Published in Bioorg Med Chem on January 04, 2008
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance. Proc Natl Acad Sci U S A (2009) 2.28
Aquaporin water channels in the nervous system. Nat Rev Neurosci (2013) 2.10
Aquaporins: important but elusive drug targets. Nat Rev Drug Discov (2014) 1.45
Aquaporins: translating bench research to human disease. J Exp Biol (2009) 1.31
Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site. Mol Pharmacol (2009) 1.13
Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assembly. Glia (2012) 1.08
Automated cell-based assay for screening of aquaporin inhibitors. Anal Chem (2009) 1.06
Aquaporin and brain diseases. Biochim Biophys Acta (2013) 1.06
Aquaporins in cerebrovascular disease: a target for treatment of brain edema? Cerebrovasc Dis (2011) 1.04
Posttraumatic reduction of edema with aquaporin-4 RNA interference improves acute and chronic functional recovery. J Cereb Blood Flow Metab (2013) 1.02
AqF026 is a pharmacologic agonist of the water channel aquaporin-1. J Am Soc Nephrol (2013) 0.99
Aquaporins: relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus. Cerebrospinal Fluid Res (2010) 0.93
Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia. FASEB J (2013) 0.93
The central role of aquaporins in the pathophysiology of ischemic stroke. Front Cell Neurosci (2015) 0.93
Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol Sci (2010) 0.90
Neuroprotective effect of aquaporin-4 deficiency in a mouse model of severe global cerebral ischemia produced by transient 4-vessel occlusion. Neurosci Lett (2014) 0.89
Hydrocephalus and aquaporins: lessons learned from the bench. Childs Nerv Syst (2010) 0.85
Structure, function and translational relevance of aquaporin dual water and ion channels. Mol Aspects Med (2012) 0.84
A high throughput screen identifies chemical modulators of the laminin-induced clustering of dystroglycan and aquaporin-4 in primary astrocytes. PLoS One (2011) 0.79
Light inactivation of water transport and protein-protein interactions of aquaporin-Killer Red chimeras. J Gen Physiol (2012) 0.78
Rapid Identification of Novel Inhibitors of the Human Aquaporin-1 Water Channel. Chem Biol Drug Des (2016) 0.77
Development of a Novel Ligand, [C]TGN-020, for Aquaporin 4 Positron Emission Tomography Imaging. ACS Chem Neurosci (2011) 0.77
1,3-propanediol binds deep inside the channel to inhibit water permeation through aquaporins. Protein Sci (2016) 0.76
Two-dimensional crystal structure of aquaporin-4 bound to the inhibitor acetazolamide. Microscopy (Oxf) (2015) 0.76
1,3-Propanediol binds inside the water-conducting pore of aquaporin 4: Does this efficacious inhibitor have sufficient potency? J Syst Integr Neurosci (2016) 0.76
Neuroscience of water molecules: a salute to professor Linus Carl Pauling. Cytotechnology (2009) 0.76
Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1. Mol Pharmacol (2016) 0.76
Can Stabilization and Inhibition of Aquaporins Contribute to Future Development of Biomimetic Membranes? Membranes (Basel) (2015) 0.75
Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury. Sci Rep (2016) 0.75
Fragment Screening of Human Aquaporin 1. Int J Mol Sci (2016) 0.75
Computing Osmotic Permeabilities of Aquaporins AQP4, AQP5, and GlpF from Near-Equilibrium Simulations. Biochim Biophys Acta (2017) 0.75
Aquaporin-4: A Potential Therapeutic Target for Cerebral Edema. Int J Mol Sci (2016) 0.75
Aquaporin-Targeted Therapeutics: State-of-the-Field. Adv Exp Med Biol (2017) 0.75
Morphologic evaluation of the inferior alveolar nerve in patients with sensory disorders by high-resolution 3D volume rendering magnetic resonance neurography on a 3.0-T system. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011) 1.56
Diacylglycerol kinase zeta inhibits G(alpha)q-induced atrial remodeling in transgenic mice. Heart Rhythm (2008) 1.54
Identification of renal transporters involved in sulfate excretion in marine teleost fish. Am J Physiol Regul Integr Comp Physiol (2009) 1.52
Analysis of ascending spinal tract degeneration in cervical spondylotic myelopathy using 3D anisotropy contrast single-shot echo planar imaging on a 3.0-T system. J Neurosurg Spine (2011) 1.47
Identification of arylsulfonamides as Aquaporin 4 inhibitors. Bioorg Med Chem Lett (2006) 1.41
Coerced training of the nondominant hand resulting in cortical reorganization: a high-field functional magnetic resonance imaging study. J Neurosurg (2004) 1.41
Absolute eigenvalue diffusion tensor analysis for human brain maturation. NMR Biomed (2003) 1.27
Abundant distribution of TARP gamma-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. Eur J Neurosci (2006) 1.24
Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish. Am J Physiol Regul Integr Comp Physiol (2008) 1.17
Aquaporins in drug discovery and pharmacotherapy. Mol Aspects Med (2012) 1.16
Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4, not by aquaporin-1: 17O JJVCPE MRI study in knockout mice. Neuroreport (2014) 1.15
In vivo visualization of senile-plaque-like pathology in Alzheimer's disease patients by MR microscopy on a 7T system. J Neuroimaging (2007) 1.14
Mutation of alpha1G T-type calcium channels in mice does not change anesthetic requirements for loss of the righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction. Anesthesiology (2007) 1.09
Inhibition of VEGF signaling pathway attenuates hemorrhage after tPA treatment. J Cereb Blood Flow Metab (2011) 1.07
Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice. Neurosci Res (2009) 1.06
Diffusion tensor analysis of peritumoral edema using lambda chart analysis indicative of the heterogeneity of the microstructure within edema. J Neurosurg (2005) 1.05
TARPs gamma-2 and gamma-7 are essential for AMPA receptor expression in the cerebellum. Eur J Neurosci (2010) 1.03
Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum. Proc Natl Acad Sci U S A (2011) 1.00
High-field, T2 reversed MRI of the hippocampus in transient global amnesia. Neurology (2005) 0.99
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Biochem J (2010) 0.95
Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg Med Chem (2008) 0.95
Flp recombinase transgenic mice of C57BL/6 strain for conditional gene targeting. Biochem Biophys Res Commun (2002) 0.94
Fast and precise independent component analysis for high field fMRI time series tailored using prior information on spatiotemporal structure. Hum Brain Mapp (2002) 0.94
Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I Kr and I Ks channel suppression in guinea pig ventricular myocytes. J Membr Biol (2008) 0.94
Cortical reorganization in patients with subcortical hemiparesis: neural mechanisms of functional recovery and prognostic implication. J Neurosurg (2003) 0.93
Dorsolateral prefrontal lobe activation declines significantly with age--functional NIRS study. J Neurol (2003) 0.93
NMO sera down-regulate AQP4 in human astrocyte and induce cytotoxicity independent of complement. J Neurol Sci (2013) 0.92
Brain developmental abnormalities in Prader-Willi syndrome detected by diffusion tensor imaging. Pediatrics (2006) 0.91
Human primary motor cortex shows hemispheric specialization for speech. Neuroreport (2006) 0.91
Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport (2013) 0.91
Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol Sci (2010) 0.90
Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure. J Exp Biol (2010) 0.90
Central auditory processing of noncontextual consonance in music: an evoked potential study. J Acoust Soc Am (2010) 0.89
Cortical processing of musical consonance: an evoked potential study. Neuroreport (2003) 0.89
Serial assessments of delayed encephalopathy after carbon monoxide poisoning using magnetic resonance spectroscopy and diffusion tensor imaging on 3.0T system. Eur Neurol (2007) 0.88
Biochemical and histopathological alterations in TAR DNA-binding protein-43 after acute ischemic stroke in rats. J Neurochem (2011) 0.87
Participation of primary motor cortex area 4a in complex sensory processing: 3.0-T fMRI study. Neuroreport (2009) 0.86
Ligand-based molecular MRI: O-17 JJVCPE amyloid imaging in transgenic mice. J Neuroimaging (2014) 0.86
Neural mechanisms underlying the orienting response to subject's own name: an event-related potential study. Psychophysiology (2012) 0.86
Molecular and functional characterization of adrenomedullin receptors in pufferfish. Am J Physiol Regul Integr Comp Physiol (2005) 0.86
Electrophysiological correlates of absolute pitch and relative pitch. Cereb Cortex (2004) 0.86
Increase in glutamate as a sensitive indicator of extracellular matrix integrity in peritumoral edema: a 3.0-tesla proton magnetic resonance spectroscopy study. J Neurosurg (2007) 0.86
Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system. Hypertension (2013) 0.85
Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes. Am J Physiol Heart Circ Physiol (2010) 0.85
Takifugu obscurus is a euryhaline fugu species very close to Takifugu rubripes and suitable for studying osmoregulation. BMC Physiol (2005) 0.85
Effects of musical training on the early auditory cortical representation of pitch transitions as indexed by change-N1. Eur J Neurosci (2012) 0.84
Diffusion tensor analysis in chronic schizophrenia. A preliminary study on a high-field (3.0T) system. Eur Arch Psychiatry Clin Neurosci (2005) 0.83
Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure. Circ J (2011) 0.82
Promising application of dynamic nuclear polarization for in vivo (13)C MR imaging. Magn Reson Med Sci (2011) 0.82
Assessment of axonal degeneration along the human visual pathway using diffusion trace analysis. Am J Ophthalmol (2006) 0.81
Electrophysiological correlates of grapheme-phoneme conversion. Neurosci Lett (2004) 0.80
Water influx into cerebrospinal fluid is significantly reduced in senile plaque bearing transgenic mice, supporting beta-amyloid clearance hypothesis of Alzheimer's disease. Neurol Res (2014) 0.80
Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis. Biochem Biophys Res Commun (2003) 0.80
Human brain detects short-time nonlinear predictability in the temporal fine structure of deterministic chaotic sounds. Phys Rev E Stat Nonlin Soft Matter Phys (2013) 0.80
High-resolution imaging with high and ultra high-field magnetic resonance imaging systems. Neuroreport (2008) 0.80
Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca²⁺ channel activity through phosphatases in heart failure. Am J Physiol Heart Circ Physiol (2012) 0.80
Effect of mild hypothermia on energy state recovery following transient forebrain ischemia in the gerbil. Exp Brain Res (2002) 0.80
Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges. Basic Clin Pharmacol Toxicol (2008) 0.79
Expression of a novel isoform of Na(+)/H(+) exchanger 3 in the kidney and intestine of banded houndshark, Triakis scyllium. Am J Physiol Regul Integr Comp Physiol (2013) 0.79
Neural substrates for visual pattern recognition learning in Igo. Brain Res (2008) 0.79
The primary motor area for voluntary diaphragmatic motion identified by high field fMRI. J Neurol (2004) 0.79
Evaluation of efficacy of an automated single-voxel proton MRS algorithm on a 3T system. Magn Reson Med Sci (2002) 0.78
Detectability of neural tracts and nuclei in the brainstem utilizing 3DAC-PROPELLER. J Neuroimaging (2013) 0.78
Tract-by-tract morphometric and diffusivity analyses in vivo of spinocerebellar degeneration. J Neuroimaging (2008) 0.78
Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice. PLoS One (2012) 0.78
Ear advantage and consonance of dichotic pitch intervals in absolute-pitch possessors. Brain Cogn (2003) 0.78
Three-dimensional anisotropy contrast periodically rotated overlapping parallel lines with enhanced reconstruction (3DAC PROPELLER) on a 3.0T system: a new modality for routine clinical neuroimaging. J Neuroimaging (2006) 0.77
Development of a Novel Ligand, [C]TGN-020, for Aquaporin 4 Positron Emission Tomography Imaging. ACS Chem Neurosci (2011) 0.77
Functional asymmetry in primary auditory cortex for processing musical sounds: temporal pattern analysis of fMRI time series. Neuroreport (2011) 0.77
N-acetylaspartate decrease in acute stage of ischemic stroke: a perspective from experimental and clinical studies. Magn Reson Med Sci (2014) 0.77
Natural preference in luminosity for frame composition. Neuroreport (2007) 0.77
Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in langendorff-perfused guinea-pig hearts. Biol Pharm Bull (2014) 0.77
Expansion of sensorimotor cortical activation for unilateral hand motion during contralateral hand deafferentation. Neuroreport (2014) 0.77