Functional role of lipoprotein receptors in Alzheimer's disease.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMID 18288927)

Published in Curr Alzheimer Res on February 01, 2008

Authors

Sebastian Jaeger1, Claus U Pietrzik

Author Affiliations

1: Institute of Physiological Chemistry and Pathobiochemistry, Molecular Neurodegeneration, Johannes-Gutenberg-University Mainz, Mainz, Germany.

Articles citing this

Mechanisms underlying inflammation in neurodegeneration. Cell (2010) 7.66

The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged. Arch Neurol (2009) 3.13

Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease. PLoS One (2010) 1.41

Pathophysiology of the neurovascular unit: disease cause or consequence? J Cereb Blood Flow Metab (2012) 1.28

The vascular contribution to Alzheimer's disease. Clin Sci (Lond) (2010) 1.21

Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease. J Neurosci Res (2010) 1.15

C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity. J Biol Chem (2012) 1.11

Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders. Am J Neurodegener Dis (2013) 1.08

A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol. Arterioscler Thromb Vasc Biol (2009) 1.04

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease. Front Aging Neurosci (2014) 1.01

Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake. J Biol Chem (2009) 1.00

Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent. Fluids Barriers CNS (2011) 0.97

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain. Free Radic Biol Med (2010) 0.95

APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice. Elife (2013) 0.90

Signaling effect of amyloid-beta(42) on the processing of AbetaPP. Exp Neurol (2009) 0.89

ATP-binding Cassette Transporter A7 (ABCA7) Loss of Function Alters Alzheimer Amyloid Processing. J Biol Chem (2015) 0.88

The role of lipoprotein receptors on the physiological function of APP. Exp Brain Res (2011) 0.84

The p75 neurotrophin receptor localization in blood-CSF barrier: expression in choroid plexus epithelium. BMC Neurosci (2011) 0.81

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits. Mol Neurodegener (2015) 0.80

LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's Disease in humans in-vivo. Neuroimage Clin (2014) 0.79

Amyloid-β sequester proteins as blood-based biomarkers of cognitive decline. Alzheimers Dement (Amst) (2015) 0.78

Immunohistochemical detection of receptor-associated protein in normal human brain and Alzheimer's disease. Patholog Res Int (2010) 0.77

Alzheimer's disease: a pathogenetic autoimmune disorder caused by herpes simplex in a gene-dependent manner. Int J Alzheimers Dis (2010) 0.77

Early diagnosis of mild cognitive impairment and Alzheimer's disease based on salivary lactoferrin. Alzheimers Dement (Amst) (2017) 0.76

Dose-responsive gene expression changes in juvenile and adult mummichogs (Fundulus heteroclitus) after arsenic exposure. Mar Environ Res (2010) 0.76

Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation. Glia (2016) 0.75

Articles by these authors

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem (2003) 2.31

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci (2007) 2.25

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. J Biol Chem (2007) 1.20

alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. J Neurochem (2009) 1.15

The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors. J Biol Chem (2008) 1.15

Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. J Biol Chem (2008) 1.13

Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci (2008) 1.05

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10. Cell Mol Life Sci (2012) 1.05

The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species. J Biol Chem (2012) 1.05

Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem (2003) 1.04

LRP1 modulates APP trafficking along early compartments of the secretory pathway. Neurobiol Dis (2008) 1.02

Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure. J Neurochem (2010) 1.02

Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model. PLoS One (2012) 1.02

LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier. Neurobiol Aging (2010) 1.02

Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. J Biol Chem (2011) 1.01

Mechanisms of C-reactive protein-induced blood-brain barrier disruption. Stroke (2009) 1.00

Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein. J Biol Chem (2005) 0.99

Presenilin is the molecular target of acidic γ-secretase modulators in living cells. PLoS One (2012) 0.97

Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling. J Biol Chem (2005) 0.94

Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. J Neurochem (2005) 0.94

Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier. J Clin Invest (2015) 0.93

Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription. Exp Cell Res (2008) 0.92

Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes. J Neuropathol Exp Neurol (2008) 0.91

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J Biol Chem (2005) 0.89

Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway. Nat Commun (2013) 0.89

Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier. J Cereb Blood Flow Metab (2012) 0.86

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms. Cell Mol Life Sci (2011) 0.86

Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis. Cell Mol Life Sci (2009) 0.86

The role of lipoprotein receptors on the physiological function of APP. Exp Brain Res (2011) 0.84

LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype. Mol Neurodegener (2013) 0.83

Functional role of the low-density lipoprotein receptor-related protein in Alzheimer's disease. Neurodegener Dis (2006) 0.82

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease. J Neural Transm (Vienna) (2011) 0.81

Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein. Neurodegener Dis (2008) 0.78

The physiological functions of the β-amyloid precursor protein APP. Exp Brain Res (2012) 0.77

Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening. ACS Chem Biol (2012) 0.77

Stx5 is a novel interactor of VLDL-R to affect its intracellular trafficking and processing. Exp Cell Res (2013) 0.76

Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells. Bioorg Med Chem (2012) 0.75