Published in Br J Cancer on February 05, 2008
Redox-directed cancer therapeutics: molecular mechanisms and opportunities. Antioxid Redox Signal (2009) 2.33
Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling. Proc Natl Acad Sci U S A (2008) 1.58
Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells. Mol Cell Proteomics (2011) 1.12
Targeting SOD1 reduces experimental non–small-cell lung cancer. J Clin Invest (2014) 1.07
A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-naïve prostate cancer. Urol Oncol (2011) 0.99
DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma. Free Radic Res (2010) 0.93
Transcriptional up-regulation of SOD1 by CEBPD: a potential target for cisplatin resistant human urothelial carcinoma cells. Biochem Pharmacol (2010) 0.92
Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse. Ann Oncol (2013) 0.89
Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells. Genetics (2013) 0.86
Copper imbalances in ruminants and humans: unexpected common ground. Adv Nutr (2012) 0.84
Copper chelation by tetrathiomolybdate inhibits lipopolysaccharide-induced inflammatory responses in vivo. Am J Physiol Heart Circ Physiol (2011) 0.84
Stimulation of angiogenesis resulting from cooperation between macrophages and MDA-MB-231 breast cancer cells: proposed molecular mechanism and effect of tetrathiomolybdate. BMC Cancer (2010) 0.83
The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies. Free Radic Biol Med (2013) 0.81
ATN-224 enhances antitumor efficacy of oncolytic herpes virus against both local and metastatic head and neck squamous cell carcinoma. Mol Ther Oncolytics (2015) 0.78
Manganese superoxide dismutase in cancer prevention. Antioxid Redox Signal (2013) 0.77
Exogenously-added copper/zinc superoxide dismutase rescues damage of endothelial cells from lethal irradiation. J Clin Biochem Nutr (2011) 0.77
Hyaluronan regulates ceruloplasmin production by gliomas and their treatment-resistant multipotent progenitors. J Child Neurol (2008) 0.77
Angiogenesis in life, disease and medicine. Nature (2005) 15.36
Angiogenesis as a therapeutic target. Nature (2005) 11.89
The multifaceted circulating endothelial cell in cancer: towards marker and target identification. Nat Rev Cancer (2006) 4.55
Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell (2005) 3.74
Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study. Clin Cancer Res (2000) 1.74
Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis. Cancer Res (2002) 1.73
Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res (2006) 1.58
Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood (2004) 1.49
Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer. Clin Cancer Res (2003) 1.40
Extracellular superoxide dismutase. Int J Biochem Cell Biol (2005) 1.34
Tetrathiomolybdate inhibits angiogenesis and metastasis through suppression of the NFkappaB signaling cascade. Mol Cancer Res (2003) 1.29
Histidine-proline-rich glycoprotein has potent antiangiogenic activity mediated through the histidine-proline-rich domain. Cancer Res (2002) 1.14
Ceruloplasmin in neurodegenerative diseases. Brain Res Brain Res Rev (2005) 1.09
Copper transport and metabolism are normal in aceruloplasminemic mice. J Biol Chem (2001) 1.07
Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer. Mol Cancer Ther (2007) 1.03
Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinoma. Mol Cancer Ther (2003) 1.03
Control of copper status for cancer therapy. Curr Cancer Drug Targets (2005) 0.99
Copper intake and assessment of copper status. Am J Clin Nutr (1998) 0.97
Copper chelation as an antiangiogenic therapy. Oncol Res (2004) 0.94
Serum superoxide dismutase 3 (extracellular superoxide dismutase) activity is a sensitive indicator of Cu status in rats. J Nutr Biochem (2005) 0.92
Red cell superoxide dismutase activity as an index of human copper nutrition. J Nutr (1985) 0.92
Biomarkers for monitoring antiangiogenic therapy. Clin Cancer Res (2007) 0.89
Heparin-released extracellular superoxide dismutase is reduced in patients with coronary artery atherosclerosis. Atherosclerosis (2005) 0.84
Comparative analyses of multi-species sequences from targeted genomic regions. Nature (2003) 13.31
Epidemiology of retinopathy of prematurity. Lancet (1988) 2.52
Breathing exercises for asthma: a randomised controlled trial. Thorax (2008) 2.46
Natural history of retinopathy of prematurity: a prospective study. Eye (Lond) (1992) 1.78
Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J Neurosci (1999) 1.78
A year in a general ophthalmic outpatient department in England. Arch Ophthalmol (1986) 1.58
Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes. Genome Biol (2001) 1.57
The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma. Clin Exp Allergy (2005) 1.52
Study of common bile duct exploration and endoscopic sphincterotomy in a consecutive series of 438 patients. Br J Surg (1987) 1.45
Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene (2011) 1.38
Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice. J Neurosci (2000) 1.37
Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction. J Biol Chem (2000) 1.31
Structural requirements for the growth factor activity of the amino-terminal domain of urokinase. J Biol Chem (1992) 1.28
Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms. Epilepsia (1999) 1.23
Two-chain high molecular weight kininogen induces endothelial cell apoptosis and inhibits angiogenesis: partial activity within domain 5. FASEB J (2000) 1.23
The role of the plasminogen activation system in angiogenesis and metastasis. Surg Oncol Clin N Am (2001) 1.20
Retinopathy of prematurity: a prospective study. Review at six months. Eye (Lond) (1992) 1.20
Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH(2)), a beta integrin antagonist, in patients with solid tumours. Br J Cancer (2006) 1.20
Clinical risk factors and periventricular leucomalacia. Arch Dis Child (1988) 1.19
Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide. Proc Natl Acad Sci U S A (1998) 1.18
Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist. Virology (2009) 1.18
Analysis of genetic alterations in primary nasopharyngeal carcinoma by comparative genomic hybridization. Genes Chromosomes Cancer (2001) 1.10
A peptide derived from the non-receptor-binding region of urokinase plasminogen activator inhibits glioblastoma growth and angiogenesis in vivo in combination with cisplatin. Proc Natl Acad Sci U S A (2000) 1.09
The effects of increased rehabilitation therapy after brain injury: results of a prospective controlled trial. Clin Rehabil (2001) 1.03
Patent ductus arteriosus and cerebral circulation in preterm infants. Dev Med Child Neurol (1990) 1.03
miR-30e reciprocally regulates the differentiation of adipocytes and osteoblasts by directly targeting low-density lipoprotein receptor-related protein 6. Cell Death Dis (2013) 1.01
A peptide derived from the nonreceptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo. FASEB J (2000) 1.01
A multivariate analysis of preoperative risk factors in patients with common bile duct stones. Implications for treatment. Ann Surg (1989) 0.99
Treatment and outcome in 52 consecutive cases of ampullary carcinoma. Br J Surg (1987) 0.99
Vision and visual acuity in an elderly population. Ophthalmic Physiol Opt (1988) 0.99
A practical method for uniform isotopic labeling of recombinant proteins in mammalian cells. Biochemistry (1992) 0.98
Estradiol (E2) elicits SRC phosphorylation in the mouse neocortex: the initial event in E2 activation of the MAPK cascade? Endocrinology (2001) 0.97
Coordination of expression of Zymomonas mobilis glycolytic and fermentative enzymes: a simple hypothesis based on mRNA stability. J Bacteriol (1992) 0.95
Response to hypoxia involves transforming growth factor-beta2 and Smad proteins in human endothelial cells. Blood (2001) 0.95
The histopathology and staging of carcinoma of the ampulla of Vater. Histopathology (1988) 0.94
Mitochondrial DNA-based analysis of genetic variation and relatedness among Sri Lankan indigenous chickens and the Ceylon junglefowl (Gallus lafayetti). Anim Genet (2008) 0.94
Refraction and refractive errors in an elderly population. Ophthalmic Physiol Opt (1988) 0.93
Engraftment and growth of patient-derived retinoblastoma tumour in severe combined immunodeficiency mice. Eur J Cancer (2000) 0.93
Senile cataract and senile macular degeneration: an investigation into possible risk factors. Trans Ophthalmol Soc U K (1986) 0.92
[Influence of capsaicin treating sciatic nerve on the pain threshold and the effect of acupuncture analgesia of rats]. Zhen Ci Yan Jiu (1993) 0.92
Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator. Biochemistry (1994) 0.91
Glucagon-like peptide 2 function in domestic animals. Domest Anim Endocrinol (2003) 0.91
A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis. Cell Mol Life Sci (2008) 0.91
Fibrin turnover in lung inflammation and neoplasia. Am J Respir Crit Care Med (2001) 0.91
Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques. Psychoneuroendocrinology (2002) 0.89
Fluid dynamics in airway bifurcations: I. Primary flows. Inhal Toxicol (2001) 0.89
Prevention of prostate-cancer metastasis in vivo by a novel synthetic inhibitor of urokinase-type plasminogen activator (uPA). Int J Cancer (1995) 0.88
Renal cell carcinoma: blood transfusion and survival. Br Med J (Clin Res Ed) (1986) 0.88
Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics. Dis Esophagus (2013) 0.88
Restricting the mobility of Gs alpha: impact on receptor and effector coupling. Biochemistry (1999) 0.87
A study on producing monoclonal antibody with one diagnostic marker screened electrophoretically from the urine of individuals infected with Schistosoma japonicum. Diagn Microbiol Infect Dis (2000) 0.86
Fluid dynamics in airway bifurcations: II. Secondary currents. Inhal Toxicol (2001) 0.86
Fluid dynamics in airway bifurcations: III. Localized flow conditions. Inhal Toxicol (2001) 0.86
Arachidonic acid amide inhibitors of gap junction cell-cell communication. Bioorg Med Chem Lett (1999) 0.85
Steroidogenic factor-1 is an essential transcriptional activator for gonad-specific expression of promoter I of the rat prolactin receptor gene. J Biol Chem (1997) 0.85
Loss of gap junctions from DDT-treated rat liver epithelial cells. Carcinogenesis (1994) 0.85
Time-related variation in normal automated static perimetry. Ophthalmology (1991) 0.85
Localization and function of the connexin 43 gap-junction protein in normal and various oncogene-expressing rat liver epithelial cells. Mol Carcinog (1996) 0.85
[The influence of electroacupuncture on the mast cells in the acupoints of the stomach meridian]. Zhen Ci Yan Jiu (1996) 0.84
[Dynamics of IL-2 and IFN-gamma levels induced by sea or Con A in spleen cells of Schistosoma japonicum-infected mice]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (1995) 0.83
A pilot study of the effects of chronic paroxetine administration on hippocampal N-acetylaspartate in generalized anxiety disorder. J Psychopharmacol (2009) 0.83
Puberty acceleration in female mice induced with a partially purified male urine extract: effects on catecholamine release from the olfactory bulbs and hypothalamus. Brain Res (1992) 0.82
An artificial intelligence approach to DNA sequence feature recognition. Trends Biotechnol (1992) 0.82
Altered metabolic and transporter characteristics of vastus lateralis in chronic obstructive pulmonary disease. J Appl Physiol (1985) (2008) 0.82
Association between genetic polymorphisms of ACE & eNOS and diabetic nephropathy. Mol Biol Rep (2014) 0.82
An integrated high-resolution physical map of the DPC/BRCA2 region at chromosome 13q12. Cancer Res (1995) 0.82
[Antimicrobial properties of Flos Lonicerae against oral pathogens]. Zhongguo Zhong Yao Za Zhi (1996) 0.81
Light and retinopathy of prematurity: does retinal location offer a clue? Pediatrics (1992) 0.81
Inhibition of gap junctional intercellular communication and enhancement of growth in BALB/c 3T3 cells treated with connexin43 antisense oligonucleotides. Mol Carcinog (1995) 0.81
Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase. J Cell Physiol (1997) 0.80
[Effects of electroacupuncture on the subcutaneous mast cells of zusanli acupoint in rat with unilateral sciatic nerve transection]. Zhen Ci Yan Jiu (1996) 0.80
A study of circulating anti-CD25 antibodies in non-small cell lung cancer. Clin Transl Oncol (2012) 0.80
uPA and uPAR contribute to NK cell invasion through the extracellular matrix. Anticancer Res (2001) 0.80
Effects of local hypothermia on neuronal cell apoptosis after intracerebral hemorrhage in rats. J Nutr Health Aging (2015) 0.79
2-Aryl indole NK1 receptor antagonists: optimisation of indole substitution. Bioorg Med Chem Lett (2001) 0.79
Detection of RNA polymerase II promoters and polyadenylation sites in human DNA sequence. Comput Chem (1996) 0.79
Muscle fiber type characteristics in females with chronic obstructive pulmonary disease. A preliminary study. J Mol Histol (2009) 0.79
Topical use of indomethacin on the day of cataract surgery. Br J Ophthalmol (1990) 0.79
A catalytic antibody produces fluorescent tracers of gap junction communication in living cells. J Biol Chem (2001) 0.79
Time-dependent effects of short-term training on muscle metabolism during the early phase of exercise. Am J Physiol Regul Integr Comp Physiol (2009) 0.79
Capsaicin inhibits Porphyromonas gingivalis growth, biofilm formation, gingivomucosal inflammatory cytokine secretion, and in vitro osteoclastogenesis. Eur J Clin Microbiol Infect Dis (2013) 0.79
Urocortin ameliorates diabetic nephropathy in obese db/db mice. Br J Pharmacol (2008) 0.79
A novel Bacillus thuringiensis strain LLB6, isolated from bryophytes, and its new cry2Ac-type gene. Lett Appl Microbiol (2007) 0.79
Macromolecular insoluble cold globulin (MICG): a marker for pluripotential hemopoietic stem cells. J Immunol (1983) 0.78
The influence of a social dose of alcohol on the central visual field. Jpn J Ophthalmol (1990) 0.78
Isoelectric focusing and study of ribosomal proteins and lactate dehydrogenase. Ann N Y Acad Sci (1973) 0.77
Supercomputer description of human lung morphology for imaging analysis. J Nucl Med (1998) 0.77
[Electroacupuncture along meridians activating subcutaneous primary afferents in acupoints--CB-HRP tracing study]. Zhen Ci Yan Jiu (1996) 0.77
Off-line breath acetone analysis in critical illness. J Breath Res (2013) 0.77
Macromolecular insoluble cold globulin (MICG): a marker for embryonic prothymocytes in the mouse. J Immunol (1981) 0.77
[Segmental influence of dorsal root action potentials evoked by stimulating the acupoints after acupuncture along meridians]. Zhen Ci Yan Jiu (1996) 0.77
Stress, peer affiliation, and transforming growth factor-beta1 in differentially reared primates. CNS Spectr (2001) 0.77
Comparison of plasma uric acid levels in five varieties of the domestic turkey, Meleagris gallopavo. Poult Sci (2006) 0.77
Dosimetric comparison of normal structures associated with accelerated partial breast irradiation and whole breast irradiation delivered by intensity modulated radiotherapy for early breast cancer after breast conserving surgery. Clin Transl Oncol (2013) 0.77
Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells. Cell Struct Funct (1998) 0.76
Taurine conjugation of ibuprofen in humans and in rat liver in vitro. Relationship to metabolic chiral inversion. J Pharmacol Exp Ther (1994) 0.76
Differential regulation of neuropeptide Y receptors in the brains of NPY knock-out mice. Peptides (2001) 0.76
Computer simulations of lung morphologies within planar gamma camera images. Nucl Med Commun (1997) 0.76
Formation of circular satellite tobacco ringspot virus RNA in protoplasts transiently expressing the linear RNA. Virology (1997) 0.76