| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2.
|
J Virol
|
2003
|
2.36
|
|
2
|
Autoreactive T cells in healthy individuals.
|
J Immunol
|
2004
|
2.29
|
|
3
|
Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus.
|
J Immunol
|
2008
|
2.21
|
|
4
|
Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination.
|
Cancer Res
|
2012
|
2.08
|
|
5
|
Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy.
|
J Allergy Clin Immunol
|
2011
|
2.04
|
|
6
|
High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.
|
J Virol
|
2007
|
2.01
|
|
7
|
Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects.
|
Diabetes
|
2002
|
2.01
|
|
8
|
Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma.
|
J Exp Med
|
2002
|
1.95
|
|
9
|
HLA class II-restricted CD4+ T cell responses directed against influenza viral antigens postinfluenza vaccination.
|
J Immunol
|
2003
|
1.69
|
|
10
|
Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide.
|
J Exp Med
|
2006
|
1.67
|
|
11
|
HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease.
|
J Clin Invest
|
2006
|
1.66
|
|
12
|
Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection.
|
J Virol
|
2008
|
1.63
|
|
13
|
Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus.
|
J Virol
|
2010
|
1.62
|
|
14
|
Autoreactive CD4(+) T cells in patients with atopic dermatitis.
|
J Allergy Clin Immunol
|
2011
|
1.61
|
|
15
|
Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.
|
J Immunol
|
2006
|
1.55
|
|
16
|
Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset.
|
PLoS Pathog
|
2013
|
1.54
|
|
17
|
Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis.
|
Hepatology
|
2010
|
1.51
|
|
18
|
Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence.
|
J Exp Med
|
2012
|
1.43
|
|
19
|
GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.
|
Diabetes
|
2004
|
1.41
|
|
20
|
Functional avidity directs T-cell fate in autoreactive CD4+ T cells.
|
Blood
|
2005
|
1.39
|
|
21
|
Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis.
|
Mol Immunol
|
2008
|
1.30
|
|
22
|
Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects.
|
J Autoimmun
|
2005
|
1.28
|
|
23
|
Multiplex mapping of CD4 T cell epitopes using class II tetramers.
|
Clin Immunol
|
2006
|
1.28
|
|
24
|
HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets.
|
Arthritis Rheum
|
2010
|
1.27
|
|
25
|
GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects.
|
J Autoimmun
|
2005
|
1.26
|
|
26
|
Direct ex vivo analysis of allergen-specific CD4+ T cells.
|
J Allergy Clin Immunol
|
2010
|
1.26
|
|
27
|
HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells.
|
Arthritis Rheum
|
2002
|
1.24
|
|
28
|
Direct killing of Epstein-Barr virus (EBV)-infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1.
|
Blood
|
2003
|
1.22
|
|
29
|
Low-avidity recognition by CD4+ T cells directed to self-antigens.
|
Eur J Immunol
|
2003
|
1.21
|
|
30
|
Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis.
|
Mol Immunol
|
2007
|
1.20
|
|
31
|
Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ).
|
J Immunol
|
2012
|
1.18
|
|
32
|
Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes.
|
Methods
|
2003
|
1.18
|
|
33
|
In vivo biotinylation of the major histocompatibility complex (MHC) class II/peptide complex by coexpression of BirA enzyme for the generation of MHC class II/tetramers.
|
Hum Immunol
|
2004
|
1.17
|
|
34
|
HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity.
|
PLoS Pathog
|
2010
|
1.17
|
|
35
|
Ara h 1-reactive T cells in individuals with peanut allergy.
|
J Allergy Clin Immunol
|
2011
|
1.15
|
|
36
|
CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope.
|
J Autoimmun
|
2008
|
1.15
|
|
37
|
Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.
|
Diabetes
|
2004
|
1.11
|
|
38
|
Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers.
|
Ann N Y Acad Sci
|
2003
|
1.10
|
|
39
|
Tetramer-guided epitope mapping reveals broad, individualized repertoires of tetanus toxin-specific CD4+ T cells and suggests HLA-based differences in epitope recognition.
|
Int Immunol
|
2007
|
1.07
|
|
40
|
HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term.
|
J Virol
|
2012
|
1.04
|
|
41
|
Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti-factor VIII immune responses.
|
Blood
|
2009
|
1.03
|
|
42
|
Extensive replicative capacity of human central memory T cells.
|
J Immunol
|
2004
|
1.02
|
|
43
|
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue.
|
PLoS Pathog
|
2011
|
1.02
|
|
44
|
Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance.
|
J Allergy Clin Immunol
|
2011
|
1.01
|
|
45
|
Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects.
|
Eur J Immunol
|
2009
|
1.01
|
|
46
|
Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.
|
J Immunol
|
2011
|
1.00
|
|
47
|
Allelic variation in key peptide-binding pockets discriminates between closely related diabetes-protective and diabetes-susceptible HLA-DQB1*06 alleles.
|
J Immunol
|
2006
|
1.00
|
|
48
|
Dominance and diversity in the primary human CD4 T cell response to replication-competent vaccinia virus.
|
J Immunol
|
2007
|
1.00
|
|
49
|
Expression of cutaneous lymphocyte-associated antigen and E-selectin ligand by circulating human memory CD4+ T lymphocytes specific for herpes simplex virus type 2.
|
J Infect Dis
|
2004
|
1.00
|
|
50
|
HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells.
|
Clin Immunol
|
2003
|
0.99
|
|
51
|
HLA class II peptide-binding and autoimmunity.
|
Tissue Antigens
|
2002
|
0.98
|
|
52
|
HLA class II polymorphisms determine responses to bacterial superantigens.
|
J Immunol
|
2004
|
0.98
|
|
53
|
Allergen-specific MHC class II tetramer+ cells are detectable in allergic, but not in nonallergic, individuals.
|
J Immunol
|
2006
|
0.97
|
|
54
|
Allergen-specific naïve and memory CD4+ T cells exhibit functional and phenotypic differences between individuals with or without allergy.
|
Eur J Immunol
|
2010
|
0.96
|
|
55
|
The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells.
|
Eur J Immunol
|
2005
|
0.96
|
|
56
|
Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis.
|
Arthritis Rheum
|
2002
|
0.95
|
|
57
|
Virologic and immunologic evidence of multifocal genital herpes simplex virus 2 infection.
|
J Virol
|
2014
|
0.95
|
|
58
|
Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers.
|
J Immunol
|
2006
|
0.94
|
|
59
|
Mutational analysis of critical residues determining antigen presentation and activation of HLA-DQ0602 restricted T-cell clones.
|
Hum Immunol
|
2002
|
0.94
|
|
60
|
Tumor antigen-specific FOXP3+ CD4 T cells identified in human metastatic melanoma: peptide vaccination results in selective expansion of Th1-like counterparts.
|
Cancer Res
|
2009
|
0.93
|
|
61
|
CD4+ T cells recognize unique and conserved 2009 H1N1 influenza hemagglutinin epitopes after natural infection and vaccination.
|
Int Immunol
|
2013
|
0.92
|
|
62
|
P53(110-124)-specific human CD4+ T-helper cells enhance in vitro generation and antitumor function of tumor-reactive CD8+ T cells.
|
Cancer Res
|
2003
|
0.92
|
|
63
|
Decline in the frequencies of Borrelia burgdorferi OspA161 175-specific T cells after antibiotic therapy in HLA-DRB1*0401-positive patients with antibiotic-responsive or antibiotic-refractory lyme arthritis.
|
J Immunol
|
2007
|
0.92
|
|
64
|
Defining antigen-specific responses with human MHC class II tetramers.
|
J Allergy Clin Immunol
|
2002
|
0.92
|
|
65
|
Yellow fever vaccination elicits broad functional CD4+ T cell responses that recognize structural and nonstructural proteins.
|
J Virol
|
2013
|
0.89
|
|
66
|
The binding of antigenic peptides to HLA-DR is influenced by interactions between pocket 6 and pocket 9.
|
J Immunol
|
2009
|
0.88
|
|
67
|
Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells.
|
J Immunol
|
2011
|
0.88
|
|
68
|
CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring.
|
Immunology
|
2013
|
0.87
|
|
69
|
Reassessing the role of HLA-DRB3 T-cell responses: evidence for significant expression and complementary antigen presentation.
|
Eur J Immunol
|
2010
|
0.87
|
|
70
|
Definition of the peptide binding motif within DRB1*1401 restricted epitopes by peptide competition and structural modeling.
|
Mol Immunol
|
2008
|
0.86
|
|
71
|
Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+ memory T cells.
|
Eur J Immunol
|
2010
|
0.86
|
|
72
|
Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection.
|
J Virol
|
2011
|
0.85
|
|
73
|
Clustering of T cell ligands on artificial APC membranes influences T cell activation and protein kinase C theta translocation to the T cell plasma membrane.
|
J Immunol
|
2005
|
0.85
|
|
74
|
H5N1 strain-specific hemagglutinin CD4+ T cell epitopes restricted by HLA DR4.
|
Vaccine
|
2009
|
0.85
|
|
75
|
Characterization of CD4+ T cell subsets in allergy.
|
Curr Opin Immunol
|
2012
|
0.85
|
|
76
|
Detection of low avidity desmoglein 3-reactive T cells in pemphigus vulgaris using HLA-DR beta 1*0402 tetramers.
|
Clin Immunol
|
2006
|
0.85
|
|
77
|
Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation.
|
Thorax
|
2013
|
0.83
|
|
78
|
Expression of HLA-DP0401 molecules for identification of DP0401 restricted antigen specific T cells.
|
J Clin Immunol
|
2005
|
0.83
|
|
79
|
Papillomavirus-specific CD4+ T cells exhibit reduced STAT-5 signaling and altered cytokine profiles in patients with recurrent respiratory papillomatosis.
|
J Immunol
|
2011
|
0.83
|
|
80
|
Peptide-MHC cellular microarray with innovative data analysis system for simultaneously detecting multiple CD4 T-cell responses.
|
PLoS One
|
2010
|
0.83
|
|
81
|
Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy.
|
J Allergy Clin Immunol
|
2007
|
0.83
|
|
82
|
Differential binding of pyruvate dehydrogenase complex-E2 epitopes by DRB1*08:01 and DRB1*11:01 Is predicted by their structural motifs and correlates with disease risk.
|
J Immunol
|
2013
|
0.82
|
|
83
|
Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.
|
J Autoimmun
|
2011
|
0.81
|
|
84
|
Differential antigen sensitivity and costimulatory requirements in human Th1 and Th2 antigen-specific CD4+ cells with similar TCR avidity.
|
J Immunol
|
2003
|
0.81
|
|
85
|
Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding.
|
J Neuroimmunol
|
2002
|
0.80
|
|
86
|
DRB1*12:01 presents a unique subset of epitopes by preferring aromatics in pocket 9.
|
Mol Immunol
|
2011
|
0.80
|
|
87
|
Low-affinity major histocompatibility complex-binding peptides in type 1 diabetes.
|
Diabetes
|
2008
|
0.79
|
|
88
|
Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells.
|
Int Immunol
|
2005
|
0.79
|
|
89
|
Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals.
|
Int Immunol
|
2008
|
0.79
|
|
90
|
Tracking antigen specific CD4+ T-cells with soluble MHC molecules.
|
Methods Mol Med
|
2007
|
0.78
|
|
91
|
CD8+ suppressor-mediated regulation of human CD4+ T cell responses to glutamic acid decarboxylase 65.
|
Eur J Immunol
|
2007
|
0.78
|
|
92
|
Cytotoxic herpes simplex type 2-specific, DQ0602-restricted CD4 T+-cell clones show alloreactivity to DQ0601.
|
Immunology
|
2006
|
0.77
|
|
93
|
Persistence of herpes simplex virus type 2 VP16-specific CD4+ T cells.
|
Hum Immunol
|
2005
|
0.77
|
|
94
|
Differential CD4+ T-cell responses of allergic and non-allergic subjects to the immunodominant epitope region of the horse major allergen Equ c 1.
|
Immunology
|
2014
|
0.76
|