Published in J Med Chem on March 05, 2008
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First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem (2010) 1.74
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Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism. PLoS One (2011) 1.22
Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy. Antimicrob Agents Chemother (2008) 1.21
Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes. Circulation (2008) 1.20
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Bulky chiral carbene ligands and their application in the palladium-catalyzed asymmetric intramolecular alpha-arylation of amides. Angew Chem Int Ed Engl (2007) 1.05
NH2-MIL-53(Al): a high-contrast reversible solid-state nonlinear optical switch. J Am Chem Soc (2012) 1.03
Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1. Biochemistry (2009) 1.02
Progranulin antibodies in autoimmune diseases. J Autoimmun (2012) 0.98
Autoantigen, innate immunity, and T cells cooperate to break B cell tolerance during bacterial infection. J Clin Invest (2005) 0.97
NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis. J Biol Chem (2010) 0.96
Current state and future directions of autologous hematopoietic stem cell transplantation in systemic lupus erythematosus. Ann Rheum Dis (2011) 0.96
Peripheral B cell abnormalities in patients with systemic lupus erythematosus in quiescent phase: decreased memory B cells and membrane CD19 expression. J Autoimmun (2009) 0.96
Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors. Bioorg Med Chem (2011) 0.96
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Synthesis of 2-substituted benzofurans and indoles using functionalized titanium benzylidene reagents on solid phase. J Org Chem (2003) 0.92
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Enantioselective organocatalytic conjugate addition of aldehydes to vinyl sulfones and vinyl phosphonates as challenging Michael acceptors. Chemistry (2009) 0.92
Transduction of dendritic cells by antigen-encoding lentiviral vectors permits antigen processing and MHC class I-dependent presentation. J Allergy Clin Immunol (2002) 0.91
Multistep N2 breathing in the metal-organic framework co(1,4-benzenedipyrazolate). J Am Chem Soc (2010) 0.90
Self-assembly of a trinuclear luminescent europium complex. Chemistry (2009) 0.90
The first enantiomerically pure helical noncovalent tripod for assembling nine-coordinate lanthanide(III) podates. Inorg Chem (2004) 0.90
B cell signature during inactive systemic lupus is heterogeneous: toward a biological dissection of lupus. PLoS One (2011) 0.90
Glycosaminoglycan analogs as a novel anti-inflammatory strategy. Front Immunol (2012) 0.89
A homogeneous 384-well high-throughput binding assay for a TNF receptor using alphascreen technology. J Biomol Screen (2003) 0.89
Single crystal X-ray diffraction studies of carbon dioxide and fuel-related gases adsorbed on the small pore scandium terephthalate metal organic framework, Sc2(O2CC6H4CO2)3. Langmuir (2009) 0.89
Electron-deficient and polycenter bonds in the high-pressure γ-B28 phase of boron. Phys Rev Lett (2011) 0.89
How hydration drastically improves adsorption selectivity for CO(2) over CH(4) in the flexible chromium terephthalate MIL-53. Angew Chem Int Ed Engl (2006) 0.88
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A cellular assay for measuring the modulation of glucose production in H4IIE cells. Assay Drug Dev Technol (2006) 0.88
An iminoboronate construction set for subcomponent self-assembly. Chemistry (2008) 0.87
How linker's modification controls swelling properties of highly flexible iron(III) dicarboxylates MIL-88. J Am Chem Soc (2011) 0.86
Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity. J Med Chem (2008) 0.85
Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in Sézary syndrome: circumvention by hexameric soluble CD40L. Blood (2004) 0.85
LiZnSO4F made in an ionic liquid: a ceramic electrolyte composite for solid-state lithium batteries. Angew Chem Int Ed Engl (2011) 0.85
Injuries significantly associated with thoracic spine fractures: a case-control study. Emerg Med Australas (2008) 0.85
Previously undescribed pulpal and periodontal ligament calcifications in systemic sclerosis: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol (2013) 0.84
Influenza virus-induced type I interferon leads to polyclonal B-cell activation but does not break down B-cell tolerance. J Virol (2007) 0.84
The hydrophobic effect as a driving force in the self-assembly of a [2 x 2] copper(I) grid. Angew Chem Int Ed Engl (2004) 0.84
Rediscovery, isolation, and asymmetric reduction of 1,2,3,4-tetrahydronaphthalene-1,4-dione and studies of its [Cr(CO)3] complex. Angew Chem Int Ed Engl (2005) 0.84
Chemical substructures in drug discovery. Drug Discov Today (2003) 0.84
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The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway. J Allergy Clin Immunol (2002) 0.84
Prediction of the conditions for breathing of metal organic framework materials using a combination of X-ray powder diffraction, microcalorimetry, and molecular simulation. J Am Chem Soc (2008) 0.84
A role for membrane IgD in the tolerance of pathological human rheumatoid factor B cells. Eur J Immunol (2002) 0.83
Tuning the decay time of lanthanide-based near infrared luminescence from micro- to milliseconds through d-->f energy transfer in discrete heterobimetallic complexes. Chemistry (2005) 0.83
Human CD34+ CD11b- cord blood stem cells generate in vitro a CD34- CD11b+ subset that is enriched in langerin+ Langerhans dendritic cell precursors. Exp Hematol (2006) 0.83
The DRY motif as a molecular switch of the human oxytocin receptor. Biochemistry (2005) 0.83
Pathogenic antiphospholipid antibody: an antigen-selected needle in a haystack. Blood (2004) 0.83
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Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity. EMBO Mol Med (2012) 0.82
Preterm labour: an overview of current and emerging therapeutics. Curr Med Chem (2003) 0.82
Synthesis of planar five-connected nodal ligands. Chemistry (2009) 0.82
Memory B cells producing somatically mutated antiphospholipid antibodies are present in healthy individuals. Blood (2003) 0.82
A self-defence mechanism of astrocytes against Fas-mediated death involving interleukin-8 and CXCR2. Neuroreport (2002) 0.81
Iron and ruthenium Lewis acid catalyzed asymmetric 1,3-dipolar cycloaddition reactions between nitrones and enals. J Am Chem Soc (2002) 0.81
Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. J Med Chem (2011) 0.80
Self-sorting chiral subcomponent rearrangement during crystallization. J Am Chem Soc (2007) 0.80
Cognitive Dysfunction and Dementia in Primary Sjögren's Syndrome. ISRN Neurol (2013) 0.80