High-throughput screening of microtubule-interacting drugs.

Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin. Bioorg Med Chem (2011) 0.75

Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues. J Med Chem (2007) 1.42

The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs. Proc Natl Acad Sci U S A (2004) 1.37

Rotational-echo double-resonance NMR distance measurements for the tubulin-bound Paclitaxel conformation. J Am Chem Soc (2007) 1.34

Site-specific orthogonal labeling of the carboxy terminus of alpha-tubulin. ACS Chem Biol (2010) 0.93

A fluorescence-based high-throughput assay for antimicrotubule drugs. Anal Biochem (2003) 0.92

Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation. Org Lett (2006) 0.91

Synthesis and biological evaluation of B-ring modified colchicine and isocolchicine analogs. Bioorg Med Chem Lett (2006) 0.84

Characterization of the colchicine binding site on avian tubulin isotype betaVI. Biochemistry (2010) 0.83

Interaction of tubulin with a new fluorescent analogue of vinblastine. Biochemistry (2002) 0.81

Syntheses and bioactivities of macrocyclic paclitaxel bis-lactones. Bioorg Med Chem (2004) 0.78

Synthesis and biological activity of 2,5-diaryl-3-methylpyrimido[4,5-c]quinolin-1(2H)-one derivatives. Bioorg Med Chem (2007) 0.75

Synthesis and biological evaluation of C-3'NH/C-10 and C-2/C-10 modified paclitaxel analogues. Bioorg Med Chem (2003) 0.75