PubRank

Kim A Caldwell

Author PubWeight™ 63.96‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 2006 7.72
2 Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet 2009 3.59
3 The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A 2007 3.39
4 Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science 2011 2.66
5 Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans. J Neurosci 2005 2.50
6 Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Dis Model Mech 2009 2.16
7 Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Proc Natl Acad Sci U S A 2008 2.09
8 Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. J Neurosci 2006 1.98
9 Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 2013 1.85
10 Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Mol Brain 2008 1.61
11 Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. Hum Mol Genet 2004 1.42
12 Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins. Hum Mol Genet 2003 1.36
13 Chemical enhancement of torsinA function in cell and animal models of torsion dystonia. Dis Model Mech 2010 1.33
14 Generation of stable transgenic C. elegans using microinjection. J Vis Exp 2008 1.29
15 Lysosomal impairment in Parkinson's disease. Mov Disord 2013 1.27
16 Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. J Cell Sci 2003 1.21
17 Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. Hum Mol Genet 2011 1.21
18 Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models. Nat Chem Biol 2009 1.19
19 TorsinA participates in endoplasmic reticulum-associated degradation. Nat Commun 2011 1.18
20 Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity. Hum Mol Genet 2012 1.15
21 The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response. Hum Mol Genet 2010 1.13
22 Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. J Neurochem 2010 1.07
23 Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms. J Biol Chem 2011 1.04
24 The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro. Cell Stress Chaperones 2010 1.01
25 VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. Neurobiol Dis 2009 1.00
26 Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease. Neurosci Lett 2008 0.99
27 C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease. Dev Dyn 2010 0.99
28 Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes. J Vis Exp 2008 0.95
29 Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res 2006 0.95
30 Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease. J Neurosci 2012 0.92
31 Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases. Antioxid Redox Signal 2013 0.90
32 The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans. Metallomics 2014 0.89
33 Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. BMC Cell Biol 2007 0.86
34 The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro. Cell Stress Chaperones 2008 0.85
35 Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission. Genetics 2009 0.84
36 Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Proc Natl Acad Sci U S A 2014 0.84
37 A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders. Neurotherapeutics 2012 0.84
38 Animal models for drug discovery in dystonia. Expert Opin Drug Discov 2008 0.84
39 TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS. Dis Model Mech 2013 0.82
40 Structural features and chaperone activity of the NudC protein family. J Mol Biol 2011 0.81
41 Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease. Methods 2010 0.80
42 Traversing a wormhole to combat Parkinson's disease. Dis Model Mech 2008 0.79
43 Modeling dopamine neuron degeneration in Caenorhabditis elegans. Methods Mol Biol 2011 0.79
44 An animal model to discern torsin function: suppression of protein aggregation in C. elegans. Adv Neurol 2004 0.78
45 Using Caenorhabditis elegans to probe toxicity of 1-alkyl-3-methylimidazolium chloride based ionic liquids. Chem Commun (Camb) 2004 0.78
46 Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling. Neurosci Lett 2013 0.76
47 Genetic and pharmacological discovery for Alzheimer's Disease using C. elegans. ACS Chem Neurosci 2017 0.75