Prophylactic but not therapeutic activity of a monoclonal antibody that neutralizes the binding of VEGF-B to VEGFR-1 in a murine collagen-induced arthritis model.

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Published in Rheumatology (Oxford) on January 19, 2008

Authors

A W Mould1, P Scotney, S A Greco, N K Hayward, A Nash, G F Kay

Author Affiliations

1: QCF Transgenic Laboratory, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Queensland 4029, Australia. arne.mould@qimr.edu.au

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Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature (1985) 9.62

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A phase II study in advanced gastro-esophageal cancer using epirubicin and cisplatin in combination with continuous infusion 5-fluorouracil (ECF). Ann Oncol (1994) 2.02

Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells. J Cell Sci (1996) 1.99

A Taq I polymorphism for the human transforming growth factor alpha gene (TGFA). Nucleic Acids Res (1987) 1.88

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Genome scan of schizophrenia. Am J Psychiatry (1998) 1.74

Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ Res (2000) 1.72

Distinct methylation of the interferon gamma (IFN-gamma) and interleukin 3 (IL-3) genes in newly activated primary CD8+ T lymphocytes: regional IFN-gamma promoter demethylation and mRNA expression are heritable in CD44(high)CD8+ T cells. J Exp Med (1998) 1.71

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Leptin and the risk of Barrett's oesophagus. Gut (2008) 1.54

DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer. Oncogene (2009) 1.53

The CDKN2A (p16) gene and human cancer. Mol Med (1997) 1.46

Gene expression of lung squamous cell carcinoma reflects mode of lymph node involvement. Eur Respir J (2007) 1.43

Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev Biol (1998) 1.41

Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma. Am J Pathol (1996) 1.36

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Bisulfite genomic sequencing-derived methylation profile of the xist gene throughout early mouse development. Genomics (1998) 1.24

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Suckling defect in mice lacking the soluble haemopoietin receptor NR6. Curr Biol (1999) 1.09

Autocrine mitogen IgEGF cooperates with c-myc or with the Hcs locus during hepatocarcinogenesis in transgenic mice. Oncogene (1995) 1.08

Lobular carcinoma in situ of the breast is not caused by constitutional mutations in the E-cadherin gene. Br J Cancer (2000) 1.07

CDKN2A/p16 is inactivated in most melanoma cell lines. Cancer Res (1997) 1.07

X-linked aqueductal stenosis: clinical and neuropathological findings in two families. Pediatrics (1973) 1.06

Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia. Mol Psychiatry (2005) 1.04

Re-excision operations in nonpalpable breast cancer. J Surg Oncol (1995) 1.04

Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study. J Natl Cancer Inst (2010) 1.04

Evidence for three tumor suppressor loci on chromosome 9p involved in melanoma development. Cancer Res (2001) 1.03

Methylation analysis using bisulfite genomic sequencing: application to small numbers of intact cells. Biotechniques (1997) 1.02

Analysis of gene amplification in head-and-neck squamous-cell carcinoma. Int J Cancer (1991) 1.00

Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome. Hum Mol Genet (1999) 0.98

Second stage of a genome scan of schizophrenia: study of five positive regions in an expanded sample. Am J Med Genet (2000) 0.98

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Functional reassessment of P16 variants using a transfection-based assay. Int J Cancer (1999) 0.97

Effects of prenatal dexamethasone on spatial learning and response to stress is influenced by maternal factors. Am J Physiol Regul Integr Comp Physiol (2000) 0.96

Hepatocellular carcinoma mutation. Nature (1991) 0.95

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A genetic model of melanoma tumorigenesis based on allelic losses. Genes Chromosomes Cancer (1995) 0.93

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The nature of conditioning nutrients for human malignant melanoma cultures. J Cell Sci (1983) 0.89

Evidence for u.v. induction of CDKN2 mutations in melanoma cell lines. Oncogene (1995) 0.89

Ferricyanide can replace pyruvate to stimulate growth and attachment of serum restricted human melanoma cells. Biochem Biophys Res Commun (1983) 0.89

The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours. Hum Mol Genet (1994) 0.88

Loss of p16 expression is associated with histological features of melanoma invasion. Melanoma Res (2002) 0.88

PTEN inactivation is rare in melanoma tumours but occurs frequently in melanoma cell lines. Melanoma Res (2002) 0.87

p53 gene in hepatocellular carcinomas from Australia. Cancer Detect Prev (1994) 0.86

Clonal loss of INT-2 alleles in sporadic and familial pancreatic endocrine tumours. Br J Cancer (1990) 0.86

Simple tandem repeat allelic deletions confirm the preferential loss of distal chromosome 6q in melanoma. Int J Cancer (1994) 0.86

Multiple splicing variants of cdc25B regulate G2/M progression. Biochem Biophys Res Commun (1999) 0.86

CDKN2A is not the principal target of deletions on the short arm of chromosome 9 in neuroendocrine (Merkel cell) carcinoma of the skin. Int J Cancer (2001) 0.86

Loss of somatic heterozygosity in hepatocellular carcinoma. Cancer Res (1991) 0.86

Interaction between Six-month-old peers. Child Dev (1983) 0.85

Evidence for microsatellite instability in bilateral breast carcinomas. Cancer Lett (2000) 0.85

CDKN2A mutation in a non-FAMMM kindred with cancers at multiple sites results in a functionally abnormal protein. Int J Cancer (1997) 0.85

Linkage mapping of melanoma (MLM) using 172 microsatellite markers. Genomics (1992) 0.85

Bicalutamide: a new antiandrogen for use in combination with castration for patients with advanced prostate cancer. Anticancer Drugs (1996) 0.85

Responses of six-month-olds to the distress of their peers. Child Dev (1981) 0.84

Single base mutation in the hormone binding domain of the thyroid hormone receptor beta gene in generalised thyroid hormone resistance demonstrated by single stranded conformation polymorphism analysis. Biochem Biophys Res Commun (1991) 0.83

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Lack of augmentation of tumor spectrum or severity in dual heterozygous Men1 and Rb1 knockout mice. Oncogene (2006) 0.83

Molecular tools for presymptomatic testing in multiple endocrine neoplasia type 1. J Intern Med (1995) 0.82

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Origin of rare Ha-ras alleles: relationship of VTR length to a 5' polymorphic Xho I site. Genet Res (1989) 0.81

Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis. Br J Pharmacol (2013) 0.81

A cluster of cases of feline dysautonomia (Key-Gaskell syndrome) in a closed colony of cats. Vet Rec (1995) 0.80

Loss of heterozygosity studies in squamous cell carcinomas of the head and neck. Head Neck (1997) 0.80

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Contribution of germline MLH1 and MSH2 mutations to lobular carcinoma in situ of the breast. Cancer Lett (2001) 0.79

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Catering services. Measuring the wasteline. Health Serv J (1997) 0.78

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Determining factors which predict response to primary medical therapy in breast cancer using a single fine needle aspirate with immunocytochemical staining and flow cytometry. Virchows Arch (1995) 0.78

Effect of N-hydroxyparacetamol on cell cycle progression. Biochem Pharmacol (1986) 0.78

Oncology: the role of the Macmillan nurse. Nurs Stand (1991) 0.78

Bicalutamide dosages used in the treatment of prostate cancer. Prostate (1999) 0.78

Adjuvant aminoglutethimide for postmenopausal patients with primary breast cancer: analysis at 8 years. J Clin Oncol (1992) 0.77

UV induction of transforming growth factor alpha in melanoma cell lines is a posttranslational event. J Cell Physiol (1992) 0.77

Injectable silicone implants as vaccine delivery vehicles. Vaccine (2002) 0.77

Refined localization of the melanoma (MLM) gene on chromosome 9p by analysis of allelic deletions. Oncogene (1994) 0.77

Cost effectiveness of statin therapy for the primary prevention of coronary heart disease. Ir Med J (2006) 0.76