| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation.
|
J Pharmacol Exp Ther
|
2007
|
1.30
|
|
2
|
P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse.
|
J Pharmacol Exp Ther
|
2002
|
1.22
|
|
3
|
A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo.
|
J Pharmacol Exp Ther
|
2005
|
1.20
|
|
4
|
Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells.
|
Mol Pharmacol
|
2003
|
1.05
|
|
5
|
Pharmacological characterization of Sch527123, a potent allosteric CXCR1/CXCR2 antagonist.
|
J Pharmacol Exp Ther
|
2007
|
1.05
|
|
6
|
Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist.
|
J Med Chem
|
2006
|
0.99
|
|
7
|
C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists.
|
Bioorg Med Chem Lett
|
2007
|
0.86
|
|
8
|
Pharmacological characterization of human S1P4 using a novel radioligand, [4,5-3H]-dihydrosphingosine-1-phosphate.
|
Br J Pharmacol
|
2004
|
0.81
|
|
9
|
Cloning and pharmacological characterization of CXCR1 and CXCR2 from Macaca fascicularis.
|
J Pharmacol Exp Ther
|
2004
|
0.80
|
|
10
|
3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists.
|
Bioorg Med Chem Lett
|
2009
|
0.77
|
|
11
|
Inhibition of fucosyltransferase VII by gallic acid and its derivatives.
|
Arch Biochem Biophys
|
2004
|
0.75
|
|
12
|
3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists.
|
Bioorg Med Chem Lett
|
2007
|
0.75
|
|
13
|
Synthesis and structure-activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists.
|
Bioorg Med Chem Lett
|
2008
|
0.75
|
|
14
|
Fluoroalkyl alpha side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2-CXCR1 dual antagonists.
|
Bioorg Med Chem Lett
|
2009
|
0.75
|
|
15
|
Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region.
|
Bioorg Med Chem Lett
|
2009
|
0.75
|