| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies.
|
Nat Rev Microbiol
|
2009
|
8.13
|
|
2
|
Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis.
|
Science
|
2009
|
3.73
|
|
3
|
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.
|
Antimicrob Agents Chemother
|
2012
|
2.41
|
|
4
|
Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis.
|
PLoS Pathog
|
2011
|
1.83
|
|
5
|
A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis.
|
ACS Chem Biol
|
2012
|
1.59
|
|
6
|
Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis.
|
PLoS Pathog
|
2011
|
1.45
|
|
7
|
Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.
|
Science
|
2012
|
1.44
|
|
8
|
Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain.
|
J Med Chem
|
2006
|
1.41
|
|
9
|
Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.
|
J Med Chem
|
2008
|
1.40
|
|
10
|
5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins.
|
J Med Chem
|
2007
|
1.39
|
|
11
|
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.
|
PLoS Pathog
|
2011
|
1.29
|
|
12
|
Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents.
|
Org Lett
|
2006
|
1.27
|
|
13
|
Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis.
|
Nat Chem Biol
|
2011
|
1.23
|
|
14
|
Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis.
|
J Med Chem
|
2008
|
1.21
|
|
15
|
The relA homolog of Mycobacterium smegmatis affects cell appearance, viability, and gene expression.
|
J Bacteriol
|
2005
|
1.16
|
|
16
|
Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles.
|
J Med Chem
|
2009
|
1.15
|
|
17
|
Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals.
|
J Am Chem Soc
|
2009
|
1.12
|
|
18
|
Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis.
|
Chem Biol
|
2011
|
1.08
|
|
19
|
Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.
|
J Med Chem
|
2009
|
1.04
|
|
20
|
Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.
|
J Med Chem
|
2006
|
1.04
|
|
21
|
Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria.
|
J Am Chem Soc
|
2011
|
1.00
|
|
22
|
HIV-1 replication is differentially regulated by distinct clinical strains of Mycobacterium tuberculosis.
|
PLoS One
|
2009
|
0.94
|
|
23
|
Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis.
|
ACS Chem Biol
|
2012
|
0.94
|
|
24
|
Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
|
Structure
|
2012
|
0.94
|
|
25
|
A novel F(420) -dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents.
|
Mol Microbiol
|
2012
|
0.92
|
|
26
|
Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs.
|
Bioorg Med Chem Lett
|
2011
|
0.91
|
|
27
|
Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles.
|
FEBS J
|
2011
|
0.91
|
|
28
|
Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in Mycobaterium tuberculosis.
|
J Am Chem Soc
|
2011
|
0.90
|
|
29
|
Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers.
|
Bioorg Med Chem
|
2012
|
0.88
|
|
30
|
Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
|
J Nat Prod
|
2009
|
0.87
|
|
31
|
Structure-activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis.
|
Bioorg Med Chem
|
2013
|
0.86
|
|
32
|
The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo.
|
Tuberculosis (Edinb)
|
2011
|
0.83
|
|
33
|
Design of Potential Bisubstrate Inhibitors against Mycobacterium tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)-Evidence of a Novel Binding Mode.
|
Medchemcomm
|
2013
|
0.83
|
|
34
|
Structure-activity relationships of antitubercular nitroimidazoles. 3. Exploration of the linker and lipophilic tail of ((s)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824).
|
J Med Chem
|
2011
|
0.81
|
|
35
|
Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii.
|
J Med Chem
|
2013
|
0.80
|
|
36
|
Structure-activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling.
|
Bioorg Med Chem
|
2012
|
0.80
|
|
37
|
The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824.
|
Bioorg Med Chem Lett
|
2010
|
0.79
|
|
38
|
Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis.
|
J Antibiot (Tokyo)
|
2012
|
0.78
|
|
39
|
Quantification of small molecule organic acids from Mycobacterium tuberculosis culture supernatant using ion exclusion liquid chromatography/mass spectrometry.
|
Rapid Commun Mass Spectrom
|
2006
|
0.77
|
|
40
|
Novel 1,4-substituted-1,2,3-triazoles as antitubercular agents.
|
ChemMedChem
|
2015
|
0.76
|