Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMC 2241789)

Published in Br J Pharmacol on October 29, 2007

Authors

H Takemasa1, T Nagatomo, H Abe, K Kawakami, T Igarashi, T Tsurugi, N Kabashima, M Tamura, M Okazaki, B P Delisle, C T January, Y Otsuji

Author Affiliations

1: Second Department of Internal Medicine, University of Occupational and Environmental Health Japan, Yahatanishi-ku, Kitakyushu, Japan.

Articles citing this

Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon? Br J Pharmacol (2007) 1.02

hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine. Naunyn Schmiedebergs Arch Pharmacol (2010) 1.02

Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance. Curr Cardiol Rev (2009) 0.98

Forward trafficking of ion channels: what the clinician needs to know. Heart Rhythm (2010) 0.97

Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents. Br J Pharmacol (2009) 0.95

Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum. Mol Pharmacol (2009) 0.91

Antidepressant-induced ubiquitination and degradation of the cardiac potassium channel hERG. J Biol Chem (2011) 0.90

Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.87

Ion channel trafficking: a new therapeutic horizon for atrial fibrillation. Heart Rhythm (2010) 0.86

Molecular determinants of pentamidine-induced hERG trafficking inhibition. Mol Pharmacol (2011) 0.86

Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane. Mol Biol Cell (2013) 0.85

Molecular Pathophysiology of Congenital Long QT Syndrome. Physiol Rev (2017) 0.85

Impact of ABCB1 allelic variants on QTc interval prolongation. Clin Cancer Res (2010) 0.81

Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells. Br J Pharmacol (2013) 0.80

Effect of high-dose fluconazole on QT interval in patients with human immunodeficiency virus (HIV)-associated cryptococcal meningitis. Int J Antimicrob Agents (2009) 0.78

Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue. Br J Pharmacol (2013) 0.78

Inside job: ligand-receptor pharmacology beneath the plasma membrane. Acta Pharmacol Sin (2013) 0.76

hERG quality control and the long QT syndrome. J Physiol (2016) 0.76

Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias. Curr Cardiol Rev (2016) 0.75

The Role of Interaction Model in Simulation of Drug Interactions and QT Prolongation. Curr Pharmacol Rep (2016) 0.75

Articles cited by this

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell (1995) 11.62

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell (1995) 10.18

HERG, a human inward rectifier in the voltage-gated potassium channel family. Science (1995) 7.26

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol (1990) 6.73

A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci U S A (2000) 4.06

Drug induced QT prolongation and torsades de pointes. Heart (2003) 3.97

Oral azole drugs as systemic antifungal therapy. N Engl J Med (1994) 3.96

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophys J (1998) 3.83

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance. Clin Pharmacokinet (2000) 2.94

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences. JAMA (1993) 2.78

Long QT syndromes and torsade de pointes. Lancet (1999) 2.70

Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin Pharmacokinet (2000) 2.60

Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites. Mol Pharmacol (2000) 1.89

Mechanisms of arsenic-induced prolongation of cardiac repolarization. Mol Pharmacol (2004) 1.83

Pentamidine-induced long QT syndrome and block of hERG trafficking. J Pharmacol Exp Ther (2004) 1.76

Temperature dependence of early and late currents in human cardiac wild-type and long Q-T DeltaKPQ Na+ channels. Am J Physiol (1998) 1.74

Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. Br J Pharmacol (2006) 1.68

Inhibition of cytochromes P450 by antifungal imidazole derivatives. Drug Metab Dispos (2002) 1.47

Systemic antifungal agents. Drug interactions of clinical significance. Drug Saf (1998) 1.39

Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block. J Biol Chem (2002) 1.33

Pentamidine reduces hERG expression to prolong the QT interval. Br J Pharmacol (2005) 1.23

Pharmacogenetics and drug-induced arrhythmias. Cardiovasc Res (2001) 1.20

Review article: cardiac adverse effects of gastrointestinal prokinetics. Aliment Pharmacol Ther (1999) 1.20

Torsades de Pointes after treatment with terfenadine and ketoconazole. Eur Heart J (1992) 1.14

Chronic inhibition of cardiac Kir2.1 and HERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking. J Biol Chem (2006) 1.10

Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel. J Pharmacol Exp Ther (2002) 1.10

Open channel block of HERG K(+) channels by vesnarinone. Mol Pharmacol (2001) 1.08

Blockade of HERG and Kv1.5 by ketoconazole. J Pharmacol Exp Ther (1998) 1.07

Mechanisms and control of repolarization. Eur Heart J (1993) 1.06

Blockade of HERG cardiac K+ current by antifungal drug miconazole. Br J Pharmacol (2005) 0.98

Estimation of potency of HERG channel blockers: impact of voltage protocol and temperature. J Pharmacol Toxicol Methods (2005) 0.98

Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656. FEBS Lett (2006) 0.87

Combined use of astemizole and ketoconazole resulting in torsade de pointes. J Formos Med Assoc (1997) 0.87

Ketoconazole induced torsades de pointes without concomitant use of QT interval-prolonging drug. J Cardiovasc Electrophysiol (2005) 0.83

Articles by these authors

Two transcription factors, DREB1 and DREB2, with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought- and low-temperature-responsive gene expression, respectively, in Arabidopsis. Plant Cell (1998) 11.21

Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development. Genes Dev (1996) 10.27

MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res (2000) 9.30

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A (1999) 7.88

Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys. Nat Med (1999) 6.91

Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model. Biochemistry (1982) 5.33

Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest (1999) 5.30

Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under drought and high-salinity conditions. Proc Natl Acad Sci U S A (2000) 5.23

Monitoring the expression pattern of 1300 Arabidopsis genes under drought and cold stresses by using a full-length cDNA microarray. Plant Cell (2001) 5.11

Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique. Circulation (1983) 4.70

Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product. Science (1988) 4.01

A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein. Nature (1988) 3.95

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophys J (1998) 3.83

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J (1999) 3.70

CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res (1999) 3.66

Angiotropic lymphoma with histologic features of neoplastic angioendotheliomatosis presenting with predominant respiratory and hematologic manifestations. Report of a case and review of the literature [corrected]. Am J Clin Pathol (1990) 2.77

Identification of endogenous gibberellins from sorghum. Plant Physiol (1986) 2.74

Zebrafish vasa homologue RNA is localized to the cleavage planes of 2- and 4-cell-stage embryos and is expressed in the primordial germ cells. Development (1997) 2.69

Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails. J Cell Biol (1997) 2.66

A role of the B-oligomer moiety of islet-activating protein, pertussis toxin, in development of the biological effects on intact cells. J Biol Chem (1983) 2.65

Molecular evidence from retroposons that whales form a clade within even-toed ungulates. Nature (1997) 2.63

HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects. J Biol Chem (1998) 2.52

NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J Immunol (1994) 2.40

Circular polarization in star-formation regions: implications for biomolecular homochirality. Science (1998) 2.38

Interpretation of near-infrared spectroscopy signals: a study with a newly developed perfused rat brain model. J Appl Physiol (1985) (2001) 2.38

Adverse effects of low dose amiodarone: a meta-analysis. J Am Coll Cardiol (1997) 2.37

Isolation of 4-chloroindolyl-3-acetic acid from immature seeds of Pisum sativum. Nature (1968) 2.34

Comparative study on adhesive performance of functional monomers. J Dent Res (2004) 2.32

Nephrotic syndrome: an under-recognised immune-mediated complication of non-myeloablative allogeneic haematopoietic cell transplantation. Br J Haematol (2005) 2.32

Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects. J Biol Chem (1999) 2.27

The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer. Br J Cancer (2011) 2.25

Hypoglossal-facial nerve side-to-end anastomosis for preservation of hypoglossal function: results of delayed treatment with a new technique. J Neurosurg (1997) 2.24

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol (1999) 2.21

The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein. Arch Biochem Biophys (1983) 2.21

Insertional mutagenesis and rapid cloning of essential genes in zebrafish. Nature (1996) 2.14

Mechanism of block and identification of the verapamil binding domain to HERG potassium channels. Circ Res (1999) 2.10

cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. Nucleic Acids Res (1993) 2.08

Investigations on the Nature of the Auxin-Wave in the Cambial Region of Pine Stems : Validation of IAA as the Auxin Component by the Avena Coleoptile Curvature Assay and by Gas Chromatography-Mass Spectrometry-Selected Ion Monitoring. Plant Physiol (1987) 2.08

Clinical importance of CD7 expression in acute myelocytic leukemia. The Japan Cooperative Group of Leukemia/Lymphoma. Blood (1993) 2.07

Slow N-acetyltransferase 2 genotype affects the incidence of isoniazid and rifampicin-induced hepatotoxicity. Int J Tuberc Lung Dis (2000) 2.07

Selective expression of a novel surface molecule by human Th2 cells in vivo. J Immunol (1999) 2.07

Molecular cloning and characterization of a cDNA encoding the gibberellin biosynthetic enzyme ent-kaurene synthase B from pumpkin (Cucurbita maxima L.). Plant J (1996) 2.04

toxB gene on pO157 of enterohemorrhagic Escherichia coli O157:H7 is required for full epithelial cell adherence phenotype. Infect Immun (2001) 2.04

The Schizosaccharomyces pombe mei4+ gene encodes a meiosis-specific transcription factor containing a forkhead DNA-binding domain. Mol Cell Biol (1998) 1.97

Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. Mol Cell Biol (1999) 1.96

Diffuse panbronchiolitis. A disease of the transitional zone of the lung. Chest (1983) 1.93

A mechanism of erythromycin treatment in patients with diffuse panbronchiolitis. Am Rev Respir Dis (1993) 1.91

Molecular cloning and expression of megakaryocyte potentiating factor cDNA. J Biol Chem (1995) 1.88

Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J Exp Med (1998) 1.88

Anomalous atlantoaxial portions of vertebral and posterior inferior cerebellar arteries. Neuroradiology (1985) 1.86

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol (1998) 1.85

A dominant negative mutant of sar1 GTPase inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus in tobacco and Arabidopsis cultured cells. Plant J (2000) 1.84

Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F. Leukemia (2007) 1.81

Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J Natl Cancer Inst (1984) 1.80

Histopathological studies of superficial-type early colorectal carcinoma. Cancer (1996) 1.76

Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor drug. Clin Cancer Res (1999) 1.76

Acute cervical cord injury without fracture or dislocation of the spinal column. J Neurosurg (2000) 1.75

Mechanism of dynamic regurgitant orifice area variation in functional mitral regurgitation: physiologic insights from the proximal flow convergence technique. J Am Coll Cardiol (1999) 1.75

Non-contrast-enhanced MR angiography using 3D ECG-synchronized half-Fourier fast spin echo. J Magn Reson Imaging (2000) 1.75

Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. Nat Genet (1999) 1.75

Temperature dependence of early and late currents in human cardiac wild-type and long Q-T DeltaKPQ Na+ channels. Am J Physiol (1998) 1.74

Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer. Br J Cancer (2011) 1.74

Short- and long-term clinical outcomes in rhesus monkeys inoculated with a highly pathogenic chimeric simian/human immunodeficiency virus. J Virol (2000) 1.73

Levels of serum granulocyte colony-stimulating factor in patients with infections. Blood (1990) 1.71

Primary structure of the alpha-subunit of Torpedo californica (Na+ + K+)ATPase deduced from cDNA sequence. Nature (1985) 1.71

Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells. Infect Immun (1997) 1.71

Long-term prognosis of medically treated patients with internal carotid or middle cerebral artery occlusion: can acetazolamide test predict it? Stroke (2001) 1.71

Complete nucleotide sequence of the prophage VT2-Sakai carrying the verotoxin 2 genes of the enterohemorrhagic Escherichia coli O157:H7 derived from the Sakai outbreak. Genes Genet Syst (1999) 1.70

What women want - quantifying the perception of hair amount: an analysis of hair diameter and density changes with age in caucasian women. Br J Dermatol (2012) 1.69

Reactions of the oxyform of horseradish peroxidase. J Biochem (1972) 1.69

Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. Br J Pharmacol (2006) 1.68

Drug-sensitivity of El Tor vibrio strains isolated in the Philippines in 1964 and 1965. Bull World Health Organ (1967) 1.67

NAD(P)H-dependent chromium (VI) reductase of Pseudomonas ambigua G-1: a Cr(V) intermediate is formed during the reduction of Cr(VI) to Cr(III). J Bacteriol (1992) 1.66

Four cases of postrenal renal failure induced by renal stone associated with rotavirus infection. Clin Nephrol (2010) 1.65

Long-term efficacy of gamma knife radiosurgery in mesial temporal lobe epilepsy. Neurology (2008) 1.64

Lower expression of Th1-related cytokines and inducible nitric oxide synthase in mice with streptozotocin-induced diabetes mellitus infected with Mycobacterium tuberculosis. Clin Exp Immunol (2005) 1.64

Noninteracting local-structure model of folding and unfolding transition in globular proteins. I. Formulation. Biopolymers (1981) 1.64

Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule. Biochim Biophys Acta (1984) 1.62

Repeated thermal therapy improves impaired vascular endothelial function in patients with coronary risk factors. J Am Coll Cardiol (2001) 1.60

Polyvalent envelope glycoprotein vaccine elicits a broader neutralizing antibody response but is unable to provide sterilizing protection against heterologous Simian/human immunodeficiency virus infection in pigtailed macaques. J Virol (2001) 1.59

Hydroxyapatite particles as a controlled release carrier of protein. Biomaterials (2004) 1.57

Impairment of T cell development in deltaEF1 mutant mice. J Exp Med (1997) 1.56

Responses in muscle sympathetic activity to acute hypoxia in humans. J Appl Physiol (1985) (1988) 1.56

Brief report: short stature caused by a mutant growth hormone. N Engl J Med (1996) 1.56

Japanese summer-type hypersensitivity pneumonitis. Geographic distribution, home environment, and clinical characteristics of 621 cases. Am Rev Respir Dis (1991) 1.54

Invasive Aspergillus stomatitis in patients with acute leukemia: report of 12 cases. Clin Infect Dis (2001) 1.54

Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish. Development (1998) 1.52

Clinical evaluation of thallium-201 SPECT in supratentorial gliomas: relationship to histologic grade, prognosis and proliferative activities. J Nucl Med (1993) 1.52

Foveal translocation with scleral imbrication in patients with myopic neovascular maculopathy. Am J Ophthalmol (2001) 1.52

Tyrosine dephosphorylation of glycogen synthase kinase-3 is involved in its extracellular signal-dependent inactivation. FEBS Lett (1996) 1.51

Linkage of familial moyamoya disease (spontaneous occlusion of the circle of Willis) to chromosome 17q25. Stroke (2000) 1.51

Noninteracting local-structure model of folding and unfolding transition in globular proteins. II. Application to two-dimensional lattice proteins. Biopolymers (1981) 1.51

Complete nucleotide sequence of the prophage VT1-Sakai carrying the Shiga toxin 1 genes of the enterohemorrhagic Escherichia coli O157:H7 strain derived from the Sakai outbreak. Gene (2000) 1.50

Gastrointestinal stromal tumors of the small intestine that expressed c-kit protein. Intern Med (2000) 1.49

The isolation, properties and amino acid sequence of erabutoxin c, a minor neurotoxic component of the venom of a sea snake Katicauda semifasciata. Biochem J (1972) 1.49

Generation of functional beta-actinin (CapZ) in an E. coli expression system. J Muscle Res Cell Motil (1998) 1.49

Neurological manifestations in Japanese Ama divers. Undersea Hyperb Med (2005) 1.49

Profiles of cytokines produced by CD4-positive T lymphocytes stimulated by anti-CD3 antibody in patients with chronic hepatitis C. J Gastroenterol (1998) 1.49

DNA transposons in vertebrate functional genomics. Cell Mol Life Sci (2005) 1.48