Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma.

PubWeight™: 1.22‹?› | Rank: Top 10%

🔗 View Article (PMC 2556972)

Published in Carcinogenesis on February 28, 2008

Authors

Hildegard M Schuller1, Hussein A N Al-Wadei, Mourad Majidi

Author Affiliations

1: Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA. hmsch@utk.edu

Articles citing this

Is cancer triggered by altered signalling of nicotinic acetylcholine receptors? Nat Rev Cancer (2009) 2.92

Social stress promotes and γ-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer. Cancer Prev Res (Phila) (2011) 1.61

Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter gamma-aminobutyric acid. Carcinogenesis (2009) 1.21

Nerve-cancer interactions in the stromal biology of pancreatic cancer. Front Physiol (2012) 1.18

Enhanced expression of G-protein coupled estrogen receptor (GPER/GPR30) in lung cancer. BMC Cancer (2012) 1.09

Prenatal nicotine exposure increases GABA signaling and mucin expression in airway epithelium. Am J Respir Cell Mol Biol (2010) 1.07

Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention. Carcinogenesis (2011) 1.02

Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas. J Pathol (2009) 1.00

Epigenetic effects and molecular mechanisms of tumorigenesis induced by cigarette smoke: an overview. J Oncol (2011) 0.93

Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN. Cancers (Basel) (2014) 0.93

Production of gamma-aminobutyric acid by Lactobacillus brevis NCL912 using fed-batch fermentation. Microb Cell Fact (2010) 0.92

Effects of chronic nicotine on the autocrine regulation of pancreatic cancer cells and pancreatic duct epithelial cells by stimulatory and inhibitory neurotransmitters. Carcinogenesis (2012) 0.92

Expression of gamma-aminobutyric acid receptors on neoplastic growth and prediction of prognosis in non-small cell lung cancer. J Transl Med (2013) 0.91

Cooperative regulation of non-small cell lung carcinoma by nicotinic and beta-adrenergic receptors: a novel target for intervention. PLoS One (2012) 0.91

Endogenous Voltage Potentials and the Microenvironment: Bioelectric Signals that Reveal, Induce and Normalize Cancer. J Clin Exp Oncol (2013) 0.90

Enhancement of γ-aminobutyric acid production in recombinant Corynebacterium glutamicum by co-expressing two glutamate decarboxylase genes from Lactobacillus brevis. J Ind Microbiol Biotechnol (2013) 0.89

Lung carcinoma signaling pathways activated by smoking. Chin J Cancer (2011) 0.87

Suppression of Human Liver Cancer Cell Migration and Invasion via the GABAA Receptor. Cancer Biol Med (2012) 0.84

GABAB receptor complex as a potential target for tumor therapy. J Histochem Cytochem (2012) 0.82

Effects of tobacco constituents and psychological stress on the beta-adrenergic regulation of non-small cell lung cancer and pancreatic cancer: implications for intervention. Cancer Biomark (2013) 0.81

GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: implications for proliferation. IUBMB Life (2009) 0.81

Acetylcholine receptor pathway in lung cancer: New twists to an old story. World J Clin Oncol (2014) 0.80

The Oncogenic Functions of Nicotinic Acetylcholine Receptors. J Oncol (2016) 0.80

GABA receptor ameliorates ventilator-induced lung injury in rats by improving alveolar fluid clearance. Crit Care (2012) 0.78

GABAergic signaling in the pulmonary neuroepithelial body microenvironment: functional imaging in GAD67-GFP mice. Histochem Cell Biol (2013) 0.78

Beta-adrenergic signaling in the development and progression of pulmonary and pancreatic adenocarcinoma. Curr Cancer Ther Rev (2012) 0.77

Differential modulation of nicotine-induced gemcitabine resistance by GABA receptor agonists in pancreatic cancer cell xenografts and in vitro. BMC Cancer (2014) 0.77

Molecular analysis of the glutamate decarboxylase locus in Streptococcus thermophilus ST110. J Ind Microbiol Biotechnol (2012) 0.77

First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development. J Biomed Nanotechnol (2016) 0.77

Galectin-3-independent Down-regulation of GABABR1 due to Treatment with Korean Herbal Extract HAD-B Reduces Proliferation of Human Colon Cancer Cells. J Pharmacopuncture (2012) 0.77

Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice. Int J Endocrinol (2015) 0.75

Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device. BMC Cancer (2017) 0.75

Regulation of nonsmall-cell lung cancer stem cell like cells by neurotransmitters and opioid peptides. Int J Cancer (2015) 0.75

Articles cited by this

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science (2004) 61.56

Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A (2001) 17.36

International lung cancer trends by histologic type: male:female differences diminishing and adenocarcinoma rates rising. Int J Cancer (2005) 3.81

Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res (2006) 3.58

Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res (2004) 3.43

The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers. Int J Cancer (2006) 2.67

Environmental and chemical carcinogenesis. Semin Cancer Biol (2004) 2.50

Establishment of human peripheral lung epithelial cell lines (HPL1) retaining differentiated characteristics and responsiveness to epidermal growth factor, hepatocyte growth factor, and transforming growth factor beta1. Cancer Res (1997) 2.22

Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers. Cancer Res (2001) 2.08

The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem Biophys Res Commun (2004) 2.05

Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells. Breast Cancer Res Treat (2003) 1.93

Cigarette smoking: cancer risks, carcinogens, and mechanisms. Langenbecks Arch Surg (2006) 1.67

The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid. Cancer Res (1999) 1.60

Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int J Cancer (2004) 1.55

NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells. Int J Cancer (2006) 1.41

Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies. Cancer Res (2007) 1.41

GABA B receptor is a novel drug target for pancreatic cancer. Cancer (2008) 1.39

Sex, GABA, and nicotine: the impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy. Biol Psychiatry (2005) 1.33

Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit. Cancer Res (2007) 1.33

Effects of germinated brown rice extracts with enhanced levels of GABA on cancer cell proliferation and apoptosis. J Med Food (2004) 1.32

The neurotransmitter gamma-aminobutyric acid is an inhibitory regulator for the migration of SW 480 colon carcinoma cells. Cancer Res (2002) 1.31

Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. Toxicol Sci (2006) 1.27

Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters. J Cancer Res Clin Oncol (2000) 1.25

Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells. Cancer Res (2007) 1.18

Functional expression of the GABAB receptor in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2006) 1.14

Overexpressed Raf-1 and phosphorylated cyclic adenosine 3'-5'-monophosphatate response element-binding protein are early markers for lung adenocarcinoma. Cancer (2007) 1.05

GABAB receptors in the lung. Trends Pharmacol Sci (1993) 1.04

The peripheral GABAergic system as a target in endocrine disorders. Auton Neurosci (2005) 1.04

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors. Cancer Res (2005) 1.01

NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways. Lung Cancer (2005) 1.00

GABA content and GAD activity in colon tumors taken from patients with colon cancer or from xenografted human colon cancer cells growing as s.c. tumors in athymic nu/nu mice. J Physiol Pharmacol (1998) 0.98

Smoking and lung cancer--a new role for an old toxicant? Proc Natl Acad Sci U S A (2006) 0.97

Functional expression of metabotropic GABAB receptors in primary cultures of astrocytes from rat cerebral cortex. Biochem Biophys Res Commun (2006) 0.91

Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase. J Biol Chem (2005) 0.88

[History and the present of metabotropic GABAB receptor]. Cesk Fysiol (2004) 0.83

Analysis of cell type and radiographic presentation as predictors of the clinical course of patients with bronchioalveolar cell carcinoma. Chest (1998) 0.77

Articles by these authors

Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review. Eur J Cancer (2002) 3.74

Nitrosamines as nicotinic receptor ligands. Life Sci (2007) 1.45

GABA B receptor is a novel drug target for pancreatic cancer. Cancer (2008) 1.39

Neurotransmission and cancer: implications for prevention and therapy. Anticancer Drugs (2008) 1.20

Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors α3, α5, and α7. Mol Cancer Res (2011) 1.11

Overexpressed Raf-1 and phosphorylated cyclic adenosine 3'-5'-monophosphatate response element-binding protein are early markers for lung adenocarcinoma. Cancer (2007) 1.05

Keratin expression in schwannoma; a study of 115 retroperitoneal and 22 peripheral schwannomas. Mod Pathol (2006) 1.04

Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention. Carcinogenesis (2011) 1.02

NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways. Lung Cancer (2005) 1.00

Neurotransmitter receptor-mediated signaling pathways as modulators of carcinogenesis. Prog Exp Tumor Res (2007) 0.94

KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer. Cancer Res (2013) 0.93

Effects of chronic nicotine on the autocrine regulation of pancreatic cancer cells and pancreatic duct epithelial cells by stimulatory and inhibitory neurotransmitters. Carcinogenesis (2012) 0.92

The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner. PLoS One (2013) 0.85

Regulatory role of the α7nAChR in cancer. Curr Drug Targets (2012) 0.85

Low concentrations of beta-carotene stimulate the proliferation of human pancreatic duct epithelial cells in a PKA-dependent manner. Cancer Genomics Proteomics (2007) 0.81

Apparent KIT Ser(715) deletion in GIST mRNA is not detectable in genomic DNA and represents a previously known splice variant of KIT transcript. Am J Pathol (2002) 0.80

Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia. Cancer Prev Res (Phila) (2012) 0.79

Pulmonary fibroblasts stimulate the proliferation of cell lines from human lung adenocarcinomas. Anticancer Drugs (2006) 0.79

Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenocarcinomas in Syrian golden hamsters contain beta 2-adrenergic receptor single-nucleotide polymorphisms. Genes Chromosomes Cancer (2005) 0.78

Chronic nicotine inhibits the therapeutic effects of gemcitabine on pancreatic cancer in vitro and in mouse xenografts. Eur J Cancer (2012) 0.78

Beta-adrenergic signaling in the development and progression of pulmonary and pancreatic adenocarcinoma. Curr Cancer Ther Rev (2012) 0.77