Published in Glia on January 01, 2008
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A (2007) 3.13
Life extension factor klotho enhances cognition. Cell Rep (2014) 1.81
Current understanding of klotho. Ageing Res Rev (2008) 1.64
Klotho and aging. Biochim Biophys Acta (2009) 1.58
Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys. J Neurosci (2010) 1.17
The effects of normal aging on myelinated nerve fibers in monkey central nervous system. Front Neuroanat (2009) 1.12
The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci (2013) 1.08
Promoter methylation and age-related downregulation of Klotho in rhesus monkey. Age (Dordr) (2011) 1.01
The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem (2014) 1.00
Identification of novel small molecules that elevate Klotho expression. Biochem J (2012) 0.95
Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease. Neurosci Lett (2013) 0.95
Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice. J Physiol (2010) 0.91
Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. J Neurosci (2015) 0.91
Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Med Chem (2012) 0.89
Gene expression profiling in the rhesus macaque: methodology, annotation and data interpretation. Methods (2009) 0.89
Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood. Brain Res (2013) 0.87
Promoter methylation confers kidney-specific expression of the Klotho gene. FASEB J (2012) 0.86
Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk. J Biol Chem (2013) 0.86
Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry (2014) 0.86
Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging. Neurogastroenterol Motil (2011) 0.83
MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro. Age (Dordr) (2013) 0.83
The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line. J Mol Neurosci (2014) 0.82
Paranodal reorganization results in the depletion of transverse bands in the aged central nervous system. Neurobiol Aging (2010) 0.80
Protective effect of selaginellin on glutamate-induced cytotoxicity and apoptosis in differentiated PC12 cells. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.79
Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides. J Nutr Biochem (2010) 0.78
Senescence-related changes in gene expression of peripheral blood mononuclear cells from octo/nonagenarians compared to their offspring. Oxid Med Cell Longev (2013) 0.78
Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group. J Gerontol A Biol Sci Med Sci (2015) 0.78
RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation. Exp Biol Med (Maywood) (2015) 0.77
Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression. PLoS One (2015) 0.77
The age-regulating protein klotho is vital to sustain retinal function. Invest Ophthalmol Vis Sci (2013) 0.76
Distinct transcriptome expression of the temporal cortex of the primate Microcebus murinus during brain aging versus Alzheimer's disease-like pathology. PLoS One (2010) 0.76
Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis. Biomed Res Int (2015) 0.75
Characteristics of diffusion-tensor imaging for healthy adult rhesus monkey brains. Neural Regen Res (2013) 0.75
Klotho Regulates 14-3-3ζ Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress. PLoS One (2015) 0.75
Klotho regulates CA1 hippocampal synaptic plasticity. Neuroscience (2017) 0.75
Klotho and fibroblast growth factor 23 in cerebrospinal fluid in children. J Bone Miner Metab (2016) 0.75
Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss. Neurobiol Aging (2017) 0.75
The spectrum of disease in chronic traumatic encephalopathy. Brain (2012) 5.10
The geometric structure of the brain fiber pathways. Science (2012) 4.50
Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet (2003) 3.77
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A (2007) 3.13
High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations. Blood (2010) 2.37
B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell (2008) 2.15
Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. J Invest Dermatol (2008) 1.93
Beta-secretase activity increases with aging in human, monkey, and mouse brain. Am J Pathol (2004) 1.70
Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: a stereological experiment using calbindin-D28k. Cerebellum (2008) 1.61
Effects on executive function following damage to the prefrontal cortex in the rhesus monkey (Macaca mulatta). Behav Neurosci (2009) 1.55
Telomere instability in the male germline. Hum Mol Genet (2005) 1.55
Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages. Aging Cell (2011) 1.51
Reversible senescence in human CD4+CD45RA+CD27- memory T cells. J Immunol (2011) 1.46
Age-Related Changes in Human Peripheral Blood IGH Repertoire Following Vaccination. Front Immunol (2012) 1.39
Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study. Neurobiol Aging (2006) 1.37
The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity (2003) 1.36
Executive system dysfunction occurs as early as middle-age in the rhesus monkey. Neurobiol Aging (2005) 1.33
Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans. Hum Mol Genet (2006) 1.30
The relationship between CD27 negative and positive B cell populations in human peripheral blood. Front Immunol (2011) 1.27
Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys. Cereb Cortex (2005) 1.25
Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor. J Gerontol A Biol Sci Med Sci (2005) 1.24
Parcellation of cortical afferents to three distinct sectors in the parahippocampal gyrus of the rhesus monkey: an anatomical and neurophysiological study. J Comp Neurol (2003) 1.22
Impairment in abstraction and set shifting in aged rhesus monkeys. Neurobiol Aging (2002) 1.21
Mechanisms of immunosenescence. Immun Ageing (2009) 1.19
Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation. J Neurochem (2006) 1.16
Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury. Fluids Barriers CNS (2011) 1.16
p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression. J Natl Cancer Inst (2003) 1.16
Normality of oligonucleotide microarray data and implications for parametric statistical analyses. Bioinformatics (2003) 1.14
DNA repair genes are selectively mutated in diffuse large B cell lymphomas. J Exp Med (2013) 1.12
Motor projections to the basis pontis in rhesus monkey. J Comp Neurol (2004) 1.10
Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. J Cell Sci (2004) 1.10
Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex. Behav Brain Res (2005) 1.09
The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci (2013) 1.08
Cell-specific processing and release of the hormone-like precursor and candidate tumor suppressor gene product, Ecrg4. Cell Tissue Res (2012) 1.06
Effect of prenatal protein malnutrition on numbers of neurons in the principal cell layers of the adult rat hippocampal formation. Hippocampus (2005) 1.05
An MRI study of age-related white and gray matter volume changes in the rhesus monkey. Neurobiol Aging (2007) 1.05
Microarray analysis of senescent vascular smooth muscle cells: A link to atherosclerosis and vascular calcification. Exp Gerontol (2009) 1.03
Melatonin promotes sleep in three species of diurnal nonhuman primates. Physiol Behav (2002) 1.02
Age-related molecular reorganization at the node of Ranvier. J Comp Neurol (2006) 1.02
Density of cerebellar basket and stellate cells in autism: evidence for a late developmental loss of Purkinje cells. J Neurosci Res (2009) 1.02
Werner Syndrome as an example of inflamm-aging: possible therapeutic opportunities for a progeroid syndrome? Rejuvenation Res (2006) 1.02
Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices. J Neurosci (2012) 1.01
Promoter methylation and age-related downregulation of Klotho in rhesus monkey. Age (Dordr) (2011) 1.01
Sex, age, and training modulate spatial memory in the rhesus monkey (Macaca mulatta). Behav Neurosci (2005) 1.00
In aging, is it gray or white? J Comp Neurol (2003) 0.99
Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms. J Cell Sci (2003) 0.98
The role of cellular senescence in Werner syndrome: toward therapeutic intervention in human premature aging. Ann N Y Acad Sci (2007) 0.98
Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkey. J Comp Neurol (2003) 0.98
Altered posterior cingulate cortical cyctoarchitecture, but normal density of neurons and interneurons in the posterior cingulate cortex and fusiform gyrus in autism. Autism Res (2011) 0.97
Fibroblast clones from patients with Hutchinson-Gilford progeria can senesce despite the presence of telomerase. Exp Gerontol (2004) 0.96
Age changes in myelinated nerve fibers of the cingulate bundle and corpus callosum in the rhesus monkey. J Comp Neurol (2010) 0.95
A non-human primate test of abstraction and set shifting: an automated adaptation of the Wisconsin Card Sorting Test. J Neurosci Methods (2005) 0.95
Identification of novel small molecules that elevate Klotho expression. Biochem J (2012) 0.95
Asymmetry of neuron numbers in the hippocampal formation of prenatally malnourished and normally nourished rats: a stereological investigation. Hippocampus (2006) 0.95
Calbindin-D28k is a more reliable marker of human Purkinje cells than standard Nissl stains: a stereological experiment. J Neurosci Methods (2007) 0.94
Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of ataxia telangiectasia and Werner syndrome fibroblasts. Biogerontology (2008) 0.94
Age-related reduction in microcolumnar structure in area 46 of the rhesus monkey correlates with behavioral decline. Proc Natl Acad Sci U S A (2004) 0.94
Telomeres and telomerase biology in vertebrates: progress towards a non-human model for replicative senescence and ageing. Biogerontology (2005) 0.93
What's behind the decline? The role of white matter in brain aging. Neurochem Res (2007) 0.93
Amyloid precursor protein interacts with notch receptors. J Neurosci Res (2005) 0.93
Prevention of accelerated cell aging in the Werner syndrome. Ann N Y Acad Sci (2006) 0.93
Light and electron microscopic immunohistochemical detection of bromodeoxyuridine-labeled cells in the brain: different fixation and processing protocols. J Histochem Cytochem (2005) 0.92
Maturational sequence of newly generated neurons in the dentate gyrus of the young adult rhesus monkey. J Comp Neurol (2006) 0.92
Impairment of executive function induced by hypertension in the rhesus monkey (Macaca mulatta). Behav Neurosci (2002) 0.91
The extent and significance of telomere loss with age. Ann N Y Acad Sci (2004) 0.91
Evaluating the role of p38 MAP kinase in growth of Werner syndrome fibroblasts. Ann N Y Acad Sci (2010) 0.90
Text-based over-representation analysis of microarray gene lists with annotation bias. Nucleic Acids Res (2009) 0.90
Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide. J Neurochem (2007) 0.90
Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts. Glia (2008) 0.90
Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells. Hum Mol Genet (2004) 0.90
Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline. Age (Dordr) (2011) 0.89
A statistically based density map method for identification and quantification of regional differences in microcolumnarity in the monkey brain. J Neurosci Methods (2005) 0.88
Replicative senescence in sheep fibroblasts is a p53 dependent process. Exp Gerontol (2005) 0.88
Cell-type dependent modulation of Notch signaling by the amyloid precursor protein. J Neurochem (2010) 0.88
Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome. Future Med Chem (2010) 0.88
Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization. Am J Neurodegener Dis (2012) 0.87
Microwave-assisted Ullmann C-S bond formation: synthesis of the P38alpha MAPK clinical candidate VX-745. J Org Chem (2009) 0.87
MRI-guided focused ultrasound surgery in the brain: tests in a primate model. Magn Reson Med (2003) 0.87
Characterization of cellular senescence mechanisms in human corneal endothelial cells. Aging Cell (2011) 0.86
Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation. Exp Cell Res (2004) 0.86
Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing. Org Biomol Chem (2006) 0.86
Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells. Bioorg Med Chem Lett (2007) 0.86
Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk. J Biol Chem (2013) 0.86
Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide. Mol Neurodegener (2009) 0.86
Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry (2014) 0.86
p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes. Biogerontology (2012) 0.85
Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy. Oncogene (2004) 0.85
Response to comment on "the geometric structure of the brain fiber pathways". Science (2012) 0.85
Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey. J Neurochem (2004) 0.84
Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts. J Gerontol A Biol Sci Med Sci (2013) 0.84
Age-related effects on cortical thickness patterns of the Rhesus monkey brain. Neurobiol Aging (2010) 0.84
Activation of early components of complement targets myelin and oligodendrocytes in the aged rhesus monkey brain. Neurobiol Aging (2005) 0.84
Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein. Mol Neurodegener (2008) 0.84