Published in Spine (Phila Pa 1976) on November 01, 2007
Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol (2013) 2.02
Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB. Am J Pathol (2013) 1.36
Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration. Spine J (2013) 1.13
Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. Arthritis Res Ther (2012) 1.02
Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc. Arthritis Res Ther (2009) 1.02
Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling. J Biol Chem (2011) 1.01
Action of fibroblast growth factor-2 on the intervertebral disc. Arthritis Res Ther (2008) 1.01
Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model. Arthritis Res Ther (2009) 0.98
Emerging technologies for molecular therapy for intervertebral disk degeneration. Orthop Clin North Am (2011) 0.92
Spine degeneration in a murine model of chronic human tobacco smokers. Osteoarthritis Cartilage (2012) 0.88
Nerve Growth Factor Is Regulated by Toll-Like Receptor 2 in Human Intervertebral Discs. J Biol Chem (2015) 0.87
Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways. Arthritis Res Ther (2013) 0.86
Region-dependent aggrecan degradation patterns in the rat intervertebral disc are affected by mechanical loading in vivo. Spine (Phila Pa 1976) (2011) 0.85
Transcript levels of major MMPs and ADAMTS-4 in relation to the clinicopathological profile of patients with lumbar disc herniation. Eur Spine J (2010) 0.83
Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration. Arthritis Res Ther (2014) 0.83
Effects of TGF-β1 and IL-1β on expression of ADAMTS enzymes and TIMP-3 in human intervertebral disc degeneration. Exp Ther Med (2013) 0.82
IL-1β promotes ADAMTS enzyme-mediated aggrecan degradation through NF-κB in human intervertebral disc. J Orthop Surg Res (2015) 0.82
Interference in the endplate nutritional pathway causes intervertebral disc degeneration in an immature porcine model. Int Orthop (2014) 0.80
The proteoglycan metabolism of articular cartilage in joint-scale culture. Tissue Eng Part A (2010) 0.80
Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc. PeerJ (2016) 0.79
The inhibitory effect of salmon calcitonin on intervertebral disc degeneration in an ovariectomized rat model. Eur Spine J (2014) 0.79
Piperine mediates LPS induced inflammatory and catabolic effects in rat intervertebral disc. Int J Clin Exp Pathol (2015) 0.79
Reconstruction of an in vitro niche for the transition from intervertebral disc development to nucleus pulposus regeneration. Stem Cells Dev (2013) 0.78
Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3. Am J Pathol (2014) 0.78
Class 3 semaphorins expression and association with innervation and angiogenesis within the degenerate human intervertebral disc. Oncotarget (2015) 0.77
Adamts5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration. Spine (Phila Pa 1976) (2017) 0.75
Biomechanical study on the effect of cervical spine fusion on adjacent-level intradiscal pressure and segmental motion. Spine (Phila Pa 1976) (2002) 3.38
A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration. Spine (Phila Pa 1976) (2005) 2.87
Are animal models useful for studying human disc disorders/degeneration? Eur Spine J (2007) 2.82
Real-time identification of liver cancers by using indocyanine green fluorescent imaging. Cancer (2009) 2.54
Portal uptake function in veno-occlusive regions evaluated by real-time fluorescent imaging using indocyanine green. J Hepatol (2012) 2.27
Association between crystals and cartilage degeneration in the ankle. J Rheumatol (2008) 2.15
Thoracic paraplegia due to missed thoracic compressive lesions after lumbar spinal decompression surgery. Report of three cases. J Neurosurg (2004) 2.07
The origin of chondrocytes in the nucleus pulposus and histologic findings associated with the transition of a notochordal nucleus pulposus to a fibrocartilaginous nucleus pulposus in intact rabbit intervertebral discs. Spine (Phila Pa 1976) (2003) 1.91
Tensile mechanical properties of bovine articular cartilage: variations with growth and relationships to collagen network components. J Orthop Res (2003) 1.87
Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol (2004) 1.77
Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation. J Biol Chem (2003) 1.76
Mechanistic background and clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma. Ann Surg Oncol (2013) 1.76
Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model. Spine (Phila Pa 1976) (2006) 1.74
Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-1. Spine (Phila Pa 1976) (2002) 1.72
Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation. J Biol Chem (2002) 1.69
Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits. Spine (Phila Pa 1976) (2005) 1.68
Effects of growth differentiation factor-5 on the intervertebral disc--in vitro bovine study and in vivo rabbit disc degeneration model study. Spine (Phila Pa 1976) (2006) 1.62
Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process? Nat Rev Mol Cell Biol (2011) 1.58
Growth factors and treatment of intervertebral disc degeneration. Spine (Phila Pa 1976) (2004) 1.57
ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochem Biophys Res Commun (2002) 1.55
The effect of leg length discrepancy on spinal motion during gait: three-dimensional analysis in healthy volunteers. Spine (Phila Pa 1976) (2003) 1.53
Quantitative ultrashort echo time (UTE) MRI of human cortical bone: correlation with porosity and biomechanical properties. J Bone Miner Res (2012) 1.53
Mechanisms of cartilage growth: modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC. Arthritis Rheum (2007) 1.52
Is autograft the gold standard in achieving radiographic fusion in one-level anterior cervical discectomy and fusion with rigid anterior plate fixation? Spine (Phila Pa 1976) (2005) 1.49
Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis. Gene (2008) 1.45
Three-dimensional in vivo measurement of lumbar spine segmental motion. Spine (Phila Pa 1976) (2006) 1.44
Augmentation of pedicle screw fixation strength using an injectable calcium phosphate cement as a function of injection timing and method. Spine (Phila Pa 1976) (2004) 1.43
Corpectomy versus discectomy for the treatment of multilevel cervical spine pathology: a finite element model analysis. Spine J (2012) 1.43
Biomechanical comparison of cervical spine reconstructive techniques after a multilevel corpectomy of the cervical spine. Spine (Phila Pa 1976) (2003) 1.42
Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration. Spine (Phila Pa 1976) (2002) 1.42
Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. Spine (Phila Pa 1976) (2007) 1.39
Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. Arthritis Rheum (2007) 1.38
Two-stage (posterior and anterior) surgical treatment using posterior spinal instrumentation for pyogenic and tuberculotic spondylitis. Spine (Phila Pa 1976) (2003) 1.36
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun (2012) 1.36
Anatomical variations of the vertebral artery segment in the lower cervical spine: analysis by three-dimensional computed tomography angiography. Spine (Phila Pa 1976) (2008) 1.35
Intraoperative fluorescent cholangiography using indocyanine green: a biliary road map for safe surgery. J Am Coll Surg (2008) 1.34
Growth of immature articular cartilage in vitro: correlated variation in tensile biomechanical and collagen network properties. Tissue Eng (2003) 1.31
Prevention of disc degeneration with growth factors. Eur Spine J (2006) 1.29
Ultrashort echo time (UTE) imaging with bi-component analysis: bound and free water evaluation of bovine cortical bone subject to sequential drying. Bone (2011) 1.22
Biological repair of intervertebral disc. Spine (Phila Pa 1976) (2003) 1.21
Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. Gene Expr Patterns (2009) 1.21
Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod (2005) 1.20
Animal models for human disc degeneration. Spine J (2005) 1.20
Age-related changes in the extracellular matrix of nucleus pulposus and anulus fibrosus of human intervertebral disc. Spine (Phila Pa 1976) (2009) 1.19
Comparison of clinical and radiographic outcome in instrumented anterior cervical discectomy and fusion with or without direct uncovertebral joint decompression. Spine J (2004) 1.19
Does rigid instrumentation increase the fusion rate in one-level anterior cervical discectomy and fusion? Spine J (2004) 1.19
Does multilevel lumbar stenosis lead to poorer outcomes?: a subanalysis of the Spine Patient Outcomes Research Trial (SPORT) lumbar stenosis study. Spine (Phila Pa 1976) (2010) 1.16
Articular cartilage mechanical and biochemical property relations before and after in vitro growth. J Biomech (2007) 1.16
Epigenetic factors influencing resistance to nuclear reprogramming. Trends Genet (2011) 1.14
The relationship of intrapsoas nerves during a transpsoas approach to the lumbar spine: anatomic study. J Spinal Disord Tech (2010) 1.14
In vivo measurements of lumbar segmental motion during axial rotation in asymptomatic and chronic low back pain male subjects. Spine (Phila Pa 1976) (2007) 1.13
Biomechanical evaluation of an injectable calcium phosphate cement for vertebroplasty. Spine (Phila Pa 1976) (2002) 1.12
Surgical outcome of 2-stage (posterior and anterior) surgical treatment using spinal instrumentation for tuberculous spondylitis. J Spinal Disord Tech (2010) 1.12
A systems biology approach to synovial joint lubrication in health, injury, and disease. Wiley Interdiscip Rev Syst Biol Med (2011) 1.12
Nerve fiber ingrowth into scar tissue formed following nucleus pulposus extrusion in the rabbit anular-puncture disc degeneration model: effects of depth of puncture. Spine (Phila Pa 1976) (2006) 1.11
Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC. Spine (Phila Pa 1976) (2007) 1.10
The apoptotic effects of oxidative stress and antiapoptotic effects of caspase inhibitors on rat notochordal cells. Spine (Phila Pa 1976) (2007) 1.10
Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses. Arthritis Rheum (2005) 1.09
Platelet-rich plasma (PRP) stimulates the extracellular matrix metabolism of porcine nucleus pulposus and anulus fibrosus cells cultured in alginate beads. Spine (Phila Pa 1976) (2006) 1.08
ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein. Biochem J (2004) 1.08
Enhancement of stability following anterior cervical corpectomy: a biomechanical study. Spine (Phila Pa 1976) (2004) 1.08
Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis. Spine J (2005) 1.07
Relevance of in vitro and in vivo models for intervertebral disc degeneration. J Bone Joint Surg Am (2006) 1.07
Biomechanical study of the lumbar spine using a unilateral pedicle screw fixation system. J Clin Neurosci (2010) 1.05
Effect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study. Arthritis Res Ther (2012) 1.05
Reliabilities of and correlations among five standard methods of assessing the sagittal alignment of the cervical spine. Spine (Phila Pa 1976) (2006) 1.04
Cartilage-specific constitutive expression of TSG-6 protein (product of tumor necrosis factor alpha-stimulated gene 6) provides a chondroprotective, but not antiinflammatory, effect in antigen-induced arthritis. Arthritis Rheum (2002) 1.04
Rheumatoid arthritis: evaluation and surgical management of the cervical spine. Spine J (2004) 1.04
Intradiscal injections of osteogenic protein-1 restore the viscoelastic properties of degenerated intervertebral discs. Spine J (2006) 1.03
The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration. Arthritis Res Ther (2011) 1.02
ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain. J Biol Chem (2002) 1.02
Reprogramming and development in nuclear transfer embryos and in interspecific systems. Curr Opin Genet Dev (2012) 1.02
Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis. Arthritis Res Ther (2011) 1.02
Notochordal cells stimulate migration of cartilage end plate chondrocytes of the intervertebral disc in in vitro cell migration assays. Spine J (2008) 1.02
Comparison of allograft to autograft in multilevel anterior cervical discectomy and fusion with rigid plate fixation. Spine J (2003) 1.02
Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension. Exp Neurol (2007) 1.01
Growth factors and the intervertebral disc. Spine J (2004) 1.01
Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling. J Biol Chem (2011) 1.01
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models. J Orthop Res (2010) 1.01