Published in Mol Pharmacol on December 13, 2007
Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev (2010) 2.97
ABCG2: a perspective. Adv Drug Deliv Rev (2008) 1.97
Drug transporters in the human blood-placental barrier. Br J Pharmacol (2009) 1.30
BCRP/ABCG2 in the placenta: expression, function and regulation. Pharm Res (2008) 1.17
Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport--an update. AAPS J (2014) 1.17
Clinical therapeutics in pregnancy. J Biomed Biotechnol (2011) 1.08
ATP-binding cassette efflux transporters in human placenta. Curr Pharm Biotechnol (2011) 0.98
Membrane topology of the human breast cancer resistance protein (BCRP/ABCG2) determined by epitope insertion and immunofluorescence. Biochemistry (2008) 0.97
Contributions of human cytochrome P450 enzymes to glyburide metabolism. Biopharm Drug Dispos (2010) 0.96
Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy. Toxicol Sci (2012) 0.92
Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice. Drug Metab Dispos (2012) 0.90
The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system. Pharmacol Res (2011) 0.86
Increased glyburide clearance in the pregnant mouse model. Drug Metab Dispos (2010) 0.85
Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy. Drug Metab Dispos (2013) 0.85
Effects of selected OATP and/or ABC transporter inhibitors on the brain and whole-body distribution of glyburide. AAPS J (2013) 0.85
Association between DNA methylation in the miR-328 5'-flanking region and inter-individual differences in miR-328 and BCRP expression in human placenta. PLoS One (2013) 0.83
Antenatal steroids and the IUGR fetus: are exposure and physiological effects on the lung and cardiovascular system the same as in normally grown fetuses? J Pregnancy (2012) 0.82
Euthanasia method for mice in rapid time-course pulmonary pharmacokinetic studies. J Am Assoc Lab Anim Sci (2009) 0.82
Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport. Am J Physiol Cell Physiol (2010) 0.82
Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein Transporter. J Pharmacol Exp Ther (2016) 0.82
Expression of ABC Efflux transporters in placenta from women with insulin-managed diabetes. PLoS One (2012) 0.80
Down-regulation of brush border efflux transporter expression in the kidneys of pregnant mice. Drug Metab Dispos (2012) 0.80
In Vitro Screening of Environmental Chemicals Identifies Zearalenone as a Novel Substrate of the Placental BCRP/ABCG2 Transporter. Toxicol Res (Camb) (2015) 0.79
Placental ABC Transporters: Biological Impact and Pharmaceutical Significance. Pharm Res (2016) 0.79
Maternal-fetal disposition of glyburide in pregnant mice is dependent on gestational age. J Pharmacol Exp Ther (2014) 0.78
The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP. Antimicrob Agents Chemother (2012) 0.78
Drug Interactions at the Human Placenta: What is the Evidence? Front Pharmacol (2012) 0.77
Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol (2014) 0.77
Effect of prostaglandin E2 on multidrug resistance transporters in human placental cells. Drug Metab Dispos (2014) 0.76
Regional expression of the BCRP/ABCG2 transporter in term human placentas. Reprod Toxicol (2013) 0.76
Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier. Sci Rep (2016) 0.75
P-gp/ABCB1 Exerts Differential Impacts On Brain and Fetal Exposure to Norbuprenorphine. Pharmacol Res (2017) 0.75
Effect of pregnancy on nitrofurantoin disposition in mice. J Pharm Sci (2009) 0.75
Buprenorphine, Norbuprenorphine, R-Methadone and S-Methadone Upregulate BCRP/ABCG2 Expression by Activating Aryl Hydrocarbon Receptor in Human Placental Trophoblasts. Mol Pharmacol (2016) 0.75
Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography. Clin Pharmacol Ther (2005) 2.35
Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPS J (2005) 2.03
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. Mol Pharmacol (2007) 1.84
Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proc Natl Acad Sci U S A (2006) 1.69
Pharmacokinetics and safety of stavudine in HIV-infected pregnant women and their infants: Pediatric AIDS Clinical Trials Group protocol 332. J Infect Dis (2004) 1.67
Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos (2007) 1.43
Pharmacokinetics of oseltamivir among pregnant and nonpregnant women. Am J Obstet Gynecol (2011) 1.36
Fecal microbiota transplantation through mid-gut for refractory Crohn's disease: safety, feasibility, and efficacy trial results. J Gastroenterol Hepatol (2015) 1.33
Structure and function of the human breast cancer resistance protein (BCRP/ABCG2). Curr Drug Metab (2010) 1.33
HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther (2004) 1.29
Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: studies of healthy humans. J Nucl Med (2009) 1.27
Profiling gene expression in human placentae of different gestational ages: an OPRU Network and UW SCOR Study. Reprod Sci (2008) 1.25
Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro. Drug Metab Dispos (2006) 1.22
Pharmacology and placental transport of 17-hydroxyprogesterone caproate in singleton gestation. Am J Obstet Gynecol (2012) 1.22
Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: mechanisms, tissue specificity, and time course. Mol Pharmacol (2008) 1.21
The role of transporters in drug interactions. Eur J Pharm Sci (2005) 1.19
Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex. Drug Metab Dispos (2013) 1.18
An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway. Mol Pharmacol (2011) 1.18
Regulation of BCRP/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cells. Am J Physiol Endocrinol Metab (2005) 1.17
Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoprotein. PLoS One (2011) 1.17
ECG-cryptography and authentication in body area networks. IEEE Trans Inf Technol Biomed (2012) 1.17
Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport--an update. AAPS J (2014) 1.17
Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: effects of pregnancy and correlations with nuclear receptors. Am J Physiol Endocrinol Metab (2006) 1.16
Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a concentration inhibition analysis, and comparison with human data. J Pharmacol Exp Ther (2006) 1.16
Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3. Am J Physiol Gastrointest Liver Physiol (2009) 1.15
In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta. Am J Physiol Regul Integr Comp Physiol (2007) 1.12
Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype. J Pharm Sci (2013) 1.12
New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine. Mol Cancer Ther (2008) 1.11
Changes in pharmacokinetics of anti-HIV protease inhibitors during pregnancy: the role of CYP3A and P-glycoprotein. J Pharmacol Exp Ther (2005) 1.11
In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier. Drug Metab Dispos (2007) 1.11
Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs. J Biol Chem (2003) 1.10
Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine. J Biol Chem (2006) 1.09
P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages. Am J Physiol Regul Integr Comp Physiol (2005) 1.09
Pharmacokinetics of metformin during pregnancy. Drug Metab Dispos (2010) 1.09
Breast cancer resistance protein 1 limits fetal distribution of nitrofurantoin in the pregnant mouse. Drug Metab Dispos (2007) 1.09
Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir. Drug Metab Dispos (2011) 1.08
The status of pharmacometrics in pregnancy: highlights from the 3(rd) American conference on pharmacometrics. Br J Clin Pharmacol (2012) 1.07
Iron deficiency generates secondary thrombocytosis and platelet activation in inflammatory bowel disease : the randomized, controlled ThromboVIT trial. Inflamm Bowel Dis (2013) 1.07
In vitro metabolism of cyclosporine A by human kidney CYP3A5. Biochem Pharmacol (2004) 1.06
Suppression of death receptor-mediated apoptosis by 1,25-dihydroxyvitamin D3 revealed by microarray analysis. J Biol Chem (2005) 1.06
The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone. Structure (2010) 1.06
Simultaneous measurement of plasma vitamin D(3) metabolites, including 4β,25-dihydroxyvitamin D(3), using liquid chromatography-tandem mass spectrometry. Anal Biochem (2011) 1.04
Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies. J Biol Chem (2002) 1.03
A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine. Biochemistry (2002) 1.03
Drug interactions at the blood-brain barrier: fact or fantasy? Pharmacol Ther (2009) 1.03
Optimized approaches for quantification of drug transporters in tissues and cells by MRM proteomics. AAPS J (2014) 1.03
Genetic diversity and population structure of Salvia miltiorrhiza Bge in China revealed by ISSR and SRAP. Genetica (2009) 1.02
Conditional QTL mapping for plant height with respect to the length of the spike and internode in two mapping populations of wheat. Theor Appl Genet (2011) 1.02
Different modes of transport for 3H-thymidine, 3H-FLT, and 3H-FMAU in proliferating and nonproliferating human tumor cells. J Nucl Med (2010) 1.00
BCRP transports dipyridamole and is inhibited by calcium channel blockers. Pharm Res (2005) 1.00
Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes. Am J Physiol Gastrointest Liver Physiol (2008) 1.00
Molecular cytogenetic identification of a novel dwarf wheat line with introgressed Thinopyrum ponticum chromatin. J Biosci (2012) 1.00
Complete defect closure of gastric submucosal tumors with purse-string sutures. Surg Endosc (2014) 1.00
ATP-binding cassette efflux transporters in human placenta. Curr Pharm Biotechnol (2011) 0.98
Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir. Drug Metab Dispos (2011) 0.98
Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep. Biochem Pharmacol (2004) 0.97
Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. Cancer Chemother Pharmacol (2006) 0.97
The role of the equilibrative nucleoside transporter 1 (ENT1) in transport and metabolism of ribavirin by human and wild-type or Ent1-/- mouse erythrocytes. J Pharmacol Exp Ther (2009) 0.97
Membrane topology of the human breast cancer resistance protein (BCRP/ABCG2) determined by epitope insertion and immunofluorescence. Biochemistry (2008) 0.97
Contributions of human cytochrome P450 enzymes to glyburide metabolism. Biopharm Drug Dispos (2010) 0.96
Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestine. Mol Pharm (2014) 0.96
Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry. Drug Metab Dispos (2012) 0.95
Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. Pharmacogenet Genomics (2008) 0.95
CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos (2010) 0.95
Antinociceptive and anti-inflammatory activities of Aquilaria sinensis (Lour.) Gilg. Leaves extract. J Ethnopharmacol (2008) 0.95
Human equilibrative nucleoside transporter-3 (hENT3) spectrum disorder mutations impair nucleoside transport, protein localization, and stability. J Biol Chem (2010) 0.94
Inhibition of P-glycoprotein activity at the primate blood-brain barrier increases the distribution of nelfinavir into the brain but not into the cerebrospinal fluid. Drug Metab Dispos (2007) 0.94
Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11. Biochemistry (2013) 0.94
Construction of an integrative linkage map and QTL mapping of grain yield-related traits using three related wheat RIL populations. Theor Appl Genet (2013) 0.93
Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities. J Clin Pharmacol (2006) 0.93
Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy. Biochem Pharmacol (2008) 0.93
A new nonlinear classifier with a penalized signed fuzzy measure using effective genetic algorithm. Pattern Recognit (2010) 0.91
Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate. J Nucl Med (2009) 0.91
In vitro LC-MS cocktail assays to simultaneously determine human cytochrome P450 activities. Biopharm Drug Dispos (2007) 0.91
Tribology study of reduced graphene oxide sheets on silicon substrate synthesized via covalent assembly. Langmuir (2010) 0.91
A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women. Drug Metab Dispos (2013) 0.91
Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19. Br J Clin Pharmacol (2014) 0.91
Pharmacometrics in pregnancy: An unmet need. Annu Rev Pharmacol Toxicol (2014) 0.91
Characterization and precise mapping of a QTL increasing spike number with pleiotropic effects in wheat. Theor Appl Genet (2010) 0.90
Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice. Drug Metab Dispos (2012) 0.90