Published in Emerg Infect Dis on March 01, 2008
Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen. Nat Rev Microbiol (2009) 3.94
Development and validation of a real-time PCR for detection of pathogenic leptospira species in clinical materials. PLoS One (2009) 2.36
Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLoS Negl Trop Dis (2015) 1.93
Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil. Acta Trop (2008) 1.66
Leptospirosis in humans. Curr Top Microbiol Immunol (2015) 1.56
Outbreak of leptospirosis after flood, the Philippines, 2009. Emerg Infect Dis (2012) 1.49
Cathelicidin Insufficiency in Patients with Fatal Leptospirosis. PLoS Pathog (2016) 1.39
First isolation and direct evidence for the existence of large small-mammal reservoirs of Leptospira sp. in Madagascar. PLoS One (2010) 1.25
Genetic diversity of the Leptospiral immunoglobulin-like (Lig) genes in pathogenic Leptospira spp. Infect Genet Evol (2008) 1.21
Leptospiral pathogenomics. Pathogens (2014) 1.20
Risk factors and predictors of severe leptospirosis in New Caledonia. PLoS Negl Trop Dis (2013) 1.19
Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years. PLoS Negl Trop Dis (2015) 1.13
Genetic affinities within a large global collection of pathogenic Leptospira: implications for strain identification and molecular epidemiology. PLoS One (2010) 1.10
Infectious diseases causing diffuse alveolar hemorrhage in immunocompetent patients: a state-of-the-art review. Lung (2012) 1.10
Functional characterization of LcpA, a surface-exposed protein of Leptospira spp. that binds the human complement regulator C4BP. Infect Immun (2010) 1.08
Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the Leptospira agent. PLoS Negl Trop Dis (2014) 1.07
Leptospirosis: public health perspectives. Biologicals (2013) 1.05
Infections by Leptospira interrogans, Seoul virus, and Bartonella spp. among Norway rats (Rattus norvegicus) from the urban slum environment in Brazil. Vector Borne Zoonotic Dis (2013) 1.02
Immune evasion of leptospira species by acquisition of human complement regulator C4BP. Infect Immun (2008) 1.00
Influence of household rat infestation on leptospira transmission in the urban slum environment. PLoS Negl Trop Dis (2014) 0.99
Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis. PLoS Negl Trop Dis (2013) 0.98
Accuracy of a dual path platform (DPP) assay for the rapid point-of-care diagnosis of human leptospirosis. PLoS Negl Trop Dis (2012) 0.97
Patterns in Leptospira Shedding in Norway Rats (Rattus norvegicus) from Brazilian Slum Communities at High Risk of Disease Transmission. PLoS Negl Trop Dis (2015) 0.97
Potent innate immune response to pathogenic leptospira in human whole blood. PLoS One (2011) 0.97
Knowledge, attitudes, and practices related to Leptospirosis among urban slum residents in Brazil. Am J Trop Med Hyg (2012) 0.94
An imprint method for detecting leptospires in the hamster model of vaccine-mediated immunity for leptospirosis. J Med Microbiol (2009) 0.92
Characterization of the immunogenic and antigenic potential of putative lipoproteins from Leptospira interrogans. Curr Microbiol (2011) 0.91
Comparative analysis of severe pediatric and adult leptospirosis in Sao Paulo, Brazil. Am J Trop Med Hyg (2012) 0.90
Reverse-Transcriptase PCR Detection of Leptospira: Absence of Agreement with Single-Specimen Microscopic Agglutination Testing. PLoS One (2015) 0.86
Bioinformatics describes novel Loci for high resolution discrimination of leptospira isolates. PLoS One (2010) 0.86
Pulmonary involvement and leptospirosis, Greece. Emerg Infect Dis (2009) 0.86
Spatiotemporal Determinants of Urban Leptospirosis Transmission: Four-Year Prospective Cohort Study of Slum Residents in Brazil. PLoS Negl Trop Dis (2016) 0.85
Source tracking of human leptospirosis: serotyping and genotyping of Leptospira isolated from rodents in the epidemic area of Guizhou province, China. BMC Microbiol (2013) 0.84
Pathogenic Leptospira spp. in wild rodents, Canary Islands, Spain. Emerg Infect Dis (2011) 0.83
High sensitive PCR method for detection of pathogenic Leptospira spp. in paraffin-embedded tissues. Rev Inst Med Trop Sao Paulo (2014) 0.82
Mannosylated LigANI produced in Pichia pastoris protects hamsters against leptospirosis. Curr Microbiol (2013) 0.82
Severe Leptospira interrogans serovar Icterohaemorrhagiae infection with hepato-renal-pulmonary involvement treated with corticosteroids. Clin Case Rep (2014) 0.82
A prime-boost strategy using the novel vaccine candidate, LemA, protects hamsters against leptospirosis. Clin Vaccine Immunol (2013) 0.80
The emergence of severe pulmonary hemorrhagic leptospirosis: questions to consider. Front Cell Infect Microbiol (2012) 0.79
Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis. Am J Trop Med Hyg (2014) 0.79
Proteomic features predict seroreactivity against leptospiral antigens in leptospirosis patients. J Proteome Res (2014) 0.79
High yield expression of leptospirosis vaccine candidates LigA and LipL32 in the methylotrophic yeast Pichia pastoris. Microb Cell Fact (2010) 0.79
A novel flagellar sheath protein, FcpA, determines filament coiling, translational motility and virulence for the Leptospira spirochete. Mol Microbiol (2016) 0.79
Immunogenicity of a novel enhanced consensus DNA vaccine encoding the leptospiral protein LipL45. Hum Vaccin Immunother (2015) 0.79
An emerging pulmonary haemorrhagic syndrome in dogs: similar to the human leptospiral pulmonary haemorrhagic syndrome? Vet Med Int (2010) 0.79
Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor. Respir Res (2014) 0.79
Leptospira and inflammation. Mediators Inflamm (2012) 0.78
Evaluation of the use of selective PCR amplification of LPS biosynthesis genes for molecular typing of leptospira at the serovar level. Curr Microbiol (2010) 0.78
Highly virulent Leptospira borgpetersenii strain characterized in the hamster model. Am J Trop Med Hyg (2011) 0.77
Efficient Detection of Pathogenic Leptospires Using 16S Ribosomal RNA. PLoS One (2015) 0.76
Heterogenic colonization patterns by Leptospira interrogans in Rattus norvegicus from urban slums. Braz J Microbiol (2015) 0.76
DNA prime-protein boost based vaccination with a conserved region of leptospiral immunoglobulin-like A and B proteins enhances protection against leptospirosis. Mem Inst Oswaldo Cruz (2015) 0.76
Lipopolysaccharide Specific Immunochromatography Based Lateral Flow Assay for Serogroup Specific Diagnosis of Leptospirosis in India. PLoS One (2015) 0.76
Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation. Am J Trop Med Hyg (2015) 0.76
Reverse Vaccinology: An Approach for Identifying Leptospiral Vaccine Candidates. Int J Mol Sci (2017) 0.76
Comparison of Bacterial Burden and Cytokine Gene Expression in Golden Hamsters in Early Phase of Infection with Two Different Strains of Leptospira interrogans. PLoS One (2015) 0.76
Development of transcriptional fusions to assess Leptospira interrogans promoter activity. PLoS One (2011) 0.76
Evaluation of truncated LipL32 expressed by Escherichia coli and Pichia pastoris for serodiagnosis of Leptospira infection in rodents. J Vet Med Sci (2015) 0.75
Evaluation of the Leptospira interrogans Outer Membrane Protein OmpL37 as a Vaccine Candidate. PLoS One (2015) 0.75
Leptospirosis among the self-supporting convicts of Andaman Island during the 1920s--the first report on pulmonary haemorrhage in leptospirosis? Indian J Med Res (2015) 0.75
Characteristics of leptospirosis with systemic inflammatory response syndrome: a multicenter study. Ann Clin Microbiol Antimicrob (2015) 0.75
Determinants of mortality and impact of therapy in patients with leptospirosis admitted for intensive care in a Sri Lankan hospital - a three year retrospective study. Pathog Glob Health (2015) 0.75
A Universal Vaccine against Leptospirosis: Are We Going in the Right Direction? Front Immunol (2017) 0.75
Leptospirosis-Associated Severe Pulmonary Hemorrhagic Syndrome with Lower Back Pain as an Initial Symptom. Am J Case Rep (2016) 0.75
Efficacy of the Rabbit Polyclonal Anti-leptospira Antibody against Homotype or Heterotype Leptospira Infection in Hamster. PLoS Negl Trop Dis (2016) 0.75
Leptospire genomic diversity revealed by microarray-based comparative genomic hybridization. Appl Environ Microbiol (2012) 0.75
Lethal pulmonary hemorrhage syndrome due to Leptospira infection transmitted by pet rat. IDCases (2017) 0.75
Leptospirosis. Clin Microbiol Rev (2001) 18.25
Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study Group. Lancet (1999) 7.90
Leptospirosis. Curr Opin Infect Dis (2005) 5.34
Epidemic leptospirosis associated with pulmonary hemorrhage-Nicaragua, 1995. J Infect Dis (1998) 3.97
Clinical spectrum of pulmonary involvement in leptospirosis in a region of endemicity, with quantification of leptospiral burden. Clin Infect Dis (2005) 2.75
A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand. PLoS Negl Trop Dis (2007) 2.65
Acute lung injury in leptospirosis: clinical and laboratory features, outcome, and factors associated with mortality. Clin Infect Dis (1999) 2.63
Prognostic factors of death in leptospirosis: a prospective cohort study in Khon Kaen, Thailand. Int J Infect Dis (2002) 1.79
Pulmonary haemorrhage as a predominant cause of death in leptospirosis in Seychelles. Trans R Soc Trop Med Hyg (2000) 1.54
Identification of new repetitive element in Leptospira interrogans serovar copenhageni and its application to PCR-based differentiation of Leptospira serogroups. J Clin Microbiol (2001) 1.48
Outbreak of leptospirosis with pulmonary involvement in north Andaman. Indian J Med Res (1995) 1.46
Lung lesions in human leptospirosis: microscopic, immunohistochemical, and ultrastructural features related to thrombocytopenia. Am J Trop Med Hyg (1997) 1.31
Leptospirosis in Chonbuk Province of Korea in 1987: a study of 93 patients. Am J Trop Med Hyg (1989) 1.27
Evaluation of four whole-cell Leptospira-based serological tests for diagnosis of urban leptospirosis. Clin Vaccine Immunol (2007) 1.16
[Hemoptysis and the adult respiratory distress syndrome as the causes of death in leptospirosis. Changes in the clinical and anatomicopathological patterns]. Rev Soc Bras Med Trop (1993) 1.11
Leptospirosis. Curr Opin Infect Dis (2005) 5.34
Impact of environment and social gradient on Leptospira infection in urban slums. PLoS Negl Trop Dis (2008) 3.07
Slum health: diseases of neglected populations. BMC Int Health Hum Rights (2007) 2.59
Pathogenic Leptospira species express surface-exposed proteins belonging to the bacterial immunoglobulin superfamily. Mol Microbiol (2003) 2.53
Endemic malaria in the Peruvian Amazon region of Iquitos. Am J Trop Med Hyg (2003) 2.43
Outbreak of Exanthematous Illness Associated with Zika, Chikungunya, and Dengue Viruses, Salvador, Brazil. Emerg Infect Dis (2015) 2.33
Population-based case-control investigation of risk factors for leptospirosis during an urban epidemic. Am J Trop Med Hyg (2002) 2.15
Disseminated leishmaniasis: a new and emerging form of leishmaniasis observed in northeastern Brazil. J Infect Dis (2002) 2.06
The OmpA-like protein Loa22 is essential for leptospiral virulence. PLoS Pathog (2007) 1.93
Surfaceome of Leptospira spp. Infect Immun (2005) 1.90
Reproducibility of interferon gamma (IFN-γ) release Assays. A systematic review. Ann Am Thorac Soc (2014) 1.70
Household transmission of leptospira infection in urban slum communities. PLoS Negl Trop Dis (2008) 1.69
Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil. Acta Trop (2008) 1.66
The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis. Vaccine (2007) 1.49
Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans. Acta Trop (2007) 1.49
Targeted mutagenesis in pathogenic Leptospira species: disruption of the LigB gene does not affect virulence in animal models of leptospirosis. Infect Immun (2008) 1.46
Leptospira immunoglobulin-like proteins as a serodiagnostic marker for acute leptospirosis. J Clin Microbiol (2007) 1.44
Genome-wide transposon mutagenesis in pathogenic Leptospira species. Infect Immun (2008) 1.41
Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil. J Infect Dis (2002) 1.37
Major surface protein LipL32 is not required for either acute or chronic infection with Leptospira interrogans. Infect Immun (2008) 1.35
Characterization of virulence of Leptospira isolates in a hamster model. Vaccine (2008) 1.32
Rapid translocation of polarized MDCK cell monolayers by Leptospira interrogans, an invasive but nonintracellular pathogen. Infect Immun (2002) 1.29
Isolation of Leptospira noguchii from sheep. Vet Microbiol (2006) 1.28
Eschar-associated spotted fever rickettsiosis, Bahia, Brazil. Emerg Infect Dis (2011) 1.26
Genetic diversity of the Leptospiral immunoglobulin-like (Lig) genes in pathogenic Leptospira spp. Infect Genet Evol (2008) 1.21
Accuracy of real-time PCR, Gram stain and culture for Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae meningitis diagnosis. BMC Infect Dis (2013) 1.21
Haemophilus influenzae meningitis 5 years after introduction of the Haemophilus influenzae type b conjugate vaccine in Brazil. Vaccine (2007) 1.17
Evaluation of four whole-cell Leptospira-based serological tests for diagnosis of urban leptospirosis. Clin Vaccine Immunol (2007) 1.16
Moderate- and low-intensity co-infections by intestinal helminths and Schistosoma mansoni, dietary iron intake, and anemia in Brazilian children. Am J Trop Med Hyg (2006) 1.13
Time Lags between Exanthematous Illness Attributed to Zika Virus, Guillain-Barré Syndrome, and Microcephaly, Salvador, Brazil. Emerg Infect Dis (2016) 1.13
Distribution of the leptospiral immunoglobulin-like (lig) genes in pathogenic Leptospira species and application of ligB to typing leptospiral isolates. J Med Microbiol (2009) 1.11
Osmotic regulation of expression of two extracellular matrix-binding proteins and a haemolysin of Leptospira interrogans: differential effects on LigA and Sph2 extracellular release. Microbiology (2007) 1.10
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. Eur J Hum Genet (2008) 1.07
Prevalence of Streptococcus pneumoniae serotype 6C among invasive and carriage isolates in metropolitan Salvador, Brazil, from 1996 to 2007. Diagn Microbiol Infect Dis (2009) 1.07
High serum nitric oxide levels in patients with severe leptospirosis. Acta Trop (2007) 1.06
Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion. J Infect Dis (2010) 1.03
Infections by Leptospira interrogans, Seoul virus, and Bartonella spp. among Norway rats (Rattus norvegicus) from the urban slum environment in Brazil. Vector Borne Zoonotic Dis (2013) 1.02
NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis. Rheumatol Int (2008) 1.02
Schistosoma mansoni population structure and persistence after praziquantel treatment in two villages of Bahia, Brazil. Int J Parasitol (2011) 1.02
Identification of seroreactive proteins of Leptospira interrogans serovar copenhageni using a high-density protein microarray approach. PLoS Negl Trop Dis (2013) 1.01
Monitoring Leptospira strain collections: the need for quality control. Am J Trop Med Hyg (2010) 1.01
The multifunctional LigB adhesin binds homeostatic proteins with potential roles in cutaneous infection by pathogenic Leptospira interrogans. PLoS One (2011) 1.00
A stochastic model for ecological systems with strong nonlinear response to environmental drivers: application to two water-borne diseases. J R Soc Interface (2008) 1.00
Leptospira noguchii and human and animal leptospirosis, Southern Brazil. Emerg Infect Dis (2009) 1.00
Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin. BMC Microbiol (2011) 0.99
Transmission of Streptococcus pneumoniae in an urban slum community. J Infect (2008) 0.98
Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis. PLoS Negl Trop Dis (2013) 0.98
Accuracy of a dual path platform (DPP) assay for the rapid point-of-care diagnosis of human leptospirosis. PLoS Negl Trop Dis (2012) 0.97
Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes. J Med Microbiol (2010) 0.97
Emergence of Congenital Zika Syndrome: Viewpoint From the Front Lines. Ann Intern Med (2016) 0.96
Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae prior to introduction of the 10-valent pneumococcal conjugate vaccine in Brazil, 2000-2007. Vaccine (2010) 0.96
Reversal of renal tubule transporter downregulation during severe leptospirosis with antimicrobial therapy. Am J Trop Med Hyg (2007) 0.96
Population-based differences in Schistosoma mansoni- and hepatitis C-induced disease. J Infect Dis (2002) 0.96
Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease. Lipids Health Dis (2010) 0.95
Detection and modelling of case clusters for urban leptospirosis. Trop Med Int Health (2008) 0.95
Knowledge, attitudes, and practices related to Leptospirosis among urban slum residents in Brazil. Am J Trop Med Hyg (2012) 0.94
Prevalence of hepatitis C virus infection in north-eastern Brazil: a population-based study. Trans R Soc Trop Med Hyg (2005) 0.93
Population-based survey of antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae from meningitis patients in Salvador, Brazil. J Clin Microbiol (2002) 0.93
An imprint method for detecting leptospires in the hamster model of vaccine-mediated immunity for leptospirosis. J Med Microbiol (2009) 0.92
Urban population genetics of slum-dwelling rats (Rattus norvegicus) in Salvador, Brazil. Mol Ecol (2013) 0.91