RNA polymerase: the vehicle of transcription.

Mechanism of bacterial transcription initiation: RNA polymerase - promoter binding, isomerization to initiation-competent open complexes, and initiation of RNA synthesis. J Mol Biol (2011) 2.50

RNA polymerase active center: the molecular engine of transcription. Annu Rev Biochem (2009) 1.94

Bridge helix and trigger loop perturbations generate superactive RNA polymerases. J Biol (2008) 1.60

RNA polymerase II with open and closed trigger loops: active site dynamics and nucleic acid translocation. Biophys J (2010) 1.14

WebGeSTer DB--a transcription terminator database. Nucleic Acids Res (2010) 1.14

Function of the Bacillus subtilis transcription elongation factor NusG in hairpin-dependent RNA polymerase pausing in the trp leader. Proc Natl Acad Sci U S A (2008) 1.11

The nucleotide addition cycle of RNA polymerase is controlled by two molecular hinges in the Bridge Helix domain. BMC Biol (2010) 1.11

Macromolecular micromovements: how RNA polymerase translocates. Curr Opin Struct Biol (2009) 1.07

The reducible complexity of a mitochondrial molecular machine. Proc Natl Acad Sci U S A (2009) 1.05

Essential biological processes of an emerging pathogen: DNA replication, transcription, and cell division in Acinetobacter spp. Microbiol Mol Biol Rev (2010) 1.04

Stalled transcription complexes promote DNA repair at a distance. Proc Natl Acad Sci U S A (2014) 1.01

Mechanism of NusG-stimulated pausing, hairpin-dependent pause site selection and intrinsic termination at overlapping pause and termination sites in the Bacillus subtilis trp leader. Mol Microbiol (2010) 1.00

RNA polymerase II flexibility during translocation from normal mode analysis. Proteins (2010) 0.97

Closing the circle: replicating RNA with RNA. Cold Spring Harb Perspect Biol (2010) 0.96

Energetic and structural details of the trigger-loop closing transition in RNA polymerase II. Biophys J (2013) 0.95

Targeting RNA polymerase primary σ70 as a therapeutic strategy against methicillin-resistant Staphylococcus aureus by antisense peptide nucleic acid. PLoS One (2012) 0.90

Inactivation of the bacterial RNA polymerase due to acquisition of secondary structure by the ω subunit. J Biol Chem (2013) 0.86

Jamming the ratchet of transcription. Nat Struct Mol Biol (2008) 0.86

Coupling of downstream RNA polymerase-promoter interactions with formation of catalytically competent transcription initiation complex. J Mol Biol (2014) 0.84

Torsion-mediated interaction between adjacent genes. PLoS Comput Biol (2014) 0.84

A model for transcription initiation in human mitochondria. Nucleic Acids Res (2015) 0.84

Trigger loop folding determines transcription rate of Escherichia coli's RNA polymerase. Proc Natl Acad Sci U S A (2014) 0.83

Mycobacterium RbpA cooperates with the stress-response σB subunit of RNA polymerase in promoter DNA unwinding. Nucleic Acids Res (2014) 0.83

A small post-translocation energy bias aids nucleotide selection in T7 RNA polymerase transcription. Biophys J (2012) 0.82

RNA polymerase: a nexus of gene regulation. Methods (2009) 0.82

Development of a "modular" scheme to describe the kinetics of transcript elongation by RNA polymerase. Biophys J (2011) 0.82

DksA regulates RNA polymerase in Escherichia coli through a network of interactions in the secondary channel that includes Sequence Insertion 1. Proc Natl Acad Sci U S A (2015) 0.82

Differences between cotranscriptional and free riboswitch folding. Nucleic Acids Res (2013) 0.82

Topology-function conservation in protein-protein interaction networks. Bioinformatics (2015) 0.81

Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes. Mol Microbiol (2014) 0.80

Transcription activation by the siderophore sensor Btr is mediated by ligand-dependent stimulation of promoter clearance. Nucleic Acids Res (2011) 0.80

Fitting experimental transcription data with a comprehensive template-dependent modular kinetic model. Biophys J (2011) 0.79

Inhibition of Mycobacterium tuberculosis RNA polymerase by binding of a Gre factor homolog to the secondary channel. J Bacteriol (2011) 0.78

Bacterial RNA Polymerase-DNA Interaction-The Driving Force of Gene Expression and the Target for Drug Action. Front Mol Biosci (2016) 0.77

Bacterial Transcription as a Target for Antibacterial Drug Development. Microbiol Mol Biol Rev (2016) 0.77

A Jump-from-Cavity Pyrophosphate Ion Release Assisted by a Key Lysine Residue in T7 RNA Polymerase Transcription Elongation. PLoS Comput Biol (2015) 0.77

Influence of Flexible "ω" on the Activity of E. coli RNA Polymerase: A Thermodynamic Analysis. Biophys J (2017) 0.75

Characterization of a minimal type of promoter containing the -10 element and a guanine at the -14 or -13 position in mycobacteria. J Bacteriol (2017) 0.75

Sensing small molecules by nascent RNA: a mechanism to control transcription in bacteria. Cell (2002) 4.67

A ratchet mechanism of transcription elongation and its control. Cell (2005) 4.48

Cooperation between translating ribosomes and RNA polymerase in transcription elongation. Science (2010) 3.87

A decade of riboswitches. Cell (2013) 3.26

The riboswitch-mediated control of sulfur metabolism in bacteria. Proc Natl Acad Sci U S A (2003) 2.83

RNA-mediated response to heat shock in mammalian cells. Nature (2006) 2.79

H2S: a universal defense against antibiotics in bacteria. Science (2011) 2.69

Termination factor Rho and its cofactors NusA and NusG silence foreign DNA in E. coli. Science (2008) 2.66

Cooperation between RNA polymerase molecules in transcription elongation. Science (2003) 2.47

Endogenous nitric oxide protects bacteria against a wide spectrum of antibiotics. Science (2009) 2.32

Extensive functional overlap between sigma factors in Escherichia coli. Nat Struct Mol Biol (2006) 2.30

Linking RNA polymerase backtracking to genome instability in E. coli. Cell (2011) 2.20

Riboswitch control of Rho-dependent transcription termination. Proc Natl Acad Sci U S A (2012) 2.10

Transcription through the roadblocks: the role of RNA polymerase cooperation. EMBO J (2003) 1.89

NO-mediated cytoprotection: instant adaptation to oxidative stress in bacteria. Proc Natl Acad Sci U S A (2005) 1.81

An allosteric mechanism of Rho-dependent transcription termination. Nature (2010) 1.73

An allosteric path to transcription termination. Mol Cell (2007) 1.73

Transcription inactivation through local refolding of the RNA polymerase structure. Nature (2008) 1.63

Thermodynamic and kinetic modeling of transcriptional pausing. Proc Natl Acad Sci U S A (2006) 1.61

Transcription-replication encounters, consequences and genomic instability. Nat Struct Mol Biol (2013) 1.54

Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages. Proc Natl Acad Sci U S A (2008) 1.49

RNA polymerase holoenzyme: structure, function and biological implications. Curr Opin Microbiol (2003) 1.48

Riboswitch-dependent gene regulation and its evolution in the plant kingdom. Genes Dev (2007) 1.47

Bacterial nitric-oxide synthases operate without a dedicated redox partner. J Biol Chem (2008) 1.41

Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response. Cell Microbiol (2009) 1.36

Bacterial nitric oxide extends the lifespan of C. elegans. Cell (2013) 1.35

Catalysis of S-nitrosothiols formation by serum albumin: the mechanism and implication in vascular control. Proc Natl Acad Sci U S A (2002) 1.23

Assessment of nitric oxide signals by triiodide chemiluminescence. Proc Natl Acad Sci U S A (2007) 1.20

Therapeutic effect of exogenous hsp70 in mouse models of Alzheimer's disease. J Alzheimers Dis (2014) 1.16

Tagetitoxin inhibits RNA polymerase through trapping of the trigger loop. J Biol Chem (2011) 1.14

Transcription regulatory elements are punctuation marks for DNA replication. Proc Natl Acad Sci U S A (2006) 1.12

Methicillin-resistant Staphylococcus aureus bacterial nitric-oxide synthase affects antibiotic sensitivity and skin abscess development. J Biol Chem (2013) 1.11

Macromolecular micromovements: how RNA polymerase translocates. Curr Opin Struct Biol (2009) 1.07

Gene control by large noncoding RNAs. Sci STKE (2006) 1.04

A unified model of transcription elongation: what have we learned from single-molecule experiments? Biophys J (2011) 1.00

Basic mechanism of transcription by RNA polymerase II. Biochim Biophys Acta (2012) 0.98

RNA polymerase and the ribosome: the close relationship. Curr Opin Microbiol (2013) 0.94

RNA polymerase stalls in a post-translocated register and can hyper-translocate. Transcription (2012) 0.90

Template switching by RNA polymerase II in vivo. Evidence and implications from a retroviral system. Mol Cell (2002) 0.89

The RNA polymerase bridge helix YFI motif in catalysis, fidelity and translocation. Biochim Biophys Acta (2012) 0.89

Jamming the ratchet of transcription. Nat Struct Mol Biol (2008) 0.86

Dynamics of endogenous Hsp70 synthesis in the brain of olfactory bulbectomized mice. Cell Stress Chaperones (2012) 0.85

Control of plasma nitric oxide bioactivity by perfluorocarbons: physiological mechanisms and clinical implications. Circulation (2004) 0.83

S-nitrosylation signaling in Escherichia coli. Sci Signal (2012) 0.83

Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing. Nature (2016) 0.82

Clamping the clamp of RNA polymerase. EMBO J (2011) 0.82

Unfolding the bridge between transcription and translation. Cell (2012) 0.80

Looking for a promoter in 3D. Nat Struct Mol Biol (2013) 0.80

Phosphorylation of Ser8 promotes zinc-induced dimerization of the amyloid-β metal-binding domain. Mol Biosyst (2014) 0.79

Response to Klyuyev and Vassylyev: on the mechanism of tagetitoxin inhibition of transcription. Transcription (2012) 0.78

Isolation and characterization of the heat shock RNA 1. Methods Mol Biol (2009) 0.77

STR2: a structure to string approach for locating G-box riboswitch shapes in pre-selected genes. In Silico Biol (2004) 0.77

Transcriptional approaches to riboswitch studies. Methods Mol Biol (2009) 0.77

Ratcheting of RNA polymerase toward structural principles of RNA polymerase operations. Transcription (2015) 0.76

Modular RNA heats up. Mol Cell (2008) 0.75