Published in Mol Cell Neurosci on January 03, 2008
Epigenetic mechanisms in Alzheimer's disease. Neurobiol Aging (2011) 3.83
A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. Am J Clin Nutr (2008) 1.37
Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither? Trends Pharmacol Sci (2011) 1.09
Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet. Exp Gerontol (2009) 1.05
The "LEARn" (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer's disease, and proposes remedial steps. Exp Gerontol (2010) 1.03
One-carbon metabolism and Alzheimer's disease: focus on epigenetics. Curr Genomics (2010) 0.99
Neuronutrition and Alzheimer's disease. J Alzheimers Dis (2010) 0.97
Epigenetic mechanisms in memory and synaptic function. Epigenomics (2011) 0.96
Normalization of hyperhomocysteinemia improves cognitive deficits and ameliorates brain amyloidosis of a transgenic mouse model of Alzheimer's disease. FASEB J (2010) 0.94
DNA methylation, a hand behind neurodegenerative diseases. Front Aging Neurosci (2013) 0.94
Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatr Dis Treat (2010) 0.94
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Ann Neurol (2014) 0.89
B-vitamin deficiency is protective against DSS-induced colitis in mice. Am J Physiol Gastrointest Liver Physiol (2011) 0.86
Epigenetic regulation in Parkinson's disease. Acta Neuropathol (2016) 0.83
Dietary deficiency increases presenilin expression, gamma-secretase activity, and Abeta levels: potentiation by ApoE genotype and alleviation by S-adenosyl methionine. J Neurochem (2009) 0.83
A platelet protein biochip rapidly detects an Alzheimer's disease-specific phenotype. Acta Neuropathol (2014) 0.82
Epigenetics of Alzheimer's disease and frontotemporal dementia. Neurotherapeutics (2013) 0.80
S-adenosylmethionine and S-adenosylhomocysteine levels in the aging brain of APP/PS1 Alzheimer mice. Neurol Sci (2009) 0.80
Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Mol Neurodegener (2015) 0.79
The potential of epigenetic therapies in neurodegenerative diseases. Front Genet (2014) 0.78
Effects of Folic Acid on Secretases Involved in Aβ Deposition in APP/PS1 Mice. Nutrients (2016) 0.78
Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β-amyloid fibrinogen interaction. J Thromb Haemost (2016) 0.78
Relationship between blood levels of methyl donor and folate and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study. J Clin Biochem Nutr (2014) 0.78
Severe In vivo hyper-homocysteinemia is not associatedwith elevation of amyloid-beta peptides in the Tg2576 mice. J Alzheimers Dis (2010) 0.78
The Herp protein pathway is not involved in the pro-amyloidogenic effect of hyperhomocysteinemia. J Alzheimers Dis (2010) 0.77
Genetic markers in biological fluids for aging-related major neurocognitive disorder. Curr Alzheimer Res (2015) 0.76
Serum homocysteine levels are correlated with behavioral and psychological symptoms of Alzheimer's disease. Neuropsychiatr Dis Treat (2014) 0.76
Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer's disease. Exp Brain Res (2012) 0.76
Nicotine exposure during adolescence: cognitive performance and brain gene expression in adult heterozygous reeler mice. Psychopharmacology (Berl) (2013) 0.75
Rescue of Early bace-1 and Global DNA Demethylation by S-Adenosylmethionine Reduces Amyloid Pathology and Improves Cognition in an Alzheimer's Model. Sci Rep (2016) 0.75
Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. Nutrients (2016) 0.75
Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer's Disease. Nutrients (2016) 0.75
Folate deficiency exacerbates apoptosis by inducing hypomethylation and resultant overexpression of DR4 together with altering DNMTs in Alzheimer's disease. Int J Clin Exp Med (2014) 0.75
Nutrition and dementia. Curr Gerontol Geriatr Res (2012) 0.75
Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases. Int J Mol Sci (2015) 0.75
Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism. PLoS One (2008) 3.09
Ultrasonic vocalizations: a tool for behavioural phenotyping of mouse models of neurodevelopmental disorders. Neurosci Biobehav Rev (2008) 2.42
Early demethylation of non-CpG, CpC-rich, elements in the myogenin 5'-flanking region: a priming effect on the spreading of active demethylation. Cell Cycle (2010) 1.72
Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptor. J Surg Res (2007) 1.51
c-Flip overexpression reduces cardiac hypertrophy in response to pressure overload. J Hypertens (2008) 1.48
S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci (2005) 1.43
An altered neonatal behavioral phenotype in Mecp2 mutant mice. Neuroreport (2006) 1.32
Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice. Toxicol Sci (2006) 1.29
Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies. Environ Health Perspect (2007) 1.26
Modulation of RhoGTPases improves the behavioral phenotype and reverses astrocytic deficits in a mouse model of Rett syndrome. Neuropsychopharmacology (2011) 1.09
Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease? FEBS Lett (2003) 1.07
Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency. Neurobiol Aging (2009) 1.05
One-carbon metabolism and Alzheimer's disease: is it all a methylation matter? Neurobiol Aging (2011) 1.05
A retrospective performance assessment of the developmental neurotoxicity study in support of OECD test guideline 426. Environ Health Perspect (2008) 1.05
Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits non-small cell lung cancer. Oncotarget (2013) 1.03
Early behavioural markers of disease in P301S tau transgenic mice. Behav Brain Res (2009) 0.99
Developmental exposure to chlorpyrifos induces alterations in thyroid and thyroid hormone levels without other toxicity signs in CD-1 mice. Toxicol Sci (2009) 0.96
Chlorpyrifos and neurodevelopmental effects: a literature review and expert elicitation on research and policy. Environ Health (2012) 0.96
A systems biology approach to cancer: fractals, attractors, and nonlinear dynamics. OMICS (2011) 0.96
S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice. Neurobiol Aging (2012) 0.95
Eicosapentaenoic acid stimulates the expression of myelin proteins in rat brain. J Neurosci Res (2008) 0.95
Antiproliferative and apoptotic effects triggered by Grape Seed Extract (GSE) versus epigallocatechin and procyanidins on colon cancer cell lines. Int J Mol Sci (2012) 0.95
Zebrafish embryo proteins induce apoptosis in human colon cancer cells (Caco2). Apoptosis (2006) 0.94
Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups. Environ Health (2009) 0.93
Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice. Toxicol Appl Pharmacol (2003) 0.92
Gestational exposure to the organophosphate chlorpyrifos alters social-emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice. Psychopharmacology (Berl) (2009) 0.92
Gene silencing through methylation: an epigenetic intervention on Alzheimer disease. J Alzheimers Dis (2006) 0.92
Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2. Br J Nutr (2010) 0.92
DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models. J Nutr Biochem (2010) 0.91
Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1. Aging Cell (2013) 0.90
Sertoli cells initiate testicular innate immune responses through TLR activation. J Immunol (2006) 0.89
Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways. J Surg Res (2012) 0.89
gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells. J Alzheimers Dis (2007) 0.89
Autocrine production of basic fibroblast growth factor translated from novel synthesized mRNA mediates thrombin-induced mitogenesis in smooth muscle cells. Cell Biochem Funct (2002) 0.89
Melatonin down-regulates MDM2 gene expression and enhances p53 acetylation in MCF-7 cells. J Pineal Res (2014) 0.89
Animal models of mental retardation: from gene to cognitive function. Neurosci Biobehav Rev (2003) 0.88
Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice. Behav Brain Res (2007) 0.87
Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells. J Pineal Res (2010) 0.86
Evaluation of chemical and diastereoisomeric stability of S-adenosylmethionine in aqueous solution by capillary electrophoresis. J Pharm Biomed Anal (2005) 0.86
Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells. J Pineal Res (2008) 0.85
Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion. Eur J Nutr (2013) 0.85
Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthood. Neurotoxicol Teratol (2008) 0.85
Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats. Exp Neurol (2004) 0.85
Long-term effects on hypothalamic neuropeptides after developmental exposure to chlorpyrifos in mice. Environ Health Perspect (2008) 0.84
Vascular endothelial growth factor increases the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cells. J Surg Res (2003) 0.83
NMR-based metabolic profiling of human hepatoma cells in relation to cell growth by culture media analysis. Biochim Biophys Acta (2006) 0.83
A social recognition test for female mice reveals behavioral effects of developmental chlorpyrifos exposure. Neurotoxicol Teratol (2006) 0.83
S-adenosylmethionine prevents oxidative stress and modulates glutathione metabolism in TgCRND8 mice fed a B-vitamin deficient diet. J Alzheimers Dis (2010) 0.83
The application of Russell and Burch 3R principle in rodent models of neurodegenerative disease: the case of Parkinson's disease. Neurosci Biobehav Rev (2008) 0.83
PARP-1 modulates amyloid beta peptide-induced neuronal damage. PLoS One (2013) 0.83
A reassessment of semiquantitative analytical procedures for DNA methylation: comparison of bisulfite- and HpaII polymerase-chain-reaction-based methods. Anal Biochem (2006) 0.82
C-section birth per se or followed by acute global asphyxia altered emotional behaviour in neonate and adult rats. Behav Brain Res (2005) 0.82
Behavioral effects of Rho GTPase modulation in a model of Alzheimer's disease. Behav Brain Res (2012) 0.81
Neurobehavioral effects of prenatal exposure to AZT: a preliminary investigation with the D1 receptor agonist SKF 38393 in mice. Neurotoxicol Teratol (2005) 0.81
PSEN1 promoter demethylation in hyperhomocysteinemic TgCRND8 mice is the culprit, not the consequence. Curr Alzheimer Res (2012) 0.81
Susceptibility to highly sulphated glycosaminoglycans of human immunodeficiency virus type 1 replication in peripheral blood lymphocytes and monocyte-derived macrophages cell cultures. Antiviral Res (2003) 0.81
Thyroid hormone metabolism and environmental chemical exposure. Environ Health (2012) 0.81
Progressive behavioural changes in the spatial open-field in the quinolinic acid rat model of Huntington's disease. Behav Brain Res (2004) 0.81
Animal models of anti-HIV drugs exposure during pregnancy: effects on neurobehavioral development. Prog Neuropsychopharmacol Biol Psychiatry (2002) 0.80
Grape seed extract triggers apoptosis in Caco-2 human colon cancer cells through reactive oxygen species and calcium increase: extracellular signal-regulated kinase involvement. Br J Nutr (2013) 0.80
Acute global anoxia during C-section birth affects dopamine-mediated behavioural responses and reactivity to stress. Behav Brain Res (2004) 0.80
Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination. J Alzheimers Dis (2010) 0.80
B vitamin deficiency promotes tau phosphorylation through regulation of GSK3beta and PP2A. J Alzheimers Dis (2010) 0.80
Transplacental exposure to AZT induces adverse neurochemical and behavioral effects in a mouse model: protection by L-acetylcarnitine. PLoS One (2013) 0.80
Role of growth factors on human parathyroid adenoma cell proliferation. World J Surg (2010) 0.80
Germ cell apoptosis control during spermatogenesis. Contraception (2005) 0.80
TCam-2 seminoma cells exposed to egg-derived microenvironment modify their shape, adhesive pattern and migratory behaviour: a molecular and morphometric analysis. PLoS One (2013) 0.80