Published in ChemMedChem on January 01, 2008
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one. Bioorg Med Chem (2008) 1.07
Using a water-immiscible ionic liquid to improve asymmetric reduction of 4-(trimethylsilyl)-3-butyn-2-one catalyzed by immobilized Candida parapsilosis CCTCC M203011 cells. BMC Biotechnol (2009) 0.99
Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. ACS Med Chem Lett (2015) 0.79
Synthesis of a Novel Siliconized Analog of Clofibrate (Silafibrate) and Comparison of their Anti-inflammatory Activities. Iran J Pharm Res (2012) 0.78
The protein network of HIV budding. Cell (2003) 7.82
A peptide inhibitor of HIV-1 assembly in vitro. Nat Struct Mol Biol (2005) 2.21
The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release. J Virol (2003) 2.19
Oxadiazoles in medicinal chemistry. J Med Chem (2012) 2.03
Live-cell visualization of dynamics of HIV budding site interactions with an ESCRT component. Nat Cell Biol (2011) 1.96
The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. J Biol Chem (2004) 1.92
Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesis. Cell Host Microbe (2008) 1.91
Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Cancer Res (2009) 1.75
Dynamics of HIV-1 assembly and release. PLoS Pathog (2009) 1.67
Common variants in P2RY11 are associated with narcolepsy. Nat Genet (2010) 1.65
NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains. J Virol (2008) 1.60
Maturation-dependent HIV-1 surface protein redistribution revealed by fluorescence nanoscopy. Science (2012) 1.50
Double-labelled HIV-1 particles for study of virus-cell interaction. Virology (2006) 1.49
The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly. Nephrol Dial Transplant (2013) 1.47
Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function. Traffic (2006) 1.39
A zwitterionic spirocyclic pentacoordinate silicon compound synthesized in water by Si--O and Si--C bond cleavage. Angew Chem Int Ed Engl (2005) 1.38
Structural analysis of HIV-1 maturation using cryo-electron tomography. PLoS Pathog (2010) 1.36
More than one door - Budding of enveloped viruses through cellular membranes. FEBS Lett (2007) 1.35
Comparison of the usefulness of the MTT, ATP, and calcein assays to predict the potency of cytotoxic agents in various human cancer cell lines. J Biomol Screen (2004) 1.27
Super-resolution microscopy reveals specific recruitment of HIV-1 envelope proteins to viral assembly sites dependent on the envelope C-terminal tail. PLoS Pathog (2013) 1.25
Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes. J Med Chem (2008) 1.25
Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes. J Biol Chem (2006) 1.24
Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells. J Biol Chem (2007) 1.20
Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins). ChemMedChem (2007) 1.19
Relevance of drug uptake and efflux for cisplatin sensitivity of tumor cells. Biochem Pharmacol (2006) 1.14
MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation. Acta Neuropathol (2013) 1.13
Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor. J Immunol (2007) 1.12
Probing HIV-1 membrane liquid order by Laurdan staining reveals producer cell-dependent differences. J Biol Chem (2009) 1.07
Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties. J Med Chem (2012) 1.06
Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli. J Biol Chem (2008) 1.04
Single-molecule coordinate-based analysis of the morphology of HIV-1 assembly sites with near-molecular spatial resolution. Histochem Cell Biol (2012) 1.02
High-performance organic thin-film transistors of J-stacked squaraine dyes. J Am Chem Soc (2014) 1.00
State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications. Drug Metab Rev (2007) 1.00
Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist. Neuropharmacology (2005) 0.99
Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. J Med Chem (2005) 0.99
The suramin analog 4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups. Mol Pharmacol (2006) 0.98
Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases. J Biol Chem (2004) 0.98
Structure-activity relationships of suramin and pyridoxal-5'-phosphate derivatives as P2 receptor antagonists. Curr Pharm Des (2002) 0.98
Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt]. J Pharmacol Exp Ther (2005) 0.97
Visualizing fusion of pseudotyped HIV-1 particles in real time by live cell microscopy. Retrovirology (2009) 0.97
Expression and function of C/EBP homology protein (GADD153) in podocytes. Am J Pathol (2006) 0.97
Fe-catalyzed oxidative coupling of heteroarenes and methylamines. Chem Asian J (2009) 0.96
Reactive oxygen species alter gene expression in podocytes: induction of granulocyte macrophage-colony-stimulating factor. J Am Soc Nephrol (2002) 0.95
NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. J Pharmacol Exp Ther (2009) 0.95
Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J Med Chem (2013) 0.95
Acquired cisplatin resistance in the head-neck cancer cell line Cal27 is associated with decreased DKK1 expression and can partially be reversed by overexpression of DKK1. Int J Cancer (2008) 0.95
The transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress. J Biol Chem (2010) 0.94
Role of the SP2 domain and its proteolytic cleavage in HIV-1 structural maturation and infectivity. J Virol (2012) 0.92
A SNAP-tagged derivative of HIV-1--a versatile tool to study virus-cell interactions. PLoS One (2011) 0.92
HIV-1-cellular interactions analyzed by single virus tracing. Eur Biophys J (2008) 0.92
Neutral six-coordinate and cationic five-coordinate silicon(IV) complexes with two bidentate monoanionic N,S-pyridine-2-thiolato(-) ligands. Inorg Chem (2013) 0.92
Synthesis and structural characterisation of neutral pentacoordinate silicon(IV) complexes with a tridentate dianionic N,N,S chelate ligand. Dalton Trans (2011) 0.91
Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease. Retrovirology (2010) 0.90
NAADP+ is an agonist of the human P2Y11 purinergic receptor. Cell Calcium (2007) 0.90
Embellicines A and B: absolute configuration and NF-κB transcriptional inhibitory activity. J Med Chem (2013) 0.89
Salt bridge switching from Arg290/Glu167 to Arg290/ATP promotes the closed-to-open transition of the P2X2 receptor. Mol Pharmacol (2012) 0.89
Gag-Pol processing during HIV-1 virion maturation: a systems biology approach. PLoS Comput Biol (2013) 0.89
Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel. Biochem Biophys Res Commun (2009) 0.89
New functional assay of P-glycoprotein activity using Hoechst 33342. Bioorg Med Chem (2007) 0.88
Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem (2010) 0.88
Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1 selective radioligand [18F]fluspidine. Eur J Nucl Med Mol Imaging (2010) 0.88
Electrochemical oxidation and cleavage of peptides analyzed with on-line mass spectrometric detection. Rapid Commun Mass Spectrom (2003) 0.87
Comprehensive mutational analysis reveals p6Gag phosphorylation to be dispensable for HIV-1 morphogenesis and replication. J Virol (2012) 0.87
Stra13, a prostaglandin E2-induced gene, regulates the cellular redox state of podocytes. FASEB J (2003) 0.87
Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes. ACS Med Chem Lett (2013) 0.87
Molecular determinants of potent P2X2 antagonism identified by functional analysis, mutagenesis, and homology docking. Mol Pharmacol (2010) 0.86
Cytocompatibility of a novel, longitudinally microstructured collagen scaffold intended for nerve tissue repair. Tissue Eng Part A (2009) 0.86
Mimicry of phase I drug metabolism--novel methods for metabolite characterization and synthesis. Rapid Commun Mass Spectrom (2007) 0.85
Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1. J Med Chem (2002) 0.84
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. Bioorg Med Chem (2011) 0.84
Identification and design of a novel series of MGAT2 inhibitors. Bioorg Med Chem Lett (2013) 0.84
Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology. ChemMedChem (2009) 0.83
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg Med Chem (2010) 0.83
Aromatic C-H bond hydroxylation by P450 peroxygenases: a facile colorimetric assay for monooxygenation activities of enzymes based on Russig's blue formation. J Biol Inorg Chem (2010) 0.83
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem (2011) 0.83
Metabolism studies of ifenprodil, a potent GluN2B receptor antagonist. J Pharm Biomed Anal (2013) 0.83
Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies. Chem Res Toxicol (2008) 0.83
Quality and functionality of saffron: quality control, species assortment and affinity of extract and isolated saffron compounds to NMDA and sigma1 (sigma-1) receptors. Planta Med (2008) 0.83
Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability. J Med Chem (2013) 0.83
Psychrophilin E, a new cyclotripeptide, from co-fermentation of two marine alga-derived fungi of the genus Aspergillus. Nat Prod Res (2014) 0.83
Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides. Bioorg Med Chem Lett (2012) 0.83
Biased inhibition by a suramin analogue of A1-adenosine receptor/G protein coupling in fused receptor/G protein tandems: the A1-adenosine receptor is predominantly coupled to Goalpha in human brain. Naunyn Schmiedebergs Arch Pharmacol (2001) 0.82
Can silicon make an excellent drug even better? An in vitro and in vivo head-to-head comparison between loperamide and its silicon analogue sila-loperamide. ChemMedChem (2015) 0.82
Structure of the σ1 receptor and its ligand binding site. J Med Chem (2013) 0.82