Published in Am J Physiol Lung Cell Mol Physiol on November 09, 2007
The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function. Br J Pharmacol (2009) 1.46
Prostaglandin E2 inhibits specific lung fibroblast functions via selective actions of PKA and Epac-1. Am J Respir Cell Mol Biol (2008) 1.45
Biochemical basis of asthma therapy. J Biol Chem (2011) 1.24
cAMP regulation of airway smooth muscle function. Pulm Pharmacol Ther (2012) 1.24
Anti-mitogenic effects of β-agonists and PGE2 on airway smooth muscle are PKA dependent. FASEB J (2010) 1.09
Role of the cAMP-binding protein Epac in cardiovascular physiology and pathophysiology. Pflugers Arch (2009) 1.07
Epac as a novel effector of airway smooth muscle relaxation. J Cell Mol Med (2011) 1.03
Protease-activated receptors and prostaglandins in inflammatory lung disease. Br J Pharmacol (2009) 1.00
cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A. Br J Pharmacol (2011) 0.96
β-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent. J Biol Chem (2014) 0.94
Role of Epac1 in mediating anti-proliferative effects of prostanoid EP(2) receptors and cAMP in human lung fibroblasts. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.94
PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res (2009) 0.93
Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells. PLoS One (2012) 0.88
Protein kinase A and the exchange protein directly activated by cAMP (Epac) modulate phenotype plasticity in human airway smooth muscle. Br J Pharmacol (2011) 0.85
The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization. J Tissue Eng Regen Med (2011) 0.85
Inhibition of ATP release from erythrocytes: a role for EPACs and PKC. Microcirculation (2011) 0.82
A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases. Br J Pharmacol (2014) 0.81
Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10: in vitro comparison with current asthma therapies. Respir Res (2012) 0.77
Real time analysis of β(2)-adrenoceptor-mediated signaling kinetics in human primary airway smooth muscle cells reveals both ligand and dose dependent differences. Respir Res (2011) 0.76
Synergistic interaction between PPAR ligands and salbutamol on human bronchial smooth muscle cell proliferation. Br J Pharmacol (2013) 0.76
Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1. Sci Rep (2016) 0.75
Epac1 agonist decreased inflammatory proteins in retinal endothelial cells, and loss of Epac1 increased inflammatory proteins in the retinal vasculature of mice. Mol Vis (2017) 0.75
Differential impact of acute and prolonged cAMP agonist exposure on protein kinase A activation and human myometrium contractile activity. J Physiol (2016) 0.75
Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway. Front Pharmacol (2017) 0.75
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem (2002) 4.19
Point: alterations in airway smooth muscle phenotype do/do not cause airway hyperresponsiveness in asthma. J Appl Physiol (1985) (2012) 2.31
Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact. FASEB J (2005) 2.13
Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration. Am J Respir Cell Mol Biol (2003) 1.91
Asthma outcomes: biomarkers. J Allergy Clin Immunol (2012) 1.88
Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest (2009) 1.83
Attitudes of physicians toward objective measures of airway function in asthma. Am J Med (2003) 1.80
CD38/cyclic ADP-ribose-mediated Ca2+ signaling contributes to airway smooth muscle hyper-responsiveness. FASEB J (2003) 1.63
PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2002) 1.57
Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. J Allergy Clin Immunol (2003) 1.52
TGF-beta potentiates airway smooth muscle responsiveness to bradykinin. Am J Physiol Lung Cell Mol Physiol (2005) 1.51
Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice. Am J Physiol Lung Cell Mol Physiol (2009) 1.50
Aclidinium bromide abrogates allergen-induced hyperresponsiveness and reduces eosinophilia in murine model of airway inflammation. Eur J Pharmacol (2010) 1.47
Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway. Am J Respir Cell Mol Biol (2004) 1.43
GABAA receptors are expressed and facilitate relaxation in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2008) 1.43
Steroids completely reverse albuterol-induced beta(2)-adrenergic receptor tolerance in human small airways. J Allergy Clin Immunol (2008) 1.41
TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis. Am J Physiol Lung Cell Mol Physiol (2012) 1.40
Placebo response in asthma: a robust and objective phenomenon. J Allergy Clin Immunol (2007) 1.38
Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists. Am J Respir Cell Mol Biol (2002) 1.37
Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. FASEB J (2003) 1.36
IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. Br J Pharmacol (2003) 1.35
IL-13 and IL-4 cause eotaxin release in human airway smooth muscle cells: a role for ERK. Am J Physiol Lung Cell Mol Physiol (2002) 1.34
Effects of cigarette smoke and alcohol on ciliated tracheal epithelium and inflammatory cell recruitment. Am J Respir Cell Mol Biol (2006) 1.31
Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1. Mol Cell Biol (2007) 1.26
Toll-like receptor 2 regulates organic dust-induced airway inflammation. Am J Respir Cell Mol Biol (2011) 1.24
The N terminus of the human alpha1D-adrenergic receptor prevents cell surface expression. J Pharmacol Exp Ther (2004) 1.23
Cytokines regulate beta-2-adrenergic receptor responsiveness in airway smooth muscle via multiple PKA- and EP2 receptor-dependent mechanisms. Biochemistry (2005) 1.23
Receptors and pathways mediating the effects of prostaglandin E2 on airway tone. Am J Physiol Lung Cell Mol Physiol (2002) 1.23
Airway smooth muscle: a modulator of airway remodeling in asthma. J Allergy Clin Immunol (2005) 1.23
Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth. Biochemistry (2005) 1.23
CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2005) 1.23
Airway smooth muscle as an immunomodulatory cell. Pulm Pharmacol Ther (2008) 1.20
IL-13 and IL-4 promote TARC release in human airway smooth muscle cells: role of IL-4 receptor genotype. Am J Physiol Lung Cell Mol Physiol (2003) 1.17
TNF-[alpha] modulates murine tracheal rings responsiveness to G-protein-coupled receptor agonists and KCl. J Appl Physiol (1985) (2003) 1.16
Nitric oxide-dependent cilia regulatory enzyme localization in bovine bronchial epithelial cells. J Histochem Cytochem (2007) 1.15
Functional expression of the GABAB receptor in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2006) 1.14
Long-term cigarette smoke exposure in a mouse model of ciliated epithelial cell function. Am J Respir Cell Mol Biol (2009) 1.14
Impact of pulmonary artery pressure on exercise function in severe COPD. Chest (2009) 1.14
Repeat organic dust exposure-induced monocyte inflammation is associated with protein kinase C activity. J Allergy Clin Immunol (2007) 1.14
Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. J Appl Physiol (1985) (2009) 1.14
Tumor necrosis factor alpha modulates airway smooth muscle function via the autocrine action of interferon beta. J Biol Chem (2003) 1.13
Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthma. Curr Opin Allergy Clin Immunol (2002) 1.11
Differential in vivo effects of whole cigarette smoke exposure versus cigarette smoke extract on mouse ciliated tracheal epithelium. Exp Lung Res (2006) 1.11
Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genet (2012) 1.09
Synthetic responses in airway smooth muscle. J Allergy Clin Immunol (2004) 1.09
Anti-mitogenic effects of β-agonists and PGE2 on airway smooth muscle are PKA dependent. FASEB J (2010) 1.09
Alcohol stimulates ciliary motility of isolated airway axonemes through a nitric oxide, cyclase, and cyclic nucleotide-dependent kinase mechanism. Alcohol Clin Exp Res (2009) 1.08
TLR3 activation stimulates cytokine secretion without altering agonist-induced human small airway contraction or relaxation. Am J Physiol Lung Cell Mol Physiol (2009) 1.08
Angiogenesis is induced by airway smooth muscle strain. Am J Physiol Lung Cell Mol Physiol (2007) 1.08
Association of chronic alcohol consumption and increased susceptibility to and pathogenic effects of pulmonary infection with respiratory syncytial virus in mice. Alcohol (2007) 1.07
Smoke exposure exacerbates an ethanol-induced defect in mucociliary clearance of Streptococcus pneumoniae. Alcohol Clin Exp Res (2005) 1.06
miR-140-3p regulation of TNF-α-induced CD38 expression in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2012) 1.06
Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11). FASEB J (2006) 1.06
Noncontractile functions of airway smooth muscle cells in asthma. Annu Rev Physiol (2009) 1.06
Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway. Mol Pharmacol (2004) 1.05
Hybrid malondialdehyde and acetaldehyde protein adducts form in the lungs of mice exposed to alcohol and cigarette smoke. Alcohol Clin Exp Res (2011) 1.05
Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization. Respir Res (2003) 1.05
MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway. FASEB J (2014) 1.05
Isoproterenol induces actin depolymerization in human airway smooth muscle cells via activation of an Src kinase and GS. Am J Physiol Lung Cell Mol Physiol (2005) 1.04
Raf-1, actin dynamics, and abelson tyrosine kinase in human airway smooth muscle cells. Am J Respir Cell Mol Biol (2012) 1.04
Transcriptional regulation of CD38 expression by tumor necrosis factor-alpha in human airway smooth muscle cells: role of NF-kappaB and sensitivity to glucocorticoids. FASEB J (2006) 1.03
Cyclic mechanical strain-induced proliferation and migration of human airway smooth muscle cells: role of EMMPRIN and MMPs. FASEB J (2005) 1.02
Alcohol intake is associated with altered pulmonary function. Alcohol (2005) 1.02
Maternal alcohol ingestion reduces surfactant protein A expression by preterm fetal lung epithelia. Alcohol (2007) 1.02
Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex. J Biol Chem (2011) 1.02
Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study. Respir Res (2008) 1.02
Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsiveness. Immunobiology (2008) 1.01
Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration. FASEB J (2004) 1.01
Oncostatin M causes eotaxin-1 release from airway smooth muscle: synergy with IL-4 and IL-13. J Allergy Clin Immunol (2005) 1.01
Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production. J Immunol (2009) 1.00
Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. Respir Res (2013) 1.00
Assays for in vitro monitoring of proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells. Nat Protoc (2006) 1.00
Direct involvement of the isotype-specific C-terminus of beta tubulin in ciliary beating. J Cell Sci (2005) 0.99
Is airway remodeling clinically relevant in asthma? Am J Med (2003) 0.99
Alcohol increases the permeability of airway epithelial tight junctions in Beas-2B and NHBE cells. Alcohol Clin Exp Res (2011) 0.98
Social stress and asthma: the role of corticosteroid insensitivity. J Allergy Clin Immunol (2010) 0.98
Airway epithelium stimulates smooth muscle proliferation. Am J Respir Cell Mol Biol (2009) 0.98
Asthma in the elderly: the role of exhaled nitric oxide measurements. Respir Med (2013) 0.98
Bronchial hyperresponsiveness: insights into new signaling molecules. Curr Opin Pharmacol (2004) 0.98
Mast cell chymase modifies cell-matrix interactions and inhibits mitogen-induced proliferation of human airway smooth muscle cells. J Immunol (2002) 0.97
Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion. Biochem Pharmacol (2013) 0.97
Hyperpolarized 3He MRI in asthma measurements of regional ventilation following allergic sensitization and challenge in mice--preliminary results. Acad Radiol (2005) 0.97
Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells. Am J Respir Cell Mol Biol (2009) 0.97
Airway smooth muscle cell hyperplasia: a therapeutic target in airway remodeling in asthma? Prog Cell Cycle Res (2003) 0.97
Airway smooth muscle in asthma: just a target for bronchodilation? Clin Chest Med (2012) 0.96
Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype. Am J Respir Cell Mol Biol (2008) 0.96
Activation of p38 MAP-kinase and caldesmon phosphorylation are essential for urokinase-induced human smooth muscle cell migration. Biol Chem (2002) 0.96
C-027 inhibits IgE-mediated passive sensitization bronchoconstriction and acts as a histamine and serotonin antagonist in human airways. Allergy Asthma Proc (2011) 0.95
Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13. Respir Res (2010) 0.95
Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis. Mol Pharmacol (2009) 0.95
Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration. Am J Physiol Lung Cell Mol Physiol (2002) 0.95
Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1beta. Am J Physiol Lung Cell Mol Physiol (2005) 0.95
Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-alpha and dexamethasone. Respir Res (2008) 0.95
Hog barn dust slows airway epithelial cell migration in vitro through a PKCalpha-dependent mechanism. Am J Physiol Lung Cell Mol Physiol (2007) 0.95
Alcohol functionally upregulates Toll-like receptor 2 in airway epithelial cells. Alcohol Clin Exp Res (2008) 0.95
Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors. Mol Pharmacol (2007) 0.94
Activation of protein kinase A accelerates bovine bronchial epithelial cell migration. Am J Physiol Lung Cell Mol Physiol (2002) 0.94
20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice. PLoS One (2010) 0.94
Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2010) 0.94