PubRank

Dai Fukumura

Author PubWeight™ 174.80‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 2004 8.78
2 Photodynamic therapy for cancer. Nat Rev Cancer 2003 8.00
3 Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 2011 5.64
4 Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat Med 2009 5.41
5 Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nat Nanotechnol 2012 4.84
6 Tissue engineering: creation of long-lasting blood vessels. Nature 2004 4.50
7 Dissecting tumour pathophysiology using intravital microscopy. Nat Rev Cancer 2002 3.96
8 Tumour biology: herceptin acts as an anti-angiogenic cocktail. Nature 2002 3.40
9 Multistage nanoparticle delivery system for deep penetration into tumor tissue. Proc Natl Acad Sci U S A 2011 3.34
10 Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nat Med 2005 3.19
11 Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood 2008 3.13
12 Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. J Clin Oncol 2009 3.02
13 Engineering vascularized tissue. Nat Biotechnol 2005 2.69
14 Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nat Biotechnol 2007 2.65
15 Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell 2013 2.64
16 Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood 2007 2.64
17 Malignant cells facilitate lung metastasis by bringing their own soil. Proc Natl Acad Sci U S A 2010 2.62
18 Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A 2012 2.50
19 Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. Cancer Res 2006 2.42
20 CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies? Clin Cancer Res 2011 2.39
21 The biology of brain metastases-translation to new therapies. Nat Rev Clin Oncol 2011 2.16
22 In vivo wide-area cellular imaging by side-view endomicroscopy. Nat Methods 2010 2.10
23 Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. Cancer Res 2002 2.09
24 Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors. Blood 2005 1.98
25 Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration. Angew Chem Int Ed Engl 2011 1.93
26 Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell 2005 1.89
27 Impaired lymphatic contraction associated with immunosuppression. Proc Natl Acad Sci U S A 2011 1.88
28 Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks. Nat Methods 2010 1.88
29 A nanoparticle size series for in vivo fluorescence imaging. Angew Chem Int Ed Engl 2010 1.84
30 Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib. Mol Cancer Ther 2008 1.83
31 Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis. Blood 2011 1.82
32 Differential transplantability of tumor-associated stromal cells. Cancer Res 2004 1.78
33 Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Res 2013 1.73
34 Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function. Cancer Res 2004 1.72
35 Cancer imaging by optical coherence tomography: preclinical progress and clinical potential. Nat Rev Cancer 2012 1.72
36 A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight. Cell Metab 2009 1.72
37 Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF. J Biol Chem 2001 1.72
38 Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking. Nat Mater 2013 1.71
39 Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. J Natl Cancer Inst 2013 1.69
40 NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. J Clin Invest 2005 1.65
41 Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand. J Am Chem Soc 2010 1.60
42 Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Res 2006 1.60
43 Perivascular nitric oxide gradients normalize tumor vasculature. Nat Med 2008 1.56
44 Scaling rules for diffusive drug delivery in tumor and normal tissues. Proc Natl Acad Sci U S A 2011 1.54
45 VEGFR1-activity-independent metastasis formation. Nature 2009 1.47
46 Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions. Biophys J 2010 1.47
47 Role of eNOS in neovascularization: NO for endothelial progenitor cells. Trends Mol Med 2004 1.42
48 Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells. Proc Natl Acad Sci U S A 2013 1.41
49 Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors. Cancer Res 2003 1.40
50 InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared. J Am Chem Soc 2010 1.39
51 Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases. PLoS One 2009 1.37
52 C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells. Proc Natl Acad Sci U S A 2010 1.30
53 Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circ Res 2004 1.30
54 Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors. Clin Cancer Res 2002 1.29
55 Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models. Cancer Res 2006 1.28
56 Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation. Proc Natl Acad Sci U S A 2011 1.27
57 Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells. PLoS One 2009 1.25
58 VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation. PLoS One 2009 1.23
59 Benefits of vascular normalization are dose and time dependent--letter. Cancer Res 2013 1.22
60 Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells. Clin Cancer Res 2004 1.17
61 Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas. Clin Cancer Res 2010 1.17
62 Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts. Clin Cancer Res 2003 1.14
63 In vivo imaging of tumors. Cold Spring Harb Protoc 2010 1.13
64 Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis. Cancer Res 2009 1.13
65 Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Proc Natl Acad Sci U S A 2012 1.09
66 Influence of tumor cell and stroma sensitivity on tumor response to radiation. Cancer Res 2007 1.09
67 Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice. Comp Med 2008 1.07
68 PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer. Clin Cancer Res 2011 1.07
69 Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast. Opt Lett 2009 1.07
70 Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy. Cancer Res 2002 1.05
71 Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts. Cancer Res 2003 1.04
72 Normalization of the tumor vasculature through oncogenic inhibition: an emerging paradigm in tumor biology. Proc Natl Acad Sci U S A 2012 0.96
73 Cationic nanoparticles have superior transvascular flux into solid tumors: insights from a mathematical model. Ann Biomed Eng 2012 0.95
74 Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo. Am J Pathol 2009 0.95
75 A transient parabiosis skin transplantation model in mice. Nat Protoc 2012 0.94
76 Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment. Intravital 2012 0.93
77 Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy. Cancer Res 2002 0.92
78 Molecular regulation of microlymphatic formation and function: role of nitric oxide. Trends Cardiovasc Med 2005 0.89
79 From the Guest Editors: Role of Tumor Microenvironment in Tumor Progression and Treatment Response: A 30 Years' Journey. Cancer J 2015 0.88
80 Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse. Comp Med 2005 0.87
81 Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model. PLoS Med 2008 0.87
82 Spontaneous nonthymic tumors in SCID mice. Comp Med 2011 0.87
83 Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells. Ann Biomed Eng 2006 0.87
84 Small blood vessel engineering. Methods Mol Med 2007 0.86
85 Transgenic mice for cGMP imaging. Circ Res 2013 0.86
86 Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo. Angew Chem Int Ed Engl 2012 0.84
87 Mammary fat pad tumor preparation in mice. Cold Spring Harb Protoc 2012 0.81
88 An isolated tumor perfusion model in mice. Nat Protoc 2012 0.81
89 Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice. Nat Protoc 2012 0.81
90 Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice. J Cell Physiol 2009 0.80
91 Multistage nanoparticles for improved delivery into tumor tissue. Methods Enzymol 2012 0.79
92 Measuring angiogenesis and hemodynamics in mice. Cold Spring Harb Protoc 2013 0.79
93 Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors. Ann Biomed Eng 2015 0.79
94 Liver tumor preparation in mice. Cold Spring Harb Protoc 2012 0.77
95 Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site. Oncol Rep 2004 0.76
96 Measuring leukocyte-endothelial interactions in mice. Cold Spring Harb Protoc 2013 0.76
97 Lymphangiography of the mouse ear. Cold Spring Harb Protoc 2012 0.76
98 Lung window preparation in mice. Cold Spring Harb Protoc 2013 0.76
99 Measuring vascular permeability in mice. Cold Spring Harb Protoc 2013 0.75
100 Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harb Perspect Med 2016 0.75
101 Anti-VEGFR-3 therapy and lymph node metastasis [corrected]. Cancer Res 2007 0.75
102 Optical methods in vascular biology and medicine. J Biomed Opt 2010 0.75
103 Measuring interstitial diffusion, convection, and binding parameters in mouse tumors. Cold Spring Harb Protoc 2013 0.75
104 Lymphangiography of the mouse tail. Cold Spring Harb Protoc 2012 0.75
105 Corneal pocket assay in rabbits. Cold Spring Harb Protoc 2012 0.75
106 Mammary fat pad chamber preparation in mice. Cold Spring Harb Protoc 2012 0.75
107 Rabbit ear chambers. Cold Spring Harb Protoc 2012 0.75
108 Lessons From 30 Years of Teaching About the Microenvironment of Tumors. Cancer J 2015 0.75
109 Pancreatic tumor preparation in mice. Cold Spring Harb Protoc 2012 0.75
110 Measuring interstitial pH and pO2 in mouse tumors. Cold Spring Harb Protoc 2013 0.75