Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons.

PubWeight™: 1.05‹?› | Rank: Top 15%

🔗 View Article (PMC 2413433)

Published in Neurobiol Dis on February 09, 2008

Authors

Da-Zhi Liu1, Xi-Yuan Cheng, Bradley P Ander, Huichun Xu, Ryan R Davis, Jeffrey P Gregg, Frank R Sharp

Author Affiliations

1: Department of Neurology, MIND Institute, Neuroscience and Genetics Graduate Programs, University of California at Davis, Sacramento, California 95817, USA. dzliu@ucdavis.edu

Articles citing this

Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab (2009) 2.85

Targeting protein kinases in central nervous system disorders. Nat Rev Drug Discov (2009) 1.45

Blood-brain barrier breakdown and repair by Src after thrombin-induced injury. Ann Neurol (2010) 1.26

Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice. J Neurosurg (2010) 1.06

PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice. Neurobiol Aging (2015) 1.02

Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice. Brain Behav Immun (2015) 0.98

Accelerated hemolysis and neurotoxicity in neuron-glia-blood clot co-cultures. J Neurochem (2010) 0.90

Systemic hemin therapy attenuates blood-brain barrier disruption after intracerebral hemorrhage. Neurobiol Dis (2014) 0.87

Inhibition of SRC family kinases protects hippocampal neurons and improves cognitive function after traumatic brain injury. J Neurotrauma (2014) 0.83

Neuroprotective effect of heme oxygenase-2 knockout in the blood injection model of intracerebral hemorrhage. BMC Res Notes (2014) 0.83

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity. J Biol Chem (2013) 0.82

Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of aberrant cell cycle diseases: an update. ScientificWorldJournal (2012) 0.81

Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of central nervous system diseases. Neurobiol Dis (2009) 0.80

PACAP38 protects rat cortical neurons against the neurotoxicity evoked by sodium nitroprusside and thrombin. Regul Pept (2008) 0.80

Intercellular cross-talk in intracerebral hemorrhage. Brain Res (2015) 0.79

Neuroprotective effects of argatroban and C5a receptor antagonist (PMX53) following intracerebral haemorrhage. Clin Exp Immunol (2014) 0.78

SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons. Neurotox Res (2015) 0.76

The Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage Looking at Mitochondria. Oxid Med Cell Longev (2016) 0.75

Src Family Kinases in Brain Edema After Acute Brain Injury. Acta Neurochir Suppl (2016) 0.75

Blood microRNAs as potential diagnostic markers for hemorrhagic stroke. Neural Regen Res (2017) 0.75

Articles cited by this

Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol (1997) 11.36

A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab (1990) 8.26

Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol (2006) 6.06

Risk factors for intracerebral hemorrhage in the general population: a systematic review. Stroke (2003) 3.56

A long twentieth century of the cell cycle and beyond. Cell (2000) 3.21

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell (2007) 3.12

Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer. Breast Cancer Res (2000) 2.14

Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc Natl Acad Sci U S A (2005) 2.10

Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron (2004) 1.99

Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. J Neurosci (2004) 1.94

Elevated body swing test: a new behavioral parameter for rats with 6-hydroxydopamine-induced hemiparkinsonism. J Neurosci (1995) 1.88

Cell cycle regulation of neuronal apoptosis in development and disease. Prog Neurobiol (2004) 1.75

Divide and die: cell cycle events as triggers of nerve cell death. J Neurosci (2004) 1.74

The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective? J Neurochem (2003) 1.69

Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination. Proc Natl Acad Sci U S A (1999) 1.63

Early detection of DNA strand breaks in the brain after transient focal ischemia: implications for the role of DNA damage in apoptosis and neuronal cell death. J Neurochem (1997) 1.57

Glutamate receptor blockade attenuates glucose hypermetabolism in perihematomal brain after experimental intracerebral hemorrhage in rat. Stroke (2004) 1.54

Cell cycle molecules and vertebrate neuron death: E2F at the hub. Cell Death Differ (2004) 1.51

Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci (1997) 1.45

Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia. Eur J Neurosci (2002) 1.37

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations. Proc Natl Acad Sci U S A (2000) 1.34

Neuronal apoptosis at the G1/S cell cycle checkpoint. Cell Tissue Res (2001) 1.33

Brain genomics of intracerebral hemorrhage. J Cereb Blood Flow Metab (2006) 1.30

Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path? Trends Neurosci (2001) 1.29

Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice. J Neurosci (2006) 1.25

Multiple functions of D-type cyclins can antagonize pRb-mediated suppression of proliferation. Cell Cycle (2005) 1.23

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. J Neurosci (1995) 1.22

Mitotic signaling by beta-amyloid causes neuronal death. FASEB J (1999) 1.21

Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists. Br J Pharmacol (2005) 1.20

Acute administration of Ginkgo biloba extract (EGb 761) affords neuroprotection against permanent and transient focal cerebral ischemia in Sprague-Dawley rats. J Neurosci Res (2002) 1.16

Genomic and functional profiling of duplicated chromosome 15 cell lines reveal regulatory alterations in UBE3A-associated ubiquitin-proteasome pathway processes. Hum Mol Genet (2006) 1.15

Src signaling regulates completion of abscission in cytokinesis through ERK/MAPK activation at the midbody. J Biol Chem (2006) 1.12

Thrombin signaling in the brain: the role of protease-activated receptors. Biol Chem (2003) 1.10

SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhage. Stroke (2007) 1.08

The cell cycle and c-Src. Curr Opin Genet Dev (1993) 1.06

Neuronal expression of cell cycle-related proteins after brain ischaemia in man. Neurosci Lett (2003) 0.99

Antiproliferative effects of Src inhibition on medullary thyroid cancer. J Clin Endocrinol Metab (2004) 0.96

Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons. J Neurochem (2007) 0.94

Signaling pathways involved in thrombin-induced cell protection. J Biol Chem (1998) 0.94

Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo. Neuroscience (2006) 0.93

Phosphorylation of retinoblastoma protein in rat brain after transient middle cerebral artery occlusion. Neuropathol Appl Neurobiol (2000) 0.89

Thrombin attenuation is neuroprotective in the injured rat optic nerve. J Neurochem (2001) 0.81

Cell cycle signaling by endothelin-1 requires Src nonreceptor protein tyrosine kinase. Mol Pharmacol (2005) 0.80

Evaluation of functional asymmetry in rats with dose-dependent lesions of dopaminergic nigrostriatal system using elevated body swing test. Physiol Behav (2004) 0.77

Thrombin preconditioning upregulates transferrin and transferrin receptor and reduces brain edema induced by lysed red blood cells. Acta Neurochir Suppl (2003) 0.77

Articles by these authors

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol (2008) 3.93

Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol (2006) 3.18

Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab (2009) 2.85

Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior. Clin Exp Metastasis (2005) 2.52

Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J Cereb Blood Flow Metab (2006) 2.20

Heme and iron metabolism: role in cerebral hemorrhage. J Cereb Blood Flow Metab (2003) 2.16

In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis. J Neurosci (2002) 2.12

Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. J Neurosci (2004) 1.94

Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain Behav Immun (2008) 1.79

Prediction of cardioembolic, arterial, and lacunar causes of cryptogenic stroke by gene expression and infarct location. Stroke (2012) 1.77

Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral blood. BMC Med Genomics (2009) 1.73

Gene expression profiling of blood for the prediction of ischemic stroke. Stroke (2010) 1.61

Gene expression changes in children with autism. Genomics (2007) 1.55

Glutamate receptor blockade attenuates glucose hypermetabolism in perihematomal brain after experimental intracerebral hemorrhage in rat. Stroke (2004) 1.54

Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J Biol Chem (2002) 1.52

Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia. J Neurochem (2002) 1.52

Validation: the new challenge for pathology. Toxicol Pathol (2004) 1.50

Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic stroke. J Cereb Blood Flow Metab (2008) 1.50

Signatures of cardioembolic and large-vessel ischemic stroke. Ann Neurol (2010) 1.50

EMT tumorigenesis in the mouse mammary gland. Lab Invest (2007) 1.47

Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling. Genes Dev (2004) 1.46

Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome. Genomics (2006) 1.39

Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ. Clin Cancer Res (2006) 1.39

Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia. Eur J Neurosci (2002) 1.37

In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia. Proc Natl Acad Sci U S A (2004) 1.37

Blood biomarkers of ischemic stroke. Neurotherapeutics (2011) 1.34

Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes. Mol Cancer Ther (2004) 1.33

Heterogeneity in the penumbra. J Cereb Blood Flow Metab (2011) 1.33

Genomics of the periinfarction cortex after focal cerebral ischemia. J Cereb Blood Flow Metab (2003) 1.32

Hypoxia preconditioning in the brain. Dev Neurosci (2005) 1.30

Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. Cancer Res (2006) 1.30

Brain genomics of intracerebral hemorrhage. J Cereb Blood Flow Metab (2006) 1.30

Molecular analysis of metastasis in a polyomavirus middle T mouse model: the role of osteopontin. Breast Cancer Res (2004) 1.27

Blood-brain barrier breakdown and repair by Src after thrombin-induced injury. Ann Neurol (2010) 1.26

Molecular alterations associated with LNCaP cell progression to androgen independence. Prostate (2004) 1.26

Utilization of lymphoblastoid cell lines as a system for the molecular modeling of autism. J Autism Dev Disord (2006) 1.26

Very brief focal ischemia simulating transient ischemic attacks (TIAs) can injure brain and induce Hsp70 protein. Brain Res (2008) 1.25

Blood expression profiles for tuberous sclerosis complex 2, neurofibromatosis type 1, and Down's syndrome. Ann Neurol (2004) 1.25

Empirical Bayes accomodation of batch-effects in microarray data using identical replicate reference samples: application to RNA expression profiling of blood from Duchenne muscular dystrophy patients. BMC Genomics (2008) 1.24

The future of genomic profiling of neurological diseases using blood. Arch Neurol (2006) 1.24

Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. J Neurosci (2003) 1.20

Effects of gender on gene expression in the blood of ischemic stroke patients. J Cereb Blood Flow Metab (2011) 1.20

Profiles of lacunar and nonlacunar stroke. Ann Neurol (2011) 1.19

Genomic and functional profiling of duplicated chromosome 15 cell lines reveal regulatory alterations in UBE3A-associated ubiquitin-proteasome pathway processes. Hum Mol Genet (2006) 1.15

Repeated cocaine administration induces gene expression changes through the dopamine D1 receptors. Neuropsychopharmacology (2005) 1.15

Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer. Proc Natl Acad Sci U S A (2013) 1.14

Bilirubin oxidation products (BOXes) and their role in cerebral vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metab (2006) 1.14

UGT1A1 is a major locus influencing bilirubin levels in African Americans. Eur J Hum Genet (2011) 1.14

Molecular characterization of the transition to malignancy in a genetically engineered mouse-based model of ductal carcinoma in situ. Mol Cancer Res (2004) 1.13

Molecular characterization of uterine fibroids and its implication for underlying mechanisms of pathogenesis. Fertil Steril (2004) 1.12

Blood gene expression profiling of neurologic diseases: a pilot microarray study. Arch Neurol (2005) 1.11

Blood genomic expression profile for neuronal injury. J Cereb Blood Flow Metab (2003) 1.10

SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhage. Stroke (2007) 1.08

Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1. Brain Res Mol Brain Res (2004) 1.08

Recombinant Fv-Hsp70 protein mediates neuroprotection after focal cerebral ischemia in rats. Stroke (2010) 1.08

Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes. J Immunol (2005) 1.07

The X-chromosome has a different pattern of gene expression in women compared with men with ischemic stroke. Stroke (2011) 1.05

Plasmodium falciparum gametocyte development 1 (Pfgdv1) and gametocytogenesis early gene identification and commitment to sexual development. PLoS Pathog (2012) 1.05

MeCP2 modulates gene expression pathways in astrocytes. Mol Autism (2013) 1.03

Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells. Prostate (2005) 1.02

Brief focal cerebral ischemia that simulates transient ischemic attacks in humans regulates gene expression in rat peripheral blood. J Cereb Blood Flow Metab (2009) 1.02

A subgroup of Tourette's patients overexpress specific natural killer cell genes in blood: a preliminary report. Am J Med Genet B Neuropsychiatr Genet (2007) 1.02

Are Underlying Assumptions of Current Animal Models of Human Stroke Correct: from STAIRs to High Hurdles? Transl Stroke Res (2011) 1.01

Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype. Cancer Res (2005) 1.01

Molecular markers and mechanisms of stroke: RNA studies of blood in animals and humans. J Cereb Blood Flow Metab (2011) 1.01

Reperfusion activates metalloproteinases that contribute to neurovascular injury. Exp Neurol (2007) 1.00

Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain. Stroke (2010) 0.99

Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ. Breast Cancer Res (2005) 0.98