Published in Anesthesiology on March 01, 2008
High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without alpha(2) adrenoceptor activation. Br J Pharmacol (2010) 1.26
Molecular mechanisms underlying the analgesic property of intrathecal dexmedetomidine and its neurotoxicity evaluation: an in vivo and in vitro experimental study. PLoS One (2013) 1.21
Dexmedetomidine reduces isoflurane-induced neuroapoptosis partly by preserving PI3K/Akt pathway in the hippocampus of neonatal rats. PLoS One (2014) 1.10
Sedation improves early outcome in severely septic Sprague Dawley rats. Crit Care (2009) 1.07
Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury. BMC Neurol (2012) 1.05
Imidazoleacetic acid-ribotide induces depression of synaptic responses in hippocampus through activation of imidazoline receptors. J Neurophysiol (2011) 0.92
Considerations for the use of anesthetics in neurotoxicity studies. Comp Med (2010) 0.91
Neonatal pain control and neurologic effects of anesthetics and sedatives in preterm infants. Clin Perinatol (2013) 0.90
Neuroprotective Effects of Dexmedetomidine Against Hypoxia-Induced Nervous System Injury are Related to Inhibition of NF-κB/COX-2 Pathways. Cell Mol Neurobiol (2015) 0.87
Dexmedetomidine post-treatment induces neuroprotection via activation of extracellular signal-regulated kinase in rats with subarachnoid haemorrhage. Br J Anaesth (2016) 0.84
Effect of dexmedetomidine on lung ischemia‑reperfusion injury. Mol Med Rep (2013) 0.82
The effects of dexmedetomidine on secondary acute lung and kidney injuries in the rat model of intra-abdominal sepsis. ScientificWorldJournal (2013) 0.80
Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats. Int Neurourol J (2017) 0.79
Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro. Neurobiol Aging (2015) 0.77
Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model. Acta Anaesthesiol Scand (2014) 0.77
Dexmedetomidine Protects against Transient Global Cerebral Ischemia/Reperfusion Induced Oxidative Stress and Inflammation in Diabetic Rats. PLoS One (2016) 0.76
Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine. Clin Pharmacokinet (2017) 0.76
Dexmedetomidine-induced neuroprotection: is it translational? Transl Perioper Pain Med (2016) 0.75
Dexmedetomidine preconditioning attenuates Cisplatin-induced ototoxicity in zebrafish. Clin Exp Otorhinolaryngol (2014) 0.75
Dexmedetomidine Protects Rat Liver against Ischemia-Reperfusion Injury Partly by the α2A-Adrenoceptor Subtype and the Mechanism Is Associated with the TLR4/NF-κB Pathway. Int J Mol Sci (2016) 0.75
Novel single chain cAMP sensors for receptor-induced signal propagation. J Biol Chem (2004) 5.00
Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest (2009) 4.12
Misrepresentation of randomized controlled trials in press releases and news coverage: a cohort study. PLoS Med (2012) 3.33
Current practice in nutritional support and its association with mortality in septic patients--results from a national, prospective, multicenter study. Crit Care Med (2008) 3.12
Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature (2005) 3.09
Current practices in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient-based study. Anesthesiology (2007) 2.83
Systemic inflammation disrupts the developmental program of white matter. Ann Neurol (2011) 2.20
Pain assessment is associated with decreased duration of mechanical ventilation in the intensive care unit: a post Hoc analysis of the DOLOREA study. Anesthesiology (2009) 2.17
Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure. Circulation (2002) 2.10
Evaluation of the pediatric Bonfils fiberscope for elective endotracheal intubation. Paediatr Anaesth (2008) 2.07
Influence of increased intra-abdominal pressure on fluid responsiveness predicted by pulse pressure variation and stroke volume variation in a porcine model. Crit Care Med (2009) 2.06
The Jak/STAT pathway is involved in synaptic plasticity. Neuron (2012) 2.02
Factors associated with difficult intubation in prehospital emergency medicine. Eur J Emerg Med (2012) 1.97
Multicenter randomized comparison of the efficacy and safety of xenon and isoflurane in patients undergoing elective surgery. Anesthesiology (2003) 1.96
Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults. Ann Neurol (2012) 1.92
Heart rate variability predicts severe hypotension after spinal anesthesia for elective cesarean delivery. Anesthesiology (2005) 1.89
Ketamine for perioperative pain management in children: a meta-analysis of published studies. Paediatr Anaesth (2011) 1.84
Can yeast isolation in peritoneal fluid be predicted in intensive care unit patients with peritonitis? Crit Care Med (2003) 1.84
A phase III, double-blind, placebo-controlled, multicenter study on the efficacy of recombinant human antithrombin in heparin-resistant patients scheduled to undergo cardiac surgery necessitating cardiopulmonary bypass. Anesthesiology (2005) 1.82
Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice. Circ Res (2002) 1.79
Many roads lead to primary autosomal recessive microcephaly. Prog Neurobiol (2009) 1.78
Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest (2004) 1.77
Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res (2007) 1.74
The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. J Intensive Care Med (2004) 1.72
Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro. Brain Behav Immun (2013) 1.66
Heart rate variability-guided prophylactic treatment of severe hypotension after subarachnoid block for elective cesarean delivery. Anesthesiology (2006) 1.65
Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough. Am J Physiol Regul Integr Comp Physiol (2002) 1.63
Laryngeal tube S II, ProSeal laryngeal mask, and EasyTube during elective surgery: a randomized controlled comparison with the endotracheal tube in nontrained professionals. Eur J Anaesthesiol (2009) 1.61
Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function. Hypertension (2011) 1.59
Possible air embolism during eye surgery. Anesth Analg (2005) 1.56
Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction. Cardiovasc Res (2007) 1.55
Overlapping induction of anesthesia: an analysis of benefits and costs. Anesthesiology (2005) 1.53
Urological surgery and antiplatelet drugs after cardiac and cerebrovascular accidents. J Urol (2010) 1.52
Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. Crit Care Med (2005) 1.51
Collaboration between prehospital emergency medical teams and palliative care networks allows a better respect of a patient's will. Eur J Emerg Med (2012) 1.48
Comparison of two bispectral index algorithms in monitoring sedation in postoperative intensive care patients. Crit Care Med (2005) 1.48
Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice. Circ Res (2007) 1.48
Pharmacokinetics of melatonin in preterm infants. Br J Clin Pharmacol (2013) 1.48
Revised resuscitation guidelines: adrenaline versus adrenaline/vasopressin in a pig model of cardiopulmonary resuscitation--a randomised, controlled trial. Resuscitation (2007) 1.47
A comparison of two depths of prolonged neuromuscular blockade induced by cisatracurium in mechanically ventilated critically ill patients. Intensive Care Med (2002) 1.47
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial. Eur J Anaesthesiol (2010) 1.45
Somatosensory evoked potentials as predictor of systemic inflammatory response syndrome in pigs? Intensive Care Med (2003) 1.45
Physical restraint in mechanically ventilated ICU patients: a survey of French practice. Intensive Care Med (2012) 1.45
Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities. Cell Rep (2012) 1.43
Parathyroid hormone-related protein in epithelial lining fluid in humans negatively correlates with the severity of lung injury. Chest (2002) 1.43
The identification of phosducin as a novel candidate gene for hypertension and its role in sympathetic activation. Curr Opin Nephrol Hypertens (2011) 1.40
Successful use of succinylcholine for cesarean delivery in a patient with postpolio syndrome. Anesthesiology (2007) 1.39
The yin and yang of microglia. Dev Neurosci (2011) 1.38
Alpha2-adrenergic receptor activation regulates cortical interneuron migration. Eur J Neurosci (2012) 1.38
Predictive factors of early postoperative urinary retention in the postanesthesia care unit. Anesth Analg (2005) 1.36
Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation. Circulation (2004) 1.36
Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes. Mol Endocrinol (2003) 1.33
Neuronal damage accompanies perinatal white-matter damage. Trends Neurosci (2007) 1.32
Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version. Ger Med Sci (2010) 1.30
A national resuscitation registry of out-of-hospital cardiac arrest in Germany-a pilot study. Resuscitation (2008) 1.28
Prospective validation of the "fifty-fifty" criteria as an early and accurate predictor of death after liver resection in intensive care unit patients. Ann Surg (2009) 1.27
Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model. Brain (2012) 1.25
Melatonin reduces inflammation and cell death in white matter in the mid-gestation fetal sheep following umbilical cord occlusion. Pediatr Res (2007) 1.23
Comparison of different methods to define regions of interest for evaluation of regional lung ventilation by EIT. Physiol Meas (2006) 1.21
Neonatal encephalopathy or hypoxic-ischemic encephalopathy? Appropriate terminology matters. Pediatr Res (2011) 1.20
The reliability of pulse contour-derived cardiac output during hemorrhage and after vasopressor administration. Anesth Analg (2007) 1.20
Heart rate variability predicts severe hypotension after spinal anesthesia. Anesthesiology (2006) 1.20
Comparison of esophageal Doppler, pulse contour analysis, and real-time pulmonary artery thermodilution for the continuous measurement of cardiac output. J Cardiothorac Vasc Anesth (2004) 1.19
Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure. PLoS One (2007) 1.14
Postreperfusion syndrome during liver transplantation for cirrhosis: outcome and predictors. Liver Transpl (2009) 1.13
All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn Schmiedebergs Arch Pharmacol (2003) 1.13
The role of JAK-STAT signaling within the CNS. JAKSTAT (2013) 1.12
Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction. Circulation (2011) 1.12
Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain. Ann Neurol (2012) 1.12
Maternal exposure to LPS induces hypomyelination in the internal capsule and programmed cell death in the deep gray matter in newborn rats. Pediatr Res (2006) 1.11
Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy? Lancet Neurol (2012) 1.11
Adrenergic receptor knockout mice: distinct functions of 9 receptor subtypes. Pharmacol Ther (2004) 1.11
Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge. Ann Neurol (2002) 1.11
Neuroendocrine stress response and heart rate variability: a comparison of total intravenous versus balanced anesthesia. Anesth Analg (2005) 1.10
Genetic dissection of alpha2-adrenoceptor functions in adrenergic versus nonadrenergic cells. Mol Pharmacol (2009) 1.10
Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation (2003) 1.10
Neuroprotective effects of dexmedetomidine against glutamate agonist-induced neuronal cell death are related to increased astrocyte brain-derived neurotrophic factor expression. Anesthesiology (2013) 1.09
A novel mouse model of Ureaplasma-induced perinatal inflammation: effects on lung and brain injury. Pediatr Res (2009) 1.09
Alpha2-adrenoceptor subtypes--unexpected functions for receptors and ligands derived from gene-targeted mouse models. Neurochem Int (2007) 1.09
Management of the predicted difficult airway: a comparison of conventional blade laryngoscopy with video-assisted blade laryngoscopy and the GlideScope. Eur J Anaesthesiol (2010) 1.08
Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling. PLoS One (2009) 1.08
Postresuscitation care with mild therapeutic hypothermia and coronary intervention after out-of-hospital cardiopulmonary resuscitation: a prospective registry analysis. Crit Care (2011) 1.08
Entry and distribution of microglial cells in human embryonic and fetal cerebral cortex. J Neuropathol Exp Neurol (2007) 1.08
Molecular mechanisms of neonatal brain injury. Neurol Res Int (2012) 1.07
Deficiency or blockade of angiotensin II type 2 receptor delays tumorigenesis by inhibiting malignant cell proliferation and angiogenesis. Int J Cancer (2010) 1.07
Sevoflurane but not propofol preserves myocardial function during minimally invasive direct coronary artery bypass surgery. Anesth Analg (2005) 1.07
Multicenter randomized comparison of xenon and isoflurane on left ventricular function in patients undergoing elective surgery. Anesthesiology (2007) 1.07
alpha2-adrenergic receptor subtypes - novel functions uncovered in gene-targeted mouse models. Biol Cell (2004) 1.07
Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Anesthesiology (2013) 1.07
Early microglial colonization of the human forebrain and possible involvement in periventricular white-matter injury of preterm infants. J Anat (2010) 1.06
Stem cell therapy for neonatal brain injury: perspectives and challenges. Ann Neurol (2011) 1.05
Effect of the AutoPulse automated band chest compression device on hemodynamics in out-of-hospital cardiac arrest resuscitation. Intensive Care Med (2010) 1.05
Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation (2011) 1.04
Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy. Am J Physiol Heart Circ Physiol (2003) 1.04