Published in Eur J Cell Biol on December 01, 1991
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest (2000) 3.47
Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III. EMBO J (1999) 2.28
Mannose 6-phosphate receptors are sorted from immature secretory granules via adaptor protein AP-1, clathrin, and syntaxin 6-positive vesicles. J Cell Biol (1998) 2.24
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. Gut (2006) 1.97
Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylation. EMBO J (1997) 1.71
Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic beta-cells. J Cell Biol (1997) 1.40
Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor. J Cell Biol (1993) 1.29
Distinct molecular mechanisms for protein sorting within immature secretory granules of pancreatic beta-cells. J Cell Biol (1994) 1.23
Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges. Protoplasma (2014) 1.12
Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer. Neoplasia (2005) 1.11
Proteomic analysis of pancreatic zymogen granules: identification of new granule proteins. J Proteome Res (2007) 1.06
Co-localization hypothesis: a mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis. World J Gastroenterol (2006) 0.96
Human pancreatitis and the role of cathepsin B. Gut (2006) 0.87
Tumor protein D52 controls trafficking of an apical endolysosomal secretory pathway in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol (2013) 0.87
Susceptibility to dental caries and the salivary proline-rich proteins. Int J Dent (2011) 0.82
GENETIC AND PHARMACOLOGIC MANIPULATION OF VACUOLAR ATPASE; EFFECTS ON ZYMOGEN ACTIVATION IN PANCREATIC ACINI. Open Access Anim Physiol (2009) 0.81
Local pH-dependent conformational changes leading to proteolytic susceptibility of cystatin C. Biochem J (1994) 0.78
Selection of AUG initiation codons differs in plants and animals. EMBO J (1987) 12.73
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell (1992) 10.53
The mannose 6-phosphate receptor and the biogenesis of lysosomes. Cell (1988) 7.22
Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur J Cell Biol (1995) 4.01
Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch A Pathol Anat Histol (1977) 3.54
Progeny vaccinia and human cytomegalovirus particles utilize early endosomal cisternae for their envelopes. Eur J Cell Biol (1993) 3.46
In exocrine pancreas, the basolateral endocytic pathway converges with the autophagic pathway immediately after the early endosome. J Cell Biol (1990) 3.08
Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. J Cell Biol (2000) 2.97
Interphase nuclei of many mammalian cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope. J Cell Biol (1997) 2.82
Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin. EMBO J (1995) 2.76
Mutant Rab7 causes the accumulation of cathepsin D and cation-independent mannose 6-phosphate receptor in an early endocytic compartment. J Cell Biol (1998) 2.64
Tubular early endosomal networks in AtT20 and other cells. J Cell Biol (1991) 2.62
The dynamic nature of the Golgi complex. J Cell Biol (1989) 2.61
Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III. EMBO J (1999) 2.28
Intracellular and extracellular vaccinia virions enter cells by different mechanisms. J Gen Virol (1998) 2.14
Characterization of the cation-independent mannose 6-phosphate receptor-enriched prelysosomal compartment in NRK cells. J Cell Sci (1990) 2.10
The dominant phosphoprotein pp65 (UL83) of human cytomegalovirus is dispensable for growth in cell culture. J Virol (1995) 2.07
Condensation-sorting events in the rough endoplasmic reticulum of exocrine pancreatic cells. J Cell Biol (1989) 2.06
Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells. J Cell Biol (1991) 2.04
The small GTP-binding protein rab6 functions in intra-Golgi transport. J Cell Biol (1994) 2.02
Extracellular enveloped vaccinia virus is resistant to complement because of incorporation of host complement control proteins into its envelope. Proc Natl Acad Sci U S A (1998) 1.97
Intracellular traffic of herpes simplex virus glycoprotein gE: characterization of the sorting signals required for its trans-Golgi network localization. J Virol (1999) 1.87
Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor. J Biol Chem (1990) 1.87
Purification and characterization of a cation-dependent mannose 6-phosphate receptor from murine P388D1 macrophages and bovine liver. J Biol Chem (1985) 1.86
Roles of vaccinia virus EEV-specific proteins in intracellular actin tail formation and low pH-induced cell-cell fusion. J Gen Virol (1998) 1.81
A casein kinase II phosphorylation site in the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor determines the high affinity interaction of the AP-1 Golgi assembly proteins with membranes. J Biol Chem (1996) 1.81
The mammalian AP-3 adaptor-like complex mediates the intracellular transport of lysosomal membrane glycoproteins. J Biol Chem (1998) 1.68
Type 1 and type 2 cytokine regulation of macrophage endocytosis: differential activation by IL-4/IL-13 as opposed to IFN-gamma or IL-10. J Immunol (1999) 1.58
Role of mannose-6-phosphate receptors in herpes simplex virus entry into cells and cell-to-cell transmission. J Virol (1995) 1.58
The vaccinia virus A36R protein is a type Ib membrane protein present on intracellular but not extracellular enveloped virus particles. Virology (2000) 1.56
Binding of AP-1 Golgi adaptors to membranes requires phosphorylated cytoplasmic domains of the mannose 6-phosphate/insulin-like growth factor II receptor. J Biol Chem (1993) 1.53
The vaccinia virus A27L protein is needed for the microtubule-dependent transport of intracellular mature virus particles. J Gen Virol (2000) 1.52
Antibodies against vaccinia virus do not neutralize extracellular enveloped virus but prevent virus release from infected cells and comet formation. J Gen Virol (1997) 1.49
Nuclear localization of the human cytomegalovirus tegument protein pp150 (ppUL32). J Gen Virol (1995) 1.47
Course and spontaneous regression of acute pancreatitis in the rat. Virchows Arch A Pathol Anat Histol (1979) 1.45
Intracellular localization and expression of the human cytomegalovirus matrix phosphoprotein pp71 (ppUL82): evidence for its translocation into the nucleus. J Gen Virol (1996) 1.43
In AtT20 and HeLa cells brefeldin A induces the fusion of tubular endosomes and changes their distribution and some of their endocytic properties. J Cell Biol (1992) 1.42
Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN. J Cell Biol (1997) 1.41
Mannose 6-phosphate receptors and ADP-ribosylation factors cooperate for high affinity interaction of the AP-1 Golgi assembly proteins with membranes. J Biol Chem (1996) 1.40
Lysosomal enzyme binding to mouse P388D1 macrophage membranes lacking the 215-kDa mannose 6-phosphate receptor: evidence for the existence of a second mannose 6-phosphate receptor. Proc Natl Acad Sci U S A (1985) 1.36
The interaction of phosphorylated oligosaccharides and lysosomal enzymes with bovine liver cation-dependent mannose 6-phosphate receptor. J Biol Chem (1987) 1.35
Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts. EMBO J (1994) 1.35
Developmental and morphological regulation of clathrin-mediated endocytosis in Trypanosoma brucei. J Cell Sci (2001) 1.33
Distribution of extracellular matrix proteins in pancreatic ductal adenocarcinoma and its influence on tumor cell proliferation in vitro. Pancreas (1987) 1.32
Intracellular transport of the glycoproteins gE and gI of the varicella-zoster virus. gE accelerates the maturation of gI and determines its accumulation in the trans-Golgi network. J Biol Chem (1998) 1.31
Bi-directional trafficking between the trans-Golgi network and the endosomal/lysosomal system. J Cell Sci (2000) 1.27
The cytoplasmic domain of alphavirus E2 glycoprotein contains a short linear recognition signal required for viral budding. EMBO J (1991) 1.27
A GDP/GTP exchange-stimulatory activity for the Rab5-RabGDI complex on clathrin-coated vesicles from bovine brain. J Biol Chem (1995) 1.26
Time course and cellular source of pancreatic regeneration following acute pancreatitis in the rat. Pancreas (1986) 1.26
Characterization of an Krox-24/Egr-1-responsive element in the human tumor necrosis factor promoter. Biochim Biophys Acta (1994) 1.25
Rapid recruitment of late endosomes and lysosomes in mouse macrophages ingesting Candida albicans. J Cell Sci (1999) 1.25
Sorting of furin at the trans-Golgi network. Interaction of the cytoplasmic tail sorting signals with AP-1 Golgi-specific assembly proteins. J Biol Chem (1999) 1.25
Mechanisms of protein sorting and coat assembly: insights from the clathrin-coated vesicle pathway. Curr Opin Cell Biol (1998) 1.24
Alteration of membrane fusion as a cause of acute pancreatitis in the rat. Dig Dis Sci (1982) 1.24
The extracellular domain of vaccinia virus protein B5R affects plaque phenotype, extracellular enveloped virus release, and intracellular actin tail formation. J Virol (1998) 1.23
Protein transport from the secretory to the endocytic pathway in mammalian cells. Biochim Biophys Acta (1998) 1.22
Phosphorylation of the cation-independent mannose 6-phosphate receptor is closely associated with its exit from the trans-Golgi network. J Cell Biol (1993) 1.22
An antibody specific for an endoproteolytic cleavage site provides evidence that pro-opiomelanocortin is packaged into secretory granules in AtT20 cells before its cleavage. J Cell Biol (1987) 1.22
Bridging the resolution gap: Imaging the same transcription factories in cryosections by light and electron microscopy. J Histochem Cytochem (1999) 1.22
Tumor necrosis factor and lymphotoxin gene expression in human tumor cell lines. Cancer Res (1988) 1.21
Human cytomegalovirus late-phase maturation is blocked by stably expressed UL32 antisense mRNA in astrocytoma cells. J Gen Virol (1997) 1.19
Human acute pancreatitis: its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells. Virchows Arch A Pathol Anat Histopathol (1986) 1.17
[E: [Electron microscopic studies on the action of cobalt chloride on the exocrine pancreatic tissue in guinea pigs]. Virchows Arch B Cell Pathol (1969) 1.14
Studies on intracellular transport of secretory proteins in the rat exocrine pancreas. II. Inhibition of antimicrotubular agents. Virchows Arch A Pathol Anat Histol (1975) 1.12
Morphological and biochemical evidence showing neuronal properties in AtT-20 cells and their growth cones. Eur J Cell Biol (1989) 1.12
Overexpression of the vaccinia virus A38L integral membrane protein promotes Ca2+ influx into infected cells. J Virol (1996) 1.11
Fate of oligosaccharide-lipid intermediates synthesized by resting rat-spleen lymphocytes. Eur J Biochem (1980) 1.11
Roles for mannose-6-phosphate receptors in lysosomal enzyme sorting, IGF-II binding and clathrin-coat assembly. Trends Cell Biol (1995) 1.11
Expression of major histocompatibility complex class II molecules in HeLa cells promotes the recruitment of AP-1 Golgi-specific assembly proteins on Golgi membranes. J Biol Chem (1996) 1.09
Targeted disruption of the mouse cation-dependent mannose 6-phosphate receptor results in partial missorting of multiple lysosomal enzymes. EMBO J (1993) 1.08
Identification of a sialidase encoded in the human major histocompatibility complex. J Biol Chem (1997) 1.07
Autocrine stimulation of TNF-alpha mRNA expression in HL-60 cells. Lymphokine Res (1987) 1.06
Secretory granules and endosomes show saltatory movement biased to the anterograde and retrograde directions, respectively, along microtubules in AtT20 cells. Eur J Cell Biol (1989) 1.06
Microtubule depolymerization inhibits transport of cathepsin D from the Golgi apparatus to lysosomes. J Cell Sci (1990) 1.05
Inhibition of human cytomegalovirus maturation by brefeldin A. J Gen Virol (1992) 1.04
A Nuclear localization signal in herpesvirus protein VP1-2 is essential for infection via capsid routing to the nuclear pore. J Virol (2012) 1.02
Effects of the immunosuppressants cyclosporin A and FK 506 on exocytosis in the rat exocrine pancreas in vitro. Br J Pharmacol (1993) 1.02
Establishment and characterisation of two cell lines with different grade of differentiation derived from one primary human pancreatic adenocarcinoma. Virchows Arch B Cell Pathol Incl Mol Pathol (1992) 1.02
Histological and fine structural features of pancreatic ductal adenocarcinomas in relation to growth and prognosis: studies in xenografted tumours and clinico-histopathological correlation in a series of 75 cases. Histopathology (1985) 1.01
Fibroblast structure and function during regeneration from hormone-induced acute pancreatitis in the rat. Pancreas (1989) 1.01
Differential expression of the hyaluronan receptors CD44 and RHAMM in human pancreatic cancer cells. Clin Cancer Res (1996) 1.00
The AP-3-dependent targeting of the melanosomal glycoprotein QNR-71 requires a di-leucine-based sorting signal. J Cell Sci (2001) 0.99
Immunocytochemical and morphometric analysis of acinar zymogen granules in human acute pancreatitis. Virchows Arch A Pathol Anat Histopathol (1989) 0.98
Re-expression of the mannose 6-phosphate receptors in receptor-deficient fibroblasts. Complementary function of the two mannose 6-phosphate receptors in lysosomal enzyme targeting. J Biol Chem (1996) 0.97
Studies on intracellular transport of secretory proteins in the rat exocrine pancreas. III. Effect of cobalt, lanthanum and antimycin A. Virchows Arch A Pathol Anat Histol (1975) 0.97
The mannose 6-phosphate/insulin-like growth factor II receptor is a nanomolar affinity receptor for glycosylated human leukemia inhibitory factor. J Biol Chem (1998) 0.96
Regulated apical secretion of zymogens in rat pancreas. Involvement of the glycosylphosphatidylinositol-anchored glycoprotein GP-2, the lectin ZG16p, and cholesterol-glycosphingolipid-enriched microdomains. J Biol Chem (2001) 0.95
Regulation of exocrine pancreatic secretory process by insulin in vivo. Horm Metab Res (1975) 0.95
Cerulein-induced pancreatitis in rats: increased lysosomal enzyme activity and autophagocytosis. Digestion (1985) 0.95
Characterization of clones of a human pancreatic adenocarcinoma cell line representing different stages of differentiation. Pancreas (1989) 0.94
Coupled induction of exocrine proteins and intracellular compartments involved in the secretory pathway in AR4-2J cells by glucocorticoids. Eur J Cell Biol (1988) 0.93
Pancreatic acinar cell dysfunction in CFTR(-/-) mice is associated with impairments in luminal pH and endocytosis. Gastroenterology (2001) 0.93
Localisation of hyaluronate (HA) in primary tumors and nude mouse xenografts of human pancreatic carcinomas using a biotinylated HA-binding protein. Virchows Arch (1994) 0.92
Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization. J Biol Chem (1992) 0.92
Repetitive cerulein-induced pancreatitis and pancreatic fibrosis in the rat. Pancreas (1992) 0.92