Published in J Biochem Mol Toxicol on February 01, 2008
Proteoliposomes as tool for assaying membrane transporter functions and interactions with xenobiotics. Pharmaceutics (2013) 0.78
Molecular mechanism of inhibition of the mitochondrial carnitine/acylcarnitine transporter by omeprazole revealed by proteoliposome assay, mutagenesis and bioinformatics. PLoS One (2013) 0.75
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity. Nat Rev Neurosci (2007) 2.77
Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery. Diabetes (2006) 1.89
Polyunsaturated fatty acids: biochemical, nutritional and epigenetic properties. J Am Coll Nutr (2004) 1.57
Bloodletting ameliorates insulin sensitivity and secretion in parallel to reducing liver iron in carriers of HFE gene mutations. Diabetes Care (2007) 1.48
Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine. Clin Cancer Res (2003) 1.45
Insulin clearance in obesity. J Am Coll Nutr (2003) 1.38
Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials. Diabetes Care (2005) 1.35
Antioxidant effect of L-carnitine and its short chain esters: relevance for the protection from oxidative stress related cardiovascular damage. Int J Cardiol (2006) 1.30
Effects of dietary fatty acids on insulin sensitivity and secretion. Diabetes Obes Metab (2004) 1.21
Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women. J Clin Endocrinol Metab (2006) 1.16
Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2. J Neurosci Res (2005) 1.08
Early hematopoietic zinc finger protein-zinc finger protein 521: a candidate regulator of diverse immature cells. Int J Biochem Cell Biol (2007) 1.04
Accumulation of overoxidized Peroxiredoxin III in aged rat liver mitochondria. Biochim Biophys Acta (2009) 1.00
Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative stress. Antioxid Redox Signal (2006) 0.99
Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? Cancer Biol Ther (2007) 0.98
L-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure. Am J Physiol Cell Physiol (2002) 0.98
Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. J Neurosci Res (2006) 0.97
A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys. Am J Med Genet A (2008) 0.96
Skeletal muscle metabolism in physiology and in cancer disease. J Cell Biochem (2003) 0.95
Carnitine-acyltransferase system inhibition, cancer cell death, and prevention of myc-induced lymphomagenesis. J Natl Cancer Inst (2013) 0.95
Human FAD synthase (isoform 2): a component of the machinery that delivers FAD to apo-flavoproteins. FEBS J (2011) 0.94
Experimental colitis: decreased Octn2 and Atb0+ expression in rat colonocytes induces carnitine depletion that is reversible by carnitine-loaded liposomes. FASEB J (2006) 0.93
Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes. J Nutr Biochem (2005) 0.92
Over-expression in Escherichia coli, purification and characterization of isoform 2 of human FAD synthetase. Protein Expr Purif (2006) 0.92
Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sex. Oncology (2007) 0.92
Mitochondrial localization of human FAD synthetase isoform 1. Mitochondrion (2010) 0.92
Acetyl-L-carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission. Aging Cell (2010) 0.91
Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: a role for the nicotinic receptor. J Neurosci Res (2009) 0.91
Systemic and brain metabolic dysfunction as a new paradigm for approaching Alzheimer's dementia. Neurochem Res (2006) 0.90
Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase. Biochem Biophys Res Commun (2006) 0.90
Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond. Expert Rev Neurother (2013) 0.90
E6 and E7 from human papillomavirus type 16 cooperate to target the PDZ protein Na/H exchange regulatory factor 1. J Virol (2011) 0.90
IkappaB kinase beta promotes cell survival by antagonizing p53 functions through DeltaNp73alpha phosphorylation and stabilization. Mol Cell Biol (2011) 0.89
L-carnitine infusions may suppress serum C-reactive protein and improve nutritional status in maintenance hemodialysis patients. J Ren Nutr (2005) 0.88
Interaction of beta-lactam antibiotics with the mitochondrial carnitine/acylcarnitine transporter. Chem Biol Interact (2008) 0.88
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity. Toxicol Appl Pharmacol (2012) 0.88
Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats. Neuropharmacology (2002) 0.88
Serum levels of fatty acid synthase in colorectal cancer patients are associated with tumor stage. J Gastrointest Cancer (2012) 0.87
Biosynthesis of flavin cofactors in man: implications in health and disease. Curr Pharm Des (2013) 0.87
Carnitine and hemodialysis. Am J Kidney Dis (2003) 0.87
Rat liver mitochondrial proteome: changes associated with aging and acetyl-L-carnitine treatment. J Proteomics (2011) 0.86
Over-expression in Escherichia coli, functional characterization and refolding of rat dimethylglycine dehydrogenase. Protein Expr Purif (2004) 0.86
Massive weight loss decreases corticosteroid-binding globulin levels and increases free cortisol in healthy obese patients: an adaptive phenomenon? Diabetes Care (2007) 0.86
Low 25-hydroxyvitamin D does not affect insulin sensitivity in obesity after bariatric surgery. Obes Res (2005) 0.86
Relationships of Cysteine and Lysine residues with the substrate binding site of the mitochondrial ornithine/citrulline carrier: an inhibition kinetic approach combined with the analysis of the homology structural model. Biochim Biophys Acta (2005) 0.85
Acetyl-L-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception. Neuropharmacology (2004) 0.85
Effect of temperature on the stability of long-chain acylcarnitines in human blood prior to plasma separation. Clin Chim Acta (2006) 0.85
Reconstitution in liposomes of the functionally active human OCTN1 (SLC22A4) transporter overexpressed in Escherichia coli. Biochem J (2011) 0.85
The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects. Br J Nutr (2004) 0.84
OCTN cation transporters in health and disease: role as drug targets and assay development. J Biomol Screen (2013) 0.84
Progression of cisplatin-induced nephrotoxicity in a carnitine-depleted rat model. Chemotherapy (2004) 0.83
Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris--functional and kinetic asymmetry revealed in proteoliposomes. Biochim Biophys Acta (2013) 0.82
Acetyl-L-carnitine protects striatal neurons against in vitro ischemia: the role of endogenous acetylcholine. Neuropharmacology (2006) 0.82
History of L-carnitine: implications for renal disease. J Ren Nutr (2003) 0.82
The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease. Biochim Biophys Acta (2011) 0.82
Inactivation by omeprazole of the carnitine transporter (OCTN2) reconstituted in liposomes. Chem Biol Interact (2008) 0.82
Growth hormone and ghrelin secretion in severely obese women before and after bariatric surgery. Obesity (Silver Spring) (2007) 0.82
Regulation by physiological cations of acetylcholine transport mediated by human OCTN1 (SLC22A4). Implications in the non-neuronal cholinergic system. Life Sci (2012) 0.81
Decreased mitochondrial carnitine translocase in skeletal muscles impairs utilization of fatty acids in insulin-resistant patients. Front Biosci (2002) 0.81
Reconstitution into liposomes and functional characterization of the carnitine transporter from renal cell plasma membrane. Biochim Biophys Acta (2004) 0.81
Conformation-dependent accessibility of Cys-136 and Cys-155 of the mitochondrial rat carnitine/acylcarnitine carrier to membrane-impermeable SH reagents. Biochim Biophys Acta (2007) 0.80
Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs. FEBS Lett (2006) 0.80
Differential carnitine/acylcarnitine translocase expression defines distinct metabolic signatures in skeletal muscle cells. J Cell Physiol (2005) 0.80
Identification of amino acid residues underlying the antiport mechanism of the mitochondrial carnitine/acylcarnitine carrier by site-directed mutagenesis and chemical labeling. Biochemistry (2014) 0.80
The B°AT1 amino acid transporter from rat kidney reconstituted in liposomes: kinetics and inactivation by methylmercury. Biochim Biophys Acta (2011) 0.80
Menopause, insulin resistance, and risk factors for cardiovascular disease. Menopause (2006) 0.80
Propionyl-L-carnitine reduces intimal hyperplasia after injury in normocholesterolemic rabbit carotid artery by modulating proliferation and caspase 3-dependent apoptosis of vascular smooth muscle cells. Atherosclerosis (2002) 0.79
The protective effect of L-carnitine in peripheral blood human lymphocytes exposed to oxidative agents. Mutagenesis (2005) 0.79
Site-directed mutagenesis of charged amino acids of the human mitochondrial carnitine/acylcarnitine carrier: insight into the molecular mechanism of transport. Biochim Biophys Acta (2010) 0.79
Identification by site-directed mutagenesis of a hydrophobic binding site of the mitochondrial carnitine/acylcarnitine carrier involved in the interaction with acyl groups. Biochim Biophys Acta (2012) 0.79
Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery. Obesity (Silver Spring) (2008) 0.79
Identification by site-directed mutagenesis and chemical modification of three vicinal cysteine residues in rat mitochondrial carnitine/acylcarnitine transporter. J Biol Chem (2005) 0.79
Leptin pulsatility in formerly obese women. FASEB J (2005) 0.79
Over-expression in E. coli and purification of the human OCTN1 transport protein. Protein Expr Purif (2009) 0.79
Ghrelin does not influence gastric emptying in obese subjects. Obes Res (2005) 0.78
Carnitine system in uremic patients: molecular and clinical aspects. Semin Nephrol (2004) 0.78
Human OCTN2 (SLC22A5) is down-regulated in virus- and nonvirus-mediated cancer. Cell Biochem Funct (2012) 0.78
Glutathione controls the redox state of the mitochondrial carnitine/acylcarnitine carrier Cys residues by glutathionylation. Biochim Biophys Acta (2013) 0.78
Acetyl-L-carnitine up-regulates expression of voltage-dependent anion channel in the rat brain. Neurochem Int (2006) 0.78
Inhibition of mitochondrial carnitine/acylcarnitine transporter by H(2)O(2): molecular mechanism and possible implication in pathophysiology. Chem Biol Interact (2013) 0.78
Identification of differentially expressed genes induced in the rat brain by acetyl-L-carnitine as evidenced by suppression subtractive hybridisation. Brain Res Mol Brain Res (2004) 0.78
Proteoliposomes as tool for assaying membrane transporter functions and interactions with xenobiotics. Pharmaceutics (2013) 0.78
Cloning, large scale over-expression in E. coli and purification of the components of the human LAT 1 (SLC7A5) amino acid transporter. Protein J (2013) 0.77
Over-expression in Escherichia coli, purification and reconstitution in liposomes of the third member of the OCTN sub-family: the mouse carnitine transporter OCTN3. Biochem Biophys Res Commun (2012) 0.77
Functional characterization of residues within the carnitine/acylcarnitine translocase RX2PANAAXF distinct motif. Mol Membr Biol (2008) 0.77
Modulatory effect of acetyl-L-carnitine on amyloid precursor protein metabolism in hippocampal neurons. Eur J Pharmacol (2008) 0.77
Reconstitution into liposomes of the glutamine/amino acid transporter from renal cell plasma membrane: functional characterization, kinetics and activation by nucleotides. Biochim Biophys Acta (2004) 0.77
Chemical modification of the mitochondrial ornithine/citrulline carrier by SH reagents: effects on the transport activity and transition from carrier to pore-like function. Biochim Biophys Acta (2003) 0.77
Effects of carnitine on thyroid hormone action. Ann N Y Acad Sci (2004) 0.77
Role of carnitine in modulating acute-phase protein synthesis in hemodialysis patients. J Ren Nutr (2005) 0.77
Site-directed mutagenesis of the His residues of the rat mitochondrial carnitine/acylcarnitine carrier: implications for the role of His-29 in the transport pathway. Biochim Biophys Acta (2009) 0.77
The glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: transport mechanism, regulation by ATP and characterization of the glutamine/glutamate antiport. Biochim Biophys Acta (2006) 0.77
Muscle unloading potentiates the effects of acetyl-L-carnitine on the slow oxidative muscle phenotype. Biofactors (2010) 0.77
Over-expression in E. coli and purification of the human OCTN2 transport protein. Mol Biotechnol (2012) 0.77
Inactivation by Hg2+ and methylmercury of the glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: Prediction of the involvement of a CXXC motif by homology modelling. Biochem Pharmacol (2010) 0.77
Effects of heavy metal cations on the mitochondrial ornithine/citrulline transporter reconstituted in liposomes. Biometals (2011) 0.77
Functional reconstitution into liposomes and characterization of the carnitine transporter from rat liver microsomes. Biochim Biophys Acta (2006) 0.76