PubRank

William H Tepp

Author PubWeight™ 53.74‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 SV2 is the protein receptor for botulinum neurotoxin A. Science 2006 4.51
2 Structural basis of cell surface receptor recognition by botulinum neurotoxin B. Nature 2006 1.97
3 An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proc Natl Acad Sci U S A 2007 1.85
4 Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells. J Cell Biol 2003 1.81
5 Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons. Mol Biol Cell 2008 1.66
6 A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4. J Mol Biol 2006 1.59
7 Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells. Proc Natl Acad Sci U S A 2004 1.40
8 A neuronal cell-based botulinum neurotoxin assay for highly sensitive and specific detection of neutralizing serum antibodies. FEBS Lett 2007 1.40
9 Subunit vaccine against the seven serotypes of botulism. Infect Immun 2007 1.39
10 Bimodal modulation of the botulinum neurotoxin protein-conducting channel. Proc Natl Acad Sci U S A 2009 1.26
11 Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. PLoS Pathog 2011 1.24
12 Comparison of the primary rat spinal cord cell (RSC) assay and the mouse bioassay for botulinum neurotoxin type A potency determination. J Pharmacol Toxicol Methods 2010 1.21
13 Novel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detection. Toxicol Sci 2012 1.21
14 Characterization of Clostridium botulinum strains associated with an infant botulism case in the United Kingdom. J Clin Microbiol 2005 1.18
15 Effects of purification on the bioavailability of botulinum neurotoxin type A. Toxicology 2008 1.16
16 SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS Pathog 2010 1.15
17 Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons. J Cell Biol 2007 1.15
18 Characterization of the antibody response to the receptor binding domain of botulinum neurotoxin serotypes A and E. Infect Immun 2005 1.10
19 Characterization of botulinum neurotoxin A subtypes 1 through 5 by investigation of activities in mice, in neuronal cell cultures, and in vitro. Infect Immun 2013 1.10
20 Expression of the Clostridium botulinum A2 neurotoxin gene cluster proteins and characterization of the A2 complex. Appl Environ Microbiol 2009 1.09
21 Recombinant holotoxoid vaccine against botulism. Infect Immun 2007 1.09
22 Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1. FEBS Lett 2010 1.07
23 Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly. Cell Host Microbe 2011 1.06
24 Microfluidic tectonics platform: A colorimetric, disposable botulinum toxin enzyme-linked immunosorbent assay system. Electrophoresis 2004 1.04
25 Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival. Nat Commun 2013 0.99
26 Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins. J Cell Sci 2012 0.96
27 Development of a delivery vehicle for intracellular transport of botulinum neurotoxin antagonists. FEBS Lett 2002 0.93
28 Construction of a nontoxigenic Clostridium botulinum strain for food challenge studies. Appl Environ Microbiol 2009 0.91
29 Sensitive and quantitative detection of botulinum neurotoxin in neurons derived from mouse embryonic stem cells. Biochem Biophys Res Commun 2010 0.90
30 Rapid immune responses to a botulinum neurotoxin Hc subunit vaccine through in vivo targeting to antigen-presenting cells. Infect Immun 2011 0.87
31 Neuronal targeting, internalization, and biological activity of a recombinant atoxic derivative of botulinum neurotoxin A. Biochem Biophys Res Commun 2011 0.87
32 Targeting botulinum A cellular toxicity: a prodrug approach. J Med Chem 2013 0.86
33 Association of toxin-producing Clostridium botulinum with the macroalga Cladophora in the Great Lakes. Environ Sci Technol 2013 0.86
34 Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH. Biochemistry 2012 0.85
35 Entry of a recombinant, full-length, atoxic tetanus neurotoxin into Neuro-2a cells. Infect Immun 2013 0.83
36 Function-oriented synthesis applied to the anti-botulinum natural product toosendanin. Bioorg Med Chem 2008 0.83
37 Bead-based microfluidic toxin sensor integrating evaporative signal amplification. Lab Chip 2008 0.82
38 Self-assembled peptide monolayers as a toxin sensing mechanism within arrayed microchannels. Anal Chem 2009 0.82
39 Subunit vaccine efficacy against Botulinum neurotoxin subtypes. Vaccine 2011 0.81
40 Enhancing the protective immune response against botulism. Infect Immun 2013 0.81
41 A microscale neuron and Schwann cell coculture model for increasing detection sensitivity of botulinum neurotoxin type A. Toxicol Sci 2013 0.81
42 Delineating the susceptibility of botulinum neurotoxins to denaturation through thermal effects. FEBS Lett 2008 0.80
43 Comparison of the catalytic properties of the botulinum neurotoxin subtypes A1 and A5. Biochim Biophys Acta 2013 0.80
44 Model for studying Clostridium botulinum neurotoxin using differentiated motor neuron-like NG108-15 cells. Biochem Biophys Res Commun 2012 0.77
45 Retargeted clostridial neurotoxins as novel agents for treating chronic diseases. Biochemistry 2011 0.77
46 Clostridium taeniosporum is a close relative of the Clostridium botulinum Group II. Anaerobe 2008 0.76
47 Multiple domains of tetanus toxin direct entry into primary neurons. Traffic 2014 0.75
48 Toosendanin: synthesis of the AB-ring and investigations of its anti-botulinum properties (Part II). Bioorg Med Chem 2009 0.75