Published in Lung Cancer on February 01, 2008
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol (2009) 15.23
Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res (2009) 7.35
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A (2011) 3.97
EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues. Am J Pathol (2009) 3.15
Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression. Mol Cancer (2010) 3.06
Anaplastic lymphoma kinase: signalling in development and disease. Biochem J (2009) 3.05
The biology and treatment of EML4-ALK non-small cell lung cancer. Eur J Cancer (2010) 3.03
Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. Arch Pathol Lab Med (2013) 2.66
Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene. Cancer Res (2010) 2.20
Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer: a success story to usher in the second decade of molecular targeted therapy in oncology. Oncologist (2012) 1.88
Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy. Expert Rev Anticancer Ther (2009) 1.73
Clinical significance of EML4-ALK fusion gene and association with EGFR and KRAS gene mutations in 208 Chinese patients with non-small cell lung cancer. PLoS One (2013) 1.57
Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP. J Hematol Oncol (2011) 1.31
Activity of EGFR-tyrosine kinase and ALK inhibitors for EML4-ALK-rearranged non-small-cell lung cancer harbored coexisting EGFR mutation. BMC Cancer (2013) 1.26
Novel ALK inhibitors in clinical use and development. J Hematol Oncol (2015) 1.24
Comparison of IHC, FISH and RT-PCR methods for detection of ALK rearrangements in 312 non-small cell lung cancer patients in Taiwan. PLoS One (2013) 1.21
Cancer genes in lung cancer: racial disparities: are there any? Genes Cancer (2012) 1.12
The potential for crizotinib in non-small cell lung cancer: a perspective review. Ther Adv Med Oncol (2011) 1.05
Translocations in epithelial cancers. Biochim Biophys Acta (2009) 1.04
A Screening Method for the ALK Fusion Gene in NSCLC. Front Oncol (2012) 1.04
Clinicopathological characteristics of patients with non-small-cell lung cancer who harbor EML4-ALK fusion gene: a meta-analysis. PLoS One (2015) 0.96
A comparison of immunohistochemical assays and FISH in detecting the ALK translocation in diagnostic histological and cytological lung tumor material. J Thorac Oncol (2014) 0.92
ALK gene amplification is associated with poor prognosis in colorectal carcinoma. Br J Cancer (2013) 0.92
A rational diagnostic algorithm for the identification of ALK rearrangement in lung cancer: a comprehensive study of surgically treated Japanese patients. PLoS One (2013) 0.91
Non-small cell lung cancer with EML4-ALK translocation in Chinese male never-smokers is characterized with early-onset. BMC Cancer (2014) 0.90
A large-scale cross-sectional study of ALK rearrangements and EGFR mutations in non-small-cell lung cancer in Chinese Han population. Sci Rep (2014) 0.88
Clinicopathological and demographical characteristics of non-small cell lung cancer patients with ALK rearrangements: a systematic review and meta-analysis. PLoS One (2014) 0.87
Clinicopathologic features of patients with non-small cell lung cancer harboring the EML4-ALK fusion gene: a meta-analysis. PLoS One (2014) 0.86
ALK and NSCLC: Targeted therapy with ALK inhibitors. F1000 Med Rep (2011) 0.85
EML4-ALK fusion transcripts in immunohistochemically ALK-positive non-small cell lung carcinomas. Exp Ther Med (2010) 0.83
Racial and Ethnic Differences in the Epidemiology and Genomics of Lung Cancer. Cancer Control (2016) 0.82
SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers. Sci Rep (2013) 0.81
Targeting EML4-ALK driven non-small cell lung cancer (NSCLC). Transl Lung Cancer Res (2013) 0.81
Roles of EGFR and KRAS Mutations in the Treatment Of Patients With Non-Small-Cell Lung Cancer. P T (2011) 0.80
EGFR, ALK, RET, KRAS and BRAF alterations in never-smokers with non-small cell lung cancer. Oncol Lett (2016) 0.79
ALK alterations and inhibition in lung cancer. Semin Cancer Biol (2016) 0.78
ALK-mutated non-small-cell lung cancer: a new strategy for cancer treatment. Lung (2012) 0.77
Characterization of a novel fusion gene EML4-NTRK3 in a case of recurrent congenital fibrosarcoma. Cold Spring Harb Mol Case Stud (2015) 0.76
Analysis of clinicopathological features of the echinoderm microtubule-associated protein-like-4-anaplastic lymphoma kinase fusion gene in Chinese patients with advanced non-small-cell lung cancer. Thorac Cancer (2014) 0.75
EML4-ALK translocation is associated with early onset of disease and other clinicopathological features in Chinese female never-smokers with non-small-cell lung cancer. Oncol Lett (2015) 0.75
Targeted inhibition in tumors with ALK dependency. Lung Cancer (Auckl) (2013) 0.75
The renal effects of ALK inhibitors. Invest New Drugs (2016) 0.75
Maternal Immunization: New Perspectives on Its Application Against Non-Infectious Related Diseases in Newborns. Vaccines (Basel) (2017) 0.75
The global burden of oral diseases and risks to oral health. Bull World Health Organ (2005) 8.15
MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proc Natl Acad Sci U S A (2009) 3.64
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Nat Genet (2008) 2.89
Intravascular ultrasound evaluation of coronary plaque regression by low density lipoprotein-apheresis in familial hypercholesterolemia: the Low Density Lipoprotein-Apheresis Coronary Morphology and Reserve Trial (LACMART). J Am Coll Cardiol (2002) 2.26
Pleomorphic carcinoma of the lung: clinicopathologic characteristics of 70 cases. Am J Surg Pathol (2008) 2.22
The global burden of periodontal disease: towards integration with chronic disease prevention and control. Periodontol 2000 (2012) 2.12
Strengthening the prevention of periodontal disease: the WHO approach. J Periodontol (2005) 2.01
Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. Gastroenterology (2002) 1.85
Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma. Int J Cancer (2008) 1.59
Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier. J Natl Cancer Inst (2007) 1.58
Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes. Cardiovasc Diabetol (2011) 1.56
PIK3CA mutation and amplification in human lung cancer. Pathol Int (2007) 1.55
Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2-null mice. J Gastroenterol Hepatol (2012) 1.53
Risk factors for post-ERCP pancreatitis in high risk patients who have undergone prophylactic pancreatic duct stenting: a multicenter retrospective study. Intern Med (2011) 1.51
The decline and fate of an iron-induced subarctic phytoplankton bloom. Nature (2004) 1.50
Long-term low-dose spironolactone therapy is safe in oligoanuric hemodialysis patients. Cardiology (2009) 1.49
Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J (2004) 1.47
Right upper lobe venous drainage posterior to the bronchus intermedius: preoperative identification by computed tomography. Ann Thorac Surg (2005) 1.45
The value of power Doppler imaging to predict the histologic components of benign prostatic hyperplasia. Prostate (2002) 1.42
Long-term nitrate use in acute myocardial infarction (the Heart Institute of Japan, Department of Cardiology nitrate evaluation program). Cardiovasc Drugs Ther (2008) 1.41
Effect of Hemodialysis on 7-Year Clinical Outcomes After Sirolimus-Eluting Stent Implantation. Circ J (2015) 1.40
Influence of source and drain contacts on the properties of indium-gallium-zinc-oxide thin-film transistors based on amorphous carbon nanofilm as barrier layer. ACS Appl Mater Interfaces (2015) 1.38
Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion. EMBO J (2003) 1.34
Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer. J Gastroenterol Hepatol (2007) 1.34
Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer. Carcinogenesis (2004) 1.30
Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways. Exp Cell Res (2007) 1.29
The discovery of pyridalyl: a novel insecticidal agent for controlling lepidopterous pests. Pest Manag Sci (2004) 1.28
Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer. Cancer Sci (2004) 1.28
Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening. Gastroenterology (2004) 1.27
Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma. Int J Gynecol Cancer (2012) 1.26
Is limited resection appropriate for radiologically "solid" tumors in small lung cancers? Ann Thorac Surg (2012) 1.24
Downregulation of EphA7 by hypermethylation in colorectal cancer. Oncogene (2005) 1.24
Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis. Am J Pathol (2009) 1.24
Comparison of estrogen receptor, progesterone receptor and Her-2 status in breast cancer pre- and post-neoadjuvant chemotherapy. Breast (2008) 1.23
A mesoscale iron enrichment in the western subarctic Pacific induces a large centric diatom bloom. Science (2003) 1.22
Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J (2004) 1.22
EPHA2/EFNA1 expression in human gastric cancer. Cancer Sci (2005) 1.21
Negative regulation of EphA2 receptor by Cbl. Biochem Biophys Res Commun (2002) 1.21
Oral health information systems--towards measuring progress in oral health promotion and disease prevention. Bull World Health Organ (2005) 1.19
Helicobacter pylori impairs DNA mismatch repair in gastric epithelial cells. Gastroenterology (2002) 1.19
Overexpression of MUC13 is associated with intestinal-type gastric cancer. Cancer Sci (2005) 1.19
IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis. J Immunol (2004) 1.18
Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers: a case-control study of a high-incidence area in Jiangsu Province, China. Cancer Lett (2002) 1.18
A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer. Gastroenterology (2010) 1.17
Gastrojejunocolic fistula after gastrectomy with Billroth II reconstruction: report of a case. Surg Today (2002) 1.17
Novel mutations of the GLA gene in Japanese patients with Fabry disease and their functional characterization by active site specific chaperone. Hum Mutat (2008) 1.17
Identification of genes whose expression is upregulated in lung adenocarcinoma cells in comparison with type II alveolar cells and bronchiolar epithelial cells in vivo. Oncogene (2004) 1.16
Methylation of mitochondrial DNA is not a useful marker for cancer detection. Clin Chem (2004) 1.16
Primary thymic extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features. Am J Pathol (2002) 1.15
Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis. Hepatology (2009) 1.15
Analysis of 95 cases of squamous cell carcinoma of the external and middle ear. Auris Nasus Larynx (2006) 1.15
Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects. J Gastroenterol Hepatol (2007) 1.14
CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls. Int J Cancer (2003) 1.13
The critical role of disulfide bond formation in protein sorting in the endosperm of rice. Plant Cell (2005) 1.10
Cardio-ankle vascular index is superior to brachial-ankle pulse wave velocity as an index of arterial stiffness. Hypertens Res (2008) 1.10
The proportion of consolidation to ground-glass opacity on high resolution CT is a good predictor for distinguishing the population of non-invasive peripheral adenocarcinoma. Lung Cancer (2003) 1.10
Imaging mass spectrometry of gastric carcinoma in formalin-fixed paraffin-embedded tissue microarray. Cancer Sci (2009) 1.09
Treatment strategy for chylothorax after pulmonary resection and lymph node dissection for lung cancer. J Thorac Cardiovasc Surg (2002) 1.09
Association between genetic polymorphisms of the base excision repair gene MUTYH and increased colorectal cancer risk in a Japanese population. Cancer Sci (2008) 1.09
Expression profile of EFNB1, EFNB2, two ligands of EPHB2 in human gastric cancer. J Cancer Res Clin Oncol (2002) 1.09
Role of Wnt pathway in medulloblastoma oncogenesis. Int J Cancer (2002) 1.09
Cardio-ankle vascular index is a new noninvasive parameter of arterial stiffness. Circ J (2007) 1.08
Fecal cyclooxygenase 2 plus matrix metalloproteinase 7 mRNA assays as a marker for colorectal cancer screening. Cancer Epidemiol Biomarkers Prev (2009) 1.08
Solitary fibrous tumor of the pleura with hemothorax at the thoracic apex. Jpn J Thorac Cardiovasc Surg (2003) 1.07
A novel secretory factor, Neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus. J Neurosci (2003) 1.06
Promoter hypermethylation in cancer silences LDHB, eliminating lactate dehydrogenase isoenzymes 1-4. Clin Chem (2003) 1.06
Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF. Cancer Sci (2008) 1.05
CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis. J Immunol (2002) 1.05
Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States). Cancer Causes Control (2003) 1.04
Voiding and incontinence frequencies: variability of diary data and required diary length. Neurourol Urodyn (2002) 1.04
Association of chemerin mRNA expression in human epicardial adipose tissue with coronary atherosclerosis. Cardiovasc Diabetol (2011) 1.04
Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epidermal growth factor receptor gene mutation. Lung Cancer (2007) 1.03
Evidence for the critical role of interleukin-12 but not interferon-gamma in the pathogenesis of experimental colitis in mice. J Gastroenterol Hepatol (2003) 1.02
hOGG1 Ser(326)Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese. Int J Cancer (2002) 1.02
Development of the adductome approach to detect DNA damage in humans. Antioxid Redox Signal (2006) 1.02
The size of consolidation on thin-section computed tomography is a better predictor of survival than the maximum tumour dimension in resectable lung cancer. Eur J Cardiothorac Surg (2012) 1.01
Lymphatic vessel invasion is a significant prognostic indicator in stage IA lung adenocarcinoma. Ann Surg Oncol (2011) 1.00
Association between cancer risk and drug-metabolizing enzyme gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) polymorphisms in cases of lung cancer in Japan. Drug Metab Pharmacokinet (2011) 1.00
Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis. Mod Pathol (2008) 1.00
Germline alterations in the CDH1 gene in familial gastric cancer in the Japanese population. Cancer Sci (2011) 0.99
Amplicons on human chromosome 11q are located in the early/late-switch regions of replication timing. Genomics (2004) 0.99
Postoperative complications and respiratory function following segmentectomy of the lung - comparison of the methods of making an inter-segmental plane. Interact Cardiovasc Thorac Surg (2010) 0.99
Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan. Cancer Epidemiol Biomarkers Prev (2006) 0.99