Published in Pharmacol Ther on December 01, 1991
Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal (2009) 2.28
Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes. Mol Syst Biol (2008) 2.17
Glutathione homeostasis and functions: potential targets for medical interventions. J Amino Acids (2012) 1.77
Urolithiasis and hepatotoxicity are linked to the anion transporter Sat1 in mice. J Clin Invest (2010) 1.38
Alkylation damage by lipid electrophiles targets functional protein systems. Mol Cell Proteomics (2014) 1.13
Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice. Am J Physiol Gastrointest Liver Physiol (2009) 1.07
Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Curr Gerontol Geriatr Res (2011) 1.01
Azathioprine pharmacokinetics after intravenous, oral, delayed release oral and rectal foam administration. Gut (1996) 0.93
Effects of Low-Dose versus High-Dose γ-Tocotrienol on the Bone Cells Exposed to the Hydrogen Peroxide-Induced Oxidative Stress and Apoptosis. Evid Based Complement Alternat Med (2012) 0.88
Free Radical-Scavenging, Anti-Inflammatory/Anti-Fibrotic and Hepatoprotective Actions of Taurine and Silymarin against CCl4 Induced Rat Liver Damage. PLoS One (2015) 0.88
Thiol regulation of endotoxin-induced release of tumour necrosis factor alpha from isolated rat Kupffer cells. Biochem J (1996) 0.87
Glutathione deficiency down-regulates hepatic lipogenesis in rats. Lipids Health Dis (2010) 0.86
N-3 long-chain polyunsaturated fatty acid supplementation significantly reduces liver oxidative stress in high fat induced steatosis. PLoS One (2012) 0.85
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants. Int J Mol Sci (2015) 0.84
Hepatic glutathione and glutathione S-conjugate transport mechanisms. Yale J Biol Med (1998) 0.84
Design of an in vivo cleavable disulfide linker in recombinant fusion proteins. Biotechniques (2010) 0.83
Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity. Int Rev Cell Mol Biol (2015) 0.83
Glutathione S-transferase class μ regulation of apoptosis signal-regulating kinase 1 protein during VCD-induced ovotoxicity in neonatal rat ovaries. Toxicol Appl Pharmacol (2012) 0.82
Metabolomics changes in a rat model of obstructive jaundice: mapping to metabolism of amino acids, carbohydrates and lipids as well as oxidative stress. J Clin Biochem Nutr (2015) 0.80
Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism in rats. Gut (2002) 0.79
Contaminant-induced oxidative stress in fish: a mechanistic approach. Fish Physiol Biochem (2015) 0.79
Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB. Biochem Pharmacol (2010) 0.78
Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke. Sci Rep (2015) 0.78
The effect of IFNgamma on the hepatocyte: cell cycle and apoptosis. Int J Exp Pathol (2001) 0.78
Hepatoprotective effects of hoveniae semen cum fructus extracts in ethanol intoxicated mice. J Exerc Nutrition Biochem (2016) 0.77
Antioxidant Activity of Tocotrienol Rich Fraction Prevents Fenitrothion-induced Renal Damage in Rats. J Toxicol Pathol (2013) 0.77
Effect of probiotic supplementation on bacterial translocation in common bile duct obstruction. Pediatr Surg Int (2014) 0.77
Gene expression profiles of colonic mucosa in healthy young adult and senior dogs. PLoS One (2010) 0.77
Oxidative stress and antioxidant responses of liver and kidney tissue after implantation of titanium or titanium oxide coated plate in rat tibiae. J Mater Sci Mater Med (2012) 0.77
Specific effects of reactive thiol drugs on mitochondrial bioenergetics. J Bioenerg Biomembr (2011) 0.77
Bioreducible polycations as shuttles for therapeutic nucleic acid and protein transfection. Antioxid Redox Signal (2014) 0.76
Glutathione metabolism in Candida albicans resistant strains to fluconazole and micafungin. PLoS One (2014) 0.76
Cadmium-mediated activation of the HSP90/HSF1 pathway regulated by reactive persulfides/polysulfides. Toxicol Sci (2017) 0.75
Downregulation of Glutathione Biosynthesis Contributes to Oxidative Stress and Liver Dysfunction in Acute Kidney Injury. Oxid Med Cell Longev (2016) 0.75
TAMH: A Useful In Vitro Model for Assessing Hepatotoxic Mechanisms. Biomed Res Int (2016) 0.75
Effects of urban land-use on largescale stonerollers in the Mobile River Basin, Birmingham, AL. Ecotoxicology (2016) 0.75
Experimental colitis and malnutrition differentially affect the metabolism of glutathione and related sulfhydryl metabolites in different tissues. Eur J Nutr (2015) 0.75
Intestinal anti-inflammatory activity of Ground Cherry (Physalis angulata L.) standardized CO2 phytopharmaceutical preparation. World J Gastroenterol (2017) 0.75
Inhibition of the Mitochondrial Glutamate Carrier SLC25A22 in Astrocytes Leads to Intracellular Glutamate Accumulation. Front Cell Neurosci (2017) 0.75
Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology (1982) 11.24
Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther (2011) 2.50
Postprandial serum bile acid for the detection of hepatobiliary disease. JAMA (1973) 2.23
The regulation of hepatic glutathione. Annu Rev Pharmacol Toxicol (1985) 1.84
A serologic follow-up of the 1942 epidemic of post-vaccination hepatitis in the United States Army. N Engl J Med (1987) 1.61
Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology (1998) 1.52
GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am J Physiol (1997) 1.42
Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology (1995) 1.35
Diagnosis, management and prevention of drug-induced liver injury. Gut (2009) 1.34
Drug induction of hepatic glutathione S-transferases in male and female rats*. Biochem J (1975) 1.34
Drug-induced hepatotoxicity. Ann Intern Med (1986) 1.33
The use of monochlorobimane to determine hepatic GSH levels and synthesis. Anal Biochem (1990) 1.29
Role of the liver in interorgan homeostasis of glutathione and cyst(e)ine. Semin Liver Dis (1998) 1.27
Sinusoidal efflux of glutathione in the perfused rat liver. Evidence for a carrier-mediated process. J Clin Invest (1985) 1.26
Liver histopathology in chronic common bile duct stenosis due to chronic alcoholic pancreatitis. Hepatology (1981) 1.23
Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J Clin Invest (1994) 1.22
Mitochondrial glutathione depletion in alcoholic liver disease. Alcohol (1994) 1.20
Contribution of no-reflow phenomenon to hepatic injury after ischemia-reperfusion: evidence for a role for superoxide anion. Hepatology (1992) 1.19
Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Invest (1991) 1.18
Role of hepatic anion-binding protein in bromsulphthalein conjugation. J Exp Med (1973) 1.17
Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease. Hepatology (1996) 1.17
Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats. J Biol Chem (1992) 1.16
Rapid oxidation in vitro of endogenous and exogenous glutathione in bile of rats. J Biol Chem (1981) 1.16
Pruritus, cimetidine, and polycythemia. N Engl J Med (1979) 1.16
Hormone-mediated down-regulation of hepatic glutathione synthesis in the rat. J Clin Invest (1991) 1.14
Recurrent drug-induced liver injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis. J Hepatol (2011) 1.14
Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol (1997) 1.13
Mitochondrial glutathione: importance and transport. Semin Liver Dis (1998) 1.13
Common bile duct stenosis from chronic pancreatitis: a clinical and pathologic spectrum. Medicine (Baltimore) (1979) 1.11
Newly identified bile acid binders in rat liver cytosol. Purification and comparison with glutathione S-transferases. J Biol Chem (1983) 1.11
Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine. Hepatology (1997) 1.11
How is the liver primed or sensitized for alcoholic liver disease? Alcohol Clin Exp Res (2001) 1.09
Causality assessment versus guilt-by-association in drug hepatotoxicity. Hepatology (2001) 1.05
Physiological significance of glutathione S-transferases. Am J Physiol (1980) 1.04
Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo. J Clin Invest (1992) 1.04
Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology (1992) 1.03
Bidirectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles. J Biol Chem (1992) 1.03
Factors influencing the efflux of hepatic glutathione into bile in rats. J Pharmacol Exp Ther (1983) 1.03
Inhibition of glutathione efflux from isolated rat hepatocytes by methionine. J Biol Chem (1984) 1.01
Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux, and response to incubation with ethanol. J Clin Invest (1987) 1.00
Oxidative stress and alcoholic liver disease. Alcohol Health Res World (1997) 0.99
Hormonal regulation of glutathione efflux. J Biol Chem (1990) 0.98
Obstructive jaundice caused by hepatocellular carcinoma. Report of three cases. Am J Dig Dis (1978) 0.98
3 alpha-hydroxysteroid dehydrogenase activity of the Y' bile acid binders in rat liver cytosol. Identification, kinetics, and physiologic significance. J Clin Invest (1987) 0.97
Changes in glutathione homeostasis during liver regeneration in the rat. Hepatology (1998) 0.97
Mechanism of inhibition of glutathione efflux by methionine from isolated rat hepatocytes. Am J Physiol (1986) 0.97
The role of cytoplasmic proteins in hepatic bile acid transport. Annu Rev Physiol (1989) 0.97
Importance and regulation of hepatic glutathione. Semin Liver Dis (1990) 0.97
Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat. J Clin Invest (1990) 0.96
Role of glutathione in gastric mucosal cytoprotection. Am J Physiol (1984) 0.95
Binding of bile acids, oleic acid, and organic anions by rat and human hepatic Z protein. Arch Biochem Biophys (1986) 0.95
Comparison of renal and hepatic glutathione S-transferases in the rat. Biochem J (1976) 0.95
Gamma-glutamylcysteine: a substrate for glutathione S-transferases. Biochem Pharmacol (1985) 0.93
Expression of rat liver reduced glutathione transport in Xenopus laevis oocytes. J Biol Chem (1993) 0.93
Kinetics of glutathione efflux from isolated rat hepatocytes. Am J Physiol (1986) 0.93
Colchicine protects mice from the lethal effect of an agonistic anti-Fas antibody. J Clin Invest (2000) 0.92
GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC. Brain Res (2000) 0.92
Evidence for a common high affinity binding site on glutathione S-transferase B for lithocholic acid and bilirubin. J Lipid Res (1984) 0.92
Drug induction and sex differences of renal glutathione S-transferases in the rat. Biochem J (1975) 0.91
Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione. Hepatology (2001) 0.91
Neutrophil accumulation in ischemic reperfused rat liver: evidence for a role for superoxide free radicals. Am J Physiol (1992) 0.91
Hepatic glutathione S-transferases: identification by gel filtration and in vitro inhibition by organic anions. Proc Soc Exp Biol Med (1975) 0.90
Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol. J Lipid Res (1992) 0.90
Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione. Expression studies in Xenopus laevis oocytes. J Biol Chem (1995) 0.90
Estimation of glutathione in rat liver by reversed-phase high-performance liquid chromatography: separation from cysteine and gamma-glutamylcysteine. J Chromatogr (1980) 0.89
Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes. Am J Physiol (1988) 0.89
Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters. Toxicol Appl Pharmacol (1995) 0.89
Expression cloning of a rat hepatic reduced glutathione transporter with canalicular characteristics. J Clin Invest (1994) 0.88
Binding of ethacrynic acid to hepatic glutathione S-transferases in vivo in the rat. Biochem Pharmacol (1980) 0.88
Glutathione-dependent thyroxine 5'-monodeiodination modulates growth hormone production by cultured nonthyrotropic rat pituitary cells. Endocrinology (1981) 0.88
Selective induction by phenobarbital of the electrogenic transport of glutathione and organic anions in rat liver canalicular membrane vesicles. J Biol Chem (1993) 0.88
Relationship between the newly identified bile acid binder and bile acid oxidoreductases in human liver. J Biol Chem (1990) 0.88
Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubin. Kinetics, sidedness, and molecular forms. J Clin Invest (1988) 0.88
Disease-specific amino acid infusion (F080) in hepatic encephalopathy: a prospective, randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr (1985) 0.88
Comparison of the binding affinities of five forms of rat glutathione S-transferases for bilirubin, sulfobromophthalein and hematin. Biochem Pharmacol (1984) 0.88
Identification and partial purification of a unique phenolic steroid sulphotransferase in rat liver cytosol. Biochem J (1984) 0.87
Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: characteristics and comparison with the canalicular transporter. Proc Natl Acad Sci U S A (1995) 0.86
Binding of bile acids by glutathione S-transferases from rat liver. J Lipid Res (1986) 0.86
Effects of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration. J Clin Invest (1989) 0.85
Effect of salicylates and phenobarbital on hepatic glutathione in the rat. J Pharmacol Exp Ther (1980) 0.85
Newly identified organic anion-binding proteins in rat liver cytosol. Biochim Biophys Acta (1982) 0.85
The glutathione S-transferases of the small intestine in the rat. Cancer Res (1977) 0.85
Significance of microscopic cholangitis in alcoholic liver disease. Gastroenterology (1978) 0.84
Transport of glutathione at blood-brain barrier of the rat: inhibition by glutathione analogs and age-dependence. J Pharmacol Exp Ther (1992) 0.84
Molecular characterization of a reduced glutathione transporter in the lens. Invest Ophthalmol Vis Sci (1995) 0.84
Mechanisms of drug-induced liver disease. Gastroenterol Clin North Am (1995) 0.83
Inhibition of rat sinusoidal GSH transporter by thioethers: specificity, sidedness, and kinetics. Am J Physiol (1996) 0.83
Bidirectional membrane transport of intact glutathione in Hep G2 cells. Am J Physiol (1993) 0.83
Interaction of azathioprine and glutathione in the liver of the rat. J Pharmacol Exp Ther (1977) 0.83
Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain. Biochem Biophys Res Commun (1994) 0.83
Hepatotoxicity of psychotropic drugs. Hepatology (1999) 0.83
Hepatobiliary diseases associated with serum antimitochondrial antibody (AMA). Am J Med (1973) 0.83
Glutathione S-transferases in elasmobranch liver. Molecular heterogeneity, catalytic and binding properties, and purification. Biochem J (1981) 0.83
Regulation of GSH in alphaA-expressing human lens epithelial cell lines and in alphaA knockout mouse lenses. Invest Ophthalmol Vis Sci (2001) 0.82
Trans-stimulation and driving forces for GSH transport in sinusoidal membrane vesicles from rat liver. Biochem Biophys Res Commun (1987) 0.82
Cytosolic bile acid binding protein in rat liver: radioimmunoassay, molecular forms, developmental characteristics and organ distribution. Hepatology (1986) 0.82
Plasma membrane and mitochondrial transport of hepatic reduced glutathione. Semin Liver Dis (1996) 0.82
Comparison of the affinities of newly identified human bile acid binder and cationic glutathione S-transferase for bile acids. J Lipid Res (1986) 0.82