Published in Biochem J on March 15, 2008
The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol (2013) 3.84
Glypicans. Genome Biol (2008) 2.76
Shaping morphogen gradients by proteoglycans. Cold Spring Harb Perspect Biol (2009) 1.96
Notum deacylates Wnt proteins to suppress signalling activity. Nature (2015) 1.93
Glypican-4 enhances insulin signaling via interaction with the insulin receptor and serves as a novel adipokine. Diabetes (2012) 1.76
The extracellular regulation of bone morphogenetic protein signaling. Development (2009) 1.69
The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function. Proc Natl Acad Sci U S A (2010) 1.29
Steep differences in wingless signaling trigger Myc-independent competitive cell interactions. Dev Cell (2011) 1.29
Heparan sulfate biosynthesis: regulation and variability. J Histochem Cytochem (2012) 1.25
GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Science (2013) 1.23
Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia. Am J Hum Genet (2009) 1.21
An introduction to proteoglycans and their localization. J Histochem Cytochem (2012) 1.08
Endocan in cancers: a lesson from a circulating dermatan sulfate proteoglycan. Int J Cell Biol (2013) 1.07
A zebrafish Notum homolog specifically blocks the Wnt/β-catenin signaling pathway. Development (2012) 1.03
Regulated tissue fluidity steers zebrafish body elongation. Development (2013) 0.96
Glypican-3 antibodies: a new therapeutic target for liver cancer. FEBS Lett (2013) 0.95
Biosynthesis and deficiencies of glycosylphosphatidylinositol. Proc Jpn Acad Ser B Phys Biol Sci (2014) 0.95
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochim Biophys Acta (2015) 0.92
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas. Cancer Rep (2011) 0.92
The glycosylphosphatidylinositol-PLC in Trypanosoma brucei forms a linear array on the exterior of the flagellar membrane before and after activation. PLoS Pathog (2009) 0.89
Down-regulation of chondroitin 4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a. J Biol Chem (2010) 0.87
Wnt/Notum spatial feedback inhibition controls neoblast differentiation to regulate reversible growth of the planarian brain. Development (2015) 0.84
Notum homolog plays a novel role in primary motor innervation. J Neurosci (2013) 0.82
Novel insights into Notum and glypicans regulation in colorectal cancer. Oncotarget (2015) 0.82
Glypican-3 is a prognostic factor and an immunotherapeutic target in hepatocellular carcinoma. World J Gastroenterol (2016) 0.82
Glypican Is a Modulator of Netrin-Mediated Axon Guidance. PLoS Biol (2015) 0.81
Differential responses to Wnt and PCP disruption predict expression and developmental function of conserved and novel genes in a cnidarian. PLoS Genet (2014) 0.80
GPI-AP release in cellular, developmental, and reproductive biology. J Lipid Res (2015) 0.80
Proteoglycans in liver cancer. World J Gastroenterol (2016) 0.78
GPC-3 in hepatocellular carcinoma: current perspectives. J Hepatocell Carcinoma (2016) 0.77
Characterization of a new monoclonal anti-glypican-3 antibody specific to the hepatocellular carcinoma cell line, HepG2. World J Hepatol (2017) 0.75
Can glypican-3 be a disease-specific biomarker? Clin Transl Med (2017) 0.75
Critical analysis of the potential of targeting GPC3 in hepatocellular carcinoma. J Hepatocell Carcinoma (2014) 0.75
Glypican-3 level assessed by the enzyme-linked immunosorbent assay is inferior to alpha-fetoprotein level for hepatocellular carcinoma diagnosis. Clin Mol Hepatol (2016) 0.75
The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling. PLoS One (2016) 0.75
An Unbiased Mass Spectrometry Approach Identifies Glypican-3 as an Interactor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR) in Hepatocellular Carcinoma Cells. J Biol Chem (2016) 0.75
Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology (2003) 2.90
Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling. Cancer Res (2005) 2.68
Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. Cancer Res (2007) 2.31
Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev Cell (2008) 1.94
DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo. Cancer Res (2011) 1.78
Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells. Microvasc Res (2007) 1.75
Trend, abrupt change, and periodicity of streamflow in the mainstream of Yellow River. Environ Monit Assess (2013) 1.54
The loss of glypican-3 induces alterations in Wnt signaling. J Biol Chem (2004) 1.47
Design strategies for water-soluble small molecular chromogenic and fluorogenic probes. Chem Rev (2013) 1.37
Soluble glypican 3 inhibits the growth of hepatocellular carcinoma in vitro and in vivo. Int J Cancer (2010) 1.36
The role of glypicans in mammalian development. Biochim Biophys Acta (2002) 1.33
Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth. J Biol Chem (2005) 1.32
Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling. J Cell Biol (2011) 1.14
Cell detachment triggers p38 mitogen-activated protein kinase-dependent overexpression of Fas ligand. A novel mechanism of Anoikis of intestinal epithelial cells. J Biol Chem (2002) 1.08
A transient increase in the activity of Src-family kinases induced by cell detachment delays anoikis of intestinal epithelial cells. Oncogene (2005) 1.07
ras Oncogene triggers up-regulation of cIAP2 and XIAP in intestinal epithelial cells: epidermal growth factor receptor-dependent and -independent mechanisms of ras-induced transformation. J Biol Chem (2005) 1.07
Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling. J Cell Sci (2014) 1.03
Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk. Mol Cell Biol (2005) 1.02
Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation. J Natl Cancer Inst (2007) 0.97
Glypican-3 regulates migration, adhesion and actin cytoskeleton organization in mammary tumor cells through Wnt signaling modulation. Breast Cancer Res Treat (2008) 0.97
Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo. Mech Dev (2005) 0.96
The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. Am J Respir Cell Mol Biol (2003) 0.96
Nitroreductase detection and hypoxic tumor cell imaging by a designed sensitive and selective fluorescent probe, 7-[(5-nitrofuran-2-yl)methoxy]-3H-phenoxazin-3-one. Anal Chem (2013) 0.95
Increased Bcl-xL expression mediates v-Src-induced resistance to anoikis in intestinal epithelial cells. Oncogene (2002) 0.95
Glypican-3 as a serum marker for hepatocellular carcinoma. Cancer Res (2005) 0.94
Expression pattern of glypican-3 (GPC3) during human embryonic and fetal development. Histol Histopathol (2008) 0.94
A new resorufin-based spectroscopic probe for simple and sensitive detection of benzoyl peroxide via deboronation. Chem Commun (Camb) (2012) 0.93
Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog. EMBO Rep (2009) 0.90
Rational design and bioimaging applications of highly selective fluorescence probes for hydrogen polysulfides. J Am Chem Soc (2014) 0.90
Therapeutic potential of targeting glypican-3 in hepatocellular carcinoma. Anticancer Agents Med Chem (2011) 0.89
A graphene oxide-peptide fluorescence sensor tailor-made for simple and sensitive detection of matrix metalloproteinase 2. Chem Commun (Camb) (2011) 0.88
Lysosomal pH rise during heat shock monitored by a lysosome-targeting near-infrared ratiometric fluorescent probe. Angew Chem Int Ed Engl (2014) 0.87
LRP1 mediates Hedgehog-induced endocytosis of the GPC3-Hedgehog complex. J Cell Sci (2012) 0.86
Maternal high-fat diet programs Wnt genes through histone modification in the liver of neonatal rats. J Mol Endocrinol (2012) 0.85
Pathogenic and molecular characterization of the H5N1 avian influenza virus isolated from the first human case in Zhejiang province, China. Diagn Microbiol Infect Dis (2007) 0.85
177Lu-labeled HPMA copolymers utilizing cathepsin B and S cleavable linkers: synthesis, characterization and preliminary in vivo investigation in a pancreatic cancer model. Nucl Med Biol (2013) 0.85
Regulation of bone morphogenetic protein signalling and cranial osteogenesis by Gpc1 and Gpc3. Bone (2013) 0.84
Synthesis and in vitro and in vivo evaluation of hypoxia-enhanced 111In-bombesin conjugates for prostate cancer imaging. J Nucl Med (2013) 0.84
Hydrogen peroxide vapor sensing with organic core/sheath nanowire optical waveguides. Adv Mater (2012) 0.84
Immunohistochemical study of glypican 3 in thyroid cancer. Oncology (2008) 0.84
Bacterial diversity in mine tailings compared by cultivation and cultivation-independent methods and their resistance to lead and cadmium. Microb Ecol (2007) 0.82
Characterization of 2-phenylbenzo[g]quinoxaline derivatives as viscosity-sensitive fluorescent probes. Talanta (2008) 0.81
Parallel comparative studies on the toxic effects of unmodified CdTe quantum dots, gold nanoparticles, and carbon nanodots on live cells as well as green gram sprouts. Talanta (2013) 0.81
Selective modification of Trp19 in beta-lactoglobulin by a new diazo fluorescence probe. J Proteome Res (2007) 0.80
Neuroprotection by manganese superoxide dismutase (MnSOD) mimics: antioxidant effect and oxidative stress regulation in acute experimental stroke. CNS Neurosci Ther (2012) 0.80
Effects of age on dynamic accommodation. Ergonomics (2010) 0.80
Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart. J Nutr Biochem (2013) 0.80
A spectroscopic off-on probe for simple and sensitive detection of carboxylesterase activity and its application to cell imaging. Analyst (2011) 0.79
An unprecedented strategy for selective and sensitive fluorescence detection of nitric oxide based on its reaction with a selenide. Chem Commun (Camb) (2011) 0.79
Oligonucleotide microarray analysis of lung adenocarcinoma in smokers and nonsmokers identifies GPC3 as a potential lung tumor suppressor. Chest (2002) 0.79
Distinguishing folate-receptor-positive cells from folate-receptor-negative cells using a fluorescence off-on nanoprobe. Anal Chem (2013) 0.79
A graphene oxide-peptide fluorescence sensor for proteolytically active prostate-specific antigen. Mol Biosyst (2012) 0.78
Development of hypoxia enhanced 111In-labeled Bombesin conjugates: design, synthesis, and in vitro evaluation in PC-3 human prostate cancer. Bioconjug Chem (2012) 0.78
7-((5-Nitrothiophen-2-yl)methoxy)-3H-phenoxazin-3-one as a spectroscopic off-on probe for highly sensitive and selective detection of nitroreductase. Chem Commun (Camb) (2013) 0.78
A simple and sensitive method for visual detection of phosgene based on the aggregation of gold nanoparticles. Chem Commun (Camb) (2010) 0.78
A highly selective and sensitive fluorescence probe for the hypochlorite anion. Chemistry (2008) 0.78
Efficient and highly selective boron-doped carbon materials-catalyzed reduction of nitroarenes. Chem Commun (Camb) (2015) 0.78
Bacterial diversity at different depths in lead-zinc mine tailings as revealed by 16S rRNA gene libraries. J Microbiol (2007) 0.78
A patient with the Simpson-Golabi-Behmel syndrome displays a loss-of-function point mutation in GPC3 that inhibits the attachment of this proteoglycan to the cell surface. Am J Med Genet A (2009) 0.77
Determination of non-protein cysteine in human serum by a designed BODIPY-based fluorescent probe. Talanta (2010) 0.77
Comparison of N-acetylcysteine and cysteine in their ability to replenish intracellular cysteine by a specific fluorescent probe. Chem Commun (Camb) (2016) 0.77
Modeling thermoelectric transport in organic materials. Phys Chem Chem Phys (2012) 0.77
Spectroscopic response of ferrocene derivatives bearing a BODIPY moiety to water: a new dissociation reaction. Chemistry (2011) 0.77
Simple and fast fluorescence detection of benzoyl peroxide in wheat flour by N-methoxy rhodamine-6G spirolactam based on consecutive chemical reactions. Anal Chim Acta (2011) 0.77
Rhodamine B piperazinoacetohydrazine: a water-soluble spectroscopic reagent for pyruvic acid labeling. Chemistry (2010) 0.77
Poly(m-phenylenediamine)-based fluorescent nanoprobe for ultrasensitive detection of matrix metalloproteinase 2. Anal Chem (2014) 0.77
[A study of rate of compliance with sepsis bundle in patients with severe sepsis and septic shock in emergency department]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue (2011) 0.76
Expression of tissue inhibitor of metalloproteinase-4 in normal human corneal cells and experimental corneal neovascularization. Ophthalmic Res (2003) 0.76
Anti-H can trigger apoptosis and down-regulate FUT1 expression in erythroid differentiated K562 cells without complement mediation. Transpl Immunol (2012) 0.76
Sensitive and selective near-infrared fluorescent off-on probe and its application to imaging different levels of β-lactamase in Staphylococcus aureus. Anal Chem (2014) 0.75
Sensitive detection of ozone by a practical resorufin-based spectroscopic probe with extremely low background signal. Sci Rep (2013) 0.75
[Effect of Acupuncture Combined Physical Training and Relearning on Stroke Rehabilitation: a Multi-center Randomized Controlled Clinical Study]. Zhongguo Zhong Xi Yi Jie He Za Zhi (2015) 0.75
Gold nanoparticles functionalized with cresyl violet and porphyrin via hyaluronic acid for targeted cell imaging and phototherapy. Chem Commun (Camb) (2014) 0.75
[Study on the genetic characteristics of the avian influenza virus strain A/Zhejiang/16/2006]. Zhonghua Liu Xing Bing Xue Za Zhi (2008) 0.75
Tuning the surface structure of supported PtNix bimetallic electrocatalysts for the methanol electro-oxidation reaction. Chem Commun (Camb) (2016) 0.75
Cross-correlation detection and analysis for California's electricity market based on analogous multifractal analysis. Chaos (2013) 0.75
[Molecular epidemiological study on rubella virus strains isolated in Zhejiang province, China, 2005-2010]. Zhonghua Liu Xing Bing Xue Za Zhi (2011) 0.75
[Establishment and evaluation of a novel mouse model of orthotopic colon cancer in the mesenteric triangle of the cecum]. Zhonghua Zhong Liu Za Zhi (2015) 0.75
[Analysis on the genetic characteristics of the wide-type measles virus circulating in Zhejiang province in 2005]. Zhonghua Liu Xing Bing Xue Za Zhi (2006) 0.75
Detection of local polarity and conformational changes at the active site of rabbit muscle creatine kinase with a new arginine-specific fluorescent probe. Biochim Biophys Acta (2007) 0.75
A near-infrared fluorescent probe for monitoring tyrosinase activity. Chem Commun (Camb) (2010) 0.75
[Histological observation and vascularization evaluation of porcine acellular dermal matrix processed with matrix metalloproteinase 7 after implanted into rats]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2014) 0.75
[Comparison and bias estimation of three methods in determination of glycated hemoglobin A1c]. Zhonghua Yi Xue Za Zhi (2016) 0.75
Erratum: Intrinsic and Extrinsic Charge Transport in CH3NH3PbI3 Perovskites Predicted from First-Principles. Sci Rep (2017) 0.75
[An immunofluorescence assay for the detection of SARS associated coronavirus antibody based on recombinant nucleocapsid antigen and its application]. Zhonghua Yi Xue Za Zhi (2005) 0.75
Toxicological effects involved in risk assessment of rare earth lanthanum on roots of Vicia faba L. seedlings. J Environ Sci (China) (2011) 0.75
Photobiodegradation of phenol with ultraviolet irradiation of new ceramic biofilm carriers. Biodegradation (2010) 0.75
[Multiplex RT-PCR for the rapid detection of influenza virus types and subtypes]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2005) 0.75
[The occurrence of actual F factor transfer during the stationary-phase mutation in Escherichia coli FC40]. Yi Chuan (2003) 0.75