concentrations and cardiovascular events in the elderly: evidence from the prospective study of pravastatin in the elderly at risk (PROSPER). Atherosclerosis (2005) 0.85
Elevated Lipoprotein(a) does not promote early atherosclerotic changes of the carotid arteries in young, healthy adults. Atherosclerosis (2006) 0.83
Lp(a) concentration and apo(a) isoform size. Relation to the presence of coronary artery disease in familial hypercholesterolemia. Arterioscler Thromb (1994) 0.81
Apolipoprotein(a) synthesis and secretion from hepatoma cells is coupled to triglyceride synthesis and secretion. J Biol Chem (1998) 0.79
[Plasma lipoprotein (a) values in familial defective ligand apo B 100 in a South European population]. An Med Interna (2004) 0.77
Screening of APOB gene mutations in subjects with clinical diagnosis of familial hypercholesterolemia. Hum Biol (2005) 0.77
Lp(a) levels in Greek patients with heterozygous familial hypercholesterolemia. Int J Cardiol (1996) 0.76
What promise does PCSK9 hold? J Am Coll Cardiol (2005) 0.75
Randomised trial of endoscopic sphincterotomy with gallbladder left in situ versus open surgery for common bileduct calculi in high-risk patients. Lancet (1996) 3.81
Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity. Virchows Arch (2008) 2.41
Reactivation and persistence of human herpesvirus-8 infection in B cells and monocytes by Th-1 cytokines increased in Kaposi's sarcoma. Blood (1999) 2.10
High HDL-cholesterol in women with rheumatoid arthritis on low-dose glucocorticoid therapy. Eur J Clin Invest (2008) 2.05
Nanoscale topography of the basement membrane underlying the corneal epithelium of the rhesus macaque. Cell Tissue Res (2000) 2.03
Paracoccidioidomycosis: a recently proposed classification of its clinical forms. Rev Soc Bras Med Trop (1989) 1.93
Apolipoprotein E polymorphism and gallstones. Gastroenterology (1996) 1.77
Effect of a fermented milk combining Lactobacillus acidophilus Cl1285 and Lactobacillus casei in the prevention of antibiotic-associated diarrhea: a randomized, double-blind, placebo-controlled trial. Can J Gastroenterol (2007) 1.76
Host-parasite relationships in paracoccidioidomycosis. J Med Vet Mycol (1987) 1.75
Mapping of the T-cell epitope in the major 43-kilodalton glycoprotein of Paracoccidioides brasiliensis which induces a Th-1 response protective against fungal infection in BALB/c mice. Infect Immun (1998) 1.69
[Aortic valve replacement with a pulmonary autograft (the Ross operation) in adult and pediatric patients. A preliminary study]. Rev Esp Cardiol (1999) 1.65
The role of diet in the prevention of type 2 diabetes. Nutr Metab Cardiovasc Dis (2011) 1.63
Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60
Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation: the effect of body position. Ann Intern Med (1992) 1.60
SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther (1997) 1.54
The structural GDP/GTP cycle of human Arf6. EMBO Rep (2001) 1.50
Homozygous Tangier disease and cardiovascular disease. Atherosclerosis (1994) 1.48
[Achilles tendon size by high resolution sonography in healthy population. Relationship with lipid levels]. Med Clin (Barc) (1998) 1.45
Beta-glucocerebrosidase gene locus as a link for Gaucher's disease and familial hypo-alpha-lipoproteinaemia. Lancet (1998) 1.44
Association of polymorphisms at the SR-BI gene locus with plasma lipid levels and body mass index in a white population. Arterioscler Thromb Vasc Biol (1999) 1.43
Lipoprotein(a) and the significance of the association between platelet glycoprotein IIIa polymorphisms and the risk of premature myocardial infarction. Atherosclerosis (1998) 1.42
Comparison of the hypolipidemic effect of gemfibrozil versus simvastatin in patients with type III hyperlipoproteinemia. Am Heart J (1999) 1.42
Observation of a centrality-dependent dijet asymmetry in lead-lead collisions at sqrt[S(NN)] =2.76 TeV with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.41
[Effectiveness of hypercholesterolemia detection in high risk individuals compared to opportunistic detection]. Med Clin (Barc) (1994) 1.40
[Impact of consensus conferences of hypercholesterolemia and hypertension in Spain]. Med Clin (Barc) (1997) 1.39
[Chlamydia pneumoniae and cerebrovascular disease]. Rev Neurol (2001) 1.39
Measurement of dijet azimuthal decorrelations in pp collisions at sqrt(s)=7 TeV. Phys Rev Lett (2011) 1.39
Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008. Nutr Metab Cardiovasc Dis (2010) 1.36
Determination of the strange-quark density of the proton from ATLAS measurements of the W→ℓν and Z→ℓℓ cross sections. Phys Rev Lett (2012) 1.34
Structure of Arf6-GDP suggests a basis for guanine nucleotide exchange factors specificity. Nat Struct Biol (2000) 1.34
A third major locus for autosomal dominant hypercholesterolemia maps to 1p34.1-p32. Am J Hum Genet (1999) 1.34
Predictive factors of the long term outcome in gastro-oesophageal reflux disease: six year follow up of 107 patients. Gut (1994) 1.33
Components of the Mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease. Eur J Clin Nutr (2007) 1.32
Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.32
Immunoreactivity of a surface wall fraction produced by spherules of Coccidioides immitis. Infect Immun (1988) 1.31
Treatment and follow-up of HIV-negative multidrug-resistant tuberculosis patients in an infectious diseases reference hospital, Buenos Aires, Argentina. Int J Tuberc Lung Dis (2004) 1.29
Observation of associated near-side and away-side long-range correlations in sqrt[s(NN)]=5.02 TeV proton-lead collisions with the ATLAS detector. Phys Rev Lett (2013) 1.27
Isolation and morphology of an immunoreactive outer wall fraction produced by spherules of Coccidioides immitis. Infect Immun (1988) 1.25
Effects of one serving of mixed nuts on serum lipids, insulin resistance and inflammatory markers in patients with the metabolic syndrome. Nutr Metab Cardiovasc Dis (2009) 1.20
Search for dark matter candidates and large extra dimensions in events with a photon and missing transverse momentum in pp collision data at sqrt[s]=7 TeV with the ATLAS detector. Phys Rev Lett (2013) 1.19
Serology of paracoccidioidomycosis. II. Correlation between class-specific antibodies and clinical forms of the disease. Trans R Soc Trop Med Hyg (1984) 1.18
Familial apolipoprotein A-I, C-III, and A-IV deficiency and premature atherosclerosis due to deletion of a gene complex on chromosome 11. J Biol Chem (1989) 1.16
Roles of lipid modifications of transducin subunits in their GDP-dependent association and membrane binding. Biochemistry (1994) 1.16
Lipid metabolism and apolipoprotein E phenotypes in patients with xanthelasma. Am J Med (1995) 1.16
Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors. J Med Chem (1998) 1.15
Restriction fragment length polymorphisms of the apolipoprotein A-I, C-III, A-IV gene locus. Relationships with lipids, apolipoproteins, and premature coronary artery disease. Atherosclerosis (1991) 1.14
Search for a supersymmetric partner to the top quark in final states with jets and missing transverse momentum at sqrt[s] = 7 TeV with the ATLAS detector. Phys Rev Lett (2012) 1.13
Co-funded expanded access programmes for new oncology drugs: creating a two-tier system for Australian cancer patients? Intern Med J (2013) 1.12
Specificities for the small G proteins ARF1 and ARF6 of the guanine nucleotide exchange factors ARNO and EFA6. J Biol Chem (2001) 1.11
Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial. Ann Intern Med (2000) 1.09
Long term outcome of infective endocarditis in patients who were not drug addicts: a 10 year study. Heart (2000) 1.09
Timing in the cerebellum: oscillations and resonance in the granular layer. Neuroscience (2009) 1.08
Early activation of splenic macrophages by tumor necrosis factor alpha is important in determining the outcome of experimental histoplasmosis in mice. Infect Immun (1992) 1.08
Crossover study of diets enriched with virgin olive oil, walnuts or almonds. Effects on lipids and other cardiovascular risk markers. Nutr Metab Cardiovasc Dis (2011) 1.08
Search for tb resonances in proton-proton collisions at √s=7 TeV with the ATLAS detector. Phys Rev Lett (2012) 1.07
Utility of biliary microscopy for the prediction of the chemical composition of gallstones and the outcome of dissolution therapy with ursodeoxycholic acid. Gastroenterology (1986) 1.07
[Type I Gaucher's disease: clinical, evolutive and therapeutic features in 8 cases]. Sangre (Barc) (1994) 1.06
Isolation of Paracoccidioides brasiliensis from armadillos (Dasypus noveminctus) captured in an endemic area of paracoccidioidomycosis. Am J Trop Med Hyg (1998) 1.05
Search for a light Higgs boson decaying to long-lived weakly interacting particles in proton-proton collisions at sqrt[s] = 7 TeV with the ATLAS detector. Phys Rev Lett (2012) 1.05
Prostaglandin production in arthritis. Ann Rheum Dis (1978) 1.04
Alpha interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononuclear cells. J Virol (1999) 1.04
Isolation of fungi from nature in the region of Botucatu, state of São Paulo, Brazil, an endemic area of paracoccidioidomycosis. Mem Inst Oswaldo Cruz (1998) 1.03
Dietary intake and major food sources of polyphenols in a Spanish population at high cardiovascular risk: the PREDIMED study. Nutr Metab Cardiovasc Dis (2013) 1.03
Post-transplant anti-HLA class II antibodies as risk factor for late kidney allograft failure. Am J Transplant (2006) 1.03
Nuts, hypertension and endothelial function. Nutr Metab Cardiovasc Dis (2011) 1.01
High frequency of Paracoccidioides brasiliensis infection in armadillos (Dasypus novemcinctus): an ecological study. Med Mycol (2003) 1.00
A common variant in the ABCA1 gene is associated with a lower risk for premature coronary heart disease in familial hypercholesterolaemia. J Med Genet (2003) 1.00
Incidence and clinical significance of sinusoidal dilatation in liver biopsies. Gastroenterology (1978) 1.00
Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk. J Epidemiol Community Health (2009) 0.99
Search for supersymmetry in events with three leptons and missing transverse momentum in √[s]=7 TeV pp collisions with the ATLAS detector. Phys Rev Lett (2012) 0.99
Report of the Spanish Gaucher's disease registry: clinical and genetic characteristics. Haematologica (2000) 0.99
Sexual reproduction and clonal growth in Reinhardtia gracilis (Palmae), an understory tropical palm. Am J Bot (1998) 0.99
Novel antiangiogenic therapies against advanced hepatocellular carcinoma (HCC). Clin Transl Oncol (2012) 0.98
Laboratory intercomparison of the cytokinesis-block micronucleus assay. Radiat Res (2013) 0.97
alpha(4)beta(7) independent pathway for CD8(+) T cell-mediated intestinal immunity to rotavirus. J Clin Invest (2000) 0.97
Utility of inpatient 24-hour intraesophageal pH monitoring in diagnosis of gastroesophageal reflux. Dig Dis Sci (1988) 0.96
LDLR Database (second edition): new additions to the database and the software, and results of the first molecular analysis. Nucleic Acids Res (1998) 0.96
Acute effects of three high-fat meals with different fat saturations on energy expenditure, substrate oxidation and satiety. Clin Nutr (2008) 0.95
Efficacy and tolerability of fluvastatin extended-release delivery system: a pooled analysis. Clin Ther (2001) 0.95
Diffuse pulmonary hemorrhage associated with anticoagulant therapy. Eur J Respir Dis (1986) 0.95
Renal acute cellular rejection: correlation between the immunophenotype and cytokine expression of the inflammatory cells in acute glomerulitis, arterial intimitis, and tubulointerstitial nephritis. Transplant Proc (2010) 0.93
Femtosecond laser-induced damage and filamentary propagation in fused silica. Phys Rev Lett (2002) 0.92
2-Phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: stimulation of neurosteroid synthesis and anticonflict action in rats. Br J Pharmacol (1999) 0.92
The Th1 /Th2 immune-type response of the recurrent aphthous ulceration analyzed by cDNA microarray. J Oral Pathol Med (2004) 0.92
Transcatheter occlusion of complex atrial septal defects. Catheter Cardiovasc Interv (2000) 0.91
Deterioration of esophageal motility with age: a manometric study of 79 healthy subjects. Am J Gastroenterol (1999) 0.91
Review of small cell carcinomas of the prostate. Prostate Cancer (2011) 0.91
Myocyte necrosis is the basis for fibrosis in renovascular hypertensive rats. Braz J Med Biol Res (1997) 0.91
Guidelines for psychosocial interventions in dementia care: a European survey and comparison. Int J Geriatr Psychiatry (2011) 0.90
Dysphagia and esophageal motor dysfunction in gastroesophageal reflux are corrected by fundoplication. J Clin Gastroenterol (1991) 0.90
Chitotriosidase genotype and serum activity in subjects with combined hyperlipidemia: effect of the lipid-lowering agents, atorvastatin and bezafibrate. Metabolism (2001) 0.90
Reversibility of exocrine pancreatic failure in chronic pancreatitis. Gastroenterology (1986) 0.90