Published in Cell Cycle on September 19, 2007
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High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization. Mol Biol Cell (2011) 0.91
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Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration. Proc Natl Acad Sci U S A (2002) 1.56
High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA. Proc Natl Acad Sci U S A (2004) 1.42
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Cells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo. Proc Natl Acad Sci U S A (2004) 1.33
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Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation. Proc Natl Acad Sci U S A (2006) 1.28
GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC. Proc Natl Acad Sci U S A (2008) 1.12
High NaCl causes Mre11 to leave the nucleus, disrupting DNA damage signaling and repair. Am J Physiol Renal Physiol (2003) 1.12
High NaCl increases TonEBP/OREBP mRNA and protein by stabilizing its mRNA. Am J Physiol Renal Physiol (2005) 1.11
Expression of osmotic stress-related genes in tissues of normal and hyposmotic rats. Am J Physiol Renal Physiol (2003) 1.10
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MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta. Proc Natl Acad Sci U S A (2008) 1.05
Mitochondrial reactive oxygen species contribute to high NaCl-induced activation of the transcription factor TonEBP/OREBP. Am J Physiol Renal Physiol (2005) 1.05
Tonicity-regulated gene expression. Methods Enzymol (2007) 1.03
Increased reactive oxygen species contribute to high NaCl-induced activation of the osmoregulatory transcription factor TonEBP/OREBP. Am J Physiol Renal Physiol (2005) 1.02
Ku86 preserves chromatin integrity in cells adapted to high NaCl. Proc Natl Acad Sci U S A (2005) 1.02
Phospholipase C-gamma1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP. Proc Natl Acad Sci U S A (2009) 1.01
Activator protein-1 contributes to high NaCl-induced increase in tonicity-responsive enhancer/osmotic response element-binding protein transactivating activity. J Biol Chem (2007) 1.00
The saltiness of the sea breaks DNA in marine invertebrates: possible implications for animal evolution. Cell Cycle (2006) 0.99
Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl. Proc Natl Acad Sci U S A (2006) 0.99
Greater tolerance of renal medullary cells for a slow increase in osmolality is associated with enhanced expression of HSP70 and other osmoprotective genes. Am J Physiol Renal Physiol (2003) 0.98
Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP. Proc Natl Acad Sci U S A (2010) 0.96
What's new about osmotic regulation of glycerophosphocholine. Physiology (Bethesda) (2009) 0.96
c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP. FASEB J (2010) 0.93
Proliferation and osmotic tolerance of renal inner medullary epithelial cells in vivo and in cell culture. Am J Physiol Renal Physiol (2002) 0.92
Tonicity-dependent regulation of osmoprotective genes in mammalian cells. Contrib Nephrol (2006) 0.92
High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization. Mol Biol Cell (2011) 0.91
Rate of increase of osmolality determines osmotic tolerance of mouse inner medullary epithelial cells. Am J Physiol Renal Physiol (2002) 0.91
DNA damage and osmotic regulation in the kidney. Am J Physiol Renal Physiol (2005) 0.90
Rac1/osmosensing scaffold for MEKK3 contributes via phospholipase C-gamma1 to activation of the osmoprotective transcription factor NFAT5. Proc Natl Acad Sci U S A (2011) 0.90
Analysis of DNA breaks, DNA damage response, and apoptosis produced by high NaCl. Am J Physiol Renal Physiol (2008) 0.89
DNA double-strand breaks induced by high NaCl occur predominantly in gene deserts. Proc Natl Acad Sci U S A (2011) 0.89
Living with DNA breaks is an everyday reality for cells adapted to high NaCl. Cell Cycle (2004) 0.88
Inhibitory phosphorylation of GSK-3β by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP). Am J Physiol Renal Physiol (2013) 0.88
Mitochondrial dysfunction is an early event in high-NaCl-induced apoptosis of mIMCD3 cells. Am J Physiol Renal Physiol (2002) 0.88
Secretion of von Willebrand factor by endothelial cells links sodium to hypercoagulability and thrombosis. Proc Natl Acad Sci U S A (2014) 0.85
Proteomic analysis of high NaCl-induced changes in abundance of nuclear proteins. Physiol Genomics (2012) 0.84
Knockout of Ku86 accelerates cellular senescence induced by high NaCl. Aging (Albany NY) (2009) 0.82
Toxicity of acetaminophen, salicylic acid, and caffeine for first-passage rat renal inner medullary collecting duct cells. J Pharmacol Exp Ther (2003) 0.82
Mutations in DNA-binding loop of NFAT5 transcription factor produce unique outcomes on protein-DNA binding and dynamics. J Phys Chem B (2013) 0.81
Increased insensible water loss contributes to aging related dehydration. PLoS One (2011) 0.80
Mre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA. Am J Physiol Regul Integr Comp Physiol (2011) 0.80
Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells. Am J Physiol Renal Physiol (2006) 0.80
Osmotic stress and DNA damage. Methods Enzymol (2007) 0.80
Three GADD45 isoforms contribute to hypertonic stress phenotype of murine renal inner medullary cells. Am J Physiol Renal Physiol (2002) 0.79
High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1. Am J Physiol Renal Physiol (2013) 0.79
Mutations that reduce its specific DNA binding inhibit high NaCl-induced nuclear localization of the osmoprotective transcription factor NFAT5. Am J Physiol Cell Physiol (2012) 0.79
Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP. PLoS One (2010) 0.79
14-3-3-β and -{varepsilon} contribute to activation of the osmoprotective transcription factor NFAT5 by increasing its protein abundance and its transactivating activity. Physiol Rep (2014) 0.78
Drying and salting send different messages. J Physiol (2004) 0.77
High NaCl- and urea-induced posttranslational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase. Proc Natl Acad Sci U S A (2013) 0.76
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Water restriction increases renal inner medullary manganese superoxide dismutase (MnSOD). Am J Physiol Renal Physiol (2012) 0.75