Prolonged-release nicotinic acid for the management of dyslipidemia: an update including results from the NAUTILUS study.

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Published in Vasc Health Risk Manag on January 01, 2007


Anja Vogt1, Ursula Kassner, Ulrike Hostalek, Elisabeth Steinhagen-Thiessen

Author Affiliations

1: Charité-Universitätsmedizin Berlin, Campus Virchow- Klinikum, Interdisziplinäres Stoffwechsel-Centrum, Lipidambulanz,Augustenburger Platz I, 13353 Berlin, Germany.

Associated clinical trials:

Niacin Plus Statin to Prevent Vascular Events | NCT00120289

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High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med (1977) 15.39

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High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation (1989) 9.97

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Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23) BMJ (1998) 7.48

Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. JAMA (1986) 7.23

Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med (1990) 6.43

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European guidelines on cardiovascular disease prevention in clinical practice: third joint task force of European and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of eight societies and by invited experts). Eur J Cardiovasc Prev Rehabil (2003) 3.43

Clofibrate and niacin in coronary heart disease. JAMA (1975) 3.39

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High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis (1996) 2.70

High density lipoprotein cholesterol and mortality. The Framingham Heart Study. Arteriosclerosis (1989) 2.65

Concentrations of high density lipoprotein cholesterol, triglycerides, and total cholesterol in ischaemic heart disease. BMJ (1989) 2.47

Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year follow-up. JAMA (1990) 2.36

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Clinical review 124: Diabetic dyslipidemia: causes and consequences. J Clin Endocrinol Metab (2001) 1.92

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