Why chronic wounds will not heal: a novel hypothesis.

PubWeight™: 2.58‹?› | Rank: Top 1%

🔗 View Article (PMID 18211573)

Published in Wound Repair Regen on January 23, 2008

Authors

Thomas Bjarnsholt1, Klaus Kirketerp-Møller, Peter Østrup Jensen, Kit G Madsen, Richard Phipps, Karen Krogfelt, Niels Høiby, Michael Givskov

Author Affiliations

1: Bioscience and Technology, Bldg 227 BioCentrum, Technical University of Denmark, Lyngby, Denmark.

Articles citing this

Factors affecting wound healing. J Dent Res (2010) 5.67

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest (2011) 3.69

Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP). PLoS One (2008) 2.87

Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis. J Bacteriol (2010) 2.11

Distribution, organization, and ecology of bacteria in chronic wounds. J Clin Microbiol (2008) 2.05

Alternative mating type configurations (a/α versus a/a or α/α) of Candida albicans result in alternative biofilms regulated by different pathways. PLoS Biol (2011) 1.84

Applying insights from biofilm biology to drug development - can a new approach be developed? Nat Rev Drug Discov (2013) 1.82

Anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles. Biomaterials (2009) 1.58

Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds. J Clin Microbiol (2009) 1.55

Evaluation of the bacterial diversity among and within individual venous leg ulcers using bacterial tag-encoded FLX and titanium amplicon pyrosequencing and metagenomic approaches. BMC Microbiol (2009) 1.45

A comparison of bacterial composition in diabetic ulcers and contralateral intact skin. Open Microbiol J (2010) 1.39

Biofilm formation by clinical isolates and the implications in chronic infections. BMC Infect Dis (2013) 1.30

Evaluation of the bacterial diversity of pressure ulcers using bTEFAP pyrosequencing. BMC Med Genomics (2010) 1.28

Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antimicrob Agents Chemother (2012) 1.23

The microbiome in wound repair and tissue fibrosis. J Pathol (2012) 1.18

From in vitro to in vivo Models of Bacterial Biofilm-Related Infections. Pathogens (2013) 1.15

Pseudomonas aeruginosa biofilms perturb wound resolution and antibiotic tolerance in diabetic mice. Med Microbiol Immunol (2012) 1.12

Loss of viability and induction of apoptosis in human keratinocytes exposed to Staphylococcus aureus biofilms in vitro. Wound Repair Regen (2009) 1.09

Reactive oxygen species mediated bacterial biofilm inhibition via zinc oxide nanoparticles and their statistical determination. PLoS One (2014) 1.04

Synergistic interactions of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro wound model. Infect Immun (2014) 1.04

The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms. Biomed Res Int (2015) 1.02

Identification of anti-virulence compounds that disrupt quorum-sensing regulated acute and persistent pathogenicity. PLoS Pathog (2014) 0.97

D-amino acids enhance the activity of antimicrobials against biofilms of clinical wound isolates of Staphylococcus aureus and Pseudomonas aeruginosa. Antimicrob Agents Chemother (2014) 0.97

Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response. PLoS One (2014) 0.97

Synergistic combination of chitosan acetate with nanoparticle silver as a topical antimicrobial: efficacy against bacterial burn infections. Antimicrob Agents Chemother (2011) 0.94

Insulin treatment modulates the host immune system to enhance Pseudomonas aeruginosa wound biofilms. Infect Immun (2013) 0.94

Prevalence of Multiple Antibiotic Resistant Infections in Diabetic versus Nondiabetic Wounds. J Pathog (2014) 0.94

Antimicrobial efficacy of two surface barrier discharges with air plasma against in vitro biofilms. PLoS One (2013) 0.93

Gene expression profile and pathogenicity of biofilm-forming Prevotella intermedia strain 17. BMC Microbiol (2009) 0.93

Testing wound dressings using an in vitro wound model. J Wound Care (2010) 0.93

Tryptophan inhibits biofilm formation by Pseudomonas aeruginosa. Antimicrob Agents Chemother (2013) 0.92

Time course study of delayed wound healing in a biofilm-challenged diabetic mouse model. Wound Repair Regen (2012) 0.91

Modulating endogenous electric currents in human corneal wounds--a novel approach of bioelectric stimulation without electrodes. Cornea (2011) 0.91

Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study. PLoS One (2011) 0.91

Topical photodynamic treatment with poly-L-lysine-chlorin p6 conjugate improves wound healing by reducing hyperinflammatory response in Pseudomonas aeruginosa-infected wounds of mice. Lasers Med Sci (2012) 0.90

Mini-review: Lactoferrin: a bioinspired, anti-biofilm therapeutic. Biofouling (2013) 0.88

Magnetic nanoparticle targeted hyperthermia of cutaneous Staphylococcus aureus infection. Ann Biomed Eng (2012) 0.87

Dual action antimicrobials: nitric oxide release from quaternary ammonium-functionalized silica nanoparticles. Biomacromolecules (2012) 0.87

Activity of imipenem against Klebsiella pneumoniae biofilms in vitro and in vivo. Antimicrob Agents Chemother (2013) 0.86

Comparison of the virulence of exopolysaccharide-producing Prevotella intermedia to exopolysaccharide non-producing periodontopathic organisms. BMC Infect Dis (2011) 0.86

Proteomic and genomic analysis of methicillin-resistant Staphylococcus aureus (MRSA) exposed to manuka honey in vitro demonstrated down-regulation of virulence markers. J Antimicrob Chemother (2013) 0.86

Generating and reversing chronic wounds in diabetic mice by manipulating wound redox parameters. J Diabetes Res (2014) 0.86

Repeated applications of cold atmospheric pressure plasma does not induce resistance in Staphylococcus aureus embedded in biofilms. GMS Hyg Infect Control (2014) 0.86

Quorum-sensing-regulated virulence factors in Pseudomonas aeruginosa are toxic to Lucilia sericata maggots. Microbiology (2009) 0.85

Ionic liquids as a class of materials for transdermal delivery and pathogen neutralization. Proc Natl Acad Sci U S A (2014) 0.84

Staphylococcus aureus induces hypoxia and cellular damage in porcine dermal explants. Infect Immun (2015) 0.84

Biofilm delays wound healing: A review of the evidence. Burns Trauma (2013) 0.83

Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing. Sci Rep (2015) 0.82

Clinical Biofilms: A Challenging Frontier in Wound Care. Adv Wound Care (New Rochelle) (2015) 0.82

The pvc operon regulates the expression of the Pseudomonas aeruginosa fimbrial chaperone/usher pathway (cup) genes. PLoS One (2013) 0.81

Transient and sustained bacterial adaptation following repeated sublethal exposure to microbicides and a novel human antimicrobial peptide. Antimicrob Agents Chemother (2014) 0.81

Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin. Endocrinology (2014) 0.81

Dermal wound transcriptomic responses to Infection with Pseudomonas aeruginosa versus Klebsiella pneumoniae in a rabbit ear wound model. BMC Clin Pathol (2014) 0.81

Flagellum-mediated biofilm defense mechanisms of Pseudomonas aeruginosa against host-derived lactoferrin. Infect Immun (2009) 0.81

Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interface. Sci Rep (2015) 0.80

Evaluation of conventional therapeutic methods versus maggot therapy in the evolution of healing of tegumental injuries in Wistar rats with and without diabetes mellitus. Parasitol Res (2016) 0.80

The immunomodulatory activity of Staphylococcus aureus products derived from biofilm and planktonic cultures. Arch Immunol Ther Exp (Warsz) (2013) 0.79

Silver oxynitrate, an unexplored silver compound with antimicrobial and antibiofilm activity. Antimicrob Agents Chemother (2015) 0.79

Prevention and treatment of Staphylococcus aureus biofilms. Expert Rev Anti Infect Ther (2015) 0.79

Pseudomonas aeruginosa uses T3SS to inhibit diabetic wound healing. Wound Repair Regen (2015) 0.78

Wound biofilms: lessons learned from oral biofilms. Wound Repair Regen (2013) 0.78

Biofilms and Wounds: An Overview of the Evidence. Adv Wound Care (New Rochelle) (2015) 0.77

Gallium-Loaded Dissolvable Microfilm Constructs that Provide Sustained Release of Ga(3+) for Management of Biofilms. Adv Healthc Mater (2015) 0.76

Compromised Wound Healing in Ischemic Type 2 Diabetic Rats. PLoS One (2016) 0.76

Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages. Sci Rep (2016) 0.76

Extracellular Bacterial Proteases in Chronic Wounds: A Potential Therapeutic Target? Adv Wound Care (New Rochelle) (2016) 0.76

Lactobacillus rhamnosus GG Lysate Increases Re-Epithelialization of Keratinocyte Scratch Assays by Promoting Migration. Sci Rep (2015) 0.76

Selective Antibiofilm Effects of Lucilia sericata Larvae Secretions/Excretions against Wound Pathogens. Evid Based Complement Alternat Med (2014) 0.76

Staphylococcus aureus Toxins and Diabetic Foot Ulcers: Role in Pathogenesis and Interest in Diagnosis. Toxins (Basel) (2016) 0.76

Global regulator Anr represses PlcH phospholipase activity in Pseudomonas aeruginosa when oxygen is limiting. Microbiology (2014) 0.76

Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation. Biochim Biophys Acta (2016) 0.75

Pyocyanin production by Pseudomonas aeruginosa confers resistance to ionic silver. Antimicrob Agents Chemother (2014) 0.75

Growth of MRSA and Pseudomonas aeruginosa in a fine-celled foam model containing sessile commensal skin bacteria. Biofouling (2016) 0.75

Phage Inhibit Pathogen Dissemination by Targeting Bacterial Migrants in a Chronic Infection Model. MBio (2017) 0.75

Wound-healing Activity of the Aqueous Leaf Extract and Fractions of Ficus exasperata (Moraceae) and its Safety Evaluation on Albino Rats. J Tradit Complement Med (2014) 0.75

The phagocytic fitness of leucopatches may impact the healing of chronic wounds. Clin Exp Immunol (2016) 0.75

Nanoparticle-Based Therapies for Wound Biofilm Infection: Opportunities and Challenges. IEEE Trans Nanobioscience (2016) 0.75

Functional Regulation of the Plasma Protein Histidine-Rich Glycoprotein by Zn(2+) in Settings of Tissue Injury. Biomolecules (2017) 0.75

Chronic Wounds in Burn Injury: A Case Report on Importance of Biofilms. World J Plast Surg (2016) 0.75

Purification and synergistic antibacterial activity of arginine derived cyclic dipeptides, from Achromobacter sp. associated with a rhabditid entomopathogenic nematode against major clinically relevant biofilm forming wound bacteria. Front Microbiol (2015) 0.75

Modulation of inflammatory response of wounds by antimicrobial photodynamic therapy. Laser Ther (2015) 0.75

Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome. MBio (2016) 0.75

Biofilm Formation Mechanisms of Pseudomonas aeruginosa Predicted via Genome-Scale Kinetic Models of Bacterial Metabolism. PLoS Comput Biol (2015) 0.75

Reactive oxygen species and bacterial biofilms in diabetic wound healing. Physiol Genomics (2016) 0.75

Effect on Microbial Growth of a New Skin Protectant Formulation. Adv Wound Care (New Rochelle) (2017) 0.75

One step closer to understanding the role of bacteria in diabetic foot ulcers: characterising the microbiome of ulcers. BMC Microbiol (2016) 0.75

A Formidable Foe Is Sabotaging Your Results: What You Should Know about Biofilms and Wound Healing. Plast Reconstr Surg (2017) 0.75

Early application of negative pressure wound therapy to acute wounds contaminated with Staphylococcus aureus: An effective approach to preventing biofilm formation. Exp Ther Med (2016) 0.75

Vitamin C Pretreatment Enhances the Antibacterial Effect of Cold Atmospheric Plasma. Front Cell Infect Microbiol (2017) 0.75

Sound waves effectively assist tobramycin in elimination of Pseudomonas aeruginosa biofilms in vitro. AAPS PharmSciTech (2014) 0.75

Activity of Norspermidine on Bacterial Biofilms of Multidrug-Resistant Clinical Isolates Associated with Persistent Extremity Wound Infections. Adv Exp Med Biol (2016) 0.75

Comparing the Effectiveness of Polymer Debriding Devices Using a Porcine Wound Biofilm Model. Adv Wound Care (New Rochelle) (2016) 0.75

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections. Drug Des Devel Ther (2017) 0.75

Modeling and Re-Engineering of Azotobacter vinelandii Alginate Lyase to Enhance Its Catalytic Efficiency for Accelerating Biofilm Degradation. PLoS One (2016) 0.75

Immune Modulating Topical S100A8/A9 Inhibits Growth of Pseudomonas aeruginosa and Mitigates Biofilm Infection in Chronic Wounds. Int J Mol Sci (2017) 0.75

The role of chloramines in treatment of diabetic foot ulcers: an exploratory multicentre randomised controlled trial. Clin Diabetes Endocrinol (2016) 0.75

Molecular Aspects of Wound Healing and the Rise of Venous Leg Ulceration: Omics Approaches to Enhance Knowledge and Aid Diagnostic Discovery. Clin Biochem Rev (2017) 0.75

Evolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production. NPJ Biofilms Microbiomes (2017) 0.75

Immune-Mediated Repair: A Matter of Plasticity. Front Immunol (2017) 0.75

Articles by these authors

Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J (2003) 5.78

Antibiotic resistance of bacterial biofilms. Int J Antimicrob Agents (2010) 5.18

A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms. Mol Microbiol (2006) 4.49

Cell death in Pseudomonas aeruginosa biofilm development. J Bacteriol (2003) 3.74

Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology (2002) 3.37

OXA-type carbapenemases. J Antimicrob Chemother (2006) 3.15

The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional. Mol Microbiol (2006) 2.94

Evolutionary dynamics of bacteria in a human host environment. Proc Natl Acad Sci U S A (2011) 2.75

Class A carbapenemases. J Antimicrob Chemother (2007) 2.72

Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood (2006) 2.71

Quorum-sensing inhibitors as anti-pathogenic drugs. Int J Med Microbiol (2006) 2.68

Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. J Clin Invest (2003) 2.54

Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients. Pediatr Pulmonol (2009) 2.53

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective. Nat Rev Microbiol (2012) 2.50

Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover. Microbiology (2002) 2.41

Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms. Environ Microbiol (2008) 2.27

First case of E anophelis outbreak in an intensive-care unit. Lancet (2013) 2.26

Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent. Microbiology (2005) 2.24

Statistical analysis of Pseudomonas aeruginosa biofilm development: impact of mutations in genes involved in twitching motility, cell-to-cell signaling, and stationary-phase sigma factor expression. Appl Environ Microbiol (2002) 2.19

The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J Bacteriol (2002) 2.18

Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. J Bacteriol (2005) 2.09

Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes. Microbiology (2009) 2.06

Distribution, organization, and ecology of bacteria in chronic wounds. J Clin Microbiol (2008) 2.05

Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa. Microbiology (2007) 2.05

Quorum sensing inhibitors: a bargain of effects. Microbiology (2006) 1.99

Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production. Antimicrob Agents Chemother (2004) 1.99

Food spoilage--interactions between food spoilage bacteria. Int J Food Microbiol (2002) 1.97

Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation. Antimicrob Agents Chemother (2005) 1.94

Etiology of diarrhea in young children in Denmark: a case-control study. J Clin Microbiol (2005) 1.89

The clinical impact of bacterial biofilms. Int J Oral Sci (2011) 1.88

Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa. Microbiology (2007) 1.88

Constitutive high expression of chromosomal beta-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD. Antimicrob Agents Chemother (2002) 1.85

Applying insights from biofilm biology to drug development - can a new approach be developed? Nat Rev Drug Discov (2013) 1.82

Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. J Antimicrob Chemother (2012) 1.81

Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients. Infect Immun (2007) 1.81

The in vivo biofilm. Trends Microbiol (2013) 1.79

Temporal trends in invasive pneumococcal disease and pneumococcal serotypes over 7 decades. Clin Infect Dis (2010) 1.73

Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice. Antimicrob Agents Chemother (2007) 1.71

Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens. Philos Trans R Soc Lond B Biol Sci (2007) 1.70

Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections. Microbiology (2005) 1.70

Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis. Infect Immun (2005) 1.69

Bacterial biofilms: prokaryotic adventures in multicellularity. Curr Opin Microbiol (2003) 1.68

Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections. FEMS Immunol Med Microbiol (2010) 1.68

Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2008) 1.67

Identity and effects of quorum-sensing inhibitors produced by Penicillium species. Microbiology (2005) 1.67

Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: results of a prospective, randomized, controlled clinical trial. Pediatr Crit Care Med (2012) 1.67

Phosphorus limitation enhances biofilm formation of the plant pathogen Agrobacterium tumefaciens through the PhoR-PhoB regulatory system. J Bacteriol (2004) 1.67

Genetic analysis of functions involved in the late stages of biofilm development in Burkholderia cepacia H111. Mol Microbiol (2002) 1.63

Quorum sensing-controlled biofilm development in Serratia liquefaciens MG1. J Bacteriol (2004) 1.62

Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model. J Infect Dis (2005) 1.62

Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection. ISME J (2011) 1.59

Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds. J Clin Microbiol (2009) 1.55

Heterogeneity of biofilms formed by nonmucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis. J Clin Microbiol (2005) 1.55

Early adaptive developments of Pseudomonas aeruginosa after the transition from life in the environment to persistent colonization in the airways of human cystic fibrosis hosts. Environ Microbiol (2010) 1.54

Epidemic spread of Pandoraea apista, a new pathogen causing severe lung disease in cystic fibrosis patients. Pediatr Pulmonol (2003) 1.50

Pseudomonas aeruginosa AmpR is a global transcriptional factor that regulates expression of AmpC and PoxB beta-lactamases, proteases, quorum sensing, and other virulence factors. Antimicrob Agents Chemother (2005) 1.48

In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections. J Bacteriol (2007) 1.46

Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants. Microbiology (2009) 1.45

Bacterial biofilm formation and treatment in soft tissue fillers. Pathog Dis (2014) 1.44

The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication. Microbiology (2005) 1.43

Towards diagnostic guidelines for biofilm-associated infections. FEMS Immunol Med Microbiol (2012) 1.43

Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients. PLoS One (2010) 1.42

Identification and characterization of an N-acylhomoserine lactone-dependent quorum-sensing system in Pseudomonas putida strain IsoF. Appl Environ Microbiol (2002) 1.40

[Antibiotic treatment in four departments of a university hospital. A descriptive period prevalence study]. Ugeskr Laeger (2005) 1.40

[Current microbiologic strategy in endocarditis]. Ugeskr Laeger (2003) 1.38

[Fatal outcome of pneumococcal pneumonia--a consequence of macrolide resistance?]. Ugeskr Laeger (2004) 1.38

The immune system vs. Pseudomonas aeruginosa biofilms. FEMS Immunol Med Microbiol (2010) 1.38