Published in Dialogues Clin Neurosci on January 01, 2007
A circadian clock in macrophages controls inflammatory immune responses. Proc Natl Acad Sci U S A (2009) 2.71
TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea. Curr Biol (2014) 1.48
Distinct functions of Period2 and Period3 in the mouse circadian system revealed by in vitro analysis. PLoS One (2010) 1.29
Loss of circadian clock accelerates aging in neurodegeneration-prone mutants. Neurobiol Dis (2011) 1.13
Circadian-independent cell mitosis in immortalized fibroblasts. Proc Natl Acad Sci U S A (2010) 1.09
Small molecule modifiers of circadian clocks. Cell Mol Life Sci (2012) 1.03
Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy. Proc Natl Acad Sci U S A (2013) 1.00
Antidepressant chronotherapeutics for bipolar depression. Dialogues Clin Neurosci (2012) 0.95
Melanopsin, photosensitive ganglion cells, and seasonal affective disorder. Neurosci Biobehav Rev (2012) 0.91
ROS stress resets circadian clocks to coordinate pro-survival signals. PLoS One (2013) 0.91
Circadian disruption, Per3, and human cytokine secretion. Integr Cancer Ther (2009) 0.90
Microglia inflammatory responses are controlled by an intrinsic circadian clock. Brain Behav Immun (2014) 0.89
Basis of robustness and resilience in the suprachiasmatic nucleus: individual neurons form nodes in circuits that cycle daily. J Biol Rhythms (2009) 0.89
How to fix a broken clock. Trends Pharmacol Sci (2013) 0.88
Mutual antagonism between circadian protein period 2 and hepatitis C virus replication in hepatocytes. PLoS One (2013) 0.88
Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer. PLoS One (2013) 0.85
Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway. Toxicol Sci (2010) 0.85
Deterministic chaos and fractal complexity in the dynamics of cardiovascular behavior: perspectives on a new frontier. Open Cardiovasc Med J (2009) 0.81
Timing Matters: Circadian Rhythm in Sepsis, Obstructive Lung Disease, Obstructive Sleep Apnea, and Cancer. Ann Am Thorac Soc (2016) 0.81
Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation. Oncol Rep (2014) 0.80
Impaired leukocyte trafficking and skin inflammatory responses in hamsters lacking a functional circadian system. Brain Behav Immun (2013) 0.79
Hepatitis B virus X protein disrupts the balance of the expression of circadian rhythm genes in hepatocellular carcinoma. Oncol Lett (2014) 0.79
Circadian Mechanisms Underlying Reward-Related Neurophysiology and Synaptic Plasticity. Front Psychiatry (2016) 0.78
Biological clocks and the practice of psychiatry. Dialogues Clin Neurosci (2007) 0.77
Lungs can tell time-a highlight from 2016 ATS session on clock genes, inflammation, immunology, and sleep. J Thorac Dis (2016) 0.75
The manifold definitions of time. Dialogues Clin Neurosci (2012) 0.75
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
Molecular bases for circadian clocks. Cell (1999) 13.96
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A (2004) 12.43
A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell (1998) 10.92
Role of the CLOCK protein in the mammalian circadian mechanism. Science (1998) 10.03
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell (2002) 9.92
Extensive and divergent circadian gene expression in liver and heart. Nature (2002) 9.64
Clock mutants of Drosophila melanogaster. Proc Natl Acad Sci U S A (1971) 8.63
Resetting central and peripheral circadian oscillators in transgenic rats. Science (2000) 8.63
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev (2000) 8.19
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature (1999) 7.86
Positional cloning of the mouse circadian clock gene. Cell (1997) 7.79
Molecular components of the mammalian circadian clock. Hum Mol Genet (2006) 7.51
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci U S A (1999) 7.48
Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro. Science (2005) 7.28
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell (1994) 7.10
Entrainment of the circadian clock in the liver by feeding. Science (2001) 7.09
Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. Science (2005) 6.95
Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage. Science (2005) 6.92
Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol (2001) 6.76
Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science (2000) 6.55
A transcription factor response element for gene expression during circadian night. Nature (2002) 6.55
System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol (2007) 6.23
An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science (2001) 6.07
The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell (2002) 6.05
A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron (2004) 5.71
Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms. Neuron (1995) 5.70
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature (1990) 5.69
Transplanted suprachiasmatic nucleus determines circadian period. Science (1990) 5.55
Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron (2001) 5.36
Circadian regulator CLOCK is a histone acetyltransferase. Cell (2006) 5.24
Post-translational modifications regulate the ticking of the circadian clock. Nat Rev Mol Cell Biol (2007) 5.24
Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat Genet (2006) 5.08
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science (2001) 5.03
Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Curr Biol (2002) 4.99
Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science (2000) 4.94
Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell (2007) 4.87
Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci U S A (1999) 4.62
Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell (2001) 4.61
Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Neuron (1998) 4.51
No transcription-translation feedback in circadian rhythm of KaiC phosphorylation. Science (2004) 4.47
Life between clocks: daily temporal patterns of human chronotypes. J Biol Rhythms (2003) 4.04
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell (2007) 3.99
The molecular clock mediates leptin-regulated bone formation. Cell (2005) 3.88
NPAS2: an analog of clock operative in the mammalian forebrain. Science (2001) 3.88
Resonating circadian clocks enhance fitness in cyanobacteria. Proc Natl Acad Sci U S A (1998) 3.84
Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes Dev (2006) 3.78
Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature (2002) 3.75
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science (2007) 3.59
NPAS2: a gas-responsive transcription factor. Science (2002) 3.54
Interplay of circadian clocks and metabolic rhythms. Annu Rev Genet (2006) 3.49
Molecular mechanisms of the biological clock in cultured fibroblasts. Science (2001) 3.46
The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Cell (2002) 3.29
A phase response curve to single bright light pulses in human subjects. J Physiol (2003) 3.29
A genomewide oscillation in transcription gates DNA replication and cell cycle. Proc Natl Acad Sci U S A (2004) 3.23
Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signaling. Curr Biol (2006) 3.20
Cellular construction of a circadian clock: period determination in the suprachiasmatic nuclei. Cell (1997) 3.19
Social jetlag: misalignment of biological and social time. Chronobiol Int (2006) 3.13
Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity. Science (2007) 3.12
Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts. Curr Biol (2000) 3.12
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science (2007) 3.05
The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification. Cell Metab (2006) 3.00
CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci (2007) 2.84
Circadian programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of mammalian cells. Curr Biol (2002) 2.79
The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1. Nat Struct Mol Biol (2005) 2.75
Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell (2007) 2.63
Circadian genes, rhythms and the biology of mood disorders. Pharmacol Ther (2007) 2.62
Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock. Science (2006) 2.62
Molecular bases of circadian rhythms. Annu Rev Cell Dev Biol (2001) 2.58
Cyanobacterial circadian pacemaker: Kai protein complex dynamics in the KaiC phosphorylation cycle in vitro. Mol Cell (2006) 2.56
Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus. Genes Cells (2001) 2.55
Reciprocal regulation of haem biosynthesis and the circadian clock in mammals. Nature (2004) 2.53
MPer1 and mper2 are essential for normal resetting of the circadian clock. J Biol Rhythms (2001) 2.45
Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers. Carcinogenesis (2005) 2.31
Circadian clock control by SUMOylation of BMAL1. Science (2005) 2.30
Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal-1 locus. Genesis (2005) 2.30
PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science (2005) 2.29
Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators. EMBO J (2001) 2.24
Properties, entrainment, and physiological functions of mammalian peripheral oscillators. J Biol Rhythms (2006) 2.21
Effects of chronic jet lag on tumor progression in mice. Cancer Res (2004) 2.21
The adaptive value of circadian clocks: an experimental assessment in cyanobacteria. Curr Biol (2004) 2.21
Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm. Cell (1990) 2.19
The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior. EMBO J (1997) 2.17
Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene. EMBO J (2001) 2.11
Identification of the circadian transcriptome in adult mouse skeletal muscle. Physiol Genomics (2007) 2.06
Chronic jet-lag increases mortality in aged mice. Curr Biol (2006) 2.01
The loss of circadian PAR bZip transcription factors results in epilepsy. Genes Dev (2004) 1.92
Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc Natl Acad Sci U S A (2005) 1.91
The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences. EMBO J (1996) 1.90
The Neurospora crassa circadian clock. Adv Genet (2007) 1.86
Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Genes Dev (2007) 1.73
Tumor suppression by the mammalian Period genes. Cancer Causes Control (2006) 1.69
The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem (2006) 1.67
A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock. Genes Dev (2007) 1.66
Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila. Curr Biol (2007) 1.66
The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Prog Nucleic Acid Res Mol Biol (2001) 1.61
Circadian oscillators of Drosophila and mammals. J Cell Sci (2006) 1.59
How plants tell the time. Biochem J (2006) 1.55
B6-responsive disorders: a model of vitamin dependency. J Inherit Metab Dis (2006) 1.55
Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J (1998) 1.52