Published in Chem Res Toxicol on February 13, 2008
From differentiating metabolites to biomarkers. Anal Bioanal Chem (2009) 1.01
Degraded protein adducts of cis-2-butene-1,4-dial are urinary and hepatocyte metabolites of furan. Chem Res Toxicol (2009) 0.87
Polyamines are traps for reactive intermediates in furan metabolism. Chem Res Toxicol (2011) 0.86
Identification of furan metabolites derived from cysteine-cis-2-butene-1,4-dial-lysine cross-links. Chem Res Toxicol (2010) 0.86
Trapping of cis-2-butene-1,4-dial to measure furan metabolism in human liver microsomes by cytochrome P450 enzymes. Drug Metab Dispos (2011) 0.79
Reactive metabolites in the biotransformation of molecules containing a furan ring. Chem Res Toxicol (2012) 0.78
Covalent modification of cytochrome c by reactive metabolites of furan. Chem Res Toxicol (2013) 0.78
Repetitive transcranial magnetic stimulation applications normalized prefrontal dysfunctions and cognitive-related metabolic profiling in aged mice. PLoS One (2013) 0.75
Comparative metabolism of furan in rodent and human cryopreserved hepatocytes. Drug Metab Dispos (2014) 0.75
Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study. Food Chem Toxicol (2016) 0.75
Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes (2009) 2.36
Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios. Clin Chem (2009) 2.02
Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J Nutr (2008) 1.78
Nonmonotonic dose-response relationships: mechanistic basis, kinetic modeling, and implications for risk assessment. Toxicol Sci (2003) 1.55
Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms. Antioxid Redox Signal (2007) 1.45
Statistical analysis of nonmonotonic dose-response relationships: research design and analysis of nasal cell proliferation in rats exposed to formaldehyde. Toxicol Sci (2003) 1.42
Expansion and differentiation of neural progenitors derived from the human adult enteric nervous system. Gastroenterology (2009) 1.32
Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing. Wound Repair Regen (2003) 1.30
Hepatic glucokinase expression is associated with lipogenesis and fatty liver in humans. J Clin Endocrinol Metab (2011) 1.24
Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles. Toxicology (2006) 1.09
Waddell's representation of the tumor incidence data of the ED01 study is strongly misleading. Toxicol Sci (2003) 1.05
Effect of the oxLDL binding protein Fc-CD68 on plaque extension and vulnerability in atherosclerosis. Circ Res (2011) 1.01
Increased brain levels of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer's disease. Neurochem Int (2006) 0.99
Impact of glycoprotein VI and platelet adhesion on atherosclerosis--a possible role of fibronectin. J Mol Cell Cardiol (2010) 0.96
Metabolomics in toxicology and preclinical research. ALTEX (2013) 0.93
Human precision-cut liver tumor slices as a tumor patient-individual predictive test system for oncolytic measles vaccine viruses. Int J Oncol (2009) 0.92
Regulatory role of lactate in wound repair. Methods Enzymol (2004) 0.91
Tests for genotoxicity and mutagenicity of furan and its metabolite cis-2-butene-1,4-dial in L5178Y tk+/- mouse lymphoma cells. Mutat Res (2008) 0.90
Metabonomic study of ochratoxin a toxicity in rats after repeated administration: phenotypic anchoring enhances the ability for biomarker discovery. Chem Res Toxicol (2009) 0.88
Effects of propofol on ultrasonic indicators of haemodynamic function in rabbits. Vet Anaesth Analg (2007) 0.87
Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinoma. Clin Endocrinol (Oxf) (2011) 0.86
Metabolic profiling of glucuronides in human urine by LC-MS/MS and partial least-squares discriminant analysis for classification and prediction of gender. Anal Chem (2006) 0.86
Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS/MS method for the analysis of estradiol product formation. Toxicology (2005) 0.86
Ochratoxin A: 13-week oral toxicity and cell proliferation in male F344/n rats. Toxicol Sci (2007) 0.85
Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans. Am J Physiol Endocrinol Metab (2010) 0.84
Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene elicits a specific T cell-dependent immune response. Cancer Immunol Immunother (2002) 0.83
Role of ADP-ribosylation in wound repair. The contributions of Thomas K. Hunt, MD. Wound Repair Regen (2003) 0.83
Are indoleamine-2,3-dioxygenase producing human dendritic cells a tool for suppression of allogeneic T-cell responses? Transplantation (2007) 0.83
Quantitation of lanosterol and its major metabolite FF-MAS in an inhibition assay of CYP51 by azoles with atmospheric pressure photoionization based LC-MS/MS. J Am Soc Mass Spectrom (2004) 0.83
Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress. Chem Res Toxicol (2009) 0.82
Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans. Endocr Res (2004) 0.81
Metabolite profiling in human urine by LC-MS/MS: method optimization and application for glucuronides from dextromethorphan metabolism. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 0.80
Strategies in case of positive in vivo results in genotoxicity testing. Mutat Res (2010) 0.80
Statistical procedures to test for linearity and estimate threshold doses for tumor induction with nonlinear dose-response relationships in bioassays for carcinogenicity. Regul Toxicol Pharmacol (2002) 0.79
Expression of functional kappa-opioid receptors on murine dendritic cells. Immunol Lett (2002) 0.78
Induction of micronuclei in human cell lines and primary cells by combination treatment with gamma-radiation and ethyl methanesulfonate. Mutagenesis (2002) 0.78
Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles. Food Chem Toxicol (2009) 0.78
Age-dependency of insulin-like growth factors, insulin-like growth factor-binding proteins, and acid labile subunit in plasma and wounds of surgical patients. Wound Repair Regen (2002) 0.77
Quantification of cortisol and 6 beta-hydroxycortisol in human urine by LC-MS/MS, and gender-specific evaluation of the metabolic ratio as biomarker of CYP3A activity. J Chromatogr B Analyt Technol Biomed Life Sci (2010) 0.76
Quantitation of mercapturic acids from acrylamide and glycidamide in human urine using a column switching tool with two trap columns and electrospray tandem mass spectrometry. J Chromatogr A (2006) 0.76
Rapamycin inhibits poly(ADP-ribosyl)ation in intact cells. Biochem Biophys Res Commun (2009) 0.76
Functional alterations after cardiac sodium-calcium exchanger overexpression in heart failure. Am J Physiol Heart Circ Physiol (2006) 0.76
Population variability in biological adaptive responses to DNA damage and the shapes of carcinogen dose-response curves. Toxicol Appl Pharmacol (2005) 0.76
Simultaneous determination of O6-methyl-2'-deoxyguanosine, 8-oxo-7,8-dihydro-2'-deoxyguanosine, and 1,N6-etheno-2'-deoxyadenosine in DNA using on-line sample preparation by HPLC column switching coupled to ESI-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.76
Dose-response relationships for cancer incidence reflect susceptibility distributions. Chem Res Toxicol (2008) 0.75
Correction: CYP2C9 genotype vs. metabolic phenotype for individual drug dosing--a correlation analysis using flurbiprofen as probe drug. PLoS One (2015) 0.75
Overexpression of ABCG1 protein attenuates arteriosclerosis and endothelial dysfunction in atherosclerotic rabbits. Heart Int (2012) 0.75
Biological significance of DNA adducts investigated by simultaneous analysis of different endpoints of genotoxicity in L5178Y mouse lymphoma cells treated with methyl methanesulfonate. Mutat Res (2007) 0.75
Time-dependent effects of sodium arsenite on DNA breakage and apoptosis observed in the comet assay. Mutat Res (2005) 0.75
Statistical calculation of detection limits for DNA adducts using the 32P-postlabeling assay with a standard addition procedure. Mutat Res (2002) 0.75
Loss of protease activity of ADAM15 abolishes protective effects on plaque progression in atherosclerosis. Int J Cardiol (2011) 0.75
LC-MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation. J Chromatogr B Analyt Technol Biomed Life Sci (2004) 0.75
Dose-incidence modeling: consequences of linking quantal measures of response to depletion of critical tissue targets. Toxicol Sci (2005) 0.75